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Joseph Craft, MD

Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Paul B. Beeson Professor of Medicine; Program Director, Investigative Medicine

Contact Information

Joseph Craft, MD

Mailing Address

  • Rheumatology

    PO Box 208031, 300 Cedar Street

    New Haven, CT 06520-8031

    United States

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Research Summary

Dr. Craft investigates CD4 T helper cells in conventional and autoimmune responses in mice and in humans, focusing upon differentiation and function of follicular helper T (Tfh) cells that promote B cell maturation. Tfh-cell dependent GC responses are critical for development of humoral immunity upon vaccine administration or infection, and for driving pathogenic autoreactive B cell responses in autoimmunity. Dr. Craft’s studies on Tfh cells build upon his earlier work in characterizing immune targets in lupus, and studies of tolerance, inflammation, and therapy. His lab also investigates other CD4 T cell populations, including those that promote immune memory and inflammation. Studies by individuals in his lab include those by graduate student Amanda Poholek, in collaboration with Shane Crotty and colleagues, demonstrated that the transcription factor Bcl6 is necessary and sufficient for Tfh-cell genesis. Postdoctoral fellow Jason Weinstein and MSTP student Edward Herman made the novel determination that Tfh cells spatially and temporally differentiate in the B cell follicle, steps necessary for B cell selection and plasma cell formation. Upon activation, CD4 T cells exhibit metabolic changes to meet their proliferative and effector needs, with the understanding of how metabolism is regulated in T helper (Th) 1 and Tfh cells incomplete. Work by grad students John Ray and Justin Shyer, with Matt Staron in Sue Kaech’s lab, was the first to decipher metabolic events that dictate Tfh-cell vs. Th1 cell development. Shyer and postdoctoral fellow Will Bailis in the Flavell lab at Yale subsequently used a CRISPR/Cas9 screen in primary T cells to reveal metabolic requirements for Th cell proliferation and effector function, a tool that will further aid identification of metabolic pathways needed for Tfh vs. Th1 differentiation.

Specialized Terms: T cell development, T cell differentiation and function, autoimmunity; lupus; tolerance

Extensive Research Description

Ongoing studies are targeted towards identification of the developmental pathways of CD4 T cells that provide B cell help and that promote inflammation, and dissection of their potential to promote autoimmunity and inflammation. Related work involves determination of tissue environmental factors that regulate T cell metabolism and effector function at inflammatory sites, such as tissues damaged in autoimmunity.

Coauthors

Research Interests

Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; Biology; Immunity; Lupus Erythematosus, Systemic; Investigative Techniques; Rheumatology; Cytokines

