Jimin Wang, PhD
Research & Publications
Biography
Research Summary
X-ray intensity corrections for crystals containing lattice-translocation defects
Lattice translocation defects are caused by the random translocation of some layers by a fixed constant within the stacked layers of a crystal. When such events result in the fragmentation of the crystal into smaller mosaic blocks, the observed intensities are simply additive from each block and independent of the translocation vector. When such events occur within one single coherent mosaic block, interference in X-ray diffraction is observed with the intensities modulated by a factor that is a function of this translocation vector and the fractions of the translocated and un-translocated layers (Wang et al., 2005). This phenomenon was first observed nearly 50 years ago (Bragg and Howells 1954; Cochran and Howells 1954; Howells and Perutz 1954). The atomic structures of crystals containing the lattice-translocation defects were considered to be unsolvable (Glauser and Rossmann 1966; Pickersgill 1987). Recently, an equation for the modulation factor caused by these defects was formulated and the observed intensities become correctable using this factor (Wang et al., 2005).
Because of lattice translocation defects, two identical but translated lattices can co-exist as a single coherent mosaic block in a crystal. The observed structure in such cases is a weighted sum of two identical but translated structures, one from each lattice; the observed structure factors are a weighted vector sum of the structure factors with identical unit amplitudes but shifted phases.
Coauthors
Selected Publications
- Substrate-independent activation pathways of the CRISPR-Cas9 HNH nucleaseWang J, Maschietto F, Qiu T, Arantes P, Skeens E, Palermo G, Lisi G, Batista V. Substrate-independent activation pathways of the CRISPR-Cas9 HNH nuclease. Biophysical Journal 2023, 122: 4635-4644. PMID: 37936350, PMCID: PMC10754686, DOI: 10.1016/j.bpj.2023.11.005.
- A quantitative assessment of (bacterio)chlorophyll assignments in the cryo-EM structure of the Chloracidobacterium thermophilum reaction centerGisriel C, Flesher D, Long Z, Liu J, Wang J, Bryant D, Batista V, Brudvig G. A quantitative assessment of (bacterio)chlorophyll assignments in the cryo-EM structure of the Chloracidobacterium thermophilum reaction center. Photosynthesis Research 2023, 1-10. PMID: 37749456, DOI: 10.1007/s11120-023-01047-5.
- Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanismMaschietto F, Qiu T, Wang J, Shi Y, Allen B, Lisi G, Lolis E, Batista V. Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism. Computational And Structural Biotechnology Journal 2023, 21: 1066-1076. PMID: 36688026, PMCID: PMC9841741, DOI: 10.1016/j.csbj.2023.01.014.
- Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexesWang J, Arantes P, Ahsan M, Sinha S, Kyro G, Maschietto F, Allen B, Skeens E, Lisi G, Batista V, Palermo G. Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexes. Frontiers In Molecular Biosciences 2023, 9: 1072733. PMID: 36699705, PMCID: PMC9868570, DOI: 10.3389/fmolb.2022.1072733.
- Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulationsFredericks A, East K, Shi Y, Liu J, Maschietto F, Ayala A, Cioffi W, Cohen M, Fairbrother W, Lefort C, Nau G, Levy M, Wang J, Batista V, Lisi G, Monaghan S. Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations. Frontiers In Molecular Biosciences 2022, 9: 1080964. PMID: 36589229, PMCID: PMC9800910, DOI: 10.3389/fmolb.2022.1080964.
- Translocation pause of remdesivir-containing primer/template RNA duplex within SARS-CoV-2’s RNA polymerase complexesShi Y, Wang J, Batista V. Translocation pause of remdesivir-containing primer/template RNA duplex within SARS-CoV-2’s RNA polymerase complexes. Frontiers In Molecular Biosciences 2022, 9: 999291. PMID: 36387272, PMCID: PMC9640752, DOI: 10.3389/fmolb.2022.999291.
- How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EMWang J, Liu J, Gisriel CJ, Wu S, Maschietto F, Flesher DA, Lolis E, Lisi GP, Brudvig GW, Xiong Y, Batista VS. How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM. Journal Of Structural Biology 2022, 214: 107902. PMID: 36202310, PMCID: PMC10226527, DOI: 10.1016/j.jsb.2022.107902.
- Structural Insights into Binding of Remdesivir Triphosphate within the Replication–Transcription Complex of SARS-CoV‑2Wang J, Shi Y, Reiss K, Maschietto F, Lolis E, Konigsberg WH, Lisi GP, Batista VS. Structural Insights into Binding of Remdesivir Triphosphate within the Replication–Transcription Complex of SARS-CoV‑2. Biochemistry 2022, 61: 1966-1973. PMID: 36044776, PMCID: PMC9469760, DOI: 10.1021/acs.biochem.2c00341.
- Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript‑1Wang J, Sachpatzidis A, Christian TD, Lomakin IB, Garen A, Konigsberg WH. Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript‑1. Biochemistry 2022, 61: 1723-1734. PMID: 35998361, DOI: 10.1021/acs.biochem.2c00192.
- Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) EnzymeWang J, Skeens E, Arantes PR, Maschietto F, Allen B, Kyro GW, Lisi GP, Palermo G, Batista VS. Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzyme. Biochemistry 2022, 61: 785-794. PMID: 35420793, PMCID: PMC9069930, DOI: 10.1021/acs.biochem.2c00127.
- Glycerol binding at the narrow channel of photosystem II stabilizes the low-spin S2 state of the oxygen-evolving complexFlesher DA, Liu J, Wiwczar JM, Reiss K, Yang KR, Wang J, Askerka M, Gisriel CJ, Batista VS, Brudvig GW. Glycerol binding at the narrow channel of photosystem II stabilizes the low-spin S2 state of the oxygen-evolving complex. Photosynthesis Research 2022, 152: 167-175. PMID: 35322325, PMCID: PMC9427693, DOI: 10.1007/s11120-022-00911-0.
- Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal IonWang J, Konigsberg WH. Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal Ion. Frontiers In Molecular Biosciences 2022, 9: 824794. PMID: 35300112, PMCID: PMC8921852, DOI: 10.3389/fmolb.2022.824794.
- Insights into Binding of Single-Stranded Viral RNA Template to the Replication–Transcription Complex of SARS-CoV‑2 for the Priming Reaction from Molecular Dynamics SimulationsWang J, Shi Y, Reiss K, Allen B, Maschietto F, Lolis E, Konigsberg WH, Lisi GP, Batista VS. Insights into Binding of Single-Stranded Viral RNA Template to the Replication–Transcription Complex of SARS-CoV‑2 for the Priming Reaction from Molecular Dynamics Simulations. Biochemistry 2022, 61: 424-432. PMID: 35199520, PMCID: PMC8887646, DOI: 10.1021/acs.biochem.1c00755.
- High-resolution cryo-electron microscopy structure of photosystem II from the mesophilic cyanobacterium, Synechocystis sp. PCC 6803Gisriel CJ, Wang J, Liu J, Flesher DA, Reiss KM, Huang HL, Yang KR, Armstrong WH, Gunner MR, Batista VS, Debus RJ, Brudvig GW. High-resolution cryo-electron microscopy structure of photosystem II from the mesophilic cyanobacterium, Synechocystis sp. PCC 6803. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 119: e2116765118. PMID: 34937700, PMCID: PMC8740770, DOI: 10.1073/pnas.2116765118.
- Corrigendum to Quantitative assessment of chlorophyll types in cryo-EM maps of photosystem I acclimated to far-red light BBA Advances 1 (2021) 100019Gisriel C, Huang H, Reiss K, Flesher D, Batista V, Bryant D, Brudvig G, Wang J. Corrigendum to Quantitative assessment of chlorophyll types in cryo-EM maps of photosystem I acclimated to far-red light BBA Advances 1 (2021) 100019. BBA Advances 2021, 1: 100024. PMID: 37206888, PMCID: PMC10189863, DOI: 10.1016/j.bbadva.2021.100024.
- Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and fGisriel CJ, Shen G, Ho MY, Kurashov V, Flesher DA, Wang J, Armstrong WH, Golbeck JH, Gunner MR, Vinyard DJ, Debus RJ, Brudvig GW, Bryant DA. Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f. Journal Of Biological Chemistry 2021, 298: 101424. PMID: 34801554, PMCID: PMC8689208, DOI: 10.1016/j.jbc.2021.101424.
- Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69Park J, Youn HS, An JY, Lee Y, Eom SH, Wang J. Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69. Frontiers In Molecular Biosciences 2021, 8: 704813. PMID: 34869578, PMCID: PMC8639217, DOI: 10.3389/fmolb.2021.704813.
- Structure of a photosystem I-ferredoxin complex from a marine cyanobacterium provides insights into far-red light photoacclimationGisriel CJ, Flesher DA, Shen G, Wang J, Ho MY, Brudvig GW, Bryant DA. Structure of a photosystem I-ferredoxin complex from a marine cyanobacterium provides insights into far-red light photoacclimation. Journal Of Biological Chemistry 2021, 298: 101408. PMID: 34793839, PMCID: PMC8689207, DOI: 10.1016/j.jbc.2021.101408.
