Joseph D. Deak, PhD
Associate Research Scientist
Research & Publications
Biography
News
Research Summary
Coauthors
Selected Publications
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implicationsLevey D, Galimberti M, Deak J, Wendt F, Bhattacharya A, Koller D, Harrington K, Quaden R, Johnson E, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal V, Empke S, Zhou H, Nunez Y, Kranzler H, Edenberg H, Agrawal A, Smoller J, Lencz T, Hougaard D, Børglum A, Demontis D, Gaziano J, Gandal M, Polimanti R, Stein M, Gelernter J. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nature Genetics 2023, 55: 2094-2103. PMID: 37985822, PMCID: PMC10703690, DOI: 10.1038/s41588-023-01563-z.
- T18. GENETIC CONTRIBUTION TO THE COMORBIDITY BETWEEN ATTENTION-DEFICIT HYPERACTIVITY DISORDER AND SUBSTANCE USE DISORDERSKoller D, Mitjans M, Kouakou M, Friligkou E, Mendoza B, Deak J, Pathak G, Kranzler H, Agrawal A, Corominas R, Demontis D, Gelernter J, Ribases M, Cormand B, Polimanti R. T18. GENETIC CONTRIBUTION TO THE COMORBIDITY BETWEEN ATTENTION-DEFICIT HYPERACTIVITY DISORDER AND SUBSTANCE USE DISORDERS. European Neuropsychopharmacology 2023, 75: s171. DOI: 10.1016/j.euroneuro.2023.08.306.
- 8. A CROSS-POPULATION GENOME-WIDE ASSOCIATION STUDY OF SLEEP DURATIONAustin-Zimmerman I, Levey D, Deak J, Galimberti M, Adhikari K, Zhou H, Di Forti M, Polimanti R, Stein M, Gelernter J. 8. A CROSS-POPULATION GENOME-WIDE ASSOCIATION STUDY OF SLEEP DURATION. European Neuropsychopharmacology 2023, 75: s60. DOI: 10.1016/j.euroneuro.2023.08.119.
- 79. A LARGE-SCALE GENOME-WIDE ASSOCIATION STUDY OF COCAINE USE DISORDERDeak J, Zhou H, Levey D, Galimberti M, Farajzadeh L, Hougaard D, Jennings M, Davis L, Sanchez-Roige S, Demontis D, Børglum A, Kranzler H, Gaziano M, Stein M, Gelernter J. 79. A LARGE-SCALE GENOME-WIDE ASSOCIATION STUDY OF COCAINE USE DISORDER. European Neuropsychopharmacology 2023, 75: s99. DOI: 10.1016/j.euroneuro.2023.08.184.
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep durationAustin-Zimmerman I, Levey D, Giannakopoulou O, Deak J, Galimberti M, Adhikari K, Zhou H, Denaxas S, Irizar H, Kuchenbaecker K, McQuillin A, Concato J, Buysse D, Gaziano J, Gottlieb D, Polimanti R, Stein M, Bramon E, Gelernter J. Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration. Nature Communications 2023, 14: 6059. PMID: 37770476, PMCID: PMC10539313, DOI: 10.1038/s41467-023-41249-y.
- Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) studyXu H, Toikumo S, Crist R, Glogowska K, Jinwala Z, Deak J, Justice A, Gelernter J, Johnson E, Kranzler H, Kember R. Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study. Addiction 2023, 118: 1942-1952. PMID: 37156939, PMCID: PMC10754226, DOI: 10.1111/add.16229.
- 3. Genetic Overlap and Causal Relationship Between Multisite Chronic Pain and Substance Use DisordersKoller D, Pathak G, Stiltner B, Levey D, Zhou H, Hatoum A, Deak J, Kranzler H, Agrawal A, Gelernter J, Polimanti R. 3. Genetic Overlap and Causal Relationship Between Multisite Chronic Pain and Substance Use Disorders. Biological Psychiatry 2023, 93: s94-s95. DOI: 10.1016/j.biopsych.2023.02.243.
- Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disordersHatoum A, Colbert S, Johnson E, Huggett S, Deak J, Pathak G, Jennings M, Paul S, Karcher N, Hansen I, Baranger D, Edwards A, Grotzinger A, Tucker-Drob E, Kranzler H, Davis L, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg H, Bogdan R, Agrawal A. Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nature Mental Health 2023, 1: 210-223. PMID: 37250466, PMCID: PMC10217792, DOI: 10.1038/s44220-023-00034-y.
- Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use DisorderDeak JD, Levey DF, Wendt FR, Zhou H, Galimberti M, Kranzler HR, Gaziano JM, Stein MB, Polimanti R, Gelernter J, Muralidhar S, Moser J, Deen J, Gaziano J, Beckham J, Chang K, Tsao P, Luoh S, Casas J, Churby L, Whitbourne S, Brewer J, Brophy M, Selva L, Shayan S, Cho K, Pyarajan S, DuVall S, Connor T, Argyres D, Aslan M, Stephens B, Concato J, Gelernter J, Gleason T, Huang G, Koenen K, Marx C, Radhakrishnan K, Schork N, Stein M, Zhao H, Kaufman J, Nunez Y, Pietrzak R, Beck D, Cissell S, Crutchfield P, Lance W, Cheung K, Li Y, Sun N, Chen Q, Rajeevan N, Sayward F, Gagnon D, Harrington K, Quaden R, O'Leary T, Ramoni R. Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. JAMA Network Open 2022, 5: e2238880. PMID: 36301540, PMCID: PMC9614582, DOI: 10.1001/jamanetworkopen.2022.38880.
- Using Local and Global Genetic Correlation Approaches to Help Elucidate the Shared Genetic Etiology of Psychiatric and Substance Use TraitsDeak J. Using Local and Global Genetic Correlation Approaches to Help Elucidate the Shared Genetic Etiology of Psychiatric and Substance Use Traits. Biological Psychiatry 2022, 92: e31-e33. PMID: 36075672, DOI: 10.1016/j.biopsych.2022.07.011.
- Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk lociDeak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. Molecular Psychiatry 2022, 27: 3970-3979. PMID: 35879402, PMCID: PMC9718667, DOI: 10.1038/s41380-022-01709-1.
- Advanced Genetic Study of Problematic Alcohol Use in > 1 Million Subjects From Multiple PopulationsZhou H, Kember R, Deak J, Dao C, Galimberti M, Levey D, Overstreet C, Xu K, Zhao H, Justice A, Stein M, Kranzler H, Gelernter J. Advanced Genetic Study of Problematic Alcohol Use in > 1 Million Subjects From Multiple Populations. Biological Psychiatry 2022, 91: s68. DOI: 10.1016/j.biopsych.2022.02.189.
- Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorderWendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.
- Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthoodDeak JD, Clark DA, Liu M, Schaefer JD, Jang SK, Durbin CE, Iacono WG, McGue M, Vrieze S, Hicks BM. Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood. Addiction 2021, 117: 1117-1127. PMID: 34590376, PMCID: PMC8931861, DOI: 10.1111/add.15697.
- Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin studySchaefer J, Jang S, Clark D, Deak J, Hicks B, Iacono W, Liu M, McGue M, Vrieze S, Wilson S. Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study. Psychological Medicine 2021, 53: 2296-2306. PMID: 37310313, PMCID: PMC10123833, DOI: 10.1017/s0033291721004116.
- Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approachYeung EW, Spychala KM, Miller AP, Otto JM, Deak JD, Kim H, Gilder DA, Ehlers CL, Wilhelmsen KC, Gizer IR. Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach. Drug And Alcohol Dependence 2021, 230: 109117. PMID: 34844060, PMCID: PMC8714681, DOI: 10.1016/j.drugalcdep.2021.109117.
- COMORBID-PHENOME PREDICTION AND PHENOTYPE RISK SCORES INCREASE DATA AVAILABILITY FOR ANXIETY AND PTSD GENE DISCOVERYWendt F, Pathak G, Deak J, De Angelis F, Koller D, Cabrera-Mendoza B, Levey D, Stein M, Kranzler H, Koenen K, Gelernter J, Huckins L, Polimanti R. COMORBID-PHENOME PREDICTION AND PHENOTYPE RISK SCORES INCREASE DATA AVAILABILITY FOR ANXIETY AND PTSD GENE DISCOVERY. European Neuropsychopharmacology 2021, 51: e6-e7. DOI: 10.1016/j.euroneuro.2021.07.023.
- 67. ADVANCED GENETIC STUDY OF PROBLEMATIC ALCOHOL USE IN MULTIPLE POPULATIONS IN > 1 MILLION SUBJECTSZhou H, Kember R, Deak J, Dao C, Galimberti M, Levey D, Overstreet C, Xu K, Zhao H, Justice A, Stein M, Kranzler H, Gelernter J. 67. ADVANCED GENETIC STUDY OF PROBLEMATIC ALCOHOL USE IN MULTIPLE POPULATIONS IN > 1 MILLION SUBJECTS. European Neuropsychopharmacology 2021, 51: e77. DOI: 10.1016/j.euroneuro.2021.07.156.
