Joshua VanHouten, PhD
Materials Assistant 3; Associate Director, MicroCT Facility, Yale Core Center for Musculoskeletal Disorders
Research & Publications
Biography
News
Locations
Coauthors
Selected Publications
- Cerebral arterial and ventricular morphology of the dogfish (Squalus acanthias), American bullfrog (Rana catesbeiana), and green iguana (Iguana iguana): Arterial high‐resolution micro‐CT, dissection, and radiography studyKier E, Conlogue G, VanHouten J. Cerebral arterial and ventricular morphology of the dogfish (Squalus acanthias), American bullfrog (Rana catesbeiana), and green iguana (Iguana iguana): Arterial high‐resolution micro‐CT, dissection, and radiography study. The Anatomical Record 2022, 306: 2015-2029. PMID: 35778853, DOI: 10.1002/ar.25028.
- HER2 signaling regulates HER2 localization and membrane retentionJeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ. HER2 signaling regulates HER2 localization and membrane retention. PLOS ONE 2017, 12: e0174849. PMID: 28369073, PMCID: PMC5378417, DOI: 10.1371/journal.pone.0174849.
- The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. Journal Of Biological Chemistry 2017, 292: 6555-6568. PMID: 28235801, PMCID: PMC5399107, DOI: 10.1074/jbc.m116.770883.
- Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related ProteinKim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein. Cancer Research 2016, 76: 5348-5360. PMID: 27450451, PMCID: PMC5026591, DOI: 10.1158/0008-5472.can-15-2614.
- Abstract 2859: Chloroquine and vitamin D3 modulate proliferation in early stage breast cancer modelsEspina V, Yeon S, VanHouten J, Wysolmerski J, Liotta L. Abstract 2859: Chloroquine and vitamin D3 modulate proliferation in early stage breast cancer models. Cancer Research 2016, 76: 2859-2859. DOI: 10.1158/1538-7445.am2016-2859.
- PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancerJeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e282-e290. PMID: 26729871, PMCID: PMC4725473, DOI: 10.1073/pnas.1516138113.
- OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium MetabolismArdeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156: 2762-2773. PMID: 25961842, PMCID: PMC4511126, DOI: 10.1210/en.2015-1232.
- Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP ProductionBoras-Granic K, Dann P, VanHouten J, Karaplis A, Wysolmerski J. Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production. PLOS ONE 2014, 9: e90418. PMID: 24785493, PMCID: PMC4006745, DOI: 10.1371/journal.pone.0090418.
- Evaluation of Cranial Bone Transport Distraction With and Without Adipose GraftingKoch FP, Yuhasz MM, Travieso R, Wong K, Clune J, Zhuang ZW, Van Houten J, Steinbacher DM. Evaluation of Cranial Bone Transport Distraction With and Without Adipose Grafting. Journal Of Craniofacial Surgery 2014, 25: 766-771. PMID: 24820707, DOI: 10.1097/scs.0000000000000769.
- Periosteal PTHrP regulates cortical bone modeling during linear growth in miceWang M, VanHouten JN, Nasiri AR, Tommasini SM, Broadus AE. Periosteal PTHrP regulates cortical bone modeling during linear growth in mice. Journal Of Anatomy 2014, 225: 71-82. PMID: 24762197, PMCID: PMC4073294, DOI: 10.1111/joa.12184.
- Comparing calvarial transport distraction with and without radiation and fat graftingYuhasz MM, Koch FP, Kwiatkowski A, Young C, Clune J, Travieso R, Wong K, Van Houten J, Steinbacher DM. Comparing calvarial transport distraction with and without radiation and fat grafting. Journal Of Cranio-Maxillofacial Surgery 2014, 42: 1412-1422. PMID: 24864072, DOI: 10.1016/j.jcms.2014.04.003.
- Abstract 57Yuhasz MM, Koch FP, Travieso R, Wong K, Clune J, Zhuang ZW, Van Houten J, Steinbacher DM. Abstract 57. Plastic & Reconstructive Surgery 2014, 133: 67. PMID: 25942168, DOI: 10.1097/01.prs.0000445090.53728.50.
- Chapter Seven Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In VivoScheller EL, Troiano N, VanHoutan JN, Bouxsein MA, Fretz JA, Xi Y, Nelson T, Katz G, Berry R, Church CD, Doucette CR, Rodeheffer MS, MacDougald OA, Rosen CJ, Horowitz MC. Chapter Seven Use of Osmium Tetroxide Staining with Microcomputerized Tomography to Visualize and Quantify Bone Marrow Adipose Tissue In Vivo. 2014, 537: 123-139. PMID: 24480344, PMCID: PMC4097010, DOI: 10.1016/b978-0-12-411619-1.00007-0.
- The remarkable migration of the medial collateral ligamentWang M, Nasiri A, VanHouten JN, Tommasini SM, Broadus AE. The remarkable migration of the medial collateral ligament. Journal Of Anatomy 2013, 224: 490-498. PMID: 24266550, PMCID: PMC3954274, DOI: 10.1111/joa.12145.
- Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium AccrualMamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual. Endocrinology 2013, 154: 3031-3042. PMID: 23782944, PMCID: PMC3749485, DOI: 10.1210/en.2012-2195.
- The calcium-sensing receptor in the breastVanHouten JN, Wysolmerski JJ. The calcium-sensing receptor in the breast. Best Practice & Research Clinical Endocrinology & Metabolism 2013, 27: 403-414. PMID: 23856268, PMCID: PMC3713417, DOI: 10.1016/j.beem.2013.02.011.
- PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growthWang M, VanHouten JN, Nasiri AR, Johnson RL, Broadus AE. PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth. Journal Of Bone And Mineral Research 2012, 28: 598-607. PMID: 23109045, PMCID: PMC3574208, DOI: 10.1002/jbmr.1801.
