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Joel Gelernter, MD

Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience; Director, Division of Human Genetics (Psychiatry)

Research & Publications
Biography
News

Research Summary

The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including opioid, cananbis, and alcohol dependence, posttraumatic stress disorder (PTSD), and anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.

The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include multicenter case/control association studies with the goal of identifying genes predisposing to opioid and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; studies of posttraumatic stress disorder (PTSD) in the US Million Veteran Program; and a VA study on the pharmacogenomics of antidepressant response. I also co-lead the Substance Use Disorders group of the Psychiatric Genomics Consortium.

Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Pharmacogenomics

Coauthors

Research Interests

Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders

Selected Publications

A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression.Ahn J, Won TW, Kaplan DE, Londin ER, Kuzmic P, Gelernter J, Gruen JR. A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression. Human Genetics 2002, 111:339-49.
Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data.Boutros NN, Gelernter J, Gooding DC, Cubells J, Young A, Krystal JH, Kosten T. Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data. Biological Psychiatry 2002, 51:683-6.
Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence.Kranzler HR, Hernandez-Avila CA, Gelernter J. Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2002, 26:115-22.
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.Luo X, Kranzler HR, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2003, 120B:97-108.
Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).Hernandez-Avila CA, Wand G, Luo X, Gelernter J, Kranzler HR. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1). American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2003, 118B:60-5.
Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics.Nellissery M, Feinn RS, Covault J, Gelernter J, Anton RF, Pettinati H, Moak D, Mueller T, Kranzler HR. Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics. Alcoholism, Clinical And Experimental Research 2003, 27:1402-8.
A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients.Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, O'Brien CP. A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2003, 28:1546-52.
The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity.Zabetian CP, Buxbaum SG, Elston RC, Köhnke MD, Anderson GM, Gelernter J, Cubells JF. The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity. American Journal Of Human Genetics 2003, 72:1389-400.
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Human Molecular Genetics 2003, 12:205-16.
Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study.Yamamoto K, Cubells JF, Gelernter J, Benkelfat C, Lalonde P, Bloom D, Lal S, Labelle A, Turecki G, Rouleau GA, Joober R. Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2003, 117B:33-8.
A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T --> C in African- and European-Americans.Zabetian CP, Romero R, Robertson D, Sharma S, Padbury JF, Kuivaniemi H, Kim KS, Kim CH, Köhnke MD, Kranzler HR, Gelernter J, Cubells JF. A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T --> C in African- and European-Americans. American Journal Of Medical Genetics. Part A 2003, 123A:190-2.
Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression.Lappalainen J, Sanacora G, Kranzler HR, Malison R, Hibbard ES, Price LH, Krystal J, Gelernter J. Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2004, 124B:81-6.
Social supports and serotonin transporter gene moderate depression in maltreated children.Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101:17316-21.
Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking.Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2004, 128B:94-101.
Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype.van Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. The American Journal Of Psychiatry 2004, 161:525-31.
Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism.Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH. Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. The American Journal Of Psychiatry 2004, 161:1776-82.
Allelic and haplotypic association of GABRA2 with alcohol dependence.Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2004, 129B:104-9.
A polymorphism of the beta1-adrenergic receptor is associated with low extraversion.Stein MB, Schork NJ, Gelernter J. A polymorphism of the beta1-adrenergic receptor is associated with low extraversion. Biological Psychiatry 2004, 56:217-24.
Association study of personality factors and the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1).Hernandez-Avila CA, Covault J, Gelernter J, Kranzler HR. Association study of personality factors and the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1). Psychiatric Genetics 2004, 14:89-92.
Genome-wide linkage scan for loci predisposing to social phobia: evidence for a chromosome 16 risk locus.Gelernter J, Page GP, Stein MB, Woods SW. Genome-wide linkage scan for loci predisposing to social phobia: evidence for a chromosome 16 risk locus. The American Journal Of Psychiatry 2004, 161:59-66.
NOTCH4 gene haplotype is associated with schizophrenia in African Americans.Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biological Psychiatry 2004, 55:112-7.
Setting priorities for genomic research.Berrettini W, Bierut L, Crowley TJ, Cubells JF, Frascella J, Gelernter J, Hewitt JK, Kreek MJ, Lachman H, Leppert M, Li MD, Madden P, Miner C, Pollock JD, Pomerleau O, Rice JP, Rutter JL, Shurtleff D, Swan GE, Tischfield JA, Tsuang M, Uhl GR, Vanyukov M, Volkow ND, Wanke K. Setting priorities for genomic research. Science (New York, N.Y.) 2004, 304:1445-7; author reply 1445-7.
Genomic regions controlling corticosterone levels in rats.Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Genomic regions controlling corticosterone levels in rats. Biological Psychiatry 2004, 55:634-41.
Typologies of drug dependence: comparative validity of a multivariate and four univariate models.Basu D, Ball SA, Feinn R, Gelernter J, Kranzler HR. Typologies of drug dependence: comparative validity of a multivariate and four univariate models. Drug And Alcohol Dependence 2004, 73:289-300.
CALCYON gene variation, schizophrenia, and cocaine dependence.Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J. CALCYON gene variation, schizophrenia, and cocaine dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2004, 125B:25-30.
Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus.Lappalainen J, Kranzler HR, Petrakis I, Somberg LK, Page G, Krystal JH, Gelernter J. Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus. Molecular Psychiatry 2004, 9:312-9.
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine 2005, 46:745-51.
DCDC2 is associated with reading disability and modulates neuronal development in the brain.Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102:17053-8.
ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. Pharmacogenetics And Genomics 2005, 15:755-68.
Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment.Yang BZ, Zhao H, Kranzler HR, Gelernter J. Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment. BMC Genetics 2005, 6:50.
Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE.Yang BZ, Zhao H, Kranzler HR, Gelernter J. Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE. Genetic Epidemiology 2005, 28:302-12.
Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus.Luo X, Gelernter J, Zhao H, Kranzler HR. Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2005, 135B:102.
Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population.Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J. Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcoholism, Clinical And Experimental Research 2005, 29:493-8.
Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP).Cubells JF, Feinn R, Pearson D, Burda J, Tang Y, Farrer LA, Gelernter J, Kranzler HR. Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Drug And Alcohol Dependence 2005, 80:23-33.
Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA).Pierucci-Lagha A, Gelernter J, Feinn R, Cubells JF, Pearson D, Pollastri A, Farrer L, Kranzler HR. Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA). Drug And Alcohol Dependence 2005, 80:303-12.
Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia.Gelernter J, Panhuysen C, Weiss R, Brady K, Hesselbrock V, Rounsaville B, Poling J, Wilcox M, Farrer L, Kranzler HR. Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2005, 136B:45-52.
Incentive program decreases no-shows in nontreatment substance abuse research.Pollastri AR, Pokrywa ML, Walsh SJ, Kranzler HR, Gelernter J. Incentive program decreases no-shows in nontreatment substance abuse research. Experimental And Clinical Psychopharmacology 2005, 13:376-80.
COMT polymorphisms and anxiety-related personality traits.Stein MB, Fallin MD, Schork NJ, Gelernter J. COMT polymorphisms and anxiety-related personality traits. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2005, 30:2092-102.
CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study.Luo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. Human Molecular Genetics 2005, 14:2421-34.
C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency.Jacobsen LK, Pugh KR, Mencl WE, Gelernter J. C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency. Psychopharmacology 2006, 188:530-40.
Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence.Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S, Yang BZ, Rasmussen A, Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2006, 141B:387-93.
Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Archives Of General Psychiatry 2006, 63:957-68.
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. American Journal Of Human Genetics 2006, 78:973-87.
Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.Yu Y, Panhuysen C, Kranzler HR, Hesselbrock V, Rounsaville B, Weiss R, Brady K, Farrer LA, Gelernter J. Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. Human Molecular Genetics 2006, 15:2192-9.
Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, Farrer L. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Human Molecular Genetics 2006, 15:3498-507.
Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis.Kleiman T, Zdanys K, Black B, Rightmer T, Grey M, Garman K, Macavoy M, Gelernter J, van Dyck C. Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis. Dementia And Geriatric Cognitive Disorders 2006, 22:73-82.
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence.Herman AI, Kranzler HR, Cubells JF, Gelernter J, Covault J. Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2006, 141B:499-503.
Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder.Stein MB, Seedat S, Gelernter J. Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder. Psychopharmacology 2006, 187:68-72.
Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence.Dahl JP, Cubells JF, Ray R, Weller AE, Lohoff FW, Ferraro TN, Oslin DW, Kampman KM, Dackis C, Tang Y, Gelernter J, Kranzler HR, O'Brien CP, Berrettini WH. Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. Addiction Biology 2006, 11:76-83.
Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia.Malison RT, Kranzler HR, Yang BZ, Gelernter J. Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. Psychiatric Genetics 2006, 16:245-9.
DOPA decarboxylase gene is associated with nicotine dependence.Zhang H, Ye Y, Wang X, Gelernter J, Ma JZ, Li MD. DOPA decarboxylase gene is associated with nicotine dependence. Pharmacogenomics 2006, 7:1159-66.
Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus.Kaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. American Journal Of Human Genetics 2006, 78:543-53.
Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease.Basso M, Gelernter J, Yang J, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease. Neurobiology Of Aging 2006, 27:1416-24.
ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.Luo X, Kranzler HR, Zuo L, Lappalainen J, Yang BZ, Gelernter J. ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2006, 31:1085-95.
Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs.Kalayasiri R, Kranzler HR, Weiss R, Brady K, Gueorguieva R, Panhuysen C, Yang BZ, Farrer L, Gelernter J, Malison RT. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. Drug And Alcohol Dependence 2006, 84:77-84.
Genomewide linkage scan for opioid dependence and related traits.Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, Kranzler HR. Genomewide linkage scan for opioid dependence and related traits. American Journal Of Human Genetics 2006, 78:759-769.
Variation at APOE and STH loci and Alzheimer's disease.Zuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J. Variation at APOE and STH loci and Alzheimer's disease. Behavioral And Brain Functions : BBF 2006, 2:13.
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Human Molecular Genetics 2006, 15:807-19.
Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children.Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry 2006, 59:673-80.
Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation.Hernandez-Avila CA, Covault J, Wand G, Zhang H, Gelernter J, Kranzler HR. Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation. Pharmacogenetics And Genomics 2007, 17:1031-8.
The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults.Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J. The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. The American Journal Of Psychiatry 2007, 164:1693-9.
