John Concato
Research & Publications
Biography
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Research Summary
As a general internist and clinical epidemiologist, Dr. Concato conducted research to address questions related to screening, prognosis, and treatment strategies, as well as to improve methods of study design and statistical analysis. This dual focus has involved a range of topics in both patient care and research methodology. Examples include evaluating the effectiveness of screening for prostate cancer, studies of prognosis in prostate cancer, comparing the results of observational studies and randomized trials, and clarifying the use of multivariable analysis in patient-oriented research. Prior to joining the FDA his “center-based” research included projects in genomic medicine, as part of the VA Cooperative Studies Program and Genomic Medicine Program.
Specialized Terms: Screening, prognosis, and treatment strategies; improving methods of research design and statistical analysis; real-world evidence.
Coauthors
Research Interests
Epidemiology; Internal Medicine; Prognosis; Research Design
Selected Publications
- Million Veteran Program: A mega-biobank to study genetic influences on health and disease.Gaziano JM, Concato J, Brophy M, Fiore L, Pyarajan S, Breeling J, Whitbourne S, Deen J, Shannon C, Humphries D, Guarino P, Aslan M, Anderson D, LaFleur R, Hammond T, Schaa K, Moser J, Huang G, Muralidhar S, Przygodzki R, O'Leary TJ. Million Veteran Program: A mega-biobank to study genetic influences on health and disease. Journal Of Clinical Epidemiology 2016, 70: 214-23. PMID: 26441289, DOI: 10.1016/j.jclinepi.2015.09.016.
- Study design and "evidence" in patient-oriented research.Concato J. Study design and "evidence" in patient-oriented research. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 1167-72. PMID: 23725613, DOI: 10.1164/rccm.201303-0521OE.
- Probability, uncertainty, and prostate cancer.Concato J. Probability, uncertainty, and prostate cancer. Annals Of Internal Medicine 2013, 158: 211-212. PMID: 23381041, DOI: 10.7326/0003-4819-158-3-201302050-00012.
- Is it time for medicine-based evidence?Concato J. Is it time for medicine-based evidence? JAMA 2012, 307: 1641-3. PMID: 22511693, DOI: 10.1001/jama.2012.482.
- Observational methods in comparative effectiveness research.Concato J, Lawler EV, Lew RA, Gaziano JM, Aslan M, Huang GD. Observational methods in comparative effectiveness research. The American Journal Of Medicine 2010, 123: e16-23. PMID: 21184862, DOI: 10.1016/j.amjmed.2010.10.004.
- The effectiveness of screening for prostate cancer: a nested case-control study.Concato J, Wells CK, Horwitz RI, Penson D, Fincke G, Berlowitz DR, Froehlich G, Blake D, Vickers MA, Gehr GA, Raheb NH, Sullivan G, Peduzzi P. The effectiveness of screening for prostate cancer: a nested case-control study. Archives Of Internal Medicine 2006, 166: 38-43. PMID: 16401808, DOI: 10.1001/archinte.166.1.38.
- Randomized, controlled trials, observational studies, and the hierarchy of research designs.Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. The New England Journal Of Medicine 2000, 342: 1887-92. PMID: 10861325, PMCID: PMC1557642, DOI: 10.1056/NEJM200006223422507.