- 71. GENOME-WIDE INVESTIGATION OF MAXIMUM HABITUAL ALCOHOL INTAKE IN 258,545 MVP EUROPEAN AND AFRICAN ANCESTRY U.S. VETERANSDeak J, Levey D, Wendt F, Zhou H, Kranzler H, Polimanti R, Stein M, Gelernter J. 71. GENOME-WIDE INVESTIGATION OF MAXIMUM HABITUAL ALCOHOL INTAKE IN 258,545 MVP EUROPEAN AND AFRICAN ANCESTRY U.S. VETERANS. European Neuropsychopharmacology 2021, 51: e79-e80. DOI: 10.1016/j.euroneuro.2021.07.160.
- Polygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthoodHicks B, Clark D, Deak J, Schaefer J, Liu M, Jang S, Durbin C, Johnson W, Wilson S, Iacono W, McGue M, Vrieze S. Polygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthood. PLOS ONE 2021, 16: e0255348. PMID: 34403414, PMCID: PMC8370636, DOI: 10.1371/journal.pone.0255348.
- The relationship between cannabis and schizophrenia: a genetically informed perspectiveJohnson EC, Hatoum AS, Deak JD, Polimanti R, Murray RM, Edenberg HJ, Gelernter J, Di Forti M, Agrawal A. The relationship between cannabis and schizophrenia: a genetically informed perspective. Addiction 2021, 116: 3227-3234. PMID: 33950550, PMCID: PMC8492483, DOI: 10.1111/add.15534.
- Polygenic Score for Smoking Is Associated With Externalizing Psychopathology and Disinhibited Personality Traits but Not Internalizing Psychopathology in AdolescenceHicks B, Clark D, Deak J, Liu M, Durbin C, Schaefer J, Wilson S, Iacono W, McGue M, Vrieze S. Polygenic Score for Smoking Is Associated With Externalizing Psychopathology and Disinhibited Personality Traits but Not Internalizing Psychopathology in Adolescence. Clinical Psychological Science 2021, 9: 1205-1213. PMID: 35003907, PMCID: PMC8741064, DOI: 10.1177/21677026211002117.
- Genetics of substance use disorders: a reviewDeak J, Johnson E. Genetics of substance use disorders: a review. Psychological Medicine 2021, 51: 2189-2200. PMID: 33879270, PMCID: PMC8477224, DOI: 10.1017/s0033291721000969.
- Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.Deak J, Gizer I, Otto J, Bizon C, Wilhelmsen K. Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. Journal Of Studies On Alcohol And Drugs 2019, 80: 585-593. PMID: 31790348, PMCID: PMC6900988, DOI: 10.15288/jsad.2019.80.585.
- Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sampleMiller A, Gizer I, Fleming Iii W, Otto J, Deak J, Martins J, Bartholow B. Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample. Psychiatry Research 2019, 279: 47-54. PMID: 31299563, PMCID: PMC6713597, DOI: 10.1016/j.psychres.2019.06.025.
- Meta‐Analysis of Genetic Influences on Initial Alcohol SensitivityEdwards A, Deak J, Gizer I, Lai D, Chatzinakos C, Wilhelmsen K, Lindsay J, Heron J, Hickman M, Webb B, Bacanu S, Foroud T, Kendler K, Dick D, Schuckit M. Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clinical And Experimental Research 2018, 42: 2349-2359. PMID: 30276832, PMCID: PMC6286211, DOI: 10.1111/acer.13896.
- Genetics of alcohol use disorder: a reviewDeak J, Miller A, Gizer I. Genetics of alcohol use disorder: a review. Current Opinion In Psychology 2018, 27: 56-61. PMID: 30170251, PMCID: PMC6368900, DOI: 10.1016/j.copsyc.2018.07.012.
- A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol UseOtto J, Gizer I, Deak J, Fleming K, Bartholow B. A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clinical And Experimental Research 2017, 41: 929-938. PMID: 28273335, PMCID: PMC5404990, DOI: 10.1111/acer.13369.
- Probing the smoking-suicide association: do smoking policy interventions affect suicide risk?Grucza R, Plunk A, Krauss M, Cavazos-Rehg P, Deak J, Gebhardt K, Chaloupka F, Bierut L. Probing the smoking-suicide association: do smoking policy interventions affect suicide risk? Nicotine & Tobacco Research 2014, 16: 1487-94. PMID: 25031313, PMCID: PMC4271090, DOI: 10.1093/ntr/ntu106.