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John Geibel

DSc, MD, AGAF, MS, FRS
Professor Emeritus of Surgery (Gastrointestinal); Vice Chair, Surgery; Director, Surgical Research; American Gastroenterological Association Fellow; Fellow of the Royal Society of Medicine

Contact Information

John Geibel, DSc, MD, AGAF, MS, FRS

Lab Location

Mailing Addresses

  • Gastrointestinal Surgery

    PO Box 208062

    New Haven, CT 06520-8062

    United States

  • Yale University

    BML 232, 310 Cedar Street

    New Haven, CT 06510

    United States

Related Links

Research Summary

Our primary focus is on real time monitoring of ion transport mechanisms in epithelia, using high-resolution microscopy. One of the crucial problems facing all epithelial cells is the control of the intracellular milieu. In an effort to maintain ionic homeostasis, epithelial cells have devised a variety of ion channels, transport proteins, and carriers to regulate and maintain the intracellular ionic concentrations. To further understand how ions are transported in epithelial cells, we have developed a variety of optical techniques to continuously monitor intracellular ionic concentrations in real time. Using high-resolution video or confocal microscopy we are presently able to monitor intracellular Ca2+, Na+, K+, Cl-, pH, and membrane potential. We are currently investigating various aspects of renal tubule and gastric tissue ion transport in intact renal tubules and gastric glands. We also are characterizing the secretory and reabsorptive properties of the colonic crypt, with a special focus on diarrheal disease.

Specialized Terms: Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease; electrophysiology; CFTR; AMPKinase volume regulation

Extensive Research Description

We are focused on 3 main areas; gastric ion transport in health and disease, intestinal ion transport in health and disease, and 3DBioprinting. For gastric ion transport we are focusing on means to modulate acid secretion and reverse erosion. We use a combination of natural products and biochemical modifications to treat acid disease at the cellular level. For studies of intestinal ion transport, we are focusing on how the calcium sensing receptor(CaSR) can modulate fluid transport during toxin induced diarrhea. We are also looking at nanoparticle therapies for Ulcerative Colitis. In addition we are investigating means to prevent ischemic injury by activating ionic pathways using the AMPKinase. Finally we are trying to prevent IBD/IBS associated epithelial injury in the gut by CaSR activation using nutraceuticals . For the 3DBioprinting area we are developing replacement conduits that can be used for the aorta, the inferior vena cava, and also as small and large intestine repair tool. Along with this research we are now examining the potential for intestinal elongation using a 3D printed replacement.

Coauthors

Research Interests

Diarrhea; Electrophysiology; Gastric Acid; Gastroenterology; Gastrointestinal Agents; Physiology; Bioprinting; Chemicals and Drugs

Research Image

Isolated Human Gastric Gland

Isolated gastric gland loaded with the pH sensitive dye BCECF and a lysosomal tracker on a Zeiss Spinning Disk confocal. Image shows 3-D reconstruction of the gland in real time.

