John Krystal, MD

• Alan Anticevic
• Ansel Hillmer
• Barbara Gulanski
• Chadi Abdallah
• David Glahn
• David Matuskey
• Deepak Cyril Dsouza
• Douglas Rothman
• Dustin Scheinost
• Frank Fortunati
• George Aghajanian
• Gerard Sanacora
• Godfrey Pearlson
• Golam Chowdhury
• Graeme Mason
• Gustavo A. Angarita
• Henk De Feyter
• Hongyu Zhao
• Ifat Levy
• Ilan Harpaz-Rotem
• Irina Esterlis
• Ismene Petrakis
• Jacob Tebes
• Jennifer Kapo
• Jie Lisa Ji
• Joel Gelernter
• John D Murray
• Katrin Preller
• Kelly Cosgrove
• Kimberly Yonkers
• Kristine Olson
• Kyung-Heup Ahn
• Lihong Jiang
• Linda Mayes
• Lynnette A. Averill
• Maggie Taylor Davis
• Matthew J Girgenti
• Matthew State
• Michael Bloch
• Mika Naganawa
• Mohamed Sherif
• Mohini Ranganathan
• Nabeel Nabulsi
• Naomi Driesen
• Nicole DellaGioia
• Peter Morgan
• Philip Corlett
• Rajita Sinha
• Ralitza Gueorguieva
• Richard Carson
• Richard Formica
• Robert Pietrzak
• Robert Rohrbaugh
• Robert Rosenheck
• Robin de Graaf
• Ronald J. Vender
• Samuel Ball
• Shivani Bhatt
• Sophie E Holmes
• Stephanie O'Malley
• Steven Southwick
• Stuart Weinzimer
• Toral Surti
• Yiyun Huang

Alcoholism; Drug Therapy; Genetics; Neurobiology; Psychiatry; Schizophrenia; Stress Disorders, Post-Traumatic; Veterans; Neuroimaging

• Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. JAMA 2011, 306: 493-502. PMID: 21813427, DOI: 10.1001/jama.2011.1080.
• NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia.Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-5. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
• Increased brain uptake and oxidation of acetate in heavy drinkers.Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. The Journal Of Clinical Investigation 2013, 123: 1605-14. PMID: 23478412, PMCID: PMC3613911, DOI: 10.1172/JCI65153.
• Computational psychiatry.Wang XJ, Krystal JH. Computational psychiatry. Neuron 2014, 84: 638-54. PMID: 25442941, PMCID: PMC4255477, DOI: 10.1016/j.neuron.2014.10.018.
• Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-6. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
• Psychiatric disorders: diagnosis to therapy.Krystal JH, State MW. Psychiatric disorders: diagnosis to therapy. Cell 2014, 157: 201-14. PMID: 24679536, PMCID: PMC4104191, DOI: 10.1016/j.cell.2014.02.042.
• Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-49. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.
• Functional hierarchy underlies preferential connectivity disturbances in schizophrenia.Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: E219-28. PMID: 26699491, PMCID: PMC4720350, DOI: 10.1073/pnas.1508436113.
• Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
• Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7 PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/eLife.35082.
• The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43: 2154-2160. PMID: 29977074, PMCID: PMC6098048, DOI: 10.1038/s41386-018-0136-3.
• Neural computations of threat in the aftermath of combat trauma.Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.
• Ketamine: A Paradigm Shift for Depression Research and Treatment.Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron 2019, 101: 774-778. PMID: 30844397, PMCID: PMC6560624, DOI: 10.1016/j.neuron.2019.02.005.
• Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.
• Lower synaptic density is associated with depression severity and network alterations.Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
• In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation.Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita-Africano G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
• Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin.Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D'Souza DC, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
• A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia. The New England Journal Of Medicine 2020, 382: 1497-1506. PMID: 32294346, DOI: 10.1056/NEJMoa1911772.
• PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
• Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience.Krystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2021, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.
• Transcriptomic organization of the human brain in post-traumatic stress disorder.Girgenti MJ, Wang J, Ji D, Cruz DA, Stein MB, Gelernter J, Young KA, Huber BR, Williamson DE, Friedman MJ, Krystal JH, Zhao H, Duman RS. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2021, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.