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Jonathan Siner, MD

Associate Professor Term; Clinical Section Chief, Section of Pulmonary, Critical Care and Sleep Medicine, Internal Medicine; Medical Director, Tele-ICU, Internal Medicine; Associate Chief Safety Officer, Yale New Haven Health

Contact Information

Jonathan Siner, MD

Mailing Address

  • Pulmonary, Critical Care & Sleep Medicine

    PO Box 208057, 300 Cedar Street

    New Haven, CT 06520-8057

    United States

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Yale Medicine

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Research Summary

Dr. Siner began his career investigating modulators of hyperoxic acute lung injury and performed translational research examining the role of circulating growth factors in the sepsis syndrome and their relationship to outcomes in the intensive care unit. He was the recipient of an F32 NIH National Research Service Award (NRSA) which supported his investigation of the role of VEGF and HO-1 in cytoprotection from hyperoxia induced acute lung injury. His has developed expertise in patient safety and quality in the domains of critical care and tele-medicine (Tele-ICU) and has several active projects to reduce adverse events from ICU readmissions and unexpected cardiac arrest. Active areas of research including improving implemenetation of low tidal volume ventilation (participant in multi-center RO1 investigating facilitators and barriers to LTVV and network effects) and a recently commenced multi-center RO1 investigating dysphagia after mechanical ventilation for acute respiratory failure. Through his leadership roles in the Tele-ICU and the Yale-New Haven Health System ICU Committee he is developing data tools to easily facilitate quality and safety improvements in the intensive care unit



Coauthors

Research Interests

Hospital Administration; Intensive Care Units; Pulmonary Medicine; Safety Management; Sepsis; Translational Medical Research