Apolipoprotein E epsilon4 allele increases risk for psychotic symptoms in Alzheimer's disease.Zdanys KF, Kleiman TG, MacAvoy MG, Black BT, Rightmer TE, Grey M, Garman KS, Tampi RR, Gelernter J, van Dyck CH. Apolipoprotein E epsilon4 allele increases risk for psychotic symptoms in Alzheimer's disease. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2007, 32:171-9.
Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects.Tang YL, Kranzler HR, Gelernter J, Farrer LA, Cubells JF. Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects. The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2007, 16:343-51.
Personality traits of agreeableness and extraversion are associated with ADH4 variation.Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J. Personality traits of agreeableness and extraversion are associated with ADH4 variation. Biological Psychiatry 2007, 61:599-608.
Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus.Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR. Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus. Biological Psychiatry 2007, 61:119-26.
Mutation screen of the GAD2 gene and association study of alcoholism in three populations.Lappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2007, 144B:183-92.
Genetic and environmental predictors of early alcohol use.Kaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J. Genetic and environmental predictors of early alcohol use. Biological Psychiatry 2007, 61:1228-34.
Variation in GABRA2 predicts drinking behavior in project MATCH subjects.Bauer LO, Covault J, Harel O, Das S, Gelernter J, Anton R, Kranzler HR. Variation in GABRA2 predicts drinking behavior in project MATCH subjects. Alcoholism, Clinical And Experimental Research 2007, 31:1780-7.
Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. Human Molecular Genetics 2007, 16:2844-53.
Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA).Pierucci-Lagha A, Gelernter J, Chan G, Arias A, Cubells JF, Farrer L, Kranzler HR. Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA). Drug And Alcohol Dependence 2007, 91:85-90.
Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.Hirunsatit R, Ilomäki R, Malison R, Räsänen P, Ilomäki E, Kranzler HR, Kosten T, Sughondhabirom A, Thavichachart N, Tangwongchai S, Listman J, Mutirangura A, Gelernter J, Lappalainen J. Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research. BMC Genetics 2007, 8:71.
Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration.Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Lappalainen J, Gelernter J, Cubells JF, Malison RT. Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration. Biological Psychiatry 2007, 61:1310-3.
Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcoholism, Clinical And Experimental Research 2007, 31:555-63.
Demographic changes and marker properties affect detection of human population differentiation.Listman JB, Malison RT, Sughondhabirom A, Yang BZ, Raaum RL, Thavichachart N, Sanichwankul K, Kranzler HR, Tangwonchai S, Mutirangura A, Disotell TR, Gelernter J. Demographic changes and marker properties affect detection of human population differentiation. BMC Genetics 2007, 8:21.
Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. Human Molecular Genetics 2007, 16:380-90.
CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness.Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness. Human Molecular Genetics 2007, 16:1557-68.
CNR1 variation modulates risk for drug and alcohol dependence.Zuo L, Kranzler HR, Luo X, Covault J, Gelernter J. CNR1 variation modulates risk for drug and alcohol dependence. Biological Psychiatry 2007, 62:616-26.
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array.Hodgkinson CA, Yuan Q, Xu K, Shen PH, Heinz E, Lobos EA, Binder EB, Cubells J, Ehlers CL, Gelernter J, Mann J, Riley B, Roy A, Tabakoff B, Todd RD, Zhou Z, Goldman D. Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol And Alcoholism (Oxford, Oxfordshire) 2008, 43:505-15.
ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects.Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2008, 147B:179-86.
Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders.Stein MB, Schork NJ, Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2008, 33:312-9.
Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2008, 147B:1028-39.
Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.Covault J, Gelernter J, Jensen K, Anton R, Kranzler HR. Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2008, 33:837-48.
Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens.Potenza MN, Brodkin ES, Yang BZ, Birnbaum SG, Nestler EJ, Gelernter J. Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2008, 33:2735-46.
It is time to take a stand for medical research and against terrorism targeting medical scientists.Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry 2008, 63:725-7.
Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.Arias AJ, Armeli S, Gelernter J, Covault J, Kallio A, Karhuvaara S, Koivisto T, Mäkelä R, Kranzler HR. Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. Alcoholism, Clinical And Experimental Research 2008, 32:1159-66.
Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.Nussbaum J, Xu Q, Payne TJ, Ma JZ, Huang W, Gelernter J, Li MD. Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers. Human Molecular Genetics 2008, 17:1569-77.
Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test.Luo X, Zuo L, Kranzler HR, Wang S, Anton RF, Gelernter J. Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. Behavioral And Brain Functions : BBF 2008, 4:42.
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry 2008, 13:531-43.
Influence of vascular endothelial growth factor variation on human hippocampus morphology.Blumberg HP, Wang F, Chepenik LG, Kalmar JH, Edmiston E, Duman RS, Gelernter J. Influence of vascular endothelial growth factor variation on human hippocampus morphology. Biological Psychiatry 2008, 64:901-3.
Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Alcoholism, Clinical And Experimental Research 2008, 32:2117-27.
Substance dependence low-density whole genome association study in two distinct American populations.Yu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA, Gelernter J. Substance dependence low-density whole genome association study in two distinct American populations. Human Genetics 2008, 123:495-506.
The validity of cocaine dependence subtypes.Kranzler HR, Wilcox M, Weiss RD, Brady K, Hesselbrock V, Rounsaville B, Farrer L, Gelernter J. The validity of cocaine dependence subtypes. Addictive Behaviors 2008, 33:41-53.
Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2008, 28:13161-72.
Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study.Meda SA, Gelernter J, Gruen JR, Calhoun VD, Meng H, Cope NA, Pearlson GD. Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals-A Preliminary Voxel Based Morphometry Study. Brain Imaging And Behavior 2008, 2:21-26.
Influence of RGS2 on anxiety-related temperament, personality, and brain function.Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB. Influence of RGS2 on anxiety-related temperament, personality, and brain function. Archives Of General Psychiatry 2008, 65:298-308.
Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4.Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J. Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. Genomics 2008, 91:61-9.
Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders.Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, Kranzler HR. Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders. Addictive Behaviors 2008, 33:1199-207.
Genetics of alcohol dependence.Gelernter J, Kranzler HR. Genetics of alcohol dependence. Human Genetics 2009, 126:91-9.
BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study.Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study. Journal Of Alzheimer's Disease : JAD 2009, 17:887-98.
Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.Tyrka AR, Price LH, Gelernter J, Schepker C, Anderson GM, Carpenter LL. Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biological Psychiatry 2009, 66:681-5.
Association study of DTNBP1 with schizophrenia in a US sample.Zuo L, Luo X, Kranzler HR, Lu L, Rosenheck RA, Cramer J, van Kammen DP, Erdos J, Charney DS, Krystal J, Gelernter J. Association study of DTNBP1 with schizophrenia in a US sample. Psychiatric Genetics 2009, 19:292-304.
Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, Gelernter J. Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. Archives Of General Psychiatry 2009, 66:1201-9.
Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.Zhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J. Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2009, 34:2508-16.
Population admixture modulates risk for alcohol dependence.Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125:605-13.
Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).Tang YL, Kranzler HR, Gelernter J, Farrer LA, Pearson D, Cubells JF. Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP). The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2009, 18:339-45.
Sources of unreliability in the diagnosis of substance dependence.Feinn R, Gelernter J, Cubells JF, Farrer L, Kranzler HR. Sources of unreliability in the diagnosis of substance dependence. Journal Of Studies On Alcohol And Drugs 2009, 70:475-81.
Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure.Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure. Journal Of Anxiety Disorders 2009, 23:369-73.
Subtypes of major depression in substance dependence.Niciu MJ, Chan G, Gelernter J, Arias AJ, Douglas K, Weiss R, Anton RF, Farrer L, Cubells JF, Kranzler HR. Subtypes of major depression in substance dependence. Addiction (Abingdon, England) 2009, 104:1700-9.
Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2009, 34:944-51.
RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depression And Anxiety 2009, 26:309-15.
Variation in RGS2 is associated with suicidal ideation in an epidemiological study of adults exposed to the 2004 Florida hurricanes.Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Variation in RGS2 is associated with suicidal ideation in an epidemiological study of adults exposed to the 2004 Florida hurricanes. Archives Of Suicide Research : Official Journal Of The International Academy For Suicide Research 2009, 13:349-57.
Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.Zuo L, Kranzler HR, Luo X, Yang BZ, Weiss R, Brady K, Poling J, Farrer L, Gelernter J. Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2009, 34:1504-13.
Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity.Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA. Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. Pharmacogenetics And Genomics 2009, 19:53-65.
MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma.Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma. Biological Psychiatry 2009, 65:417-24.
Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents.Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. Biological Psychiatry 2009, 65:671-9.
Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment.Koenen KC, Aiello AE, Bakshis E, Amstadter AB, Ruggiero KJ, Acierno R, Kilpatrick DG, Gelernter J, Galea S. Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment. American Journal Of Epidemiology 2009, 169:704-11.
Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.Kranzler HR, Gelernter J, Anton RF, Arias AJ, Herman A, Zhao H, Burian L, Covault J. Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. Alcoholism, Clinical And Experimental Research 2009, 33:925-30.
Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.Zhang H, Kranzler HR, Weiss RD, Luo X, Brady KT, Anton RF, Farrer LA, Gelernter J. Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies. Biological Psychiatry 2009, 66:128-36.
Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample.Amstadter AB, Nugent NR, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Psychiatry 2009, 72:360-9.
Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10.Gelernter J, Kranzler HR, Panhuysen C, Weiss RD, Brady K, Poling J, Farrer L. Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. Biological Psychiatry 2009, 65:111-5.
The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.Zuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenetics And Genomics 2009, 19:437-46.
Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder.Shah MP, Wang F, Kalmar JH, Chepenik LG, Tie K, Pittman B, Jones MM, Constable RT, Gelernter J, Blumberg HP. Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2009, 34:1301-10.
Genetic variation in 5HTTLPR is associated with emotional resilience.Stein MB, Campbell-Sills L, Gelernter J. Genetic variation in 5HTTLPR is associated with emotional resilience. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2009, 150B:900-6.
Association of variants in MANEA with cocaine-related behaviors.Farrer LA, Kranzler HR, Yu Y, Weiss RD, Brady KT, Anton R, Cubells JF, Gelernter J. Association of variants in MANEA with cocaine-related behaviors. Archives Of General Psychiatry 2009, 66:267-74.
Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals.Ford JD, Gelernter J, DeVoe JS, Zhang W, Weiss RD, Brady K, Farrer L, Kranzler HR. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. Drug And Alcohol Dependence 2009, 99:193-203.
Measurement of admixture proportions and description of admixture structure in different U.S. populations.Halder I, Yang BZ, Kranzler HR, Stein MB, Shriver MD, Gelernter J. Measurement of admixture proportions and description of admixture structure in different U.S. populations. Human Mutation 2009, 30:1299-309.
Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.Zhang H, Kranzler HR, Poling J, Gelernter J. Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2010, 35:2211-24.
Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources.Sadeh N, Javdani S, Jackson JJ, Reynolds EK, Potenza MN, Gelernter J, Lejuez CW, Verona E. Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources. Journal Of Abnormal Psychology 2010, 119:604-9.
Meta-analysis of 15 genome-wide linkage scans of smoking behavior.Han S, Gelernter J, Luo X, Yang BZ. Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biological Psychiatry 2010, 67:12-9.
Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.Sherva R, Kranzler HR, Yu Y, Logue MW, Poling J, Arias AJ, Anton RF, Oslin D, Farrer LA, Gelernter J. Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2010, 35:1921-31.
Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Farrer LA, Gelernter J. Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2010, 35:1684-92.
Confirmation and generalization of an alcohol-dependence locus on chromosome 10q.Panhuysen CI, Kranzler HR, Yu Y, Weiss RD, Brady K, Poling J, Farrer LA, Gelernter J. Confirmation and generalization of an alcohol-dependence locus on chromosome 10q. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2010, 35:1325-32.
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia.Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2010, 53:1007-15.
Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.Zhang H, Gelernter J, Gruen JR, Kranzler HR, Herman AI, Simen AA. Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region. Journal Of Human Genetics 2010, 55:278-84.
A prospective cohort study investigating factors associated with depression during medical internship.Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A prospective cohort study investigating factors associated with depression during medical internship. Archives Of General Psychiatry 2010, 67:557-65.
Identification of population substructure among Jews using STR markers and dependence on reference populations included.Listman JB, Hasin D, Kranzler HR, Malison RT, Mutirangura A, Sughondhabirom A, Aharonovich E, Spivak B, Gelernter J. Identification of population substructure among Jews using STR markers and dependence on reference populations included. BMC Genetics 2010, 11:48.
Arguable assumptions, debatable conclusions.Kaufman J, Gelernter J, Kaffman A, Caspi A, Moffitt T. Arguable assumptions, debatable conclusions. Biological Psychiatry 2010, 67:e19-20; author reply e21-3.
NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depression And Anxiety 2010, 27:270-5.
Adolescent cannabis use increases risk for cocaine-induced paranoia.Kalayasiri R, Gelernter J, Farrer L, Weiss R, Brady K, Gueorguieva R, Kranzler HR, Malison RT. Adolescent cannabis use increases risk for cocaine-induced paranoia. Drug And Alcohol Dependence 2010, 107:196-201.
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X, Landi MT, Ma JZ, Short SE, Stephens SH, Stevens VL, Sun L, Wang Y, Wenzlaff AS, Aggen SH, Breslau N, Broderick P, Chatterjee N, Chen J, Heath AC, Heliövaara M, Hoft NR, Hunter DJ, Jensen MK, Martin NG, Montgomery GW, Niu T, Payne TJ, Peltonen L, Pergadia ML, Rice JP, Sherva R, Spitz MR, Sun J, Wang JC, Weiss RB, Wheeler W, Witt SH, Yang BZ, Caporaso NE, Ehringer MA, Eisen T, Gapstur SM, Gelernter J, Houlston R, Kaprio J, Kendler KS, Kraft P, Leppert MF, Li MD, Madden PA, Nöthen MM, Pillai S, Rietschel M, Rujescu D, Schwartz A, Amos CI, Bierut LJ. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genetics 2010, 6.
Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders.Douglas KR, Chan G, Gelernter J, Arias AJ, Anton RF, Weiss RD, Brady K, Poling J, Farrer L, Kranzler HR. Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders. Addictive Behaviors 2010, 35:7-13.
The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates.Coplan JD, Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Smith EL, Dwork AJ, Perera TD, Pantol G, Carpenter D, Rosenblum LA, Shungu DC, Gelernter J, Kaffman A, Jackowski A, Kaufman J, Gorman JM. The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates. Neuroscience Letters 2010, 480:93-6.
Genetics of drug dependence.Gelernter J, Kranzler HR. Genetics of drug dependence. Dialogues In Clinical Neuroscience 2010, 12:77-84.
Genetic associations of brain structural networks in schizophrenia: a preliminary study.Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruaño G, Assaf M, Pearlson GD. Genetic associations of brain structural networks in schizophrenia: a preliminary study. Biological Psychiatry 2010, 68:657-66.
ADH1A variation predisposes to personality traits and substance dependence.Zuo L, Gelernter J, Kranzler HR, Stein MB, Zhang H, Wei F, Sen S, Poling J, Luo X. ADH1A variation predisposes to personality traits and substance dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2010, 153B:376-386.
A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls.Amin Z, Kanarek K, Krupitsky E, Walderhaug E, Ilomäki R, Blumberg H, Price LH, Bhagwagar Z, Carpenter LL, Tyrka AR, Magnusson A, Landrø NI, Zvartau E, Gelernter J, Epperson CN, Räsänen P, Siironen J, Lappalainen J. A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2010, 153B:332-5.
A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits.Stein MB, Yang BZ, Chavira DA, Hitchcock CA, Sung SC, Shipon-Blum E, Gelernter J. A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits. Biological Psychiatry 2011, 69:825-31.
Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates.Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. Psychiatry Research 2011, 192:37-44.
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.Chen J, Brunzell DH, Jackson K, van der Vaart A, Ma JZ, Payne TJ, Sherva R, Farrer LA, Gejman P, Levinson DF, Holmans P, Aggen SH, Damaj I, Kuo PH, Webb BT, Anton R, Kranzler HR, Gelernter J, Li MD, Kendler KS, Chen X. ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PloS One 2011, 6:e28790.
Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.Ittiwut R, Listman JB, Ittiwut C, Cubells JF, Weiss RD, Brady K, Oslin D, Farrer LA, Kranzler HR, Gelernter J. Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2011, 156B:651-60.
Empirically derived subtypes of opioid use and related behaviors.Chan G, Gelernter J, Oslin D, Farrer L, Kranzler HR. Empirically derived subtypes of opioid use and related behaviors. Addiction (Abingdon, England) 2011, 106:1146-54.
Agitated depression in substance dependence.Leventhal AM, Gelernter J, Oslin D, Anton RF, Farrer LA, Kranzler HR. Agitated depression in substance dependence. Drug And Alcohol Dependence 2011, 116:163-9.
Variation in NGFB is associated with primary affective disorders in women.Cui D, Zhang H, Yang BZ, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. Variation in NGFB is associated with primary affective disorders in women. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2011, 156B:401-12.
Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence.Milivojevic V, Kranzler HR, Gelernter J, Burian L, Covault J. Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence. Alcoholism, Clinical And Experimental Research 2011, 35:946-52.
Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics.Herman AI, Conner TS, Anton RF, Gelernter J, Kranzler HR, Covault J. Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics. Addiction Biology 2011, 16:124-32.
Association of CHRNA4 polymorphisms with smoking behavior in two populations.Han S, Yang BZ, Kranzler HR, Oslin D, Anton R, Gelernter J. Association of CHRNA4 polymorphisms with smoking behavior in two populations. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2011, 156B:421-9.
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.Li D, Zhao H, Gelernter J. Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biological Psychiatry 2011, 70:504-12.
Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophrenia.Jamadar S, Powers NR, Meda SA, Gelernter J, Gruen JR, Pearlson GD. Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophrenia. Schizophrenia Research 2011, 129:141-8.
Developmental perspective on the role of genes in smoking risk.Gelernter J. Developmental perspective on the role of genes in smoking risk. Biological Psychiatry 2011, 69:616-7.
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biological Psychiatry 2011, 70:528-36.
A genomewide linkage scan of cocaine dependence and major depressive episode in two populations.Yang BZ, Han S, Kranzler HR, Farrer LA, Gelernter J. A genomewide linkage scan of cocaine dependence and major depressive episode in two populations. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2011, 36:2422-30.
5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder.Douglas K, Chan G, Gelernter J, Arias AJ, Anton RF, Poling J, Farrer L, Kranzler HR. 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder. Psychiatric Genetics 2011, 21:240-8.
Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA).Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, Gueorguieva R, Kranzler HR, Gelernter J. Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Addictive Behaviors 2011, 36:156-60.
Components of cross-frequency modulation in health and disease.Allen EA, Liu J, Kiehl KA, Gelernter J, Pearlson GD, Perrone-Bizzozero NI, Calhoun VD. Components of cross-frequency modulation in health and disease. Frontiers In Systems Neuroscience 2011, 5:59.
The association of genetic variation in CACNA1C with structure and function of a frontotemporal system.Wang F, McIntosh AM, He Y, Gelernter J, Blumberg HP. The association of genetic variation in CACNA1C with structure and function of a frontotemporal system. Bipolar Disorders 2011, 13:696-700.
A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women.Kranzler HR, Feinn R, Nelson EC, Covault J, Anton RF, Farrer L, Gelernter J. A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2011, 156B:960-8.
Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study. Psychoneuroendocrinology 2011, 36:289-93.
Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.Yang BZ, Han S, Kranzler HR, Farrer LA, Elston RC, Gelernter J. Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2012, 159B:361-9.
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.Han S, Yang BZ, Kranzler HR, Oslin D, Anton R, Farrer LA, Gelernter J. Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. Biological Psychiatry 2012, 72:637-44.
Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.Sun J, Bi J, Chan G, Oslin D, Farrer L, Gelernter J, Kranzler HR. Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors. Addictive Behaviors 2012, 37:1138-44.
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.Zhang H, Wang F, Kranzler HR, Anton RF, Gelernter J. Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. Behavioral And Brain Functions : BBF 2012, 8:23.
Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases.Li D, Zhao H, Gelernter J. Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases. Human Genetics 2012, 131:1361-74.
Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM. Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal Of Human Genetics : EJHG 2012, 20:1078-84.
The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex.Amstadter AB, Macpherson L, Wang F, Banducci AN, Reynolds EK, Potenza MN, Gelernter J, Lejuez CW. The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex. Journal Of Psychiatric Research 2012, 46:940-5.
Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples.Chen X, Listman JB, Slack FJ, Gelernter J, Zhao H. Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples. Genetic Epidemiology 2012, 36:549-60.
Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study.Xie P, Kranzler HR, Farrer L, Gelernter J. Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2012, 159B:644-52.
ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.Chen XD, Xiong DH, Yang TL, Pei YF, Guo YF, Li J, Yang F, Pan F, Tan LJ, Yan H, Liu XG, Lei SF, Li X, Ning LL, Zhu XZ, Levy S, Kranzler HR, Farrer LA, Gelernter J, Recker RR, Deng HW. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. Chinese Medical Journal 2012, 125:1127-34.
Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.Zhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J. Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. Journal Of Human Genetics 2012, 57:670-5.
GABRA2 genotype, impulsivity, and body mass.Bauer LO, Yang BZ, Houston RJ, Kranzler HR, Gelernter J. GABRA2 genotype, impulsivity, and body mass. The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2012, 21:404-10.
Identification of POMC exonic variants associated with substance dependence and body mass index.Wang F, Gelernter J, Kranzler HR, Zhang H. Identification of POMC exonic variants associated with substance dependence and body mass index. PloS One 2012, 7:e45300.
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X. Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2012, 37:557-66.
Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males.Xie P, Kranzler HR, Zhang H, Oslin D, Anton RF, Farrer LA, Gelernter J. Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2012, 37:669-76.
Genetic associations with performance on a behavioral measure of distress intolerance.Amstadter AB, Daughters SB, Macpherson L, Reynolds EK, Danielson CK, Wang F, Potenza MN, Gelernter J, Lejuez CW. Genetic associations with performance on a behavioral measure of distress intolerance. Journal Of Psychiatric Research 2012, 46:87-94.
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.Li D, Zhao H, Gelernter J. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Human Genetics 2012, 131:725-37.
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen LP, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan J, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Viikari J, Kähönen M, Kendler KS, Lehtimäki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi J, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Völzke H, Wei Q, Wichmann HE, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives Of General Psychiatry 2012, 69:854-60.
Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals.Arias AJ, Chan G, Gelernter J, Farrer L, Kranzler HR. Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals. The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2012, 21:5-10.
Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.Li D, Zhao H, Kranzler HR, Oslin D, Anton RF, Farrer LA, Gelernter J. Association of COL25A1 with comorbid antisocial personality disorder and substance dependence. Biological Psychiatry 2012, 71:733-40.
GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.Ittiwut C, Yang BZ, Kranzler HR, Anton RF, Hirunsatit R, Weiss RD, Covault J, Farrer LA, Gelernter J. GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. Alcoholism, Clinical And Experimental Research 2012, 36:588-93.
M(3): an improved SNP calling algorithm for Illumina BeadArray data.Li G, Gelernter J, Kranzler HR, Zhao H. M(3): an improved SNP calling algorithm for Illumina BeadArray data. Bioinformatics (Oxford, England) 2012, 28:358-65.
Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.Zhang H, Wang F, Kranzler HR, Zhao H, Gelernter J. Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. PloS One 2013, 8:e65648.
Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.Xie P, Kranzler HR, Yang C, Zhao H, Farrer LA, Gelernter J. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. Biological Psychiatry 2013, 74:656-63.
Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study.Jamadar S, Powers NR, Meda SA, Calhoun VD, Gelernter J, Gruen JR, Pearlson GD. Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study. Brain Imaging And Behavior 2013, 7:15-27.
Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma.Cartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma. JAMA Dermatology 2013, 149:1110-1.
Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use Disorders.Wang F, Gelernter J, Zhang H. Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use Disorders. Journal Of Addiction Research & Therapy 2013, 4.
Variant callers for next-generation sequencing data: a comparison study.Liu X, Han S, Wang Z, Gelernter J, Yang BZ. Variant callers for next-generation sequencing data: a comparison study. PloS One 2013, 8:e75619.
The role and challenges of exome sequencing in studies of human diseases.Wang Z, Liu X, Yang BZ, Gelernter J. The role and challenges of exome sequencing in studies of human diseases. Frontiers In Genetics 2013, 4:160.
Array-based profiling of DNA methylation changes associated with alcohol dependence.Zhang H, Herman AI, Kranzler HR, Anton RF, Zhao H, Zheng W, Gelernter J. Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcoholism, Clinical And Experimental Research 2013, 37 Suppl 1:E108-15.
Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: a pilot study.Pietrzak RH, Galea S, Southwick SM, Gelernter J. Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: a pilot study. Journal Of Affective Disorders 2013, 148:123-8.
Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genetic Epidemiology 2013, 37:846-59.
Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. American Journal Of Human Genetics 2013, 93:1027-34.
Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample.Peer K, Rennert L, Lynch KG, Farrer L, Gelernter J, Kranzler HR. Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample. Drug And Alcohol Dependence 2013, 127:215-9.
Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults.White S, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, Gelernter J, Williamson V, McMichael O, Vladimirov VI, Amstadter AB. Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults. Journal Of Anxiety Disorders 2013, 27:678-83.
Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans.Han S, Gelernter J, Kranzler HR, Yang BZ. Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans. Human Genetics 2013, 132:397-403.
Child abuse and epigenetic mechanisms of disease risk.Yang BZ, Zhang H, Ge W, Weder N, Douglas-Palumberi H, Perepletchikova F, Gelernter J, Kaufman J. Child abuse and epigenetic mechanisms of disease risk. American Journal Of Preventive Medicine 2013, 44:101-7.
COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers.Herman AI, Jatlow PI, Gelernter J, Listman JB, Sofuoglu M. COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. The Pharmacogenomics Journal 2013, 13:490-7.
A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.Zayats T, Yang BZ, Xie P, Poling J, Farrer LA, Gelernter J. A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. PloS One 2013, 8:e49368.
Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample.Meyers JL, Shmulewitz D, Aharonovich E, Waxman R, Frisch A, Weizman A, Spivak B, Edenberg HJ, Gelernter J, Hasin DS. Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample. Alcoholism, Clinical And Experimental Research 2013, 37:1872-81.
Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways.Zhang H, Wang F, Xu H, Liu Y, Liu J, Zhao H, Gelernter J. Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways. Human Genetics 2014, 133:1383-94.
Genetic association of impulsivity in young adults: a multivariate study.Khadka S, Narayanan B, Meda SA, Gelernter J, Han S, Sawyer B, Aslanzadeh F, Stevens MC, Hawkins KA, Anticevic A, Potenza MN, Pearlson GD. Genetic association of impulsivity in young adults: a multivariate study. Translational Psychiatry 2014, 4:e451.
Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort.Kalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort. Addiction (Abingdon, England) 2014, 109:965-76.
A Preliminary Examination of the Relationship Between the 5-HTTLPR and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old Youth.Banducci AN, Gomes M, MacPherson L, Lejuez CW, Potenza MN, Gelernter J, Amstadter AB. A Preliminary Examination of the Relationship Between the 5-HTTLPR and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old Youth. Psychological Trauma : Theory, Research, Practice And Policy 2014, 6:1-7.
The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men.Sartor CE, Wang Z, Xu K, Kranzler HR, Gelernter J. The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men. Alcoholism, Clinical And Experimental Research 2014, 38:2907-14.
Posttreatment effects of topiramate treatment for heavy drinking.Kranzler HR, Wetherill R, Feinn R, Pond T, Gelernter J, Covault J. Posttreatment effects of topiramate treatment for heavy drinking. Alcoholism, Clinical And Experimental Research 2014, 38:3017-23.
Characteristics and course of dependence in cocaine-dependent individuals who never used alcohol or marijuana or used cocaine first.Sartor CE, Kranzler HR, Gelernter J. Characteristics and course of dependence in cocaine-dependent individuals who never used alcohol or marijuana or used cocaine first. Journal Of Studies On Alcohol And Drugs 2014, 75:423-7.
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation.Chung D, Yang C, Li C, Gelernter J, Zhao H. GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genetics 2014, 10:e1004787.
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Molecular Psychiatry 2014, 19:717-23.
Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.Richardson TG, Minica C, Heron J, Tavare J, MacKenzie A, Day I, Lewis G, Hickman M, Vink JM, Gelernter J, Kranzler HR, Farrer LA, Munafò M, Wynick D. Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2014, 165B:654-64.
Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism.Kranzler HR, Covault J, Feinn R, Armeli S, Tennen H, Arias AJ, Gelernter J, Pond T, Oncken C, Kampman KM. Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. The American Journal Of Psychiatry 2014, 171:445-52.
Genetic risk prediction and neurobiological understanding of alcoholism.Levey DF, Le-Niculescu H, Frank J, Ayalew M, Jain N, Kirlin B, Learman R, Winiger E, Rodd Z, Shekhar A, Schork N, Kiefer F, Wodarz N, Müller-Myhsok B, Dahmen N, Nöthen M, Sherva R, Farrer L, Smith AH, Kranzler HR, Rietschel M, Gelernter J, Niculescu AB. Genetic risk prediction and neurobiological understanding of alcoholism. Translational Psychiatry 2014, 4:e391.
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Gelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH, Anton R, Preuss UW, Ridinger M, Rujescu D, Wodarz N, Zill P, Zhao H, Farrer LA. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. Molecular Psychiatry 2014, 19:41-9.
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA. Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. Biological Psychiatry 2014, 76:66-74.
Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.Li D, Sulovari A, Cheng C, Zhao H, Kranzler HR, Gelernter J. Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2014, 39:907-18.
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.Yang C, Li C, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. Human Genetics 2014, 133:617-24.
Sex-biased methylome and transcriptome in human prefrontal cortex.Xu H, Wang F, Liu Y, Yu Y, Gelernter J, Zhang H. Sex-biased methylome and transcriptome in human prefrontal cortex. Human Molecular Genetics 2014, 23:1260-70.
Improving genetic risk prediction by leveraging pleiotropy.Li C, Yang C, Gelernter J, Zhao H. Improving genetic risk prediction by leveraging pleiotropy. Human Genetics 2014, 133:639-50.
SLC6A4 polymorphism, population genetics, and psychiatric traits.Gelernter J. SLC6A4 polymorphism, population genetics, and psychiatric traits. Human Genetics 2014, 133:459-61.
Rate of progression from first use to dependence on cocaine or opioids: a cross-substance examination of associated demographic, psychiatric, and childhood risk factors.Sartor CE, Kranzler HR, Gelernter J. Rate of progression from first use to dependence on cocaine or opioids: a cross-substance examination of associated demographic, psychiatric, and childhood risk factors. Addictive Behaviors 2014, 39:473-9.
Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders.Kos MZ, Glahn DC, Carless MA, Olvera R, McKay DR, Quillen EE, Gelernter J, Chen XD, Deng HW, Kent JW, Dyer TD, Göring HH, Curran JE, Duggirala R, Blangero J, Almasy L. Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2014, 165B:294-302.
Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.McClure-Begley TD, Papke RL, Stone KL, Stokes C, Levy AD, Gelernter J, Xie P, Lindstrom J, Picciotto MR. Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors. The Journal Of Pharmacology And Experimental Therapeutics 2014, 348:410-20.
Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Addiction Biology 2014, 19:955-64.
Novel gene identified in an exome-wide association study of tanning dependence.Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome-wide association study of tanning dependence. Experimental Dermatology 2014, 23:757-9.
Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans.Arias AJ, Gelernter J, Gueorguieva R, Ralevski E, Petrakis IL. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans. The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2014, 23:288-93.
Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, Lipschitz D, Douglas-Palumberi H, Ge M, Perepletchikova F, O'Loughlin K, Hudziak JJ, Gelernter J, Kaufman J. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. Journal Of The American Academy Of Child And Adolescent Psychiatry 2014, 53:417-24.e5.
The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders.Jensen KP, Kranzler HR, Stein MB, Gelernter J. The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2014, 165B:175-83.
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EE, Chen XD, Almasy L, Yang F, He H, Li X, Wang XY, Liu TQ, Hao W, Deng HW, Kranzler HR, Gelernter J. ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2014, 165B:103-10.
Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes.Zhang H, Wang F, Kranzler HR, Yang C, Xu H, Wang Z, Zhao H, Gelernter J. Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. Human Genetics 2014, 133:1093-104.
DSM-5 gambling disorder: prevalence and characteristics in a substance use disorder sample.Rennert L, Denis C, Peer K, Lynch KG, Gelernter J, Kranzler HR. DSM-5 gambling disorder: prevalence and characteristics in a substance use disorder sample. Experimental And Clinical Psychopharmacology 2014, 22:50-6.
Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis.Bi J, Gelernter J, Sun J, Kranzler HR. Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2014, 165B:148-56.
Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss.Haraksingh RR, Jahanbani F, Rodriguez-Paris J, Gelernter J, Nadeau KC, Oghalai JS, Schrijver I, Snyder MP. Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss. BMC Genomics 2014, 15:1155.
Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria.Kilcoyne B, Shmulewitz D, Meyers JL, Aharonovich E, Greenstein E, Frisch A, Weizman A, Spivak B, Edenberg HJ, Gelernter J, Hasin DS. Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. Journal Of Studies On Alcohol And Drugs 2014, 75:635-42.
The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children.Kaufman J, Gelernter J, Hudziak JJ, Tyrka AR, Coplan JD. The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children. Journal Of The American Academy Of Child And Adolescent Psychiatry 2015, 54:617-25.
Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons.Xiang Y, Kim KY, Gelernter J, Park IH, Zhang H. Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons. PloS One 2015, 10:e0134907.
FKBP5 variation is associated with the acute and chronic effects of nicotine.Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2015, 15:340-6.
Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets.Vongpaisarnsin K, Listman JB, Malison RT, Gelernter J. Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets. Legal Medicine (Tokyo, Japan) 2015, 17:245-50.
Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.Repunte-Canonigo V, Herman MA, Kawamura T, Kranzler HR, Sherva R, Gelernter J, Farrer LA, Roberto M, Sanna PP. Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans. Biological Psychiatry 2015, 77:870-879.
Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers.Meyers JL, Shmulewitz D, Wall MM, Keyes KM, Aharonovich E, Spivak B, Weizman A, Frisch A, Edenberg HJ, Gelernter J, Grant BF, Hasin D. Childhood adversity moderates the effect of ADH1B on risk for alcohol-related phenotypes in Jewish Israeli drinkers. Addiction Biology 2015, 20:205-14.
Genome-wide association study of copy number variations (CNVs) with opioid dependence.Li D, Zhao H, Kranzler HR, Li MD, Jensen KP, Zayats T, Farrer LA, Gelernter J. Genome-wide association study of copy number variations (CNVs) with opioid dependence. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2015, 40:1016-26.
A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.Jensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2015, 40:2813-21.
Genetics of complex traits in psychiatry.Gelernter J. Genetics of complex traits in psychiatry. Biological Psychiatry 2015, 77:36-42.
Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.Xu K, Kranzler HR, Sherva R, Sartor CE, Almasy L, Koesterer R, Zhao H, Farrer LA, Gelernter J. Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. Alcoholism, Clinical And Experimental Research 2015, 39:1137-47.
Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS.Wang Q, Yang C, Gelernter J, Zhao H. Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Human Genetics 2015, 134:1195-209.
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. Biological Psychiatry 2015, 77:493-503.
Further analyses support the association between light eye color and alcohol dependence.Sulovari A, Kranzler HR, Farrer LA, Gelernter J, Li D. Further analyses support the association between light eye color and alcohol dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2015, 168:757-60.
Inter-observer reliability of DSM-5 substance use disorders.Denis CM, Gelernter J, Hart AB, Kranzler HR. Inter-observer reliability of DSM-5 substance use disorders. Drug And Alcohol Dependence 2015, 153:229-35.
Eye color: A potential indicator of alcohol dependence risk in European Americans.Sulovari A, Kranzler HR, Farrer LA, Gelernter J, Li D. Eye color: A potential indicator of alcohol dependence risk in European Americans. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2015, 168B:347-53.
The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores.Mbarek H, Milaneschi Y, Fedko IO, Hottenga JJ, de Moor MH, Jansen R, Gelernter J, Sherva R, Willemsen G, Boomsma DI, Penninx BW, Vink JM. The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2015, 168:739-48.
Dissecting ancestry genomic background in substance dependence genome-wide association studies.Polimanti R, Yang C, Zhao H, Gelernter J. Dissecting ancestry genomic background in substance dependence genome-wide association studies. Pharmacogenomics 2015, 16:1487-98.
CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O'Malley SS, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2016, 18:1845-52.
RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.Montalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2016, 171B:81-91.
Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?Hart AB, Lynch KG, Farrer L, Gelernter J, Kranzler HR. Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence? Addiction Biology 2016, 21:924-38.
Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.Agrawal A, Edenberg HJ, Gelernter J. Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. Journal Of Studies On Alcohol And Drugs 2016, 77:676-80.
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.Stringer S, Minică CC, Verweij KJ, Mbarek H, Bernard M, Derringer J, van Eijk KR, Isen JD, Loukola A, Maciejewski DF, Mihailov E, van der Most PJ, Sánchez-Mora C, Roos L, Sherva R, Walters R, Ware JJ, Abdellaoui A, Bigdeli TB, Branje SJ, Brown SA, Bruinenberg M, Casas M, Esko T, Garcia-Martinez I, Gordon SD, Harris JM, Hartman CA, Henders AK, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Huizink AC, Irons DE, Kahn RS, Korhonen T, Kranzler HR, Krauter K, van Lier PA, Lubke GH, Madden PA, Mägi R, McGue MK, Medland SE, Meeus WH, Miller MB, Montgomery GW, Nivard MG, Nolte IM, Oldehinkel AJ, Pausova Z, Qaiser B, Quaye L, Ramos-Quiroga JA, Richarte V, Rose RJ, Shin J, Stallings MC, Stiby AI, Wall TL, Wright MJ, Koot HM, Paus T, Hewitt JK, Ribasés M, Kaprio J, Boks MP, Snieder H, Spector T, Munafò MR, Metspalu A, Gelernter J, Boomsma DI, Iacono WG, Martin NG, Gillespie NA, Derks EM, Vink JM. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Translational Psychiatry 2016, 6:e769.
Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder.Khadka S, Pearlson GD, Calhoun VD, Liu J, Gelernter J, Bessette KL, Stevens MC. Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder. Frontiers In Psychiatry 2016, 7:128.
Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women.Polimanti R, Kranzler HR, Gelernter J. Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2016, 41:2688-96.
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 2016, 73:695-704.
CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving.Shmulewitz D, Meyers JL, Wall MM, Aharonovich E, Frisch A, Spivak B, Weizman A, Edenberg HJ, Gelernter J, Hasin DS. CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving. Journal Of Studies On Alcohol And Drugs 2016, 77:227-37.
Genetic Relationship between Schizophrenia and Nicotine Dependence.Chen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BW, Tyndale RF, Ware JJ, Vink JM, Kaprio J, Munafò M, Chen X. Genetic Relationship between Schizophrenia and Nicotine Dependence. Scientific Reports 2016, 6:25671.
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry 2016, 73:472-80.
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.Clarke TK, Smith AH, Gelernter J, Kranzler HR, Farrer LA, Hall LS, Fernandez-Pujals AM, MacIntyre DJ, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, Thomson PA, Porteous DJ, Deary IJ, McIntosh AM. Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addiction Biology 2016, 21:469-80.
DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders.Wang F, Xu H, Zhao H, Gelernter J, Zhang H. DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Scientific Reports 2016, 6:19430.
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL. Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behavior Genetics 2016, 46:151-69.
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits.Polimanti R, Yang BZ, Zhao H, Gelernter J. Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits. PloS One 2016, 11:e0160654.
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315:71-4.
Evidence of CNIH3 involvement in opioid dependence.Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. Evidence of CNIH3 involvement in opioid dependence. Molecular Psychiatry 2016, 21:608-14.
Genome-wide association study of body mass index in subjects with alcohol dependence.Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study of body mass index in subjects with alcohol dependence. Addiction Biology 2017, 22:535-549.
Review: DNA methylation and alcohol use disorders: Progress and challenges.Zhang H, Gelernter J. Review: DNA methylation and alcohol use disorders: Progress and challenges. The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2017, 26:502-515.
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74:1153-1160.
Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents.Bountress K, Danielson CK, Williamson V, Vladmirov V, Gelernter J, Ruggiero K, Amstadter A. Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents. The American Journal On Addictions / American Academy Of Psychiatrists In Alcoholism And Addictions 2017, 26:623-631.
Alcohol Misuse and Co-Occurring Mental Disorders Among New Soldiers in the U.S. Army.Stein MB, Campbell-Sills L, Gelernter J, He F, Heeringa SG, Nock MK, Sampson NA, Sun X, Jain S, Kessler RC, Ursano RJ. Alcohol Misuse and Co-Occurring Mental Disorders Among New Soldiers in the U.S. Army. Alcoholism, Clinical And Experimental Research 2017, 41:139-148.
Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior.Tielbeek JJ, Johansson A, Polderman TJC, Rautiainen MR, Jansen P, Taylor M, Tong X, Lu Q, Burt AS, Tiemeier H, Viding E, Plomin R, Martin NG, Heath AC, Madden PAF, Montgomery G, Beaver KM, Waldman I, Gelernter J, Kranzler HR, Farrer LA, Perry JRB, Munafò M, LoParo D, Paunio T, Tiihonen J, Mous SE, Pappa I, de Leeuw C, Watanabe K, Hammerschlag AR, Salvatore JE, Aliev F, Bigdeli TB, Dick D, Faraone SV, Popma A, Medland SE, Posthuma D. Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior. JAMA Psychiatry 2017, 74:1242-1250.
Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.Do C, Shearer A, Suzuki M, Terry MB, Gelernter J, Greally JM, Tycko B. Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era. Genome Biology 2017, 18:120.
Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury.Polimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB. Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. Journal Of Neurotrauma 2017, 34:781-789.
Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.Polimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genetics 2017, 13:e1006618.
Sex-specific linkage scans in opioid dependence.Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex-specific linkage scans in opioid dependence. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2017, 174:261-268.
Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.Polimanti R, Jensen KP, Gelernter J. Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers. Scientific Reports 2017, 7:1034.
Genomewide association studies of suicide attempts in US soldiers.Stein MB, Ware EB, Mitchell C, Chen CY, Borja S, Cai T, Dempsey CL, Fullerton CS, Gelernter J, Heeringa SG, Jain S, Kessler RC, Naifeh JA, Nock MK, Ripke S, Sun X, Beckham JC, Kimbrel NA, Ursano RJ, Smoller JW. Genomewide association studies of suicide attempts in US soldiers. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2017, 174:786-797.
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry 2017, 74:1234-1241.
Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.Justice AC, McGinnis KA, Tate J, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR. Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. Alcoholism, Clinical And Experimental Research 2017, 41:998-1003.
S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours.Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. Journal Of Psychiatry & Neuroscience : JPN 2017, 42:252-261.
Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal Of Clinical Psychiatry 2017, 78:e1058-e1059.
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.Polimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J. A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder. Genome Medicine 2017, 9:99.
Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center.Rungnirundorn T, Verachai V, Gelernter J, Malison RT, Kalayasiri R. Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center. Journal Of Addiction Medicine 2017, 11:19-27.
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards A, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati AA, Poland RS, Rood B, Patterson DG, Walsh D, Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PA, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M, Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Alcoholism, Clinical And Experimental Research 2017, 41:911-928.
Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions.Wang Q, Polimanti R, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Human Genetics 2017, 136:75-83.
GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcoholism, Clinical And Experimental Research 2017, 41:2025-2032.
Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2017, 94:139-147.
Genetic risk variants for social anxiety.Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J. Genetic risk variants for social anxiety. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2017, 174:470-482.
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2017, 42:598-605.
Schizophrenia and substance use comorbidity: a genome-wide perspective.Polimanti R, Agrawal A, Gelernter J. Schizophrenia and substance use comorbidity: a genome-wide perspective. Genome Medicine 2017, 9:25.
Genetic risk variants for social anxiety.Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J. Genetic risk variants for social anxiety. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2017, 174:120-131.
Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.Xu H, Wang F, Kranzler HR, Gelernter J, Zhang H. Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes. Scientific Reports 2017, 7:41816.
Effects of ANK3 variation on gray and white matter in bipolar disorder.Lippard ET, Jensen KP, Wang F, Johnston JA, Spencer L, Pittman B, Gelernter J, Blumberg HP. Effects of ANK3 variation on gray and white matter in bipolar disorder. Molecular Psychiatry 2017, 22:1345-1351.
A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. Molecular Psychiatry 2017, 22:242-249.
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Molecular Psychiatry 2017, 22:346-352.
Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2017, 174:846-853.
Predictors of tanning dependence in white non-Hispanic females and males.Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non-Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology : JEADV 2017, 31:1223-1228.
Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes.Lu J, Sun J, Wang X, Kranzler HR, Gelernter J, Bi J. Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes. Proceedings. IEEE International Conference On Bioinformatics And Biomedicine 2017, 2017:392-397.
Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder.Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder. Molecular Psychiatry 2017, 22:1225.
Genetically determined schizophrenia is not associated with impaired glucose homeostasis.Polimanti R, Gelernter J, Stein DJ. Genetically determined schizophrenia is not associated with impaired glucose homeostasis. Schizophrenia Research 2018, 195:286-289.
Psychiatric Genomics: An Update and an Agenda.Sullivan PF, Agrawal A, Bulik CM, Andreassen OA, Børglum AD, Breen G, Cichon S, Edenberg HJ, Faraone SV, Gelernter J, Mathews CA, Nievergelt CM, Smoller JW, O'Donovan MC. Psychiatric Genomics: An Update and an Agenda. The American Journal Of Psychiatry 2018, 175:15-27.
Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia.Zheutlin AB, Chekroud AM, Polimanti R, Gelernter J, Sabb FW, Bilder RM, Freimer N, London ED, Hultman CM, Cannon TD. Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia. Schizophrenia Bulletin 2018, 44:1045-1052.
Genome-wide analysis of insomnia disorder.Stein MB, McCarthy MJ, Chen CY, Jain S, Gelernter J, He F, Heeringa SG, Kessler RC, Nock MK, Ripke S, Sun X, Wynn GH, Smoller JW, Ursano RJ. Genome-wide analysis of insomnia disorder. Molecular Psychiatry 2018, 23:2238-2250.
Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease.Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease. Neurobiology Of Aging 2018, 61:207-214.
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Acta Psychiatrica Scandinavica 2018, 137:148-156.
Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans. Biological Psychiatry 2018, 84:762-770.
Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.Mota NP, Han S, Harpaz-Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2018, 35:168-177.
Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. Alcoholism, Clinical And Experimental Research 2018, 42:861-868.
ADH1B: From alcoholism, natural selection, and cancer to the human phenome.Polimanti R, Gelernter J. ADH1B: From alcoholism, natural selection, and cancer to the human phenome. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2018, 177:113-125.
A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus. Molecular Psychiatry 2018, 23:154-160.
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Molecular Psychiatry 2018, 23:2277-2286.
Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.Polimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Medicine 2018, 10:24.
AUDIT-C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations.Justice AC, Smith RV, Tate JP, McGinnis K, Xu K, Becker WC, Lee KY, Lynch K, Sun N, Concato J, Fiellin DA, Zhao H, Gelernter J, Kranzler HR. AUDIT-C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations. Addiction (Abingdon, England) 2018, 113:2214-2224.
Genome-wide association meta-analysis of age at first cannabis use.Minică CC, Verweij KJH, van der Most PJ, Mbarek H, Bernard M, van Eijk KR, Lind PA, Liu MZ, Maciejewski DF, Palviainen T, Sánchez-Mora C, Sherva R, Taylor M, Walters RK, Abdellaoui A, Bigdeli TB, Branje SJT, Brown SA, Casas M, Corley RP, Smith GD, Davies GE, Ehli EA, Farrer L, Fedko IO, Garcia-Martínez I, Gordon SD, Hartman CA, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Kahn RS, Kaprio J, Korhonen T, Kranzler HR, Krauter K, van Lier PAC, Madden PAF, Medland SE, Neale MC, Meeus WHJ, Montgomery GW, Nolte IM, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Richarte V, Rose RJ, Shin J, Stallings MC, Wall TL, Ware JJ, Wright MJ, Zhao H, Koot HM, Paus T, Hewitt JK, Ribasés M, Loukola A, Boks MP, Snieder H, Munafò MR, Gelernter J, Boomsma DI, Martin NG, Gillespie NA, Vink JM, Derks EM. Genome-wide association meta-analysis of age at first cannabis use. Addiction (Abingdon, England) 2018, 113:2073-2086.
Methylation in OTX2 and related genes, maltreatment, and depression in children.Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Methylation in OTX2 and related genes, maltreatment, and depression in children. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 2018, 43:2204-2211.
Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers.Jensen KP, Valentine G, Buta E, DeVito EE, Gelernter J, Sofuoglu M. Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers. Pharmacology, Biochemistry, And Behavior 2018, 173:36-43.
Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.Zhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2018, 177:511-519.
Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth.Kaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth. The Journal Of Pediatrics 2018, 202:150-156.e3.
Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders.Ravera S, Carrasco N, Gelernter J, Polimanti R. Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders. Journal Of Clinical Medicine 2018, 7.
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.Smith AH, Ovesen PL, Skeldal S, Yeo S, Jensen KP, Olsen D, Diazgranados N, Zhao H, Farrer LA, Goldman D, Glerup S, Kranzler HR, Nykjaer A, Gelernter J. Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. Alcoholism, Clinical And Experimental Research 2018, 42:2337-2348.
Inferring phenotypes from substance use via collaborative matrix completion.Lu J, Sun J, Wang X, Kranzler H, Gelernter J, Bi J. Inferring phenotypes from substance use via collaborative matrix completion. BMC Systems Biology 2018, 12:104.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience 2018, 21:1656-1669.
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, de Wit H, Davis LK, MacKillop J, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience 2018, 21:1161-1170.
Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8:208.
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Molecular Psychiatry 2018, 23:666-673.
Using DNA methylation to validate an electronic medical record phenotype for smoking.McGinnis KA, Justice AC, Tate JP, Kranzler HR, Tindle HA, Becker WC, Concato J, Gelernter J, Li B, Zhang X, Zhao H, Crothers K, Xu K. Using DNA methylation to validate an electronic medical record phenotype for smoking. Addiction Biology 2019, 24:1056-1065.
Genetic associations with suicide attempt severity and genetic overlap with major depression.Levey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Genetic associations with suicide attempt severity and genetic overlap with major depression. Translational Psychiatry 2019, 9:22.
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ, Andreassen OA, Asherson P, Burton CL, Boomsma DI, Cormand B, Dalsgaard S, Franke B, Gelernter J, Geschwind D, Hakonarson H, Haavik J, Kranzler HR, Kuntsi J, Langley K, Lesch KP, Middeldorp C, Reif A, Rohde LA, Roussos P, Schachar R, Sklar P, Sonuga-Barke EJS, Sullivan PF, Thapar A, Tung JY, Waldman ID, Medland SE, Stefansson K, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Daly MJ, Faraone SV, Børglum AD, Neale BM. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics 2019, 51:63-75.
GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.Xiang B, Yang BZ, Zhou H, Kranzler H, Gelernter J. GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2019, 180:3-11.
Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B.Radhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B. International Journal Of Methods In Psychiatric Research 2019, 28:e1767.
Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women. Scientific Reports 2019, 9:4660.
Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants.Polimanti R, Nuñez YZ, Gelernter J. Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants. Journal Of Clinical Medicine 2019, 8.
Genetics of Alcoholism.Edenberg HJ, Gelernter J, Agrawal A. Genetics of Alcoholism. Current Psychiatry Reports 2019, 21:26.
Alcohol-responsive genes identified in human iPSC-derived neural cultures.Jensen KP, Lieberman R, Kranzler HR, Gelernter J, Clinton K, Covault J. Alcohol-responsive genes identified in human iPSC-derived neural cultures. Translational Psychiatry 2019, 9:96.
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10:1499.
Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans.Harrington KM, Quaden R, Stein MB, Honerlaw JP, Cissell S, Pietrzak RH, Zhao H, Radhakrishnan K, Aslan M, Gaziano JM, Concato J, Gagnon DR, Gelernter J, Cho K. Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans. Journal Of Traumatic Stress 2019, 32:226-237.
Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10:2275.
Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol-Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort.Meda SA, Narayanan B, Chorlian D, Meyers JL, Gelernter J, Hesselbrock V, Bauer L, Calhoun VD, Porjesz B, Pearlson GD. Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol-Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort. Alcoholism, Clinical And Experimental Research 2019, 43:1462-1477.
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86:365-376.
Inviting in the Exome for Alcohol and Smoking Traits.Gelernter J. Inviting in the Exome for Alcohol and Smoking Traits. Biological Psychiatry 2019, 85:889-890.
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium.Polimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H, Medland SE, Streit F, Agrawal A, Edenberg HJ, Kendler KS, Lewis CM, Sullivan PF, Wray NR, Gelernter J, Derks EM. Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Psychological Medicine 2019, 49:1218-1226.
Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study.Polimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study. JAMA Network Open 2019, 2:e193447.
Genome-wide analyses of psychological resilience in U.S. Army soldiers.Stein MB, Choi KW, Jain S, Campbell-Sills L, Chen CY, Gelernter J, He F, Heeringa SG, Maihofer AX, Nievergelt C, Nock MK, Ripke S, Sun X, Kessler RC, Smoller JW, Ursano RJ. Genome-wide analyses of psychological resilience in U.S. Army soldiers. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2019, 180:310-319.
Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence.Rosato AJ, Chen X, Tanaka Y, Farrer LA, Kranzler HR, Nunez YZ, Henderson DC, Gelernter J, Zhang H. Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence. Epigenomics 2019, 11:739-749.
Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability.Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, de Wit H, Davis LK, MacKillop J, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability. Nature Neuroscience 2019, 22:1196.
Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study.Rentsch CT, Edelman EJ, Justice AC, Marshall BDL, Xu K, Smith AH, Crystal S, Gaither JR, Gordon AJ, Smith RV, Kember RL, Polimanti R, Gelernter J, Fiellin DA, Tate JP, Kranzler HR, Becker WC. Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study. AIDS And Behavior 2019, 23:3340-3349.
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nature Neuroscience 2019, 22:1394-1401.
Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10:4050.
Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.Averill LA, Abdallah CG, Levey DF, Han S, Harpaz-Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36:834-845.
Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans.Xu K, Montalvo-Ortiz JL, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans. Alcoholism, Clinical And Experimental Research 2019, 43:2111-2121.
Genome-wide scan identifies opioid overdose risk locus close to MCOLN1.Cheng Z, Yang BZ, Zhou H, Nunez Y, Kranzler HR, Gelernter J. Genome-wide scan identifies opioid overdose risk locus close to MCOLN1. Addiction Biology 2020, 25:e12811.
Differentiating Types of Self-Reported Alcohol Abstinence.Gordon KS, McGinnis K, Dao C, Rentsch CT, Small A, Smith RV, Kember RL, Gelernter J, Kranzler HR, Bryant KJ, Tate JP, Justice AC. Differentiating Types of Self-Reported Alcohol Abstinence. AIDS And Behavior 2020, 24:655-665.
Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z, Li MD, Vink JM, Minica CC, Willemsen G, Boomsma DI, Qaiser B, Madden PAF, Korhonen T, Jousilahti P, Hällfors J, Gelernter J, Kranzler HR, Sherva R, Farrer L, Maher B, Vanyukov M, Taylor M, Ware JJ, Munafò MR, Lutz SM, Hokanson JE, Gu F, Landi MT, Caporaso NE, Hancock DB, Gaddis NC, Baker TB, Bierut LJ, Johnson EO, Chenoweth M, Lerman C, Tyndale R, Kaprio J, Chen X. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco 2020, 22:900-909.
A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interactionSun J, Kranzler HR, Gelernter J, Bi J. A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction Journal Of Psychiatry & Neuroscience : JPN 2020, 45:34-44.
Case control and family-based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents.Zalsman G, Frisch A, King RA, Pauls DL, Grice DE, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman JF. Case control and family-based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. American Journal Of Medical Genetics 2001, 105:451-7.
The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS.Gelernter J, Kennedy JL, van Tol HH, Civelli O, Kidd KK. The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 1992, 13:208-10.
Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM.Gelernter J, Pakstis AJ, Grandy D, Litt M, Retief AE, Kennedy JL, Hing-Loh A, Schoolfield G, Civelli O, Kidd KK. Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM. Cytogenetics And Cell Genetics 1992, 60:26-8.
Sequence tagged site (STS) TaqI RFLP at dopamine beta-hydroxylase (DBH).Gelernter J, Gejman PV, Bisighini S, Kidd KK. Sequence tagged site (STS) TaqI RFLP at dopamine beta-hydroxylase (DBH). Nucleic Acids Research 1991, 19:1957.
Parallelizing genetic linkage analysis: a case study for applying parallel computation in molecular biology.Miller PL, Nadkarni P, Gelernter JE, Carriero N, Pakstis AJ, Kidd KK. Parallelizing genetic linkage analysis: a case study for applying parallel computation in molecular biology. Computers And Biomedical Research, An International Journal 1991, 24:234-48.
Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature 1990, 347:80-3.
Gilles de la Tourette syndrome is not linked to D2-dopamine receptor.Gelernter J, Pakstis AJ, Pauls DL, Kurlan R, Gancher ST, Civelli O, Grandy D, Kidd KK. Gilles de la Tourette syndrome is not linked to D2-dopamine receptor. Archives Of General Psychiatry 1990, 47:1073-7.
Manic depressive illness not linked to factor IX region in an independent series of pedigrees.Gejman PV, Detera-Wadleigh S, Martinez MM, Berrettini WH, Goldin LR, Gelernter J, Hsieh WT, Gershon ES. Manic depressive illness not linked to factor IX region in an independent series of pedigrees. Genomics 1990, 8:648-55.
The current status of linkage studies in schizophrenia.Gelernter J, Kidd KK. The current status of linkage studies in schizophrenia. Research Publications - Association For Research In Nervous And Mental Disease 1991, 69:137-52.
No linkage between D2 dopamine receptor gene region and schizophrenia.Moises HW, Gelernter J, Giuffra LA, Zarcone V, Wetterberg L, Civelli O, Kidd KK, Cavalli-Sforza LL, Grandy DK, Kennedy JL. No linkage between D2 dopamine receptor gene region and schizophrenia. Archives Of General Psychiatry 1991, 48:643-7.
Neuropeptide Y-like immunoreactivity in schizophrenia. Relationships with clinical measures.Peters J, Van Kammen DP, Gelernter J, Yao J, Shaw D. Neuropeptide Y-like immunoreactivity in schizophrenia. Relationships with clinical measures. Schizophrenia Research 1990, 3:287-94.
X-chromosome markers and manic-depressive illness. Rejection of linkage to Xq28 in nine bipolar pedigrees.Berrettini WH, Goldin LR, Gelernter J, Gejman PV, Gershon ES, Detera-Wadleigh S. X-chromosome markers and manic-depressive illness. Rejection of linkage to Xq28 in nine bipolar pedigrees. Archives Of General Psychiatry 1990, 47:366-73.
Temporal lobe measurement in primary affective disorder by magnetic resonance imaging.Hauser P, Altshuler LL, Berrettini W, Dauphinais ID, Gelernter J, Post RM. Temporal lobe measurement in primary affective disorder by magnetic resonance imaging. The Journal Of Neuropsychiatry And Clinical Neurosciences 1989, 1:128-34.
Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms.Kidd KK, Bowcock AM, Schmidtke J, Track RK, Ricciuti F, Hutchings G, Bale A, Pearson P, Willard HF, Gelernter J. Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms. Cytogenetics And Cell Genetics 1989, 51:622-947.
Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y.Berrettini WH, Garrick NA, Nurnberger JI, Simmons-Alling S, Gelernter J, Gold PW, Rubinow DR, Murphy DL. Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y. Biological Psychiatry 1989, 26:623-30.
Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia.Hauser P, Dauphinais ID, Berrettini W, DeLisi LE, Gelernter J, Post RM. Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia. Biological Psychiatry 1989, 26:659-68.
The effects of field inversion electrophoresis on small DNA fragment mobility and its relevance to DNA polymorphism research.Gejman PV, Sitaram N, Hsieh WT, Gelernter J, Gershon ES. The effects of field inversion electrophoresis on small DNA fragment mobility and its relevance to DNA polymorphism research. Applied And Theoretical Electrophoresis : The Official Journal Of The International Electrophoresis Society 1988, 1:29-34.
Schizophrenia: instability in norepinephrine, serotonin, and gamma-aminobutyric acid systems.Gelernter J, van Kammen DP. Schizophrenia: instability in norepinephrine, serotonin, and gamma-aminobutyric acid systems. International Review Of Neurobiology 1988, 29:309-47.
Expert systems and diagnostic monitors in psychiatry.Gelernter D, Gelernter J. Expert systems and diagnostic monitors in psychiatry. Medical Informatics = Medecine Et Informatique 1986, 11:23-8.
Medical informatics is a research field.Gelernter D, Gelernter J. Medical informatics is a research field. Medical Informatics = Medecine Et Informatique 1984, 9:221.
Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome.Gelernter J, Rao PA, Pauls DL, Hamblin MW, Sibley DR, Kidd KK. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Genomics 1995, 26:207-9.
Eliminating mitochondrial DNA competition for nuclear DNA primers.Zullo S, Kennedy JL, Gelernter J, Polymeropoulos MH, Tallini G, Pakstis AJ, Shapiro MB, Merril CR, Kidd KK. Eliminating mitochondrial DNA competition for nuclear DNA primers. PCR Methods And Applications 1993, 3:39-45.
Genetics of bipolar affective disorder: time for another reinvention?Gelernter J. Genetics of bipolar affective disorder: time for another reinvention? American Journal Of Human Genetics 1995, 56:1262-6.
Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17.Gelernter J, Pakstis AJ, Kidd KK. Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17. Human Genetics 1995, 95:677-80.
Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia.Gelernter J, Kranzler HR, Satel SL, Rao PA. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 1994, 11:195-200.
Assignment of the norepinephrine transporter protein (NET1) locus to chromosome 16.Gelernter J, Kruger S, Pakstis AJ, Pacholczyk T, Sparkes RS, Kidd KK, Amara S. Assignment of the norepinephrine transporter protein (NET1) locus to chromosome 16. Genomics 1993, 18:690-2.
PstI RFLP at the SERT locus.Gelernter J, Freimer M. PstI RFLP at the SERT locus. Human Molecular Genetics 1994, 3:383.
Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine.Rao PA, Pickar D, Gejman PV, Ram A, Gershon ES, Gelernter J. Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Archives Of General Psychiatry 1994, 51:912-7.
The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal.Gelernter J, Goldman D, Risch N. The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA 1993, 269:1673-7.
TaqI RFLP at norepinephrine transporter protein (NET) locus.Gelernter J, Kruger S, Kidd KK, Amara S. TaqI RFLP at norepinephrine transporter protein (NET) locus. Human Molecular Genetics 1993, 2:820.
No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis.Gejman PV, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, Blum K, Noble EP, Kranzler HR, O'Malley S. No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 1994, 271:204-8.
Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor.Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara RK, Niznik HB. Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. The American Journal Of Psychiatry 1993, 150:449-53.
The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome.Gelernter J, Vandenbergh D, Kruger SD, Pauls DL, Kurlan R, Pakstis AJ, Kidd KK, Uhl G. The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome. Genomics 1995, 30:459-63.
Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH).Cubells JF, Kobayashi K, Nagatsu T, Kidd KK, Kidd JR, Calafell F, Kranzler HR, Ichinose H, Gelernter J. Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH). American Journal Of Medical Genetics 1997, 74:374-9.
Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients.Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. The American Journal Of Psychiatry 1997, 154:1451-3.
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects.Gelernter J, Kranzler H, Coccaro E, Siever L, New A, Mulgrew CL. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. American Journal Of Human Genetics 1997, 61:1144-52.
Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects.Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Human Genetics 1997, 101:243-6.
Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study.New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. American Journal Of Medical Genetics 1998, 81:13-7.
Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation.Cubells JF, van Kammen DP, Kelley ME, Anderson GM, O'Connor DT, Price LH, Malison R, Rao PA, Kobayashi K, Nagatsu T, Gelernter J. Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation. Human Genetics 1998, 102:533-40.
D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene.Laruelle M, Gelernter J, Innis RB. D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Molecular Psychiatry 1998, 3:261-5.
Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder.McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Molecular Psychiatry 1998, 3:270-3.
DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects.Gelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics 1998, 51:21-6.
Variants in the alpha2A AR adrenergic receptor gene in psychiatric patients.Feng J, Sobell JL, Heston LL, Goldman D, Cook E, Kranzler HR, Gelernter J, Sommer SS. Variants in the alpha2A AR adrenergic receptor gene in psychiatric patients. American Journal Of Medical Genetics 1998, 81:405-10.
Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1).Kranzler HR, Gelernter J, O'Malley S, Hernandez-Avila CA, Kaufman D. Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1). Alcoholism, Clinical And Experimental Research 1998, 22:1359-62.
Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects.Gelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. The American Journal Of Psychiatry 1998, 155:1332-8.
Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)).Gelernter J, Kranzler H, Lacobelle J. Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic factor (CNTF)). Genomics 1998, 52:289-97.
No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans.Gelernter J, Kranzler H, Satel SL. No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. Biological Psychiatry 1999, 45:340-5.
Population studies of polymorphisms of the serotonin transporter protein gene.Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK. Population studies of polymorphisms of the serotonin transporter protein gene. American Journal Of Medical Genetics 1999, 88:61-6.
No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder.Gelernter J, Southwick S, Goodson S, Morgan A, Nagy L, Charney DS. No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. Biological Psychiatry 1999, 45:620-5.
D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype.Gelernter J, Kranzler H. D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology 1999, 20:640-9.
Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.Gelernter J, Kranzler H, Cubells J. Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects. Molecular Psychiatry 1999, 4:476-83.
Genetic polymorphism at the CLOCK gene locus and major depression.Desan PH, Oren DA, Malison R, Price LH, Rosenbaum J, Smoller J, Charney DS, Gelernter J. Genetic polymorphism at the CLOCK gene locus and major depression. American Journal Of Medical Genetics 2000, 96:418-21.
Prediction of dopamine transporter binding availability by genotype: a preliminary report.Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. Prediction of dopamine transporter binding availability by genotype: a preliminary report. The American Journal Of Psychiatry 2000, 157:1700-3.
Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence.Zabetian CP, Gelernter J, Cubells JF. Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence. American Journal Of Medical Genetics 2000, 96:638-45.
Family-based study of DRD2 alleles in alcohol and drug dependence.Blomqvist O, Gelernter J, Kranzler HR. Family-based study of DRD2 alleles in alcohol and drug dependence. American Journal Of Medical Genetics 2000, 96:659-64.
An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans.Feng J, Zheng J, Gelernter J, Kranzler H, Cook E, Goldman D, Jones IR, Craddock N, Heston LL, Delisi L, Peltonen L, Bennett WP, Sommer SS. An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans. Molecular Psychiatry 2001, 6:168-72.
Family-based association study of serotonin transporter promoter in suicidal adolescents: no association with suicidality but possible role in violence traits.Zalsman G, Frisch A, Bromberg M, Gelernter J, Michaelovsky E, Campino A, Erlich Z, Tyano S, Apter A, Weizman A. Family-based association study of serotonin transporter promoter in suicidal adolescents: no association with suicidality but possible role in violence traits. American Journal Of Medical Genetics 2001, 105:239-45.
Suicide, impulsive aggression, and HTR1B genotype.New AS, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J, Siever LJ. Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry 2001, 50:62-5.
Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence.Covault J, Gelernter J, Kranzler H. Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. Molecular Psychiatry 2001, 6:501-2.
Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion.Moreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Molecular Psychiatry 2002, 7:213-6.
No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence.Freimer M, Kranzler H, Satel S, Lacobelle J, Skipsey K, Charney D, Gelernter J. No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. Addiction Biology 1996, 1:281-7.
No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples.Chang SC, Xie P, Anton RF, De Vivo I, Farrer LA, Kranzler HR, Oslin D, Purcell SM, Roberts AL, Smoller JW, Uddin M, Gelernter J, Koenen KC. No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples. Molecular Psychiatry 2012, 17:239-41.
GABRA2 and KIBRA genotypes predict early relapse to substance use.Bauer LO, Covault J, Gelernter J. GABRA2 and KIBRA genotypes predict early relapse to substance use. Drug And Alcohol Dependence 2012, 123:154-9.
Support for association of RORA variant and post traumatic stress symptoms in a population-based study of hurricane exposed adults.Amstadter AB, Sumner JA, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, Gelernter J. Support for association of RORA variant and post traumatic stress symptoms in a population-based study of hurricane exposed adults. Molecular Psychiatry 2013, 18:1148-9.
The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder.Jensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. Translational Psychiatry 2014, 4:e353.
