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John K Forrest

MD, FACC, FSCAI
Associate Professor of Medicine (Cardiovascular Medicine); Director of Interventional Cardiology, Cardiovascular Medicine; Director of Structural Heart Disease, Yale Medicine; Director, Structural Heart Disease Program, Cardiovascular Medicine

Contact Information

John K Forrest, MD, FACC, FSCAI

Mailing Address

  • Cardiovascular Medicine

    PO Box 208017

    New Haven, CT 06520-8017

    United States

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Yale Medicine

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Research Summary

My research focus is in the area of interventional cardiology with a particular interest in transcatheter therapies and structural heart disease. My work in this area has focused on large scale national and international clinical studies. I have served as principal investigator at Yale for over 20 studies in the field of interventional cardiology and structural heart disease, and presently serve as the National Principal Investigator for the Evolut Low Risk TAVR Study and the Low Risk Bicuspid TAVR study. These studies, which have completed enrollment and will have 10 year patient follow-up have had their early results published in the New England Journal of Medicine and JAMA Cardiology respectively, and will be the sentinel studies for our understanding of trancathter aortic valve replacement (TAVR) in low surgical risk patients. I also serve nationally on a number of research and quality improvement groups through the Society for Thoracic Surgery (STS) and the American College of Cardiology (ACC) including the STS/ACC TVT Risk Model Subcommittee and ACC/STS Transcatheter Valve Therapies Dataset Working Group.

