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Joel Gelernter, MD

Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience; Director, Division of Human Genetics (Psychiatry)

Contact Information

Joel Gelernter, MD

Mailing Address

  • Psychiatry

    VA CT Healthcare Center S116A2, 950 Campbell Avenue

    West Haven, CT, 06516

    United States

Research Summary

The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including opioid, cananbis, and alcohol dependence, posttraumatic stress disorder (PTSD), and anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.

The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include multicenter case/control association studies with the goal of identifying genes predisposing to opioid and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; studies of posttraumatic stress disorder (PTSD) in the US Million Veteran Program; and a VA study on the pharmacogenomics of antidepressant response. I also co-lead the Substance Use Disorders group of the Psychiatric Genomics Consortium.

Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Pharmacogenomics

Coauthors

Research Interests

Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders

Selected Publications

Clinical Trials

ConditionsStudy Title
Addictive Behaviors; Mental Health & Behavioral ResearchThe effects of a GWAS-significant, pharmacokinetic variant (rs73568641*C) for methadone dose on µ-opiate receptor (µOR) availability as measured by 13C-Carfentanil PET
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco AddictionEffects of E-Cigarette Flavors on Adults TCORS 2.0
Diseases of the Nervous System; Mental Health & Behavioral ResearchC4 Gene Dose Effects using 11C-UCB-J PET
Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral ResearchBrain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Addictive Behaviors; Alcohol Addiction; Mental Health & Behavioral ResearchKappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors