John Krystal, MD
Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry and of Neuroscience; Co-Director, Yale Center for Clinical Investigation; Chair, Department of Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD
Research & Publications
Biography
News
Research Summary
Neurobiology; pharmacotherapy; genetics; neuroimaging; computational neuroscience
schizophrenia; alcoholism; PTSD; depression
Coauthors
Research Interests
Alcoholism; Drug Therapy; Genetics; Neurobiology; Psychiatry; Schizophrenia; Stress Disorders, Post-Traumatic; Veterans; Neuroimaging
Selected Publications
- Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. JAMA 2011, 306:493-502.
- NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia.Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109:16720-5.
- Increased brain uptake and oxidation of acetate in heavy drinkers.Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. The Journal Of Clinical Investigation 2013, 123:1605-14.
- Computational psychiatry.Wang XJ, Krystal JH. Computational psychiatry. Neuron 2014, 84:638-54.
- Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111:18031-6.
- Psychiatric disorders: diagnosis to therapy.Krystal JH, State MW. Psychiatric disorders: diagnosis to therapy. Cell 2014, 157:201-14.
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22:238-49.
- Functional hierarchy underlies preferential connectivity disturbances in schizophrenia.Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113:E219-28.
- Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence.Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114:8390-8395.
- Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7.