Coauthors

Research Interests

Cardiology; Heart Diseases; Stents; Transcatheter Aortic Valve Replacement

Selected Publications

  • Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis.Forrest JK, Ramlawi B, Deeb GM, Zahr F, Song HK, Kleiman NS, Chetcuti SJ, Michelena HI, Mangi AA, Skiles JA, Huang J, Popma JJ, Reardon MJ. Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis. JAMA Cardiology 2021, 6: 50-57. PMID: 33031491, PMCID: PMC7542521, DOI: 10.1001/jamacardio.2020.4738.
  • A Case of Presyncope After Transcatheter Aortic Valve Replacement.Workman V, Forrest JK, Enriquez A. A Case of Presyncope After Transcatheter Aortic Valve Replacement. Circulation 2021, 143: 857-861. PMID: 33617312, DOI: 10.1161/CIRCULATIONAHA.120.049693.
  • Randomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement: REFLECT II.Nazif TM, Moses J, Sharma R, Dhoble A, Rovin J, Brown D, Horwitz P, Makkar R, Stoler R, Forrest J, Messé S, Dickerman S, Brennan J, Zivadinov R, Dwyer MG, Lansky AJ. Randomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement: REFLECT II. JACC. Cardiovascular Interventions 2021, 14: 515-527. PMID: 33663779, DOI: 10.1016/j.jcin.2020.11.011.
  • Predictors and Risk Calculator of Early Unplanned Hospital Readmission Following Contemporary Self-Expanding Transcatheter Aortic Valve Replacement from the STS/ACC TVT Registry.Sanchez CE, Hermiller JB, Pinto DS, Chetcuti SJ, Arshi A, Forrest JK, Huang J, Yakubov SJ. Predictors and Risk Calculator of Early Unplanned Hospital Readmission Following Contemporary Self-Expanding Transcatheter Aortic Valve Replacement from the STS/ACC TVT Registry. Cardiovascular Revascularization Medicine : Including Molecular Interventions 2020, 21: 263-270. PMID: 31255552, DOI: 10.1016/j.carrev.2019.05.032.
  • The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions.Nazif TM, Chen S, Codner P, Grossman PM, Menees DS, Sanchez CE, Yakubov SJ, White J, Kapadia S, Whisenant BK, Forrest JK, Krishnaswamy A, Arshi A, Orford JL, Leon MB, Dizon JM, Kodali SK, Chetcuti SJ. The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2020, 95: 1051-1056. PMID: 31478304, DOI: 10.1002/ccd.28476.
  • Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.Saito Y, Nazif T, Baumbach A, Tchétché D, Latib A, Kaple R, Forrest J, Prendergast B, Lansky A. Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. JAMA Cardiology 2020, 5: 92-101. PMID: 31721980, DOI: 10.1001/jamacardio.2019.4367.
  • Three Generations of Self-Expanding Transcatheter Aortic Valves: A Report From the STS/ACC TVT Registry.Forrest JK, Kaple RK, Tang GHL, Yakubov SJ, Nazif TM, Williams MR, Zhang A, Popma JJ, Reardon MJ. Three Generations of Self-Expanding Transcatheter Aortic Valves: A Report From the STS/ACC TVT Registry. JACC. Cardiovascular Interventions 2020, 13: 170-179. PMID: 31973793, DOI: 10.1016/j.jcin.2019.08.035.
  • TAVR in Low-Risk Patients: FDA Approval, the New NCD, and Shared Decision-Making.Coylewright M, Forrest JK, McCabe JM, Nazif TM. TAVR in Low-Risk Patients: FDA Approval, the New NCD, and Shared Decision-Making. Journal Of The American College Of Cardiology 2020, 75: 1208-1211. PMID: 32164894, DOI: 10.1016/j.jacc.2019.12.057.
  • Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry.Forrest JK, Kaple RK, Ramlawi B, Gleason TG, Meduri CU, Yakubov SJ, Jilaihawi H, Liu F, Reardon MJ. Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry. JACC. Cardiovascular Interventions 2020, 13: 1749-1759. PMID: 32473890, DOI: 10.1016/j.jcin.2020.03.022.
  • Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve.Attizzani GF, Dallan LAP, Markowitz A, Yakubov SJ, Deeb GM, Reardon MJ, Forrest JK, Mangi AA, Huang J, Popma JJ. Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve. JACC. Cardiovascular Interventions 2020, 13: 1816-1824. PMID: 32763073, DOI: 10.1016/j.jcin.2020.04.028.
  • Three-Year Outcomes With a Contemporary Self-Expanding Transcatheter Valve From the Evolut PRO US Clinical Study.Wyler von Ballmoos MC, Reardon MJ, Williams MR, Mangi AA, Kleiman NS, Yakubov SJ, Watson D, Kodali S, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Oh JK, Qiao H, Forrest JK. Three-Year Outcomes With a Contemporary Self-Expanding Transcatheter Valve From the Evolut PRO US Clinical Study. Cardiovascular Revascularization Medicine : Including Molecular Interventions 2021, 26: 12-16. PMID: 33199247, DOI: 10.1016/j.carrev.2020.11.007.