Selected Publications

  • Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. The American Journal Of Physiology 1996, 271: C635-49. PMID: 8770005, DOI: 10.1152/ajpcell.1996.271.2.C635.
  • A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion.Courtois-Coutry N, Roush D, Rajendran V, McCarthy JB, Geibel J, Kashgarian M, Caplan MJ. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion. Cell 1997, 90: 501-10. PMID: 9267030.
  • Sorting of ion pumps in polarized epithelial cells.Dunbar LA, Roush DL, Courtois-Coutry N, Muth TR, Gottardi CJ, Rajendran V, Geibel J, Kashgarian M, Caplan MJ. Sorting of ion pumps in polarized epithelial cells. Annals Of The New York Academy Of Sciences 1997, 834: 514-23. PMID: 9405853.
  • Cyclic strain induces reorganization of integrin alpha 5 beta 1 and alpha 2 beta 1 in human umbilical vein endothelial cells.Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin alpha 5 beta 1 and alpha 2 beta 1 in human umbilical vein endothelial cells. Journal Of Cellular Biochemistry 1997, 64: 505-13. PMID: 9057108, DOI: 10.1002/(sici)1097-4644(19970301)64:3<505::aid-jcb17>3.0.co;2-e.
  • Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope.Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biology International 1997, 21: 759-68. PMID: 9768474, DOI: 10.1006/cbir.1997.0220.
  • Sorting of P-type ATPases in polarized epithelial cells.Dunbar LA, Courtois-Coutry N, Roush DL, Muth TR, Gottardi CJ, Rajendran V, Geibel J, Kashgarian M, Caplan MJ. Sorting of P-type ATPases in polarized epithelial cells. Acta Physiologica Scandinavica. Supplementum 1998, 643: 289-95. PMID: 9789572.
  • Atomic force microscopy on living cells: aldosterone-induced localized cell swelling.Schneider SW, Pagel P, Storck J, Yano Y, Sumpio BE, Geibel JP, Oberleithner H. Atomic force microscopy on living cells: aldosterone-induced localized cell swelling. Kidney & Blood Pressure Research 1998, 21: 256-8. PMID: 9762848, DOI: 10.1159/000025869.
  • Cl-dependent Na-H exchange. A novel colonic crypt transport mechanism.Binder HJ, Rajendran VM, Geibel JP. Cl-dependent Na-H exchange. A novel colonic crypt transport mechanism. Annals Of The New York Academy Of Sciences 2000, 915: 43-53. PMID: 11193600, DOI: 10.1111/j.1749-6632.2000.tb05222.x.
  • The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion.Geibel JP, Wagner CA, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. The stomach divalent ion-sensing receptor scar is a modulator of gastric acid secretion. The Journal Of Biological Chemistry 2001, 276: 39549-52. PMID: 11507103, DOI: 10.1074/jbc.M107315200.
  • Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells.Egan ME, Glöckner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ. Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells. Nature Medicine 2002, 8: 485-92. PMID: 11984593, DOI: 10.1038/nm0502-485.
  • Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status.Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney International 2002, 62: 2109-17. PMID: 12427135, DOI: 10.1046/j.1523-1755.2002.00671.x.
  • Cloning and expression of a chloride-dependent Na+-H+ exchanger.Sangan P, Rajendran VM, Geibel JP, Binder HJ. Cloning and expression of a chloride-dependent Na+-H+ exchanger. The Journal Of Biological Chemistry 2002, 277: 9668-75. PMID: 11773056, DOI: 10.1074/jbc.M110852200.
  • Acid-base transport in the collecting duct.Wagner CA, Geibel JP. Acid-base transport in the collecting duct. Journal Of Nephrology 2002, 15 Suppl 5: S112-27. PMID: 12027210.
  • Microscopy as a tool for renal research.Geibel JP. Microscopy as a tool for renal research. Journal Of Nephrology 2002, 15 Suppl 5: S161-9. PMID: 12027215.
  • Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion.Cheng SX, Okuda M, Hall AE, Geibel JP, Hebert SC. Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2002, 283: G240-50. PMID: 12065312, DOI: 10.1152/ajpgi.00500.2001.
  • Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis.Stehberger PA, Schulz N, Finberg KE, Karet FE, Giebisch G, Lifton RP, Geibel JP, Wagner CA. Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis. Journal Of The American Society Of Nephrology : JASN 2003, 14: 3027-38. PMID: 14638902, DOI: 10.1097/01.asn.0000099375.74789.ab.