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.Hancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K. Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. Translational Psychiatry 2015, 5:e651.
No allelic association of an exon 13 polymorphism of the Gsα gene to alcohol and/or drug dependence.Kranzler HR, McCAUL ME, Gelernter J, Wand GS. No allelic association of an exon 13 polymorphism of the Gsα gene to alcohol and/or drug dependence. Addiction Biology 1997, 2:309-16.
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.Hancock DB, Guo Y, Reginsson GW, Gaddis NC, Lutz SM, Sherva R, Loukola A, Minica CC, Markunas CA, Han Y, Young KA, Gudbjartsson DF, Gu F, McNeil DW, Qaiser B, Glasheen C, Olson S, Landi MT, Madden PAF, Farrer LA, Vink J, Saccone NL, Neale MC, Kranzler HR, McKay J, Hung RJ, Amos CI, Marazita ML, Boomsma DI, Baker TB, Gelernter J, Kaprio J, Caporaso NE, Thorgeirsson TE, Hokanson JE, Bierut LJ, Stefansson K, Johnson EO. Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. Molecular Psychiatry 2018, 23:1911-1919.
Genome-wide association study identifies a novel locus for cannabis dependence.Agrawal A, Chou YL, Carey CE, Baranger DAA, Zhang B, Sherva R, Wetherill L, Kapoor M, Wang JC, Bertelsen S, Anokhin AP, Hesselbrock V, Kramer J, Lynskey MT, Meyers JL, Nurnberger JI, Rice JP, Tischfield J, Bierut LJ, Degenhardt L, Farrer LA, Gelernter J, Hariri AR, Heath AC, Kranzler HR, Madden PAF, Martin NG, Montgomery GW, Porjesz B, Wang T, Whitfield JB, Edenberg HJ, Foroud T, Goate AM, Bogdan R, Nelson EC. Genome-wide association study identifies a novel locus for cannabis dependence. Molecular Psychiatry 2018, 23:1293-1302.
Detection of marker associations with a dominant disease gene in genetically complex and heterogeneous diseases.Gershon ES, Martinez M, Goldin L, Gelernter J, Silver J. Detection of marker associations with a dominant disease gene in genetically complex and heterogeneous diseases. American Journal Of Human Genetics 1989, 45:578-85.
Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.Xu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC. Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. Nature Communications 2020, 11:5302.
A large-scale genome-wide association study meta-analysis of cannabis use disorder.Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Davis LK, Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A. A large-scale genome-wide association study meta-analysis of cannabis use disorder. The Lancet. Psychiatry 2020, 7:1032-1045.
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB. Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Nature Communications 2020, 11:5562.
GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals.Yang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals. Addictive Behaviors 2021, 114:106695.
Characterizing the effect of background selection on the polygenicity of brain-related traits.Wendt FR, Pathak GA, Overstreet C, Tylee DS, Gelernter J, Atkinson EG, Polimanti R. Characterizing the effect of background selection on the polygenicity of brain-related traits. Genomics 2021, 113:111-119.
Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study.Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study. Biological Psychiatry 2021, 89:878-887.
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome.Wendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome. Nature Human Behaviour 2021, 5:482-496.
Transcriptomic organization of the human brain in post-traumatic stress disorder.Girgenti MJ, Wang J, Ji D, Cruz DA, Stein MB, Gelernter J, Young KA, Huber BR, Williamson DE, Friedman MJ, Krystal JH, Zhao H, Duman RS. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2021, 24:24-33.
Study design and implementation of the PRecision Medicine In MEntal health Care (PRIME Care) Trial.Oslin DW, Chapman S, Duvall SL, Gelernter J, Ingram E, Kranzler HR, Lehmann LS, Lynch JA, Lynch KG, Pyne JM, Shih MC, Stone A, Thase ME, Wray LO. Study design and implementation of the PRecision Medicine In MEntal health Care (PRIME Care) Trial. Contemporary Clinical Trials 2021, 101:106247.
Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality.Polimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. Translational Psychiatry 2021, 11:34.
Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms.Pathak GA, Wendt FR, De Lillo A, Nunez YZ, Goswami A, De Angelis F, Fuciarelli M, Kranzler HR, Gelernter J, Polimanti R. Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms. Circulation. Genomic And Precision Medicine 2021, 14:e003011.
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nature Genetics 2021, 53:174-184.
Identifying factors associated with opioid cessation in a biracial sample using machine learning.Cox JW, Sherva RM, Lunetta KL, Saitz R, Kon M, Kranzler HR, Gelernter J, Farrer LA. Identifying factors associated with opioid cessation in a biracial sample using machine learning. Exploration Of Medicine 2020, 1:27-41.
Prevalence of predicted gene-drug interactions for antidepressants in the treatment of major depressive disorder in the Precision Medicine in Mental Health Care Study.Ramsey CM, Lynch KG, Thase ME, Gelernter J, Kranzler HR, Pyne JM, Shih MC, Stone A, Oslin DW. Prevalence of predicted gene-drug interactions for antidepressants in the treatment of major depressive disorder in the Precision Medicine in Mental Health Care Study. Journal Of Affective Disorders 2021, 282:1272-1277.
Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality.Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14:100309.
Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style.Asch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH. Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style. The World Journal Of Biological Psychiatry : The Official Journal Of The World Federation Of Societies Of Biological Psychiatry 2021, 1-8.
Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.Pathak GA, Wendt FR, Levey DF, Mecca AP, Dyck CH, Gelernter J, Polimanti R. Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Human Molecular Genetics 2021, 30:1360-1370.
The Impact of Removing Former Drinkers from Genome-wide Association Studies of AUDIT-C.Dao C, Zhou H, Small A, Gordon KS, Li B, Kember RL, Ye Y, Gelernter J, Xu K, Kranzler HR, Zhao H, Justice AC. The Impact of Removing Former Drinkers from Genome-wide Association Studies of AUDIT-C. Addiction (Abingdon, England) 2021.
Integration of Evidence across Human and Model Organism Studies: A Meeting Report.Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Ursu O, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Qing L, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. Integration of Evidence across Human and Model Organism Studies: A Meeting Report. Genes, Brain, And Behavior 2021, e12738.
Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes.Campbell-Sills L, Sun X, Choi KW, He F, Ursano RJ, Kessler RC, Levey DF, Smoller JW, Gelernter J, Jain S, Stein MB. Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes. Psychological Medicine 2021, 1-9.
The relationship between cannabis and schizophrenia: a genetically informed perspective.Johnson EC, Hatoum AS, Deak JD, Polimanti R, Murray RM, Edenberg HJ, Gelernter J, Di Forti M, Agrawal A. The relationship between cannabis and schizophrenia: a genetically informed perspective. Addiction (Abingdon, England) 2021.
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. Nature Neuroscience 2021, 24:954-963.
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH, Abramova L, Adorjan K, Agerbo E, Al Eissa M, Albani D, Alliey-Rodriguez N, Anjorin A, Antilla V, Antoniou A, Awasthi S, Baek JH, Bækvad-Hansen M, Bass N, Bauer M, Beins EC, Bergen SE, Birner A, Bøcker Pedersen C, Bøen E, Boks MP, Bosch R, Brum M, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Bybjerg-Grauholm J, Byerley W, Cairns M, Casas M, Cervantes P, Clarke TK, Cruceanu C, Cuellar-Barboza A, Cunningham J, Curtis D, Czerski PM, Dale AM, Dalkner N, David FS, Degenhardt F, Djurovic S, Dobbyn AL, Douzenis A, Elvsåshagen T, Escott-Price V, Ferrier IN, Fiorentino A, Foroud TM, Forty L, Frank J, Frei O, Freimer NB, Frisén L, Gade K, Garnham J, Gelernter J, Giørtz Pedersen M, Gizer IR, Gordon SD, Gordon-Smith K, Greenwood TA, Grove J, Guzman-Parra J, Ha K, Haraldsson M, Hautzinger M, Heilbronner U, Hellgren D, Herms S, Hoffmann P, Holmans PA, Huckins L, Jamain S, Johnson JS, Kalman JL, Kamatani Y, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koromina M, Kranz TM, Kranzler HR, Kubo M, Kupka R, Kushner SA, Lavebratt C, Lawrence J, Leber M, Lee HJ, Lee PH, Levy SE, Lewis C, Liao C, Lucae S, Lundberg M, MacIntyre DJ, Magnusson SH, Maier W, Maihofer A, Malaspina D, Maratou E, Martinsson L, Mattheisen M, McCarroll SA, McGregor NW, McGuffin P, McKay JD, Medeiros H, Medland SE, Millischer V, Montgomery GW, Moran JL, Morris DW, Mühleisen TW, O'Brien N, O'Donovan C, Olde Loohuis LM, Oruc L, Papiol S, Pardiñas AF, Perry A, Pfennig A, Porichi E, Potash JB, Quested D, Raj T, Rapaport MH, DePaulo JR, Regeer EJ, Rice JP, Rivas F, Rivera M, Roth J, Roussos P, Ruderfer DM, Sánchez-Mora C, Schulte EC, Senner F, Sharp S, Shilling PD, Sigurdsson E, Sirignano L, Slaney C, Smeland OB, Smith DJ, Sobell JL, Søholm Hansen C, Soler Artigas M, Spijker AT, Stein DJ, Strauss JS, Świątkowska B, Terao C, Thorgeirsson TE, Toma C, Tooney P, Tsermpini EE, Vawter MP, Vedder H, Walters JTR, Witt SH, Xi S, Xu W, Yang JMK, Young AH, Young H, Zandi PP, Zhou H, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Babadjanova G, Backlund L, Baune BT, Bellivier F, Bengesser S, Berrettini WH, Blackwood DHR, Boehnke M, Børglum AD, Breen G, Carr VJ, Catts S, Corvin A, Craddock N, Dannlowski U, Dikeos D, Esko T, Etain B, Ferentinos P, Frye M, Fullerton JM, Gawlik M, Gershon ES, Goes FS, Green MJ, Grigoroiu-Serbanescu M, Hauser J, Henskens F, Hillert J, Hong KS, Hougaard DM, Hultman CM, Hveem K, Iwata N, Jablensky AV, Jones I, Jones LA, Kahn RS, Kelsoe JR, Kirov G, Landén M, Leboyer M, Lewis CM, Li QS, Lissowska J, Lochner C, Loughland C, Martin NG, Mathews CA, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Michie P, Milani L, Mitchell PB, Morken G, Mors O, Mortensen PB, Mowry B, Müller-Myhsok B, Myers RM, Neale BM, Nievergelt CM, Nordentoft M, Nöthen MM, O'Donovan MC, Oedegaard KJ, Olsson T, Owen MJ, Paciga SA, Pantelis C, Pato C, Pato MT, Patrinos GP, Perlis RH, Posthuma D, Ramos-Quiroga JA, Reif A, Reininghaus EZ, Ribasés M, Rietschel M, Ripke S, Rouleau GA, Saito T, Schall U, Schalling M, Schofield PR, Schulze TG, Scott LJ, Scott RJ, Serretti A, Shannon Weickert C, Smoller JW, Stefansson H, Stefansson K, Stordal E, Streit F, Sullivan PF, Turecki G, Vaaler AE, Vieta E, Vincent JB, Waldman ID, Weickert TW, Werge T, Wray NR, Zwart JA, Biernacka JM, Nurnberger JI, Cichon S, Edenberg HJ, Stahl EA, McQuillin A, Di Florio A, Ophoff RA, Andreassen OA. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics 2021, 53:817-829.
Combined analysis of the moderating effect of a GRIK1 polymorphism on the effects of topiramate for treating alcohol use disorder.Kranzler HR, Hartwell EE, Feinn R, Pond T, Witkiewitz K, Gelernter J, Crist RC. Combined analysis of the moderating effect of a GRIK1 polymorphism on the effects of topiramate for treating alcohol use disorder. Drug And Alcohol Dependence 2021, 225:108762.
Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.Mundy J, Hübel C, Gelernter J, Levey D, Murray RM, Skelton M, Stein MB, Vassos E, Breen G, Coleman JRI. Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder. Psychological Medicine 2021, 1-10.
Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.Sherva R, Zhu C, Wetherill L, Edenberg HJ, Johnson E, Degenhardt L, Agrawal A, Martin NG, Nelson E, Kranzler HR, Gelernter J, Farrer LA. Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. Exploration Of Medicine 2021, 2:60-73.
Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990-1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006.Radhakrishnan K, Hauser ER, Polimanti R, Helmer DA, Provenzale D, McNeil RB, Maffucci A, Quaden R, Zhao H, Whitbourne SB, Harrington KM, Vahey J, Gelernter J, Levey DF, Huang GD, Gaziano JM, Concato J, Aslan M. Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990-1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006. Brain Sciences 2021, 11.
Genetics of substance use disorders in the era of big data.Gelernter J, Polimanti R. Genetics of substance use disorders in the era of big data. Nature Reviews. Genetics 2021.
Genome-wide association study of stimulant dependence.Cox J, Sherva R, Wetherill L, Foroud T, Edenberg HJ, Kranzler HR, Gelernter J, Farrer LA. Genome-wide association study of stimulant dependence. Translational Psychiatry 2021, 11:363.
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 2021, 1-9.
Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression.Stein MB, Jain S, Campbell-Sills L, Ware EB, Choi KW, He F, Ge T, Gelernter J, Smoller JW, Kessler RC, Ursano RJ. Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics 2021.

Clinical Trials

Conditions	Study Title
Addictive Behaviors; Mental Health & Behavioral Research	The effects of a GWAS-significant, pharmacokinetic variant (rs73568641*C) for methadone dose on µ-opiate receptor (µOR) availability as measured by 13C-Carfentanil PET
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco Addiction	Effects of E-Cigarette Flavors on Adults TCORS 2.0
Diseases of the Nervous System; Mental Health & Behavioral Research	C4 Gene Dose Effects using 11C-UCB-J PET
Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral Research	Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Addictive Behaviors; Alcohol Addiction; Mental Health & Behavioral Research	Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors

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Joel Gelernter, MD

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