  • Planning for the Next Transcatheter Aortic Valve Replacement Starts Today.Cavender MA, Forrest JK. Planning for the Next Transcatheter Aortic Valve Replacement Starts Today. Circulation. Cardiovascular Interventions 2020, 13: e010226. PMID: 33272033, DOI: 10.1161/CIRCINTERVENTIONS.120.010226.
  • Trends in volume and risk profiles of patients undergoing isolated surgical and transcatheter aortic valve replacement.Mori M, Bin Mahmood SU, Geirsson A, Yun JJ, Cleman MW, Forrest JK, Mangi AA. Trends in volume and risk profiles of patients undergoing isolated surgical and transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2019, 93: E337-E342. PMID: 30269424, DOI: 10.1002/ccd.27855.
  • Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients.Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O'Hair D, Bajwa T, Heiser JC, Merhi W, Kleiman NS, Askew J, Sorajja P, Rovin J, Chetcuti SJ, Adams DH, Teirstein PS, Zorn GL, Forrest JK, Tchétché D, Resar J, Walton A, Piazza N, Ramlawi B, Robinson N, Petrossian G, Gleason TG, Oh JK, Boulware MJ, Qiao H, Mugglin AS, Reardon MJ. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients. The New England Journal Of Medicine 2019, 380: 1706-1715. PMID: 30883053, DOI: 10.1056/NEJMoa1816885.
  • Early Outcomes With the Evolut PRO Repositionable Self-Expanding Transcatheter Aortic Valve With Pericardial Wrap.Forrest JK, Mangi AA, Popma JJ, Khabbaz K, Reardon MJ, Kleiman NS, Yakubov SJ, Watson D, Kodali S, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Saul S, Qiao H, Oh JK, Williams MR. Early Outcomes With the Evolut PRO Repositionable Self-Expanding Transcatheter Aortic Valve With Pericardial Wrap. JACC. Cardiovascular Interventions 2018, 11: 160-168. PMID: 29348010, DOI: 10.1016/j.jcin.2017.10.014.
  • Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.Lansky AJ, Messé SR, Brickman AM, Dwyer M, Bart van der Worp H, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Scala Moy C, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. European Heart Journal 2018, 39: 1687-1697. PMID: 28171522, PMCID: PMC6251670, DOI: 10.1093/eurheartj/ehx037.
  • Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999-2014.Goldsweig AM, Wang Y, Forrest JK, Cleman MW, Minges KE, Mangi AA, Aronow HD, Krumholz HM, Curtis JP. Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999-2014. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2018, 92: 1104-1115. PMID: 29513365, DOI: 10.1002/ccd.27576.
  • The SURTAVI study: TAVI for patients with intermediate risk.Jones DA, Tchétché D, Forrest J, Hellig F, Lansky A, Moat N. The SURTAVI study: TAVI for patients with intermediate risk. EuroIntervention : Journal Of EuroPCR In Collaboration With The Working Group On Interventional Cardiology Of The European Society Of Cardiology 2017, 13: e617-e620. PMID: 28781252, DOI: 10.4244/EIJV13I5A97.
  • Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.Lansky AJ, Messé SR, Brickman AM, Dwyer M, van der Worp HB, Lazar RM, Pietras CG, Abrams KJ, McFadden E, Petersen NH, Browndyke J, Prendergast B, Ng VG, Cutlip DE, Kapadia S, Krucoff MW, Linke A, Moy CS, Schofer J, van Es GA, Virmani R, Popma J, Parides MK, Kodali S, Bilello M, Zivadinov R, Akar J, Furie KL, Gress D, Voros S, Moses J, Greer D, Forrest JK, Holmes D, Kappetein AP, Mack M, Baumbach A. Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative. Journal Of The American College Of Cardiology 2017, 69: 679-691. PMID: 28183511, DOI: 10.1016/j.jacc.2016.11.045.
  • 1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses.Deeb GM, Chetcuti SJ, Reardon MJ, Patel HJ, Grossman PM, Schreiber T, Forrest JK, Bajwa TK, O'Hair DP, Petrossian G, Robinson N, Katz S, Hartman A, Dauerman HL, Schmoker J, Khabbaz K, Watson DR, Yakubov SJ, Oh JK, Li S, Kleiman NS, Adams DH, Popma JJ. 1-Year Results in Patients Undergoing Transcatheter Aortic Valve Replacement With Failed Surgical Bioprostheses. JACC. Cardiovascular Interventions 2017, 10: 1034-1044. PMID: 28521921, DOI: 10.1016/j.jcin.2017.03.018.
  • Biomarkers in Transcatheter Aortic Valve Replacement: Prevalent, But Are They Prognostic?Forrest JK, Hermany PL. Biomarkers in Transcatheter Aortic Valve Replacement: Prevalent, But Are They Prognostic? JACC. Cardiovascular Interventions 2017, 10: 1561-1563. PMID: 28797434, DOI: 10.1016/j.jcin.2017.06.043.
