Joseph N. Contessa, MD, PhD
Professor of Therapeutic Radiology and of Pharmacology; Co-Leader, Radiobiology and Radiotherapy, Yale Cancer Center; Vice Chair for Basic Science Research, Therapeutic Radiology; Director, Central Nervous System Radiotherapy Program, Therapeutic Radiology
Research & Publications
Biography
News
Locations
Extensive Research Description
Therapeutic approaches for the treatment of EGFR and FGFR addicted lung cancer
Radiosensitization of malignant gliomas
Novel small molecule inhibitors of N-linked glycosylation
Molecular Imaging of the Epidermal Growth Factor Receptor
Drug Discovery and High Throughput Screening
Targeted therapy for head and neck squamous cell carcinoma
Coauthors
Research Interests
Neoplasms; Radiobiology; Chemicals and Drugs
Selected Publications
- Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity.Baro M, Lopez Sambrooks C, Quijano A, Saltzman WM, Contessa JN. Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2019, 25:784-795.
- Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Wei C, Greninger P, Egan RK, Patel AA, Benes CH, Saltzman WM, Contessa JN. Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors. Cancer Research 2018, 78:5094-5106.
- Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.Rinis N, Golden JE, Marceau CD, Carette JE, Van Zandt MC, Gilmore R, Contessa JN. Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors. Cell Chemical Biology 2018, 25:1231-1241.e4.
- Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nature Chemical Biology 2016, 12:1023-1030.
- A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity.Puschnik AS, Marceau CD, Ooi YS, Majzoub K, Rinis N, Contessa JN, Carette JE. A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity. Cell Reports 2017, 21:3032-3039.
- Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis.Johung KL, Yeh N, Desai NB, Williams TM, Lautenschlaeger T, Arvold ND, Ning MS, Attia A, Lovly CM, Goldberg S, Beal K, Yu JB, Kavanagh BD, Chiang VL, Camidge DR, Contessa JN. Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2016, 34:123-9.
- Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP. Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncology 2017, 3:827-831.