- Heterogeneous Composition of Oxygen-Evolving Complexes in Crystal Structures of Dark-Adapted Photosystem IIWang J, Gisriel CJ, Reiss K, Huang HL, Armstrong WH, Brudvig GW, Batista VS. Heterogeneous Composition of Oxygen-Evolving Complexes in Crystal Structures of Dark-Adapted Photosystem II. Biochemistry 2021, 60: 3374-3384. PMID: 34714055, DOI: 10.1021/acs.biochem.1c00611.
- Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular levelWang J, Maschietto F, Guberman-Pfeffer MJ, Reiss K, Allen B, Xiong Y, Lolis E, Batista VS. Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level. Computational And Structural Biotechnology Journal 2021, 19: 5019-5028. PMID: 34540146, PMCID: PMC8442599, DOI: 10.1016/j.csbj.2021.08.053.
- Quantitative assessment of chlorophyll types in cryo-EM maps of photosystem I acclimated to far-red lightGisriel C, Huang H, Reiss K, Flesher D, Batista V, Bryant D, Brudvig G, Wang J. Quantitative assessment of chlorophyll types in cryo-EM maps of photosystem I acclimated to far-red light. BBA Advances 2021, 1: 100019. PMID: 37082022, PMCID: PMC10074859, DOI: 10.1016/j.bbadva.2021.100019.
- Do crystallographic XFEL data support binding of a water molecule to the oxygen-evolving complex of photosystem II exposed to two flashes of light?Wang J, Armstrong WH, Batista VS. Do crystallographic XFEL data support binding of a water molecule to the oxygen-evolving complex of photosystem II exposed to two flashes of light? Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2023982118. PMID: 34117119, PMCID: PMC8214663, DOI: 10.1073/pnas.2023982118.
- Mechanism of Inhibition of the Reproduction of SARS-CoV‑2 and Ebola Viruses by RemdesivirWang J, Reiss K, Shi Y, Lolis E, Lisi GP, Batista VS. Mechanism of Inhibition of the Reproduction of SARS-CoV‑2 and Ebola Viruses by Remdesivir. Biochemistry 2021, 60: 1869-1875. PMID: 34110129, PMCID: PMC8204756, DOI: 10.1021/acs.biochem.1c00292.
- Identification of Mg2+ ions next to nucleotides in cryo‐EM maps using electrostatic potential mapsWang J, Natchiar SK, Moore PB, Klaholz BP. Identification of Mg2+ ions next to nucleotides in cryo‐EM maps using electrostatic potential maps. Acta Crystallographica Section D, Structural Biology 2021, 77: 534-539. PMID: 33825713, PMCID: PMC8025889, DOI: 10.1107/s2059798321001893.
- Structural analyses of an RNA stability element interacting with poly(A)Torabi SF, Chen YL, Zhang K, Wang J, DeGregorio SJ, Vaidya AT, Su Z, Pabit SA, Chiu W, Pollack L, Steitz JA. Structural analyses of an RNA stability element interacting with poly(A). Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2026656118. PMID: 33785601, PMCID: PMC8040590, DOI: 10.1073/pnas.2026656118.
- RNA stabilization by a poly(A) tail 3′-end binding pocket and other modes of poly(A)-RNA interactionTorabi SF, Vaidya AT, Tycowski KT, DeGregorio SJ, Wang J, Shu MD, Steitz TA, Steitz JA. RNA stabilization by a poly(A) tail 3′-end binding pocket and other modes of poly(A)-RNA interaction. Science 2021, 371 PMID: 33414189, PMCID: PMC9491362, DOI: 10.1126/science.abe6523.
- Thermodynamics of the S 2 -to-S 3 state transition of the oxygen-evolving complex of photosystem IIAmin M, Kaur D, Yang KR, Wang J, Mohamed Z, Brudvig GW, Gunner MR, Batista V. Thermodynamics of the S 2 -to-S 3 state transition of the oxygen-evolving complex of photosystem II. Physical Chemistry Chemical Physics 2019, 21: 20840-20848. PMID: 31517382, DOI: 10.1039/c9cp02308a.
- Visualization of H atoms in the X‐ray crystal structure of photoactive yellow protein: Does it contain low‐barrier hydrogen bonds?Wang J. Visualization of H atoms in the X‐ray crystal structure of photoactive yellow protein: Does it contain low‐barrier hydrogen bonds? Protein Science 2019, 28: 1966-1972. PMID: 31441173, PMCID: PMC6798185, DOI: 10.1002/pro.3716.