  • Intravascular Ultrasound in Lower Extremity Peripheral Vascular Interventions: Variation in Utilization and Impact on In-Hospital Outcomes From the Nationwide Inpatient Sample (2006-2011).Panaich SS, Arora S, Patel N, Patel NJ, Savani C, Patel A, Thakkar B, Singh V, Patel S, Patel N, Agnihotri K, Bhatt P, Deshmukh A, Gupta V, Attaran RR, Mena CI, Grines CL, Cleman M, Forrest JK, Badheka AO. Intravascular Ultrasound in Lower Extremity Peripheral Vascular Interventions: Variation in Utilization and Impact on In-Hospital Outcomes From the Nationwide Inpatient Sample (2006-2011). Journal Of Endovascular Therapy : An Official Journal Of The International Society Of Endovascular Specialists 2016, 23: 65-75. PMID: 26637836, DOI: 10.1177/1526602815620780.
  • Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial).Lansky AJ, Brown D, Pena C, Pietras CG, Parise H, Ng VG, Meller S, Abrams KJ, Cleman M, Margolis P, Petrossian G, Brickman AM, Voros S, Moses J, Forrest JK. Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial). The American Journal Of Cardiology 2016, 118: 1519-1526. PMID: 27645761, DOI: 10.1016/j.amjcard.2016.08.013.
  • Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with cirrhosis.Thakkar B, Patel A, Mohamad B, Patel NJ, Bhatt P, Bhimani R, Patel A, Arora S, Savani C, Solanki S, Sonani R, Patel S, Patel N, Deshmukh A, Mohamad T, Grines C, Cleman M, Mangi A, Forrest J, Badheka AO. Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with cirrhosis. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2016, 87: 955-62. PMID: 26699085, DOI: 10.1002/ccd.26345.
  • Impact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006-2011).Arora S, Panaich SS, Patel N, Patel NJ, Lahewala S, Thakkar B, Savani C, Jhamnani S, Singh V, Patel N, Patel S, Sonani R, Patel A, Tripathi B, Deshmukh A, Chothani A, Patel J, Bhatt P, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Mena CI, Schreiber T, Grines C, Cleman M, Forrest JK, Badheka AO. Impact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006-2011). Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2016, 88: 605-616. PMID: 26914274, DOI: 10.1002/ccd.26452.
  • Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials).Forrest JK, Adams DH, Popma JJ, Reardon MJ, Deeb GM, Yakubov SJ, Hermiller JB, Huang J, Skelding KA, Lansky A. Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials). The American Journal Of Cardiology 2016, 118: 396-402. PMID: 27346591, DOI: 10.1016/j.amjcard.2016.05.013.
  • Multivessel Percutaneous Coronary Interventions in the United States: Insights From the Nationwide Inpatient Sample.Arora S, Panaich SS, Patel NJ, Patel N, Solanki S, Deshmukh A, Singh V, Lahewala S, Savani C, Thakkar B, Dave A, Patel A, Bhatt P, Sonani R, Patel A, Cleman M, Forrest JK, Schreiber T, Badheka AO, Grines C. Multivessel Percutaneous Coronary Interventions in the United States: Insights From the Nationwide Inpatient Sample. Angiology 2016, 67: 326-35. PMID: 26145455, DOI: 10.1177/0003319715593853.
  • Variability in utilization of drug eluting stents in United States: Insights from nationwide inpatient sample.Panaich SS, Badheka AO, Arora S, Patel NJ, Thakkar B, Patel N, Singh V, Chothani A, Deshmukh A, Agnihotri K, Jhamnani S, Lahewala S, Manvar S, Panchal V, Patel A, Patel N, Bhatt P, Savani C, Patel J, Savani GT, Solanki S, Patel S, Kaki A, Mohamad T, Elder M, Kondur A, Cleman M, Forrest JK, Schreiber T, Grines C. Variability in utilization of drug eluting stents in United States: Insights from nationwide inpatient sample. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2016, 87: 23-33. PMID: 26032938, DOI: 10.1002/ccd.25977.
  • Transcatheter Aortic Valve Replacement Versus Surgery in Women at High Risk for Surgical Aortic Valve Replacement (from the CoreValve US High Risk Pivotal Trial).Skelding KA, Yakubov SJ, Kleiman NS, Reardon MJ, Adams DH, Huang J, Forrest JK, Popma JJ. Transcatheter Aortic Valve Replacement Versus Surgery in Women at High Risk for Surgical Aortic Valve Replacement (from the CoreValve US High Risk Pivotal Trial). The American Journal Of Cardiology 2016, 118: 560-6. PMID: 27381665, DOI: 10.1016/j.amjcard.2016.05.051.
  • Relationship of Annular Sizing Using Multidetector Computed Tomographic Imaging and Clinical Outcomes After Self-Expanding CoreValve Transcatheter Aortic Valve Replacement.Popma JJ, Gleason TG, Yakubov SJ, Harrison JK, Forrest JK, Maini B, Ruiz CE, Pinto DS, Costa M, Resar J, Conte J, Crestanello J, Chang Y, Oh JK, Reardon MJ, Adams DH. Relationship of Annular Sizing Using Multidetector Computed Tomographic Imaging and Clinical Outcomes After Self-Expanding CoreValve Transcatheter Aortic Valve Replacement. Circulation. Cardiovascular Interventions 2016, 9 PMID: 27369803, DOI: 10.1161/CIRCINTERVENTIONS.115.003282.
