Research & Publications
The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including opioid, cananbis, and alcohol dependence, posttraumatic stress disorder (PTSD), and anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.
The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include multicenter case/control association studies with the goal of identifying genes predisposing to opioid and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; studies of posttraumatic stress disorder (PTSD) in the US Million Veteran Program; and a VA study on the pharmacogenomics of antidepressant response. I also co-lead the Substance Use Disorders group of the Psychiatric Genomics Consortium.
Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Pharmacogenomics
Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders