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John Greg Howe, PhD

Professor Emeritus of Laboratory Medicine

Contact Information

John Greg Howe, PhD

Mailing Address

  • Laboratory Medicine

    PO Box 208035, 333 Cedar Street

    New Haven, CT 06520-8035

    United States

Research Summary

The mission of the Molecular Diagnostics Laboratory is to develop and bring into clinical use already published molecular pathology assays as well as to develop new and innovative molecular tests for the diagnosis of disease and the monitoring of therapy. Various tests have been developed and are in clinical use such as detection of mutations in the prothrombin and Factor V genes that are associated with coagulation abnormalities and tests to determine monoclonality in patients with suspected hematological malignancies. We have applied quantitative polymerase chain reaction (QPCR) methods to the measurement of BCR-ABL translocation as well as less common translocations.

Specialized Terms: Molecular Diagnostics; Hematopathology


Research Interests

Factor V; Prothrombin; Medical Laboratory Science; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Diagnostic Techniques

Selected Publications