Joao P. De Aquino, MD

• Brian Fuehrlein
• David Moore
• David Ross
• Deepak Cyril Dsouza
• Elina A. Stefanovics
• John Cahill
• Jose Cortes-Briones
• Kirsten Wilkins
• Mehmet Sofuoglu
• Mohamed Sherif
• Mohini Ranganathan
• Oluwole Jegede
• Rajiv Radhakrishnan
• Ralitza Gueorguieva
• Robert Rosenheck
• Tanner Bommersbach
• Thomas Hickey
• Victor J. Avila-Quintero

Analgesia; Analgesics, Opioid; Buprenorphine; Cannabinoids; Cannabis; Drug Administration Routes; Drug Interactions; Methadone; Pain Measurement; Pharmacokinetics; Psychopharmacology; Psychophysics; Reward; Sensory Thresholds; Substance Withdrawal Syndrome; Clinical Trial, Phase II; Craving; Addiction Medicine

Clinical Guidelines; Pharmacoepidemiology

• Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies.De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.
• Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta-analysis with implications for drug development.De Aquino JP, Flores JM, Avila-Quintero VJ, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta-analysis with implications for drug development. Addiction Biology 2021, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.
• The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder.De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.
• Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study.De Aquino JP, Sofuoglu M, Stefanovics EA, Rosenheck RA. Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: a nationwide longitudinal VA study. The American Journal Of Drug And Alcohol Abuse 2020, 46: 812-822. PMID: 33035104, DOI: 10.1080/00952990.2020.1818248.
• Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only.De Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R. Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only. The American Journal Of Drug And Alcohol Abuse 2019, 45: 527-537. PMID: 31112429, DOI: 10.1080/00952990.2019.1607363.
• Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use.Bommersbach T, Ross DA, De Aquino JP. Perpetual Hunger: The Neurobiological Consequences of Long-Term Opioid Use. Biological Psychiatry 2020, 87: e1-e3. PMID: 31806086, PMCID: PMC7830805, DOI: 10.1016/j.biopsych.2019.10.007.
• Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again?De Aquino JP, Bahji A, D'Souza DC (2021) Letter to the Editor: Cannabis as a solution to the opioid crisis: Is the cart before the horse again?, Cannabis and Cannabinoid Research X:X, 1–3, DOI: 10.1089/can.2021.0155.
• Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia.De Aquino JP, Ross DA. Cannabinoids and Pain: Weeding Out Undesired Effects With a Novel Approach to Analgesia. Biological Psychiatry 2018, 84: e67-e69. PMID: 30360776, PMCID: PMC6697049, DOI: 10.1016/j.biopsych.2018.09.003.
• The Psychiatric Consequences of Cannabinoids.De Aquino JP, Sherif M, Radhakrishnan R, Cahill JD, Ranganathan M, D'Souza DC. The Psychiatric Consequences of Cannabinoids. Clinical Therapeutics 2018, 40: 1448-1456. PMID: 29678279, DOI: 10.1016/j.clinthera.2018.03.013.
• High potency synthetic opioids: Curbing the third wave of the opioid crisis.Parida S, De Aquino JP, Sofuoglu M. High potency synthetic opioids: Curbing the third wave of the opioid crisis. Neuroscience And Biobehavioral Reviews 2019, 106: 9-10. PMID: 31251966, DOI: 10.1016/j.neubiorev.2019.06.019.
• Kraepelin's Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up.De Aquino JP, Ross DA. Kraepelin's Crumbling Twin Pillars: Using Biology to Reconstruct Psychiatric Nosology From the Bottom Up. Biological Psychiatry 2017, 82: e71-e74. PMID: 29031920, PMCID: PMC5714270, DOI: 10.1016/j.biopsych.2017.09.008.
• Feasibility and effects of galantamine on cognition in humans with cannabis use disorder.Sugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology, Biochemistry, And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.
• Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans.Ranganathan M, De Aquino JP, Cortes-Briones JA, Radhakrishnan R, Pittman B, Bhakta S, D'Souza DC. Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Psychopharmacology 2019, 236: 3209-3219. PMID: 31187152, DOI: 10.1007/s00213-019-05273-5.
• Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis.Gupta S, De Aquino JP, D'Souza DC, Ranganathan M. Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis. Psychopharmacology 2019, 236: 2635-2640. PMID: 30919005, PMCID: PMC6697616, DOI: 10.1007/s00213-019-05235-x.
• Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study.De Aquino JP, Moore DT, Wilkins K, Fuehrlein B. Enhancement of Medical Student Attitudes in the Treatment of Patients with Substance Use Disorders: a Follow-up Study. Academic Psychiatry : The Journal Of The American Association Of Directors Of Psychiatric Residency Training And The Association For Academic Psychiatry 2019, 43: 350-351. PMID: 30756269, DOI: 10.1007/s40596-019-01038-6.
• Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting.De Aquino JP, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020 PMID: 32011408, DOI: 10.1097/ADM.0000000000000618.
• Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder.Jegede O, Parida S, De Aquino JP. Buprenorphine Treatment of Fentanyl-Related Opioid Use Disorder. The Primary Care Companion For CNS Disorders 2022, 24 PMID: 35486939, DOI: 10.4088/PCC.21cr03163.
• Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence.De Aquino JP, Parida S, Sofuoglu M. Buprenorphine Microinduction: Logistical Barriers and the Need for Convergent Evidence. Clinical Drug Investigation 2021, 41: 665. PMID: 34106434, DOI: 10.1007/s40261-021-01049-y.
• Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory scienceDe Aquino, JP, MacLean, RR, Gueorguieva, R, DeVito, EE, Eid, T, Sofuoglu, M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology. 2022; 27 (2):e13161. doi:10.1111/adb.13161
• Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans.De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022 PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.
• Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes.Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, DOI: 10.1080/15504263.2022.2053264.