  • Molecular cloning and characterization of Atp6v1b1, the murine vacuolar H+ -ATPase B1-subunit.Finberg KE, Wagner CA, Stehberger PA, Geibel JP, Lifton RP. Molecular cloning and characterization of Atp6v1b1, the murine vacuolar H+ -ATPase B1-subunit. Gene 2003, 318: 25-34. PMID: 14585495, DOI: 10.1016/s0378-1119(03)00790-x.
  • Intracellular pH activates membrane-bound Na(+)/H(+) exchanger and vacuolar H(+)-ATPase in human embryonic kidney (HEK) cells.Lang K, Wagner C, Haddad G, Burnekova O, Geibel J. Intracellular pH activates membrane-bound Na(+)/H(+) exchanger and vacuolar H(+)-ATPase in human embryonic kidney (HEK) cells. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2003, 13: 257-62. PMID: 14586169, DOI: 10.1159/000074540.
  • Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon.Ikuma M, Geibel J, Binder HJ, Rajendran VM. Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon. American Journal Of Physiology. Cell Physiology 2003, 285: C912-21. PMID: 12826602, DOI: 10.1152/ajpcell.00396.2002.
  • Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands.Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP. Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2003, 285: G1242-8. PMID: 12907430, DOI: 10.1152/ajpgi.00165.2003.
  • A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse.Wagner CA, Lükewille U, Valles P, Breton S, Brown D, Giebisch GH, Geibel JP. A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Pflügers Archiv : European Journal Of Physiology 2003, 446: 623-32. PMID: 12748863, DOI: 10.1007/s00424-003-1082-3.
  • Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epithelium.Fidzinski P, Salvador-Silva M, Choritz L, Geibel J, Coca-Prados M. Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epithelium. American Journal Of Physiology. Cell Physiology 2004, 287: C655-63. PMID: 15140751, DOI: 10.1152/ajpcell.00552.2003.
  • Renal vacuolar H+-ATPase.Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Renal vacuolar H+-ATPase. Physiological Reviews 2004, 84: 1263-314. PMID: 15383652, DOI: 10.1152/physrev.00045.2003.
  • Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor.Cheng SX, Geibel JP, Hebert SC. Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Gastroenterology 2004, 126: 148-58. PMID: 14699496, DOI: 10.1053/j.gastro.2003.10.064.
  • Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract.Hebert SC, Cheng S, Geibel J. Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract. Cell Calcium 2004, 35: 239-47. PMID: 15200147, DOI: 10.1016/j.ceca.2003.10.015.
  • Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.Winter C, Schulz N, Giebisch G, Geibel JP, Wagner CA. Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 2636-41. PMID: 14983061, PMCID: PMC357002, DOI: 10.1073/pnas.0307321101.
  • Fluorescent imaging of Cl- in Amphiuma red blood cells: how the nuclear exclusion of Cl- affects the plasma membrane potential.Hoffman JF, Geibel JP. Fluorescent imaging of Cl- in Amphiuma red blood cells: how the nuclear exclusion of Cl- affects the plasma membrane potential. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 921-6. PMID: 15637151, PMCID: PMC545567, DOI: 10.1073/pnas.0408597102.
  • L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells.Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2005, 289: G664-9. PMID: 15961860, DOI: 10.1152/ajpgi.00096.2005.
  • The B1-subunit of the H(+) ATPase is required for maximal urinary acidification.Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13616-21. PMID: 16174750, PMCID: PMC1224669, DOI: 10.1073/pnas.0506769102.
  • Bicarbonate secretion: a neglected aspect of colonic ion transport.Binder HJ, Rajendran V, Sadasivan V, Geibel JP. Bicarbonate secretion: a neglected aspect of colonic ion transport. Journal Of Clinical Gastroenterology 2005, 39: S53-8. PMID: 15758660, DOI: 10.1097/01.mcg.0000155521.81382.3a.
  • The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands.Dufner MM, Kirchhoff P, Remy C, Hafner P, Müller MK, Cheng SX, Tang LQ, Hebert SC, Geibel JP, Wagner CA. The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2005, 289: G1084-90. PMID: 16109841, DOI: 10.1152/ajpgi.00571.2004.
  • Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane.Eisenberg ML, Maker AV, Slezak LA, Nathan JD, Sritharan KC, Jena BP, Geibel JP, Andersen DK. Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2005, 15: 51-8. PMID: 15665515, DOI: 10.1159/000083638.
  • Role of short-chain fatty acids in colonic HCO(3) secretion.Vidyasagar S, Barmeyer C, Geibel J, Binder HJ, Rajendran VM. Role of short-chain fatty acids in colonic HCO(3) secretion. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2005, 288: G1217-26. PMID: 15677553, DOI: 10.1152/ajpgi.00415.2004.
  • Secretion and absorption by colonic crypts.Geibel JP. Secretion and absorption by colonic crypts. Annual Review Of Physiology 2005, 67: 471-90. PMID: 15709966, DOI: 10.1146/annurev.physiol.67.031103.153530.
  • Role of potassium in acid secretion.Geibel JP. Role of potassium in acid secretion. World Journal Of Gastroenterology : WJG 2005, 11: 5259-65. PMID: 16149129, PMCID: PMC4622792, DOI: 10.3748/wjg.v11.i34.5259.
  • The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion.Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. The Journal Of Biological Chemistry 2006, 281: 23740-7. PMID: 16754665, DOI: 10.1074/jbc.M604155200.
  • An amino acid transporter involved in gastric acid secretion.Kirchhoff P, Dave MH, Remy C, Kosiek O, Busque SM, Dufner M, Geibel JP, Verrey F, Wagner CA. An amino acid transporter involved in gastric acid secretion. Pflügers Archiv : European Journal Of Physiology 2006, 451: 738-48. PMID: 16308696, DOI: 10.1007/s00424-005-1507-2.
  • Hypertonic saline attenuates colonic tumor cell metastatic potential by activating transmembrane sodium conductance.Shields CJ, Winter DC, Geibel JP, O'Sullivan GC, Wang JH, Redmond HP. Hypertonic saline attenuates colonic tumor cell metastatic potential by activating transmembrane sodium conductance. The Journal Of Membrane Biology 2006, 211: 35-42. PMID: 16988862, DOI: 10.1007/s00232-006-0011-8.
  • Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.Geibel J, Sritharan K, Geibel R, Geibel P, Persing JS, Seeger A, Roepke TK, Deichstetter M, Prinz C, Cheng SX, Martin D, Hebert SC. Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 9390-7. PMID: 16760252, PMCID: PMC1475505, DOI: 10.1073/pnas.0602996103.
  • Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium.Ghosh S, Choritz L, Geibel J, Coca-Prados M. Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium. Molecular And Cellular Endocrinology 2006, 253: 63-75. PMID: 16764985, DOI: 10.1016/j.mce.2006.05.002.
  • An update on acid secretion.Geibel JP, Wagner C. An update on acid secretion. Reviews Of Physiology, Biochemistry And Pharmacology 2006, 156: 45-60. PMID: 16634146, DOI: 10.1007/s10254-005-0003-0.
  • Distal tubule acidification.Geibel JP. Distal tubule acidification. Journal Of Nephrology 2006, 19 Suppl 9: S18-26. PMID: 16736436.
  • DeltaF508 mutation results in impaired gastric acid secretion.Sidani SM, Kirchhoff P, Socrates T, Stelter L, Ferreira E, Caputo C, Roberts KE, Bell RL, Egan ME, Geibel JP. DeltaF508 mutation results in impaired gastric acid secretion. The Journal Of Biological Chemistry 2007, 282: 6068-74. PMID: 17178714, DOI: 10.1074/jbc.M608427200.
  • Intragastric injection of botulinum toxin A for the treatment of obesity.Mittermair R, Keller C, Geibel J. Intragastric injection of botulinum toxin A for the treatment of obesity. Obesity Surgery 2007, 17: 732-6. PMID: 17879570, DOI: 10.1007/s11695-007-9135-x.
  • We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors.Geibel J. We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. MedGenMed : Medscape General Medicine 2007, 9: 9. PMID: 17435618, PMCID: PMC1925006.
  • SLC26A7 can function as a chloride-loading mechanism in parietal cells.Kosiek O, Busque SM, Föller M, Shcheynikov N, Kirchhoff P, Bleich M, Muallem S, Geibel JP. SLC26A7 can function as a chloride-loading mechanism in parietal cells. Pflügers Archiv : European Journal Of Physiology 2007, 454: 989-98. PMID: 17404755, DOI: 10.1007/s00424-007-0254-y.
  • Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.Barmeyer C, Ye JH, Sidani S, Geibel J, Binder HJ, Rajendran VM. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells. Pflügers Archiv : European Journal Of Physiology 2007, 454: 441-50. PMID: 17492310, DOI: 10.1007/s00424-007-0213-7.
  • Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands.Remy C, Kirchhoff P, Hafner P, Busque SM, Müeller MK, Geibel JP, Wagner CA. Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2007, 19: 33-42. PMID: 17310098, DOI: 10.1159/000099190.
  • PI3 kinase dependent stimulation of gastric acid secretion by dexamethasone.Lang PA, Schniepp R, Kirchhoff P, Socrates T, Sidani SM, Geibel JP. PI3 kinase dependent stimulation of gastric acid secretion by dexamethasone. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2007, 20: 527-34. PMID: 17762179, DOI: 10.1159/000107536.
  • Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents.Jakab M, Lach S, Bacová Z, Langelüddecke C, Strbák V, Schmidt S, Iglseder E, Paulmichl M, Geibel J, Ritter M. Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2008, 22: 567-78. PMID: 19088439, DOI: 10.1159/000185541.
  • Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins.Wagner CA, Loffing-Cueni D, Yan Q, Schulz N, Fakitsas P, Carrel M, Wang T, Verrey F, Geibel JP, Giebisch G, Hebert SC, Loffing J. Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins. American Journal Of Physiology. Renal Physiology 2008, 294: F1373-80. PMID: 18322017, DOI: 10.1152/ajprenal.00613.2007.
  • The phytostilbene resveratrol induces apoptosis in INS-1E rat insulinoma cells.Bortolotti C, Kunit T, Moder A, Hufnagl C, Schmidt S, Hartl A, Langelueddecke C, Fürst J, Geibel JP, Ritter M, Jakab M. The phytostilbene resveratrol induces apoptosis in INS-1E rat insulinoma cells. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2009, 23: 245-54. PMID: 19471092, DOI: 10.1159/000218171.
  • AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion.Sidani S, Kopic S, Socrates T, Kirchhoff P, Föller M, Murek M, Capasso A, Geibel JP. AMP-activated protein kinase: a physiological off switch for murine gastric acid secretion. Pflügers Archiv : European Journal Of Physiology 2009, 459: 39-46. PMID: 19621238, DOI: 10.1007/s00424-009-0698-3.
  • The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract.Geibel JP, Hebert SC. The functions and roles of the extracellular Ca2+-sensing receptor along the gastrointestinal tract. Annual Review Of Physiology 2009, 71: 205-17. PMID: 19575679, DOI: 10.1146/annurev.physiol.010908.163128.
  • Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection.Kopic S, Geibel JP. Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection. Toxins 2010, 2: 2132-57. PMID: 22069677, PMCID: PMC3153279, DOI: 10.3390/toxins2082132.
  • The calcium-sensing receptor.Geibel JP. The calcium-sensing receptor. Journal Of Nephrology 2010, 23 Suppl 16: S130-5. PMID: 21170870.
  • Commentary on 'Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof'.Kopic S, Murek M, Geibel JP. Commentary on 'Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof'. Experimental Physiology 2010, 95: 484-5. PMID: 20233894, DOI: 10.1113/expphysiol.2009.051912.
  • Revisiting the parietal cell.Kopic S, Murek M, Geibel JP. Revisiting the parietal cell. American Journal Of Physiology. Cell Physiology 2010, 298: C1-C10. PMID: 19889964, DOI: 10.1152/ajpcell.00478.2009.
  • Update on the mechanisms of gastric acid secretion.Kopic S, Geibel JP. Update on the mechanisms of gastric acid secretion. Current Gastroenterology Reports 2010, 12: 458-64. PMID: 20821079, DOI: 10.1007/s11894-010-0137-9.
  • Ethanol inhibits gastric acid secretion in rats through increased AMP-kinase activity.Kopic S, Corradini S, Sidani S, Murek M, Vardanyan A, Föller M, Ritter M, Geibel JP. Ethanol inhibits gastric acid secretion in rats through increased AMP-kinase activity. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2010, 25: 195-202. PMID: 20110680, DOI: 10.1159/000276553.
  • Evidence for intestinal chloride secretion.Murek M, Kopic S, Geibel J. Evidence for intestinal chloride secretion. Experimental Physiology 2010, 95: 471-8. PMID: 20233891, DOI: 10.1113/expphysiol.2009.049445.
  • Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts.Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP. Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2011, 28: 513-20. PMID: 22116365, PMCID: PMC3709473, DOI: 10.1159/000335112.
  • The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis.Wagner CA, Mohebbi N, Capasso G, Geibel JP. The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2011, 28: 497-504. PMID: 22116363, DOI: 10.1159/000335111.
  • Hypoxia inhibits colonic ion transport via activation of AMP kinase.Collins D, Kopic S, Bachlechner J, Ritter M, Winter DC, Geibel JP. Hypoxia inhibits colonic ion transport via activation of AMP kinase. Annals Of Surgery 2011, 254: 957-63. PMID: 21562404, DOI: 10.1097/SLA.0b013e31821d477f.
  • Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion.Kirchhoff P, Socrates T, Sidani S, Duffy A, Breidthardt T, Grob C, Viehl CT, Beglinger C, Oertli D, Geibel JP. Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion. The American Journal Of Gastroenterology 2011, 106: 62-70. PMID: 20736941, DOI: 10.1038/ajg.2010.327.
  • The flavonone naringenin inhibits chloride secretion in isolated colonic epithelia.Collins D, Kopic S, Geibel JP, Hogan AM, Medani M, Baird AW, Winter DC. The flavonone naringenin inhibits chloride secretion in isolated colonic epithelia. European Journal Of Pharmacology 2011, 668: 271-7. PMID: 21762688, DOI: 10.1016/j.ejphar.2011.06.052.
  • Calcium-modulated chloride pathways contribute to chloride flux in murine cystic fibrosis-affected macrophages.Shenoy A, Kopic S, Murek M, Caputo C, Geibel JP, Egan ME. Calcium-modulated chloride pathways contribute to chloride flux in murine cystic fibrosis-affected macrophages. Pediatric Research 2011, 70: 447-52. PMID: 21796019, PMCID: PMC3189336, DOI: 10.1203/PDR.0b013e31822f2448.
  • Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, Geibel JP, Fuerst J, Ritter M. Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2012, 29: 75-86. PMID: 22415077, DOI: 10.1159/000337589.
  • Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell.Kopic S, Wagner ME, Griessenauer C, Socrates T, Ritter M, Geibel JP. Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Pflügers Archiv : European Journal Of Physiology 2012, 463: 419-27. PMID: 22146938, DOI: 10.1007/s00424-011-1060-0.
  • Functional role of NHE4 as a pH regulator in rat and human colonic crypts.Arena EA, Longo WE, Roberts KE, Geibel P, Nateqi J, Brandstetter M, Geibel JP. Functional role of NHE4 as a pH regulator in rat and human colonic crypts. American Journal Of Physiology. Cell Physiology 2012, 302: C412-8. PMID: 22049213, DOI: 10.1152/ajpcell.00163.2011.
  • Gastric acid, calcium absorption, and their impact on bone health.Kopic S, Geibel JP. Gastric acid, calcium absorption, and their impact on bone health. Physiological Reviews 2013, 93: 189-268. PMID: 23303909, DOI: 10.1152/physrev.00015.2012.
  • Activation of the Ca²+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane.Jouret F, Wu J, Hull M, Rajendran V, Mayr B, Schöfl C, Geibel J, Caplan MJ. Activation of the Ca²+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane. Journal Of Cell Science 2013, 126: 5132-42. PMID: 24013548, PMCID: PMC3828589, DOI: 10.1242/jcs.127555.
  • Identification of functionally distinct Na-HCO3 co-transporters in colon.Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of functionally distinct Na-HCO3 co-transporters in colon. PloS One 2013, 8: e62864. PMID: 23690961, PMCID: PMC3653958, DOI: 10.1371/journal.pone.0062864.
  • The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule.Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Kidney International 2013, 84: 277-84. PMID: 23615500, DOI: 10.1038/ki.2013.137.
  • Activation of AMPK inhibits cholera toxin stimulated chloride secretion in human and murine intestine.Rogers AC, Huetter L, Hoekstra N, Collins D, Collaco A, Baird AW, Winter DC, Ameen N, Geibel JP, Kopic S. Activation of AMPK inhibits cholera toxin stimulated chloride secretion in human and murine intestine. PloS One 2013, 8: e69050. PMID: 23935921, PMCID: PMC3728293, DOI: 10.1371/journal.pone.0069050.
  • Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR.Collaco AM, Geibel P, Lee BS, Geibel JP, Ameen NA. Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR. American Journal Of Physiology. Cell Physiology 2013, 305: C981-96. PMID: 23986201, PMCID: PMC4109618, DOI: 10.1152/ajpcell.00067.2013.
  • Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts.Roginiel AC, Kohut DL, Kaur S, Saleh AM, Weber T, Geibel P, Singh H, Geibel JP. Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts. American Journal Of Physiology. Cell Physiology 2013, 305: C512-8. PMID: 23739181, DOI: 10.1152/ajpcell.00303.2012.
  • Calcium-sensing receptor 20 years later.Alfadda TI, Saleh AM, Houillier P, Geibel JP. Calcium-sensing receptor 20 years later. American Journal Of Physiology. Cell Physiology 2014, 307: C221-31. PMID: 24871857, PMCID: PMC4121584, DOI: 10.1152/ajpcell.00139.2014.
  • A novel device to preserve intestinal tissue ex-vivo by cold peristaltic perfusion.Narayan RR, Pancer NE, Loeb BW, Oki K, Crouch A, Backus S, Chauhan Y, Patrón-Lozano R, Rodriguez-Davalos MI, Geibel JP, Fan RE, Zinter JP. A novel device to preserve intestinal tissue ex-vivo by cold peristaltic perfusion. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2014, 2014: 3118-21. PMID: 25570651, DOI: 10.1109/EMBC.2014.6944283.
  • The putative role of the non-gastric H⁺/K⁺-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H⁺/K⁺ ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells.Jakab M, Hofer S, Ravasio A, Huber F, Schmidt S, Hitzl W, Geibel JP, Fürst J, Ritter M. The putative role of the non-gastric H⁺/K⁺-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H⁺/K⁺ ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2014, 34: 1507-26. PMID: 25322912, DOI: 10.1159/000366355.
  • A new method to measure intestinal secretion using fluorescein isothiocyanate-inulin in small bowel of rats.Munoz-Abraham AS, Judeeba S, Alkukhun A, Alfadda T, Patron-Lozano R, Rodriguez-Davalos MI, Geibel JP. A new method to measure intestinal secretion using fluorescein isothiocyanate-inulin in small bowel of rats. The Journal Of Surgical Research 2015, 197: 225-30. PMID: 25976849, DOI: 10.1016/j.jss.2015.02.049.
  • Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium.McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nature Communications 2015, 6: 6952. PMID: 25914116, PMCID: PMC4480796, DOI: 10.1038/ncomms7952.
  • Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1.Vucic E, Alfadda T, MacGregor GG, Dong K, Wang T, Geibel JP. Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflügers Archiv : European Journal Of Physiology 2015, 467: 1457-1468. PMID: 25127675, DOI: 10.1007/s00424-014-1593-0.
  • Three-dimensional Printing in the Intestine.Wengerter BC, Emre G, Park JY, Geibel J. Three-dimensional Printing in the Intestine. Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association 2016, 14: 1081-5. PMID: 27189913, DOI: 10.1016/j.cgh.2016.05.008.
  • Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells.Ferstl FS, Kitay AM, Trattnig RM, Alsaihati A, Geibel JP. Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells. Pflügers Archiv : European Journal Of Physiology 2016, 468: 1877-1883. PMID: 27757581, DOI: 10.1007/s00424-016-1889-3.
  • Extracorporeal Hypothermic Perfusion Device for Intestinal Graft Preservation to Decrease Ischemic Injury During Transportation.Muñoz-Abraham AS, Patrón-Lozano R, Narayan RR, Judeeba SS, Alkukhun A, Alfadda TI, Belter JT, Mulligan DC, Morotti R, Zinter JP, Geibel JP, Rodríguez-Dávalos MI. Extracorporeal Hypothermic Perfusion Device for Intestinal Graft Preservation to Decrease Ischemic Injury During Transportation. Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract 2016, 20: 313-21. PMID: 26487331, DOI: 10.1007/s11605-015-2986-x.
  • Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury.AlKukhun A, Caturegli G, Munoz-Abraham AS, Judeeba S, Patron-Lozano R, Morotti R, Rodriguez-Davalos MI, Geibel JP. Use of Fluorescein Isothiocyanate-Inulin as a Marker for Intestinal Ischemic Injury. Journal Of The American College Of Surgeons 2017, 224: 1066-1073. PMID: 28017811, DOI: 10.1016/j.jamcollsurg.2016.12.016.
  • Stomach and Bone.Kitay AM, Geibel JP. Stomach and Bone. Advances In Experimental Medicine And Biology 2017, 1033: 97-131. PMID: 29101653, DOI: 10.1007/978-3-319-66653-2_6.
  • Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury.Bertacco A, Dehner CA, Caturegli G, D'Amico F, Morotti R, Rodriguez MI, Mulligan DC, Kriegel MA, Geibel JP. Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury. Frontiers In Physiology 2017, 8: 1064. PMID: 29311987, PMCID: PMC5742259, DOI: 10.3389/fphys.2017.01064.
  • Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats.Kitay AM, Link A, Geibel JP. Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2017, 44: 1606-1615. PMID: 29212068, DOI: 10.1159/000485755.
  • Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation.Aldajani MM, Vanicek CN, Alhazzaa N, Lysyy T, Agarwal R, Geibel JP. Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2017, 44: 377-387. PMID: 29132138, DOI: 10.1159/000484914.
  • Modulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure.Kitay AM, Schneebacher MT, Schmitt A, Heschl K, Kopic S, Alfadda TI, Alsaihati A, Link A, Geibel JP. Modulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2018, 315: G36-G42. PMID: 29517927, DOI: 10.1152/ajpgi.00132.2017.