Selected Publications

  • Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells.Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE. Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells. Arthritis And Rheumatism 2010, 62: 1693-701. PMID: 20178121, PMCID: PMC2885535, DOI: 10.1002/art.27408.
  • An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 2011, 35: 792-805. PMID: 22118527, PMCID: PMC3431922, DOI: 10.1016/j.immuni.2011.09.017.
  • Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice.Look M, Stern E, Wang QA, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice. The Journal Of Clinical Investigation 2013, 123: 1741-9. PMID: 23454752, PMCID: PMC3613921, DOI: 10.1172/JCI65907.
  • CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity.Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity 2013, 39: 733-43. PMID: 24076051, PMCID: PMC3819035, DOI: 10.1016/j.immuni.2013.08.029.
  • Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells.Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity 2014, 40: 367-77. PMID: 24631156, PMCID: PMC3992517, DOI: 10.1016/j.immuni.2014.02.005.
  • B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen.Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J. B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. Journal Of Immunology (Baltimore, Md. : 1950) 2014, 192: 3166-79. PMID: 24610013, PMCID: PMC3991608, DOI: 10.4049/jimmunol.1302617.
  • Dynamic signaling by T follicular helper cells during germinal center B cell selection.Shulman Z, Gitlin AD, Weinstein JS, Lainez B, Esplugues E, Flavell RA, Craft JE, Nussenzweig MC. Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science (New York, N.Y.) 2014, 345: 1058-62. PMID: 25170154, PMCID: PMC4519234, DOI: 10.1126/science.1257861.
  • Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes.Weinstein JS, Lezon-Geyda K, Maksimova Y, Craft S, Zhang Y, Su M, Schulz VP, Craft J, Gallagher PG. Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes. Blood 2014, 124: 3719-29. PMID: 25331115, PMCID: PMC4263981, DOI: 10.1182/blood-2014-06-582700.
  • CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity 2014, 41: 633-45. PMID: 25308332, PMCID: PMC4324721, DOI: 10.1016/j.immuni.2014.09.007.
  • Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nature Immunology 2015, 16: 871-9. PMID: 26147684, PMCID: PMC4713030, DOI: 10.1038/ni.3224.
  • Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity.Choi JY, Ho JH, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Gonçalves CR, Costa PR, Kallas EG, Bonfa E, Craft J. Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity. Arthritis & Rheumatology (Hoboken, N.J.) 2015, 67: 988-99. PMID: 25581113, PMCID: PMC4450082, DOI: 10.1002/art.39020.
  • PTENtiating autoimmunity through Treg cell deregulation.Ray JP, Craft J. PTENtiating autoimmunity through Treg cell deregulation. Nature Immunology 2015, 16: 139-40. PMID: 25594458, PMCID: PMC4447107, DOI: 10.1038/ni.3082.
  • The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa.Marshall HD, Ray JP, Laidlaw BJ, Zhang N, Gawande D, Staron MM, Craft J, Kaech SM. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. ELife 2015, 4: e04851. PMID: 25569154, PMCID: PMC4337607, DOI: 10.7554/eLife.04851.
  • Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus.Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. Immunity 2015, 42: 552-65. PMID: 25786178, PMCID: PMC4456685, DOI: 10.1016/j.immuni.2015.02.015.
  • The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity 2015, 43: 690-702. PMID: 26410627, PMCID: PMC4618086, DOI: 10.1016/j.immuni.2015.08.017.
  • A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control.Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W. A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. Cell Reports 2015, 13: 1118-1124. PMID: 26527008, PMCID: PMC4859432, DOI: 10.1016/j.celrep.2015.09.069.
  • The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nature Reviews. Immunology 2016, 16: 102-11. PMID: 26781939, PMCID: PMC4860014, DOI: 10.1038/nri.2015.10.
  • TFH cells progressively differentiate to regulate the germinal center response.Weinstein JS, Herman EI, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. TFH cells progressively differentiate to regulate the germinal center response. Nature Immunology 2016, 17: 1197-1205. PMID: 27573866, PMCID: PMC5030190, DOI: 10.1038/ni.3554.
  • Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus.Choi JY, Seth A, Kashgarian M, Terrillon S, Fung E, Huang L, Wang LC, Craft J. Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus. Journal Of Immunology (Baltimore, Md. : 1950) 2017, 198: 2578-2588. PMID: 28219887, PMCID: PMC5360548, DOI: 10.4049/jimmunol.1601687.