Selected Publications

  • Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure.Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M. Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure. Dysphagia 2021, 36: 831-841. PMID: 33156398, DOI: 10.1007/s00455-020-10199-8.
  • Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis.Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang SY, Price C, Bona RD, Ochoa Chaar CI, Chun HJ, Pine AB, Rinder HM, Siner JM, Neuberg DS, Owusu KA, Lee AI. Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis. American Journal Of Hematology 2021, 96: 471-479. PMID: 33476420, PMCID: PMC8013588, DOI: 10.1002/ajh.26102.
  • Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: a propensity score-matched analysis.Meizlish ML, Goshua G, Liu Y, Fine R, Amin K, Chang E, DeFilippo N, Keating C, Liu Y, Mankbadi M, McManus D, Wang S, Price C, Bona RD, Chaar CIO, Chun HJ, Pine AB, Rinder HM, Siner J, Neuberg DS, Owusu KA, Lee AI. Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: a propensity score-matched analysis. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33469595, PMCID: PMC7814841, DOI: 10.1101/2021.01.12.21249577.
  • Lung-Protective Ventilation Over 6 Years at a Large Academic Medical Center: An Evaluation of Trends, Adherence, and Perceptions of Benefit.Gao CA, Howard FM, Siner JM, Candido TD, Ferrante LE. Lung-Protective Ventilation Over 6 Years at a Large Academic Medical Center: An Evaluation of Trends, Adherence, and Perceptions of Benefit. Critical Care Explorations 2021, 3: e0325. PMID: 33458691, PMCID: PMC7803935, DOI: 10.1097/CCE.0000000000000325.
  • Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection.McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PloS One 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.
  • Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet. Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/S2352-3026(20)30216-7.
  • Development of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors.Moss M, White SD, Warner H, Dvorkin D, Fink D, Gomez-Taborda S, Higgins C, Krisciunas GP, Levitt JE, McKeehan J, McNally E, Rubio A, Scheel R, Siner JM, Vojnik R, Langmore SE. Development of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors. Chest 2020, 158: 1923-1933. PMID: 32721404, PMCID: PMC7674978, DOI: 10.1016/j.chest.2020.07.051.
  • Ventilator Sharing Using Volume-controlled Ventilation during the COVID-19 Pandemic.Milner A, Siner JM, Balcezak T, Fajardo E. Ventilator Sharing Using Volume-controlled Ventilation during the COVID-19 Pandemic. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1317-1319. PMID: 32744456, PMCID: PMC7605199, DOI: 10.1164/rccm.202006-2452LE.
  • The Association Between Endotracheal Tube Size and Aspiration (During Flexible Endoscopic Evaluation of Swallowing) in Acute Respiratory Failure Survivors.Krisciunas GP, Langmore SE, Gomez-Taborda S, Fink D, Levitt JE, McKeehan J, McNally E, Scheel R, Rubio AC, Siner JM, Vojnik R, Warner H, White SD, Moss M. The Association Between Endotracheal Tube Size and Aspiration (During Flexible Endoscopic Evaluation of Swallowing) in Acute Respiratory Failure Survivors. Critical Care Medicine 2020, 48: 1604-1611. PMID: 32804785, PMCID: PMC7644217, DOI: 10.1097/CCM.0000000000004554.
  • Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients.Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. JAMA Neurology 2020 PMID: 32897296, PMCID: PMC7489395, DOI: 10.1001/jamaneurol.2020.3263.
  • Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure.Borders JC, Fink D, Levitt JE, McKeehan J, McNally E, Rubio A, Scheel R, Siner JM, Taborda SG, Vojnik R, Warner H, White SD, Langmore SE, Moss M, Krisciunas GP. Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure. Dysphagia 2019, 34: 521-528. PMID: 30694412, PMCID: PMC6660370, DOI: 10.1007/s00455-019-09980-1.
  • Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours?Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours? The Annals Of Otology, Rhinology, And Laryngology 2019, 128: 619-624. PMID: 30841709, DOI: 10.1177/0003489419836115.
  • Principles of Geriatric Critical CareSiner J, Pisani M. Respiratory Critical Care in the Elderly. Eds. S Akhtar & S. Rosenbaum, Principles of Geriatric Critical Care (pp 51-62). Cambridge University Press. 2018.
  • "Deterioration to Door Time": An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients.Sankey CB, McAvay G, Siner JM, Barsky CL, Chaudhry SI. "Deterioration to Door Time": An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients. Journal Of General Internal Medicine 2016, 31: 895-900. PMID: 26969311, PMCID: PMC4945556, DOI: 10.1007/s11606-016-3654-x.
  • Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula.Leder SB, Siner JM, Bizzarro MJ, McGinley BM, Lefton-Greif MA. Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula. Dysphagia 2016, 31: 154-9. PMID: 26590570, DOI: 10.1007/s00455-015-9669-3.
  • FIRST, "KNOW" HARM: Response to Letter to the Editor.Bizzarro MJ, Lefton-Greif MA, McGinley BM, Siner JM. FIRST, "KNOW" HARM: Response to Letter to the Editor. Dysphagia 2016, 31: 783-785. PMID: 27638423, DOI: 10.1007/s00455-016-9748-0.
  • Prospective Validation of Central Line-Days Derived From an Electronic Medical Record System.Boyce JM, Paci G, Feidner C, Hubbard L, Devin L, Reilly L, Gentile A, Siner JM. Prospective Validation of Central Line-Days Derived From an Electronic Medical Record System. Infection Control And Hospital Epidemiology 2015, 36: 1098-9. PMID: 26054019, DOI: 10.1017/ice.2015.137.