  • Generating vascular conduits: from tissue engineering to three-dimensional bioprinting.Maina RM, Barahona MJ, Finotti M, Lysyy T, Geibel P, D'Amico F, Mulligan D, Geibel JP. Generating vascular conduits: from tissue engineering to three-dimensional bioprinting. Innovative Surgical Sciences 2018, 3: 203-213. PMID: 31579784, PMCID: PMC6604577, DOI: 10.1515/iss-2018-0016.
  • Design and implementation of novel nutraceuticals and derivatives for treating intestinal disorders.Barahona MJ, Baratta V, Ollodart J, Mulligan D, Geibel JP. Design and implementation of novel nutraceuticals and derivatives for treating intestinal disorders. Future Medicinal Chemistry 2019, 11: 847-855. PMID: 30994367, PMCID: PMC8008207, DOI: 10.4155/fmc-2018-0313.
  • Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine.Barahona MJ, Maina RM, Lysyy T, Finotti M, Caturegli G, Baratta V, D'Amico F, Mulligan D, Geibel JP. Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine. Frontiers In Physiology 2019, 10: 439. PMID: 31130866, PMCID: PMC6509940, DOI: 10.3389/fphys.2019.00439.
  • The calcium-sensing receptor: A novel target for treatment and prophylaxis of neratinib-induced diarrhea.Lysyy T, Lalani AS, Olek EA, Diala I, Geibel JP. The calcium-sensing receptor: A novel target for treatment and prophylaxis of neratinib-induced diarrhea. Pharmacology Research & Perspectives 2019, 7: e00521. PMID: 31523434, PMCID: PMC6743423, DOI: 10.1002/prp2.521.
  • Induction of Secretagogue Independent Gastric Acid Secretion via a Novel Aspirin-Activated Pathway.Kitay AM, Ferstl FS, Link A, Geibel JP. Induction of Secretagogue Independent Gastric Acid Secretion via a Novel Aspirin-Activated Pathway. Frontiers In Physiology 2019, 10: 1264. PMID: 31649553, PMCID: PMC6795678, DOI: 10.3389/fphys.2019.01264.
  • In Pursuit of the Parietal Cell - An Evolution of Scientific Methodology and Techniques.Baratta V, Own J, Di Renzo C, Ollodart J, Geibel JP, Barahona M. In Pursuit of the Parietal Cell - An Evolution of Scientific Methodology and Techniques. Frontiers In Physiology 2019, 10: 1497. PMID: 31920702, PMCID: PMC6920182, DOI: 10.3389/fphys.2019.01497.
  • Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions.Lysyy T, Finotti M, Maina RM, Morotti R, Munoz-Abraham AS, Bertacco A, Ibarra C, Barahona M, Agarwal R, D'Amico F, Rodriguez-Davalos MI, Mulligan D, Geibel J. Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions. Transplantation Proceedings 2020, 52: 2934-2940. PMID: 32768284, DOI: 10.1016/j.transproceed.2020.06.031.
  • Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt.Baratta VM, Norz V, Barahona MJ, Gisinger TM, Mulligan D, Geibel JP. Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt. Cellular Physiology And Biochemistry : International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology 2020, 54: 1132-1142. PMID: 33175479, PMCID: PMC8095381, DOI: 10.33594/000000305.
  • Hydrogel-based 3D bioprints repair rat small intestine injuries and integrate into native intestinal tissue.Maina RM, Barahona MJ, Geibel P, Lysyy T, Finotti M, Isaji T, Wengerter B, Mentone S, Dardik A, Geibel JP. Hydrogel-based 3D bioprints repair rat small intestine injuries and integrate into native intestinal tissue. Journal Of Tissue Engineering And Regenerative Medicine 2021, 15: 129-138. PMID: 33197151, DOI: 10.1002/term.3157.
  • Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario.D'Amico F, Bertacco A, Finotti M, Di Renzo C, Rodriguez-Davalos MI, Gondolesi GE, Cillo U, Mulligan D, Geibel J. Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. Frontiers In Surgery 2021, 8: 621525. PMID: 33796547, PMCID: PMC8009296, DOI: 10.3389/fsurg.2021.621525.
  • 3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications.Chen EP, Toksoy Z, Davis BA, Geibel JP. 3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications. Frontiers In Bioengineering And Biotechnology 2021, 9: 664188. PMID: 34055761, PMCID: PMC8158943, DOI: 10.3389/fbioe.2021.664188.
  • Colonic Fluid and Electrolyte Transport 2022: An Update.Negussie AB, Dell AC, Davis BA, Geibel JP. Colonic Fluid and Electrolyte Transport 2022: An Update. Cells 2022, 11 PMID: 35626748, DOI: 10.3390/cells11101712.
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