  • STAT4 and T-bet control follicular helper T cell development in viral infections.Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. STAT4 and T-bet control follicular helper T cell development in viral infections. The Journal Of Experimental Medicine 2018, 215: 337-355. PMID: 29212666, PMCID: PMC5748849, DOI: 10.1084/jem.20170457.
  • Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs.Kim ST, Choi JY, Lainez B, Schulz VP, Karas DE, Baum ED, Setlur J, Gallagher PG, Craft J. Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs. Journal Of Immunology (Baltimore, Md. : 1950) 2018, 201: 1359-1372. PMID: 30030323, PMCID: PMC6112860, DOI: 10.4049/jimmunol.1701217.
  • Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection.Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W. Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection. Nature Communications 2018, 9: 5037. PMID: 30487586, PMCID: PMC6261948, DOI: 10.1038/s41467-018-07492-4.
  • scFTD-seq: freeze-thaw lysis based, portable approach toward highly distributed single-cell 3' mRNA profiling.Dura B, Choi JY, Zhang K, Damsky W, Thakral D, Bosenberg M, Craft J, Fan R. scFTD-seq: freeze-thaw lysis based, portable approach toward highly distributed single-cell 3' mRNA profiling. Nucleic Acids Research 2019, 47: e16. PMID: 30462277, PMCID: PMC6379653, DOI: 10.1093/nar/gky1173.
  • T follicular helper cell heterogeneity: Time, space, and function.Song W, Craft J. T follicular helper cell heterogeneity: Time, space, and function. Immunological Reviews 2019, 288: 85-96. PMID: 30874350, PMCID: PMC6422039, DOI: 10.1111/imr.12740.
  • Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature 2019, 571: 403-407. PMID: 31217581, PMCID: PMC6939459, DOI: 10.1038/s41586-019-1311-3.
  • Spatial and functional heterogeneity of follicular helper T cells in autoimmunity.Seth A, Craft J. Spatial and functional heterogeneity of follicular helper T cells in autoimmunity. Current Opinion In Immunology 2019, 61: 1-9. PMID: 31374450, PMCID: PMC7255639, DOI: 10.1016/j.coi.2019.06.005.
  • Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis.Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.
  • Characteristics of an established cell line of retinoblastoma.Reid TW, Albert DM, Rabson AS, Russell P, Craft J, Chu EW, Tralka TS, Wilcox JL. Characteristics of an established cell line of retinoblastoma. Journal Of The National Cancer Institute 1974, 53: 347-60. PMID: 4135597.
  • Ultrastructural description of a "cylinder organelle" in the outer plexiform layer of human retinas.Craft J, Albert DM, Reid TW. Ultrastructural description of a "cylinder organelle" in the outer plexiform layer of human retinas. Investigative Ophthalmology 1975, 14: 923-7. PMID: 1193806.
  • Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone mice.Peng SL, Cappadona J, McNiff JM, Madaio MP, Owen MJ, Hayday AC, Craft J. Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone mice. Clinical And Experimental Immunology 1998, 111: 107-16. PMID: 9472669, PMCID: PMC1904839, DOI: 10.1046/j.1365-2249.1998.00424.x.
  • Autoreactive T cells in murine lupus: origins and roles in autoantibody production.Craft J, Peng S, Fujii T, Okada M, Fatenejad S. Autoreactive T cells in murine lupus: origins and roles in autoantibody production. Immunologic Research 1999, 19: 245-57. PMID: 10493178, DOI: 10.1007/BF02786492.
  • Roles of Fas and Fas ligand during mammary gland remodeling.Song J, Sapi E, Brown W, Nilsen J, Tartaro K, Kacinski BM, Craft J, Naftolin F, Mor G. Roles of Fas and Fas ligand during mammary gland remodeling. The Journal Of Clinical Investigation 2000, 106: 1209-20. PMID: 11086022, PMCID: PMC381435, DOI: 10.1172/JCI10411.
  • Regulation of T cell-dependent autoantibody production by a gammadelta T cell line derived from lupus-prone mice.Fujii T, Okada M, Craft J. Regulation of T cell-dependent autoantibody production by a gammadelta T cell line derived from lupus-prone mice. Cellular Immunology 2002, 217: 23-35. PMID: 12425998, DOI: 10.1016/s0008-8749(02)00509-9.
  • Detection of anti-elongation factor 2 kinase (calmodulin-dependent protein kinase III) antibodies in patients with systemic lupus erythematosus.Arora S, Yang JM, Craft J, Hait W. Detection of anti-elongation factor 2 kinase (calmodulin-dependent protein kinase III) antibodies in patients with systemic lupus erythematosus. Biochemical And Biophysical Research Communications 2002, 293: 1073-6. PMID: 12051769, DOI: 10.1016/S0006-291X(02)00324-8.
  • IL-10 regulates murine lupus.Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 regulates murine lupus. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 169: 2148-55. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.
  • Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. The Journal Of Biological Chemistry 2002, 277: 35466-74. PMID: 12107190, DOI: 10.1074/jbc.M206395200.
  • T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells.Yin Z, Chen C, Szabo SJ, Glimcher LH, Ray A, Craft J. T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2002, 168: 1566-71. PMID: 11823483, DOI: 10.4049/jimmunol.168.4.1566.
  • Role of the H-2 haplotype in Fas-intact lupus-prone MRL mice: association with autoantibodies but not renal disease.Kong PL, Zhu T, Madaio MP, Craft J. Role of the H-2 haplotype in Fas-intact lupus-prone MRL mice: association with autoantibodies but not renal disease. Arthritis And Rheumatism 2003, 48: 2992-5. PMID: 14558109, DOI: 10.1002/art.11308.
  • Gamma delta T cells provide an early source of interferon gamma in tumor immunity.Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. Gamma delta T cells provide an early source of interferon gamma in tumor immunity. The Journal Of Experimental Medicine 2003, 198: 433-42. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.
  • CD4+ T cells from lupus-prone mice avoid antigen-specific tolerance induction in vivo.Bouzahzah F, Jung S, Craft J. CD4+ T cells from lupus-prone mice avoid antigen-specific tolerance induction in vivo. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 170: 741-8. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.
  • Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite.Ramsburg E, Tigelaar R, Craft J, Hayday A. Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite. The Journal Of Experimental Medicine 2003, 198: 1403-14. PMID: 14597739, PMCID: PMC2194243, DOI: 10.1084/jem.20030050.
  • IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection.Wang T, Scully E, Yin Z, Kim JH, Wang S, Yan J, Mamula M, Anderson JF, Craft J, Fikrig E. IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. Journal Of Immunology (Baltimore, Md. : 1950) 2003, 171: 2524-31. PMID: 12928402, DOI: 10.4049/jimmunol.171.5.2524.
  • Intrinsic T cell defects in systemic autoimmunity.Kong PL, Odegard JM, Bouzahzah F, Choi JY, Eardley LD, Zielinski CE, Craft JE. Intrinsic T cell defects in systemic autoimmunity. Annals Of The New York Academy Of Sciences 2003, 987: 60-7. PMID: 12727624, DOI: 10.1111/j.1749-6632.2003.tb06033.x.
  • STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1879-84. PMID: 12571365, PMCID: PMC149927, DOI: 10.1073/pnas.0237137100.
  • Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration.Gutting BW, Bouzahzah F, Kong PL, Updyke LW, Amacher DE, Craft J. Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration. Toxicology And Applied Pharmacology 2003, 189: 120-33. PMID: 12781630, DOI: 10.1016/s0041-008x(03)00091-7.
  • Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus.Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172: 1287-94. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.
  • Activation of naive CD4+ T cells in vivo by a self-peptide mimic: mechanism of tolerance maintenance and preservation of immunity.Choi JY, Craft J. Activation of naive CD4+ T cells in vivo by a self-peptide mimic: mechanism of tolerance maintenance and preservation of immunity. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172: 7399-407. PMID: 15187117, DOI: 10.4049/jimmunol.172.12.7399.
  • The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression.Kong PL, Morel L, Croker BP, Craft J. The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 172: 2785-94. PMID: 14978078, DOI: 10.4049/jimmunol.172.5.2785.
  • Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus.Park HB, Kim KC, Park JH, Kang TY, Lee HS, Kim TH, Jun JB, Bae SC, Yoo DH, Craft J, Jung S. Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus. The Journal Of Rheumatology 2004, 31: 2151-5. PMID: 15517626.
  • Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response.Pan M, Kang I, Craft J, Yin Z. Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response. Journal Of Clinical Immunology 2004, 24: 481-91. PMID: 15359107, DOI: 10.1023/B:JOCI.0000040919.16739.44.
  • Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine.Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine. Journal Of Immunology (Baltimore, Md. : 1950) 2004, 173: 673-81. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.
  • Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation.Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. Journal Of Immunology (Baltimore, Md. : 1950) 2005, 174: 5100-9. PMID: 15814741, DOI: 10.4049/jimmunol.174.8.5100.
  • Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice.Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. Journal Of Immunology (Baltimore, Md. : 1950) 2006, 177: 1825-32. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.
  • Abrogation of skin disease in LUPUS-prone MRL/FASlpr mice by means of a novel tylophorine analog.Choi JY, Gao W, Odegard J, Shiah HS, Kashgarian M, McNiff JM, Baker DC, Cheng YC, Craft J. Abrogation of skin disease in LUPUS-prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis And Rheumatism 2006, 54: 3277-83. PMID: 17009262, DOI: 10.1002/art.22119.
  • Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection.Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MS. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. Journal Of Virology 2006, 80: 5338-48. PMID: 16699014, PMCID: PMC1472130, DOI: 10.1128/JVI.00274-06.
  • Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells.Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. Journal Of Immunology (Baltimore, Md. : 1950) 2007, 178: 2730-6. PMID: 17312115, DOI: 10.4049/jimmunol.178.5.2730.
  • ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. The Journal Of Experimental Medicine 2008, 205: 2873-86. PMID: 18981236, PMCID: PMC2585848, DOI: 10.1084/jem.20080840.
  • Editing antigen presentation: antigen transfer between human B lymphocytes and macrophages mediated by class A scavenger receptors.Harvey BP, Quan TE, Rudenga BJ, Roman RM, Craft J, Mamula MJ. Editing antigen presentation: antigen transfer between human B lymphocytes and macrophages mediated by class A scavenger receptors. Journal Of Immunology (Baltimore, Md. : 1950) 2008, 181: 4043-51. PMID: 18768860, PMCID: PMC2701691, DOI: 10.4049/jimmunol.181.6.4043.
  • Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nature Immunology 2009, 10: 1125-32. PMID: 19734905, PMCID: PMC2751862, DOI: 10.1038/ni.1783.
  • Barrier immunity and IL-17.Marks BR, Craft J. Barrier immunity and IL-17. Seminars In Immunology 2009, 21: 164-71. PMID: 19386512, PMCID: PMC2692766, DOI: 10.1016/j.smim.2009.03.001.
  • Competing for help: new insights into the function of follicular helper T cells.Poholek AC, Craft J. Competing for help: new insights into the function of follicular helper T cells. Immunology And Cell Biology 2009, 87: 438-9. PMID: 19381158, PMCID: PMC3612525, DOI: 10.1038/icb.2009.26.
  • ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus. Journal Of Immunology (Baltimore, Md. : 1950) 2009, 182: 4076-84. PMID: 19299705, PMCID: PMC2746004, DOI: 10.4049/jimmunol.0800758.
  • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (New York, N.Y.) 2009, 325: 1006-10. PMID: 19608860, PMCID: PMC2766560, DOI: 10.1126/science.1175870.
  • Emerging from the shadows: follicular helper T cells in autoimmunity.DiPlacido LD, Craft J. Emerging from the shadows: follicular helper T cells in autoimmunity. Arthritis And Rheumatism 2010, 62: 6-8. PMID: 20039423, PMCID: PMC2806501, DOI: 10.1002/art.25045.
  • Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM. Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells. Self/nonself 2010, 1: 335-340. PMID: 21487509, PMCID: PMC3062389, DOI: 10.4161/self.1.4.13946.
  • Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus.Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: R53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.
  • Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin.He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185: 126-33. PMID: 20525896, PMCID: PMC3813958, DOI: 10.4049/jimmunol.0903767.
  • In vivo regulation of Bcl6 and T follicular helper cell development.Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. In vivo regulation of Bcl6 and T follicular helper cell development. Journal Of Immunology (Baltimore, Md. : 1950) 2010, 185: 313-26. PMID: 20519643, PMCID: PMC2891136, DOI: 10.4049/jimmunol.0904023.
  • Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Rα blockade.Gonzalez-Quintial R, Lawson BR, Scatizzi JC, Craft J, Kono DH, Baccala R, Theofilopoulos AN. Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Rα blockade. PloS One 2011, 6: e27528. PMID: 22102903, PMCID: PMC3213145, DOI: 10.1371/journal.pone.0027528.
  • Dissecting the immune cell mayhem that drives lupus pathogenesis.Craft JE. Dissecting the immune cell mayhem that drives lupus pathogenesis. Science Translational Medicine 2011, 3: 73ps9. PMID: 21389262, PMCID: PMC3694130, DOI: 10.1126/scitranslmed.3002138.
  • The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (New York, N.Y.) 2011, 332: 478-84. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.
  • Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection.Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity 2011, 35: 633-46. PMID: 22018471, PMCID: PMC3444169, DOI: 10.1016/j.immuni.2011.08.016.
  • T cells that promote B-Cell maturation in systemic autoimmunity.Weinstein JS, Hernandez SG, Craft J. T cells that promote B-Cell maturation in systemic autoimmunity. Immunological Reviews 2012, 247: 160-71. PMID: 22500839, PMCID: PMC3334351, DOI: 10.1111/j.1600-065X.2012.01122.x.
  • Follicular helper T cells in immunity and systemic autoimmunity.Craft JE. Follicular helper T cells in immunity and systemic autoimmunity. Nature Reviews. Rheumatology 2012, 8: 337-47. PMID: 22549246, PMCID: PMC3604997, DOI: 10.1038/nrrheum.2012.58.
  • IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. Journal Of Immunology (Baltimore, Md. : 1950) 2012, 188: 1656-67. PMID: 22231702, PMCID: PMC3618484, DOI: 10.4049/jimmunol.1003871.
  • IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.Kim JS, Cho BA, Sim JH, Shah K, Woo CM, Lee EB, Lee DS, Kang JS, Lee WJ, Park CG, Craft J, Kang I, Kim HR. IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus. Rheumatology (Oxford, England) 2012, 51: 1587-94. PMID: 22661557, PMCID: PMC3418646, DOI: 10.1093/rheumatology/kes100.
  • The pathogenesis of systemic lupus erythematosus-an update.Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus-an update. Current Opinion In Immunology 2012, 24: 651-7. PMID: 23131610, PMCID: PMC3508331, DOI: 10.1016/j.coi.2012.10.004.
  • Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens.Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis And Rheumatism 2012, 64: 1247-56. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.
  • Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells.Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 2013, 121: 1595-603. PMID: 23223361, PMCID: PMC3587322, DOI: 10.1182/blood-2012-09-457465.
  • Roquin paralogs add a new dimension to ICOS regulation.Bertino SA, Craft J. Roquin paralogs add a new dimension to ICOS regulation. Immunity 2013, 38: 624-6. PMID: 23601678, PMCID: PMC3786165, DOI: 10.1016/j.immuni.2013.03.007.
  • Transfer of antigen from human B cells to dendritic cells.Harvey BP, Raycroft MT, Quan TE, Rudenga BJ, Roman RM, Craft J, Mamula MJ. Transfer of antigen from human B cells to dendritic cells. Molecular Immunology 2014, 58: 56-65. PMID: 24309484, PMCID: PMC4234097, DOI: 10.1016/j.molimm.2013.10.013.
  • The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus.Look M, Saltzman WM, Craft J, Fahmy TM. The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus. Biomaterials 2014, 35: 1089-95. PMID: 24183697, PMCID: PMC4164020, DOI: 10.1016/j.biomaterials.2013.10.046.
  • PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation.Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM. PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation. PloS One 2014, 9: e99127. PMID: 24921943, PMCID: PMC4055678, DOI: 10.1371/journal.pone.0099127.
  • IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells.Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. Journal Of Immunology (Baltimore, Md. : 1950) 2015, 195: 5251-60. PMID: 26519529, PMCID: PMC4655158, DOI: 10.4049/jimmunol.1500777.
  • Reply: To PMID 25581113.Choi J, Craft J. Reply: To PMID 25581113. Arthritis & Rheumatology (Hoboken, N.J.) 2015, 67: 3094-5. PMID: 26245163, DOI: 10.1002/art.39290.
  • The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science (New York, N.Y.) 2016, 352: 99-103. PMID: 27034374, PMCID: PMC4935984, DOI: 10.1126/science.aaf1358.
  • Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science (New York, N.Y.) 2017, 356: 1072-1076. PMID: 28495875, PMCID: PMC5556699, DOI: 10.1126/science.aai8132.
  • Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response.Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Science Immunology 2017, 2 PMID: 29054998, PMCID: PMC5846620, DOI: 10.1126/sciimmunol.aan4767.
  • Correction: STAT4 and T-bet control follicular helper T cell development in viral infections.Weinstein JS, Laidlaw BJ, Lu Y, Wang JK, Schulz VP, Li N, Herman EI, Kaech SM, Gallagher PG, Craft J. Correction: STAT4 and T-bet control follicular helper T cell development in viral infections. The Journal Of Experimental Medicine 2018, 215: 999. PMID: 29440270, PMCID: PMC5839754, DOI: 10.1084/jem.2017045702062018c.
  • Identification of a T follicular helper cell subset that drives anaphylactic IgE.Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science (New York, N.Y.) 2019, 365 PMID: 31371561, PMCID: PMC6901029, DOI: 10.1126/science.aaw6433.
  • Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature 2019, 573: E2. PMID: 31447485, DOI: 10.1038/s41586-019-1490-y.
  • Georgia Abortion Law and Our Commitment to Patients.Craft JE, Crow MK, Diamond B, Elkon KB, Flood J, Fox DA, Gabriel SE, Gilkeson GS, Hahn BH, Hardin JA, Koopman WJ, Lockshin MD, Salmon JE, Seaman WE, Sergent JS, Uknis AB, Weinblatt ME, Wofsy D. Georgia Abortion Law and Our Commitment to Patients. Arthritis & Rheumatology (Hoboken, N.J.) 2020, 72: 377-378. PMID: 31637878, DOI: 10.1002/art.41143.

Clinical Trials

ConditionsStudy Title
Immune SystemYale Lupus and Connective Tissue Disease Bio-Repository / Yale Rheumatology Bio-Repository
Diseases of the Nervous System; Mental Health & Behavioral ResearchTeen Brain and Behavior Study
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