  • Advances and Challenges in Critical Care Medicine.Honiden S, Siner JM. Advances and Challenges in Critical Care Medicine. Clinics In Chest Medicine 2015, 36: xv-xvi. PMID: 26304290, DOI: 10.1016/j.ccm.2015.07.002.
  • Attitudes of Pulmonary and Critical Care Training Program Directors toward Quality Improvement Education.Kahn JM, Feemster LC, Fruci CM, Hyzy RC, Savant AP, Siner JM, Weiss CH, Patel B. Attitudes of Pulmonary and Critical Care Training Program Directors toward Quality Improvement Education. Annals Of The American Thoracic Society 2015, 12: 587-90. PMID: 25723649, PMCID: PMC5466183, DOI: 10.1513/AnnalsATS.201501-061BC.
  • Clinical Reasoning and Risk in the Intensive Care Unit.Connors GR, Siner JM. Clinical Reasoning and Risk in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 449-59. PMID: 26304282, DOI: 10.1016/j.ccm.2015.05.016.
  • Adverse Event Reporting and Quality Improvement in the Intensive Care Unit.Heavner JJ, Siner JM. Adverse Event Reporting and Quality Improvement in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 461-7. PMID: 26304283, DOI: 10.1016/j.ccm.2015.05.005.
  • Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O'Brien J, O'Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS. Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. Critical Care Medicine 2015, 43: 2076-84. PMID: 26110488, PMCID: PMC5673100, DOI: 10.1097/CCM.0000000000001157.
  • Protocol-Based Care versus Individualized Management of Patients in the Intensive Care Unit.Siner JM, Connors GR. Protocol-Based Care versus Individualized Management of Patients in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2015, 36: 870-7. PMID: 26595047, DOI: 10.1055/s-0035-1566157.
  • Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.Checkley W, Martin GS, Brown SM, Chang SY, Dabbagh O, Fremont RD, Girard TD, Rice TW, Howell MD, Johnson SB, O'Brien J, Park PK, Pastores SM, Patil NT, Pietropaoli AP, Putman M, Rotello L, Siner J, Sajid S, Murphy DJ, Sevransky JE. Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. Critical Care Medicine 2014, 42: 344-56. PMID: 24145833, PMCID: PMC4035482, DOI: 10.1097/CCM.0b013e3182a275d7.
  • A tale of two ligands: angiopoietins, the endothelium, and outcomes.Siner JM. A tale of two ligands: angiopoietins, the endothelium, and outcomes. Critical Care (London, England) 2013, 17: 1007. PMID: 24131798, PMCID: PMC4057381, DOI: 10.1186/cc13066.
  • An exogenous cough.Siner JM. An exogenous cough. Critical Care Medicine 2013, 41: 929-30. PMID: 23425835, DOI: 10.1097/CCM.0b013e31827bf4ee.
  • Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease.Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, Homer R, Gulati M, Siner J, Elias J, Bucala R, Herzog E. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis And Rheumatism 2011, 63: 2484-94. PMID: 21484765, PMCID: PMC3651701, DOI: 10.1002/art.30386.
  • Success stories: use of patient vignettes to assess the ability of physicians to predict extubation success.Siner JM, Siegel MD. Success stories: use of patient vignettes to assess the ability of physicians to predict extubation success. Respiratory Care 2011, 56: 1050-1. PMID: 21740729, DOI: 10.4187/respcare.01438.
  • Spontaneous hemothorax and recurrent hemoptysis in a 26-year-old man with skin lesions.Selim B, Lane CR, Rubinowitz AN, Siner JM. Spontaneous hemothorax and recurrent hemoptysis in a 26-year-old man with skin lesions. Chest 2010, 137: 480-3. PMID: 20133296, DOI: 10.1378/chest.09-1030.
  • Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype.Mathai SK, Gulati M, Peng X, Russell TR, Shaw AC, Rubinowitz AN, Murray LA, Siner JM, Antin-Ozerkis DE, Montgomery RR, Reilkoff RA, Bucala RJ, Herzog EL. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Laboratory Investigation; A Journal Of Technical Methods And Pathology 2010, 90: 812-23. PMID: 20404807, PMCID: PMC3682419, DOI: 10.1038/labinvest.2010.73.
  • Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis.Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock (Augusta, Ga.) 2009, 31: 348-53. PMID: 18791490, DOI: 10.1097/SHK.0b013e318188bd06.
  • Mechanical ventilation and acute respiratory distress syndrome in older patients.Siner JM, Pisani MA. Mechanical ventilation and acute respiratory distress syndrome in older patients. Clinics In Chest Medicine 2007, 28: 783-91, vii. PMID: 17967294, DOI: 10.1016/j.ccm.2007.08.008.
  • Liberation from mechanical ventilation: what monitoring matters?Siner JM, Manthous CA. Liberation from mechanical ventilation: what monitoring matters? Critical Care Clinics 2007, 23: 613-38. PMID: 17900486, DOI: 10.1016/j.ccc.2007.05.005.
  • VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo.Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ. VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2007, 21: 1422-32. PMID: 17264168, DOI: 10.1096/fj.06-6661com.
  • Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder.Siner J, Paredes A, Hosselet C, Hammond T, Strange K, Harris HW. Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. The American Journal Of Physiology 1996, 270: C372-81. PMID: 8772465, DOI: 10.1152/ajpcell.1996.270.1.C372.

Clinical Trials

ConditionsStudy Title
Diseases of the Respiratory SystemsEvaluation of Efficacy and Safety of PLN-74809 in Patients With Idiopathic Pulmonary Fibrosis
Diseases of the LungSaracatinib (AZD0530) in the Treatment of Patients with Idiopathic Pulmonary Fibrosis
Women's Health; COVID-19 Inpatient; COVID-19 OutpatientI-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill Patients
Diseases of the Blood; Infectious DiseasesCrystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)
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