John Wysolmerski, MD

• Alan Kliger
• Arthur Broadus
• Caren Carpenter
• David F. Stern
• David Rimm
• Diego Grinman
• Elizabeth H. Holt
• Herbert Yu
• Jaekwang Jeong
• Julie Hens
• Karl Insogna
• Laleh Ardeshirpour
• Leonard Milstone
• Margaret Bia
• Mark Horowitz
• Matthew Rodeheffer
• Ramanaiah Mamillapalli
• Robert Camp
• Robert Udelsman
• Valerie Horsley
• William Philbrick

Bone Diseases; Breast Neoplasms; Endocrine System Diseases; Neoplasms; Paraneoplastic Endocrine Syndromes; Parathyroid Diseases

• Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. The Journal Of Biological Chemistry 1987, 262:7151-6.
• Defining the roles of parathyroid hormone-related protein in normal physiology.Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76:127-73.
• The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor.Wysolmerski JJ, Stewart AF. The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annual Review Of Physiology 1998, 60:431-60.
• PTHrP regulates epidermal differentiation in adult mice.Foley J, Longely BJ, Wysolmerski JJ, Dreyer BE, Broadus AE, Philbrick WM. PTHrP regulates epidermal differentiation in adult mice. The Journal Of Investigative Dermatology 1998, 111:1122-8.
• Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development.Dunbar ME, Dann PR, Robinson GW, Hennighausen L, Zhang JP, Wysolmerski JJ. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development (Cambridge, England) 1999, 126:3485-93.
• Activation of PTHrP gene expression in squamous carcinoma cell lines by mutant isoforms of the tumor suppressor p53.Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP gene expression in squamous carcinoma cell lines by mutant isoforms of the tumor suppressor p53. Oncology Research 2000, 12:71-81.
• Posttransplant bone disease: evidence for a high bone resorption state.Cayco AV, Wysolmerski J, Simpson C, Mitnick MA, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M. Posttransplant bone disease: evidence for a high bone resorption state. Transplantation 2000, 70:1722-8.
• Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development.Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development (Cambridge, England) 2001, 128:513-25.
• Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes.Dunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ. Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. The Journal Of Endocrinology 2001, 171:403-16.
• Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study.Cruz DN, Wysolmerski JJ, Brickel HM, Gundberg CG, Simpson CA, Mitnick MA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study. Transplantation 2001, 72:83-8.
• Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis.Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2002, 17:1164-70.
• Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate.Cruz DN, Brickel HM, Wysolmerski JJ, Gundberg CG, Simpson CA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2002, 2:62-7.
• Nipple connective tissue and its development: insights from the K14-PTHrP mouse.Abdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J. Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Mechanisms Of Development 2002, 115:63-77.
• The evolutionary origins of maternal calcium and bone metabolism during lactation.Wysolmerski JJ. The evolutionary origins of maternal calcium and bone metabolism during lactation. Journal Of Mammary Gland Biology And Neoplasia 2002, 7:267-76.
• Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice.VanHouten JN, Wysolmerski JJ. Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 2003, 144:5521-9.
• Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. The Journal Of Clinical Investigation 2003, 112:1429-36.
• A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor.Kifor O, Moore FD, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. The Journal Of Clinical Endocrinology And Metabolism 2003, 88:60-72.
• Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (Cambridge, England) 2004, 131:4819-29.
• The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport.VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. The Journal Of Clinical Investigation 2004, 113:598-608.
• Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer.Wysolmerski J. Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer. Journal Of Mammary Gland Biology And Neoplasia 2005, 10:101-3.
• Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland.Hens JR, Wysolmerski JJ. Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research : BCR 2005, 7:220-4.
• TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro.Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2005, 20:1103-13.
• Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D.Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF. Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2005, 20:1792-803.
• Hypercalcemia in breast cancer: an echo of bone mobilization during lactation?DeMauro S, Wysolmerski J. Hypercalcemia in breast cancer: an echo of bone mobilization during lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10:157-67.
• The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland.Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2006, 38:787-93.
• Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene.VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. The Journal Of Clinical Endocrinology And Metabolism 2006, 91:580-3.
• Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice.Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 2007, 148:3875-86.
• BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development (Cambridge, England) 2007, 134:1221-30.
• The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.VanHouten JN, Neville MC, Wysolmerski JJ. The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 2007, 148:5943-54.
• Transcellular calcium transport in mammary epithelial cells.VanHouten JN, Wysolmerski JJ. Transcellular calcium transport in mammary epithelial cells. Journal Of Mammary Gland Biology And Neoplasia 2007, 12:223-35.
• Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. The Journal Of Biological Chemistry 2008, 283:24435-47.
• Wnt signaling in breast organogenesis.Boras-Granic K, Wysolmerski JJ. Wnt signaling in breast organogenesis. Organogenesis 2008, 4:116-22.
• Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis.Hens J, Dann P, Hiremath M, Pan TC, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP-/- mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics : An Official Publication Of The American Association Of Anatomists 2009, 238:2713-24.
• PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107:11405-10.
• The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells.Mamillapalli R, Wysolmerski J. The calcium-sensing receptor couples to Galpha(s) and regulates PTHrP and ACTH secretion in pituitary cells. The Journal Of Endocrinology 2010, 204:287-97.
• Molecular mechanisms guiding embryonic mammary gland development.Cowin P, Wysolmerski J. Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harbor Perspectives In Biology 2010, 2:a003251.
• Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Developmental Biology 2010, 10:4.
• Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton.Ardeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and decreased estrogens alter bone turnover but do not reproduce the full effects of lactation on the skeleton. Endocrinology 2010, 151:5591-601.
• Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation.Wysolmerski JJ. Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation. Annals Of The New York Academy Of Sciences 2010, 1192:161-9.
• Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland.Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid hormone-related protein is not required for normal ductal or alveolar development in the post-natal mammary gland. PloS One 2011, 6:e27278.
• Skeletal recovery after weaning does not require PTHrP.Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2011, 26:1242-51.
• Site-specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice.Liu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ. Site-specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2012, 27:865-75.
• Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme.Hiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development (Cambridge, England) 2012, 139:4239-49.
• PTHrP and breast cancer: more than hypercalcemia and bone metastases.Boras-Granic K, Wysolmerski JJ. PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Research : BCR 2012, 14:307.
• Osteocytic osteolysis: time for a second look?Wysolmerski JJ. Osteocytic osteolysis: time for a second look? BoneKEy Reports 2012, 1:229.
• Parathyroid hormone-related protein: an update.Wysolmerski JJ. Parathyroid hormone-related protein: an update. The Journal Of Clinical Endocrinology And Metabolism 2012, 97:2947-56.
• Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation.Qing H, Ardeshirpour L, Pajevic PD, Dusevich V, Jähn K, Kato S, Wysolmerski J, Bonewald LF. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2012, 27:1018-29.
• The calcium-sensing receptor in the breast.Vanhouten JN, Wysolmerski JJ. The calcium-sensing receptor in the breast. Best Practice & Research. Clinical Endocrinology & Metabolism 2013, 27:403-14.
• Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual.Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 2013, 154:3031-42.
• Parathyroid hormone-related protein specifies the mammary mesenchyme and regulates embryonic mammary development.Hiremath M, Wysolmerski J. Parathyroid hormone-related protein specifies the mammary mesenchyme and regulates embryonic mammary development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18:171-7.
• Attacking breast cancer at the preinvasion stage by targeting autophagy.Espina V, Wysolmerski J, Edmiston K, Liotta LA. Attacking breast cancer at the preinvasion stage by targeting autophagy. Women's Health (London, England) 2013, 9:157-70.
• Osteocytes remove and replace perilacunar mineral during reproductive cycles.Wysolmerski JJ. Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 2013, 54:230-6.
• Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production.Boras-Granic K, Dann P, Vanhouten J, Karaplis A, Wysolmerski J. Deletion of the nuclear localization sequences and C-terminus of PTHrP impairs embryonic mammary development but also inhibits PTHrP production. PloS One 2014, 9:e90418.
• Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland.Boras-Granic K, Dann P, Wysolmerski JJ. Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland. Breast Cancer Research : BCR 2014, 16:487.
• OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism.Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156:2762-73.
• Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein.Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Research 2016, 76:5348-60.
• PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113:E282-90.
• Calcium-Sensing Receptor in Breast Physiology and Cancer.Kim W, Wysolmerski JJ. Calcium-Sensing Receptor in Breast Physiology and Cancer. Frontiers In Physiology 2016, 7:440.
• HER2 signaling regulates HER2 localization and membrane retention.Jeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ. HER2 signaling regulates HER2 localization and membrane retention. PloS One 2017, 12:e0174849.
• The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. The Journal Of Biological Chemistry 2017, 292:6555-6568.
• Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.Zwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9:3592.
• Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.Jeong J, Choi J, Kim W, Dann P, Takyar F, Gefter JV, Friedman PA, Wysolmerski J. Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. The Journal Of Biological Chemistry 2019, 294:887-901.
• NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland.Jeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ. NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. Endocrinology 2019, 160:1797-1810.
• Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression.Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier V, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. The Journal Of Clinical Investigation 2019, 129:3058-3071.
• Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development (Cambridge, England) 1998, 125:1285-94.
• Calcium Metabolism and Breast Cancer: Echoes of Lactation?Grinman D, Athonvarungkul D, Wysolmerski J, Jeong J. Calcium Metabolism and Breast Cancer: Echoes of Lactation? Current Opinion In Endocrine And Metabolic Research 2020, 15:63-70.
• Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91:1133-7.
• Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein.Wysolmerski JJ, Broadus AE. Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein. Annual Review Of Medicine 1994, 45:189-200.
• Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene.Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Molecular Endocrinology (Baltimore, Md.) 1993, 7:273-82.
• Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development.Wysolmerski JJ, McCaughern-Carucci JF, Daifotis AG, Broadus AE, Philbrick WM. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development (Cambridge, England) 1995, 121:3539-47.
• Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice.Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Research 1996, 56:1043-9.
• Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM. Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53. Cancer Research 1996, 56:4056-62.
• Parathyroid hormone-related protein: from hypercalcemia of malignancy to developmental regulatory molecule.Dunbar ME, Wysolmerski JJ, Broadus AE. Parathyroid hormone-related protein: from hypercalcemia of malignancy to developmental regulatory molecule. The American Journal Of The Medical Sciences 1996, 312:287-94.
• Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein.Dunbar ME, Young P, Zhang JP, McCaughern-Carucci J, Lanske B, Orloff JJ, Karaplis A, Cunha G, Wysolmerski JJ. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein. Developmental Biology 1998, 203:75-89.
• Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.Dunbar ME, Wysolmerski JJ. Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development. Journal Of Mammary Gland Biology And Neoplasia 1999, 4:21-34.
• Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site.Foley J, Wysolmerski JJ, Missero C, King CS, Philbrick WM. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156:13-23.
• Mammary ductal and alveolar development: lesson learned from genetically manipulated mice.Dunbar ME, Wysolmerski JJ. Mammary ductal and alveolar development: lesson learned from genetically manipulated mice. Microscopy Research And Technique 2001, 52:163-70.
• Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction.Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, Roume J, Delezoide AL, Silve C. Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction. The Journal Of Clinical Endocrinology And Metabolism 2001, 86:1788-94.