  • Influence of hospital volume and outcomes of adult structural heart procedures.Panaich SS, Patel N, Arora S, Patel NJ, Patel SV, Savani C, Singh V, Sonani R, Deshmukh A, Cleman M, Mangi A, Forrest JK, Badheka AO. Influence of hospital volume and outcomes of adult structural heart procedures. World Journal Of Cardiology 2016, 8: 302-9. PMID: 27152142, PMCID: PMC4840163, DOI: 10.4330/wjc.v8.i4.302.
  • Trends of Hospitalizations in the United States from 2000 to 2012 of Patients >60 Years With Aortic Valve Disease.Badheka AO, Singh V, Patel NJ, Arora S, Patel N, Thakkar B, Jhamnani S, Pant S, Chothani A, Macon C, Panaich SS, Patel J, Manvar S, Savani C, Bhatt P, Panchal V, Patel N, Patel A, Patel D, Lahewala S, Deshmukh A, Mohamad T, Mangi AA, Cleman M, Forrest JK. Trends of Hospitalizations in the United States from 2000 to 2012 of Patients >60 Years With Aortic Valve Disease. The American Journal Of Cardiology 2015, 116: 132-41. PMID: 25983278, DOI: 10.1016/j.amjcard.2015.03.053.
  • Effect of Hospital Volume on Outcomes of Transcatheter Aortic Valve Implantation.Badheka AO, Patel NJ, Panaich SS, Patel SV, Jhamnani S, Singh V, Pant S, Patel N, Patel N, Arora S, Thakkar B, Manvar S, Dhoble A, Patel A, Savani C, Patel J, Chothani A, Savani GT, Deshmukh A, Grines CL, Curtis J, Mangi AA, Cleman M, Forrest JK. Effect of Hospital Volume on Outcomes of Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2015, 116: 587-94. PMID: 26092276, DOI: 10.1016/j.amjcard.2015.05.019.
  • Impact of Hospital Volume on Outcomes of Lower Extremity Endovascular Interventions (Insights from the Nationwide Inpatient Sample [2006 to 2011]).Arora S, Panaich SS, Patel N, Patel N, Lahewala S, Solanki S, Patel P, Patel A, Manvar S, Savani C, Tripathi B, Thakkar B, Jhamnani S, Singh V, Patel S, Patel J, Bhimani R, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Grines C, Mena CI, Cleman M, Forrest J, Badheka AO. Impact of Hospital Volume on Outcomes of Lower Extremity Endovascular Interventions (Insights from the Nationwide Inpatient Sample [2006 to 2011]). The American Journal Of Cardiology 2015, 116: 791-800. PMID: 26100585, DOI: 10.1016/j.amjcard.2015.05.050.
  • A balloon-expandable sheath facilitates transfemoral TAVR in patients with peripheral vascular disease and tortuosity.Goldsweig AM, Faheem O, Cleman MW, Forrest JK. A balloon-expandable sheath facilitates transfemoral TAVR in patients with peripheral vascular disease and tortuosity. Therapeutic Advances In Cardiovascular Disease 2015, 9: 95-102. PMID: 25784499, DOI: 10.1177/1753944715575970.
  • Multi-drug-resistant hypertension caused by severe aortic coarctation presenting in late adulthood.Meller SM, Fahey JT, Setaro JF, Forrest JK. Multi-drug-resistant hypertension caused by severe aortic coarctation presenting in late adulthood. Journal Of Clinical Hypertension (Greenwich, Conn.) 2015, 17: 313-6. PMID: 25644790, DOI: 10.1111/jch.12495.
  • Impact of Hospital Volume on Outcomes of Endovascular Stenting for Adult Aortic Coarctation.Bhatt P, Patel NJ, Patel A, Sonani R, Patel A, Panaich SS, Thakkar B, Savani C, Jhamnani S, Patel N, Patel N, Pant S, Patel S, Arora S, Dave A, Singh V, Chothani A, Patel J, Ansari M, Deshmukh A, Bhimani R, Grines C, Cleman M, Mangi A, Forrest JK, Badheka AO. Impact of Hospital Volume on Outcomes of Endovascular Stenting for Adult Aortic Coarctation. The American Journal Of Cardiology 2015, 116: 1418-24. PMID: 26471501, DOI: 10.1016/j.amjcard.2015.07.066.
  • Effect of Hospital Volume on Outcomes of Transcatheter Mitral Valve Repair: An Early US Experience.Patel NJ, Badheka AO, Jhamnani S, Panaich SS, Singh V, Patel N, Arora S, Grines CL, Cleman M, Forrest JK. Effect of Hospital Volume on Outcomes of Transcatheter Mitral Valve Repair: An Early US Experience. Journal Of Interventional Cardiology 2015, 28: 464-71. PMID: 26489974, DOI: 10.1111/joic.12228.
  • Comparison of inhospital mortality, length of hospitalization, costs, and vascular complications of percutaneous coronary interventions guided by ultrasound versus angiography.Singh V, Badheka AO, Arora S, Panaich SS, Patel NJ, Patel N, Pant S, Thakkar B, Chothani A, Deshmukh A, Manvar S, Lahewala S, Patel J, Patel S, Jhamnani S, Bhinder J, Patel P, Savani GT, Patel A, Mohamad T, Gidwani UK, Brown M, Forrest JK, Cleman M, Schreiber T, Grines C. Comparison of inhospital mortality, length of hospitalization, costs, and vascular complications of percutaneous coronary interventions guided by ultrasound versus angiography. The American Journal Of Cardiology 2015, 115: 1357-66. PMID: 25824542, DOI: 10.1016/j.amjcard.2015.02.037.
  • Vaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES.Chothani A, Shah N, Patel NJ, Deshmukh A, Singh V, Patel N, Panaich SS, Arora S, Patel A, Savani C, Thakkar B, Bhatt P, Cohen MG, Grines C, Forrest JK, Badheka AO. Vaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES. Postgraduate Medicine 2015, 127: 561-4. PMID: 26174358, DOI: 10.1080/00325481.2015.1064300.
  • Safety and performance of a novel embolic deflection device in patients undergoing transcatheter aortic valve replacement: results from the DEFLECT I study.Baumbach A, Mullen M, Brickman AM, Aggarwal SK, Pietras CG, Forrest JK, Hildick-Smith D, Meller SM, Gambone L, den Heijer P, Margolis P, Voros S, Lansky AJ. Safety and performance of a novel embolic deflection device in patients undergoing transcatheter aortic valve replacement: results from the DEFLECT I study. EuroIntervention : Journal Of EuroPCR In Collaboration With The Working Group On Interventional Cardiology Of The European Society Of Cardiology 2015, 11: 75-84. PMID: 25868876, DOI: 10.4244/EIJY15M04_01.
  • Comparison of Inhospital Outcomes of Surgical Aortic Valve Replacement in Hospitals With and Without Availability of a Transcatheter Aortic Valve Implantation Program (from a Nationally Representative Database).Singh V, Badheka AO, Patel SV, Patel NJ, Thakkar B, Patel N, Arora S, Patel N, Patel A, Savani C, Ghatak A, Panaich SS, Jhamnani S, Deshmukh A, Chothani A, Sonani R, Patel A, Bhatt P, Dave A, Bhimani R, Mohamad T, Grines C, Cleman M, Forrest JK, Mangi A. Comparison of Inhospital Outcomes of Surgical Aortic Valve Replacement in Hospitals With and Without Availability of a Transcatheter Aortic Valve Implantation Program (from a Nationally Representative Database). The American Journal Of Cardiology 2015, 116: 1229-36. PMID: 26297512, DOI: 10.1016/j.amjcard.2015.07.039.
  • A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial.Lansky AJ, Schofer J, Tchetche D, Stella P, Pietras CG, Parise H, Abrams K, Forrest JK, Cleman M, Reinöhl J, Cuisset T, Blackman D, Bolotin G, Spitzer S, Kappert U, Gilard M, Modine T, Hildick-Smith D, Haude M, Margolis P, Brickman AM, Voros S, Baumbach A. A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial. European Heart Journal 2015, 36: 2070-2078. PMID: 25990342, DOI: 10.1093/eurheartj/ehv191.
  • Comparison of outcomes of balloon aortic valvuloplasty plus percutaneous coronary intervention versus percutaneous aortic balloon valvuloplasty alone during the same hospitalization in the United States.Singh V, Patel NJ, Badheka AO, Arora S, Patel N, Macon C, Savani GT, Manvar S, Patel J, Thakkar B, Panchal V, Solanki S, Patel N, Chothani A, Panaich SS, Ram V, Kliger CA, Schreiber T, O' Neill W, Cohen MG, Alfonso CE, Grines CL, Mangi A, Pfau S, Forrest JK, Cleman M, Makkar R. Comparison of outcomes of balloon aortic valvuloplasty plus percutaneous coronary intervention versus percutaneous aortic balloon valvuloplasty alone during the same hospitalization in the United States. The American Journal Of Cardiology 2015, 115: 480-6. PMID: 25543235, DOI: 10.1016/j.amjcard.2014.11.032.
  • Comparison of Inhospital Outcomes and Hospitalization Costs of Peripheral Angioplasty and Endovascular Stenting.Panaich SS, Arora S, Patel N, Patel NJ, Lahewala S, Solanki S, Manvar S, Savani C, Jhamnani S, Singh V, Patel SV, Thakkar B, Patel A, Deshmukh A, Chothani A, Bhatt P, Savani GT, Patel J, Mavani K, Bhimani R, Tripathi B, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Grines C, Mena CI, Cleman M, Forrest JK, Badheka AO. Comparison of Inhospital Outcomes and Hospitalization Costs of Peripheral Angioplasty and Endovascular Stenting. The American Journal Of Cardiology 2015, 116: 634-41. PMID: 26096999, DOI: 10.1016/j.amjcard.2015.05.031.
  • Transcatheter aortic valve replacement: US experience.Forrest JK, Mangi A, Vaitkeviciute I. Transcatheter aortic valve replacement: US experience. Current Opinion In Anaesthesiology 2015, 28: 107-12. PMID: 25486491, DOI: 10.1097/ACO.0000000000000142.
  • Mechanical circulatory support devices and transcatheter aortic valve implantation (from the National Inpatient Sample).Singh V, Patel SV, Savani C, Patel NJ, Patel N, Arora S, Panaich SS, Deshmukh A, Cleman M, Mangi A, Forrest JK, Badheka AO. Mechanical circulatory support devices and transcatheter aortic valve implantation (from the National Inpatient Sample). The American Journal Of Cardiology 2015, 116: 1574-80. PMID: 26434512, DOI: 10.1016/j.amjcard.2015.08.020.