- Lactation and Neonatal Nutrition: Defining and Refining the Critical QuestionsNeville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions. Journal Of Mammary Gland Biology And Neoplasia 2012, 17: 167-188. PMID: 22752723, PMCID: PMC3428522, DOI: 10.1007/s10911-012-9261-5.
- Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowingFrey MA, Michaud M, VanHouten JN, Insogna KL, Madri JA, Barrett SE. Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5190-5195. PMID: 22431609, PMCID: PMC3325667, DOI: 10.1073/pnas.1117293109.
- Site‐specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in miceLiu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ. Site‐specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice. Journal Of Bone And Mineral Research 2011, 27: 865-875. PMID: 22189918, DOI: 10.1002/jbmr.1503.
- Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary GlandBoras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland. PLOS ONE 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.
- An Atypical Degenerative Osteoarthropathy in Hyp Mice is Characterized by a Loss in the Mineralized Zone of Articular CartilageLiang G, VanHouten J, Macica C. An Atypical Degenerative Osteoarthropathy in Hyp Mice is Characterized by a Loss in the Mineralized Zone of Articular Cartilage. Calcified Tissue International 2011, 89: 151-162. PMID: 21643724, DOI: 10.1007/s00223-011-9502-4.
- Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the SkeletonArdeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 5454-5454. DOI: 10.1210/jcem.95.12.9987.
- Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the SkeletonArdeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. Endocrinology 2010, 151: 5591-5601. PMID: 21047946, PMCID: PMC2999486, DOI: 10.1210/en.2010-0566.
- Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the SkeletonArdeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. Endocrine Reviews 2010, 31: 940-940. DOI: 10.1210/edrv.31.6.9976.
- PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancerVanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-11410. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.
- Does Increased Expression of the Plasma Membrane Calcium-ATPase Isoform 2 Confer Resistance to Apoptosis on Breast Cancer Cells?VanHouten J. Does Increased Expression of the Plasma Membrane Calcium-ATPase Isoform 2 Confer Resistance to Apoptosis on Breast Cancer Cells? 2008 DOI: 10.21236/ada493700.
- Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*. Journal Of Biological Chemistry 2008, 283: 24435-24447. PMID: 18621740, PMCID: PMC2528989, DOI: 10.1074/jbc.m801738200.
- Transcellular Calcium Transport in Mammary Epithelial CellsVanHouten JN, Wysolmerski JJ. Transcellular Calcium Transport in Mammary Epithelial Cells. Journal Of Mammary Gland Biology And Neoplasia 2007, 12: 223-235. PMID: 17999165, DOI: 10.1007/s10911-007-9057-1.
- The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into MilkVanHouten JN, Neville MC, Wysolmerski JJ. The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into Milk. Endocrinology 2007, 148: 5943-5954. PMID: 17823248, PMCID: PMC7108505, DOI: 10.1210/en.2007-0850.
- Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice.Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 2007, 148: 3875-86. PMID: 17495007, DOI: 10.1210/en.2006-1467.
- The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary glandArdeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2005, 38: 787-793. PMID: 16377269, DOI: 10.1016/j.bone.2005.11.009.
- Maternal calcium and bone metabolism during lactationVanHouten J. Maternal calcium and bone metabolism during lactation. Current Opinion In Endocrinology Diabetes And Obesity 2005, 12: 477-482. DOI: 10.1097/01.med.0000185780.49783.84.
- Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene.VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. The Journal Of Clinical Endocrinology & Metabolism 2005, 91: 580-3. PMID: 16263810, DOI: 10.1210/jc.2005-2095.
- Calcium Sensing by the Mammary GlandVanHouten JN. Calcium Sensing by the Mammary Gland. Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 129-139. PMID: 16025220, DOI: 10.1007/s10911-005-5396-y.
- Maternal calcium and bone metabolism during lactationVanHouten, Joshua N. Maternal calcium and bone metabolism during lactation. Current Opinion in Endocrinology & Diabetes: December 2005 - Volume 12 - Issue 6 - p 477-482 doi: 10.1097/01.med.0000185780.49783.84
- The calcium-sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transportVanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport. Journal Of Clinical Investigation 2004, 113: 598-608. PMID: 14966569, PMCID: PMC338258, DOI: 10.1172/jci18776.
- Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactationVanHouten J, Dann P, Stewart A, Watson C, Pollak M, Karaplis A, Wysolmerski J. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2004, 113: 492-492. DOI: 10.1172/jci19504c1.
- Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactationVanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2003, 112: 1429-1436. PMID: 14597768, PMCID: PMC228471, DOI: 10.1172/jci19504.
- Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice.VanHouten JN, Wysolmerski JJ. Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 2003, 144: 5521-9. PMID: 14500568, DOI: 10.1210/en.2003-0892.
- Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypesDunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ. Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. Journal Of Endocrinology 2001, 171: 403-416. PMID: 11739006, DOI: 10.1677/joe.0.1710403.
- Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomasVanHouten J, Asch H, Asch B. Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. Oncogene 2001, 20: 5366-5372. PMID: 11536049, DOI: 10.1038/sj.onc.1204701.
- Role of a Placenta-Specific Gene in Mammary TumorigenesisVanHouten J. Role of a Placenta-Specific Gene in Mammary Tumorigenesis. 1999 DOI: 10.21236/ada382827.
- Frequent ectopic expression of a placenta-specific gene at high levels in BALB/c mouse mammary carcinomas.VanHouten J, Natoli F, Asch B. Frequent ectopic expression of a placenta-specific gene at high levels in BALB/c mouse mammary carcinomas. Oncogene 1996, 12: 2241-5. PMID: 8668351.