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Jude Clancy, MD

Associate Professor Term; Director, Lead Management Program

Research Summary

I perform clinical trials at Yale related to the treatment and ablation of arrhythmias as well as new cardiac device implants. I also perform clinical and basic science research in the field of pacemaker and defibrillator lead management and extraction.

Extensive Research Description

I am actively involved in clinical and animal research in the field of lead extraction. This involves the research of venous biology which results in the adherence and fibrosis of pacemaker and defibrillator leads. We collect tissue from the devices we extract and are trying to elucidate the mechanisms of tissue fibrosis and binding of leads to cardiac structures. In addition we perform research in the field of pacemaker and ICD infections. This includes using electronic medical systems to identify infected patients, identifying high risk features of individuals with cardiac device infections, and developing algorithms for best practice management of these patients to optimize outcomes. I also perform animal research to look at lead and cardiac structure interaction in a porcine model. Specifically we are trying to develop an animal model with accelerated fibrosis of pacemaker and defibrillator leads. This would allow us to study the biology of lead fibrosis, train other physicians in the techniques of lead extraction and develop and evaluate extraction tools. I have developed a rescue balloon to be used in extraction cases if there is a tear of the SVC. This balloon's purpose is to stabilize the patient so surgical repair can be performed. I developed it in animals and further evaluated its safety and efficacy in a multicenter trial in which Yale was the primary center. It is now the only rescue tool in extraction and is being routinely used on an international level.

Coauthors

Research Interests

Clinical Trials as Topic; Investigative Techniques; Analytical, Diagnostic and Therapeutic Techniques and Equipment

Public Health Interests

Cardiovascular Diseases; Clinical Trials

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Selected Publications