  • Transcatheter pulmonary valve implantation: a cross-sectional US experience.Patel A, Patel A, Bhatt P, Savani C, Thakkar B, Sonani R, Patel NJ, Arora S, Panaich S, Singh V, Patel S, Pant S, Ansari MM, Deshmukh A, Patel N, Dave A, Grines C, Cleman M, Forrest JK, Badheka AO. Transcatheter pulmonary valve implantation: a cross-sectional US experience. International Journal Of Cardiology 2015, 199: 186-8. PMID: 26197405, DOI: 10.1016/j.ijcard.2015.07.021.
  • Evaluation of XIENCE V everolimus-eluting and Taxus Express2 paclitaxel-eluting coronary stents in patients with jailed side branches from the SPIRIT IV trial at 2 years.Forrest JK, Lansky AJ, Meller SM, Hou L, Sood P, Applegate RJ, Wang JC, Skelding KA, Shah A, Kereiakes DJ, Sudhir K, Cristea E, Yaqub M, Stone GW. Evaluation of XIENCE V everolimus-eluting and Taxus Express2 paclitaxel-eluting coronary stents in patients with jailed side branches from the SPIRIT IV trial at 2 years. The American Journal Of Cardiology 2013, 111: 1580-6. PMID: 23499270, DOI: 10.1016/j.amjcard.2013.01.330.
  • Transcatheter aortic valve replacement: design, clinical application, and future challenges.Forrest JK. Transcatheter aortic valve replacement: design, clinical application, and future challenges. The Yale Journal Of Biology And Medicine 2012, 85: 239-47. PMID: 22737052, PMCID: PMC3375667.
  • Aggregation of misfolded proteins can be a selective process dependent upon peptide composition.Milewski MI, Mickle JE, Forrest JK, Stanton BA, Cutting GR. Aggregation of misfolded proteins can be a selective process dependent upon peptide composition. The Journal Of Biological Chemistry 2002, 277: 34462-70. PMID: 12084728, DOI: 10.1074/jbc.M205420200.
  • A PDZ-binding motif is essential but not sufficient to localize the C terminus of CFTR to the apical membrane.Milewski MI, Mickle JE, Forrest JK, Stafford DM, Moyer BD, Cheng J, Guggino WB, Stanton BA, Cutting GR. A PDZ-binding motif is essential but not sufficient to localize the C terminus of CFTR to the apical membrane. Journal Of Cell Science 2001, 114: 719-26. PMID: 11171377.
  • Cadmium disrupts the signal transduction pathway of both inhibitory and stimulatory receptors regulating chloride secretion in the shark rectal gland.Forrest JN, Aller SG, Wood SJ, Ratner MA, Forrest JK, Kelley GG. Cadmium disrupts the signal transduction pathway of both inhibitory and stimulatory receptors regulating chloride secretion in the shark rectal gland. The Journal Of Experimental Zoology 1997, 279: 530-6. PMID: 9392874, DOI: 10.1002/(sici)1097-010x(19971201)279:5<530::aid-jez17>3.0.co;2-b.
  • Composite Metric for Benchmarking Site Performance in Transcatheter Aortic Valve Replacement: Results From the STS/ACC TVT Registry.Desai ND, O'Brien SM, Cohen DJ, Carroll J, Vemulapalli S, Arnold SV, Forrest JK, Thourani VH, Kirtane AJ, O'Neil B, Manandhar P, Shahian DM, Badhwar V, Bavaria JE. Composite Metric for Benchmarking Site Performance in Transcatheter Aortic Valve Replacement: Results From the STS/ACC TVT Registry. Circulation 2021, 144: 186-194. PMID: 33947202, DOI: 10.1161/CIRCULATIONAHA.120.051456.
  • Outcomes of Prosthesis-Patient Mismatch Following Supra-Annular Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry.Tang GHL, Sengupta A, Alexis SL, Bapat VN, Adams DH, Sharma SK, Kini AS, Kodali SK, Ramlawi B, Gada H, Vora AN, Forrest JK, Kaple RK, Liu F, Reardon MJ. Outcomes of Prosthesis-Patient Mismatch Following Supra-Annular Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry. JACC. Cardiovascular Interventions 2021, 14: 964-976. PMID: 33958170, DOI: 10.1016/j.jcin.2021.03.040.
  • A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial.Lansky AJ, Makkar R, Nazif T, Messé S, Forrest J, Sharma R, Schofer J, Linke A, Brown D, Dhoble A, Horwitz P, Zang M, DeMarco F, Rajagopal V, Dwyer MG, Zivadinov R, Stella P, Rovin J, Parise H, Kodali S, Baumbach A, Moses J. A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial. European Heart Journal 2021, 42: 2670-2679. PMID: 34000004, DOI: 10.1093/eurheartj/ehab213.
  • Summary: international consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. Summary: international consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes. European Journal Of Cardio-thoracic Surgery : Official Journal Of The European Association For Cardio-thoracic Surgery 2021, 60: 481-496. PMID: 34292332, DOI: 10.1093/ejcts/ezab039.
  • International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes. European Journal Of Cardio-thoracic Surgery : Official Journal Of The European Association For Cardio-thoracic Surgery 2021, 60: 448-476. PMID: 34293102, DOI: 10.1093/ejcts/ezab038.
  • International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes.Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes. The Annals Of Thoracic Surgery 2021, 112: e203-e235. PMID: 34304860, DOI: 10.1016/j.athoracsur.2020.08.119.
  • Summary: International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes.Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. Summary: International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes. The Annals Of Thoracic Surgery 2021, 112: 1005-1022. PMID: 34304861, DOI: 10.1016/j.athoracsur.2021.05.001.
  • Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional, and research purposes.Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, Khoury GE, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional, and research purposes. The Journal Of Thoracic And Cardiovascular Surgery 2021, 162: 781-797. PMID: 34304894, DOI: 10.1016/j.jtcvs.2021.05.008.
  • International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes. The Journal Of Thoracic And Cardiovascular Surgery 2021, 162: e383-e414. PMID: 34304896, DOI: 10.1016/j.jtcvs.2021.06.019.
  • Alternate accesses for transcatheter aortic valve replacement: A network meta-analysis.Hameed I, Oakley CT, Hameed NUF, Ahmed A, Naeem N, Singh S, Rizwana K, Brackett A, Forrest JK, Kaple R, Mangi A, Salemi A, Geirsson A, Gaudino M, Vallabhajosyula P. Alternate accesses for transcatheter aortic valve replacement: A network meta-analysis. Journal Of Cardiac Surgery 2021, 36: 4308-4319. PMID: 34494307, DOI: 10.1111/jocs.15961.
  • International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes.Michelena HI, Corte AD, Evangelista A, Maleszewski JJ, Edwards WD, Roman MJ, Devereux RB, Fernández B, Asch FM, Barker AJ, Sierra-Galan LM, De Kerchove L, Fernandes SM, Fedak PWM, Girdauskas E, Delgado V, Abbara S, Lansac E, Prakash SK, Bissell MM, Popescu BA, Hope MD, Sitges M, Thourani VH, Pibarot P, Chandrasekaran K, Lancellotti P, Borger MA, Forrest JK, Webb J, Milewicz DM, Makkaar R, Leon MB, Sanders SP, Markl M, Ferrari VA, Roberts WC, Song JK, Blanke P, White CS, Siu S, Svensson LG, Braverman AC, Bavaria J, Sundt TM, El Khoury G, De Paulis R, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ. International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes. Radiology. Cardiothoracic Imaging 2021, 3: e200496. PMID: 34505060, PMCID: PMC8424700, DOI: 10.1148/ryct.2021200496.
  • Transcatheter Aortic Valve Replacement With Self-Expandable Supra-Annular Valves for Degenerated Surgical Bioprostheses: Insights From Transcatheter Valve Therapy Registry.Dallan LAP, Forrest JK, Reardon MJ, Szeto WY, George I, Kodali S, Kleiman NS, Yakubov SJ, Grubb KJ, Liu F, Baeza C, Attizzani GF. Transcatheter Aortic Valve Replacement With Self-Expandable Supra-Annular Valves for Degenerated Surgical Bioprostheses: Insights From Transcatheter Valve Therapy Registry. Journal Of The American Heart Association 2021, 10: e021871. PMID: 34514840, PMCID: PMC8649494, DOI: 10.1161/JAHA.121.021871.
  • Redo-transcatheter aortic valve replacement with the supra-annular, self-expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry.Attizzani GF, Dallan LAP, Forrest JK, Reardon MJ, Szeto WY, Liu F, Pelletier M. Redo-transcatheter aortic valve replacement with the supra-annular, self-expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry. Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions 2021 PMID: 34533891, DOI: 10.1002/ccd.29941.
  • Coronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis.Patel KP, Michail M, Treibel TA, Rathod K, Jones DA, Ozkor M, Kennon S, Forrest JK, Mathur A, Mullen MJ, Lansky A, Baumbach A. Coronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis. JACC. Cardiovascular Interventions 2021, 14: 2083-2096. PMID: 34620388, DOI: 10.1016/j.jcin.2021.07.058.
  • The Dos and Don'ts of Mitral Valve-in-Valve and Valve-in-Ring.Simonato M, Forrest JK, Dvir D. The Dos and Don'ts of Mitral Valve-in-Valve and Valve-in-Ring. Innovations (Philadelphia, Pa.) 2021, 16: 402-408. PMID: 34839722, DOI: 10.1177/15569845211048940.

Clinical Trials

ConditionsStudy Title
Diseases of the Cardiovascular SystemClinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
Diseases of the Cardiovascular SystemTranscatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation (APOLLO)
Diseases of the Cardiovascular SystemTranscatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
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