- Crystallographic identification of spontaneous oxidation intermediates and products of protein sulfhydryl groupsWang J. Crystallographic identification of spontaneous oxidation intermediates and products of protein sulfhydryl groups. Protein Science 2019, 28: 472-477. PMID: 30592103, PMCID: PMC6371210, DOI: 10.1002/pro.3568.
- Crystallographic evidence for two‐metal‐ion catalysis in human pol ηWang J, Smithline ZB. Crystallographic evidence for two‐metal‐ion catalysis in human pol η. Protein Science 2018, 28: 439-447. PMID: 30368948, PMCID: PMC6319759, DOI: 10.1002/pro.3541.
- Structural and biochemical insights into inhibition of human primase by citrateLee JG, Park KR, An JY, Kang JY, Shen H, Wang J, Eom SH. Structural and biochemical insights into inhibition of human primase by citrate. Biochemical And Biophysical Research Communications 2018, 507: 383-388. PMID: 30446220, DOI: 10.1016/j.bbrc.2018.11.047.
- On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiationWang J, Liu Z, Crabtree RH, Frank J, Moore PB. On the damage done to the structure of the Thermoplasma acidophilum proteasome by electron radiation. Protein Science 2018, 27: 2051-2061. PMID: 30242932, PMCID: PMC6237698, DOI: 10.1002/pro.3511.
- Misreading chaperone–substrate complexes from random noiseWang J. Misreading chaperone–substrate complexes from random noise. Nature Structural & Molecular Biology 2018, 25: 989-990. PMID: 30297779, DOI: 10.1038/s41594-018-0144-3.
- Reduced Occupancy of the Oxygen-Evolving Complex of Photosystem II Detected in Cryo-Electron Microscopy MapsWang J, Reiss K, Brudvig GW, Batista VS. Reduced Occupancy of the Oxygen-Evolving Complex of Photosystem II Detected in Cryo-Electron Microscopy Maps. Biochemistry 2018, 57: 5925-5929. PMID: 30260634, DOI: 10.1021/acs.biochem.8b00609.
- Identification of ions in experimental electrostatic potential mapsWang J, Liu Z, Frank J, Moore PB. Identification of ions in experimental electrostatic potential maps. IUCrJ 2018, 5: 375-381. PMID: 30002838, PMCID: PMC6038950, DOI: 10.1107/s2052252518006292.
- Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1: a novel mode of regulation for AAA+ ATPasesChase A, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1: a novel mode of regulation for AAA+ ATPases. The FASEB Journal 2018, 32: 114.1-114.1. DOI: 10.1096/fasebj.2018.32.1_supplement.114.1.
- Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.Tian L, Kim MS, Li H, Wang J, Yang W. Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 507-512. PMID: 29295939, PMCID: PMC5777007, DOI: 10.1073/pnas.1719746115.
- Chapter 6 Structure Determination at Low-resolution, Anisotropic Data and Crystal TwinningSymersky J, Guo Y, Wang J, Lu M. Chapter 6 Structure Determination at Low-resolution, Anisotropic Data and Crystal Twinning. 2018, 140-156. DOI: 10.1039/9781788010504-00140.
- Structural insights into the oligomerization of FtsH periplasmic domain from Thermotoga maritimaAn JY, Sharif H, Kang GB, Park KJ, Lee JG, Lee S, Jin MS, Song JJ, Wang J, Eom SH. Structural insights into the oligomerization of FtsH periplasmic domain from Thermotoga maritima. Biochemical And Biophysical Research Communications 2017, 495: 1201-1207. PMID: 29180014, DOI: 10.1016/j.bbrc.2017.11.158.
- Determination of chemical identity and occupancy from experimental density mapsWang J. Determination of chemical identity and occupancy from experimental density maps. Protein Science 2017, 27: 411-420. PMID: 29027293, PMCID: PMC5775170, DOI: 10.1002/pro.3325.
- On the relationship between cumulative correlation coefficients and the quality of crystallographic data setsWang J, Brudvig GW, Batista VS, Moore PB. On the relationship between cumulative correlation coefficients and the quality of crystallographic data sets. Protein Science 2017, 26: 2410-2416. PMID: 28960580, PMCID: PMC5699489, DOI: 10.1002/pro.3314.
- Crystallographic Data Support the Carousel Mechanism of Water Supply to the Oxygen-Evolving Complex of Photosystem IIWang J, Askerka M, Brudvig GW, Batista VS. Crystallographic Data Support the Carousel Mechanism of Water Supply to the Oxygen-Evolving Complex of Photosystem II. ACS Energy Letters 2017, 2: 2299-2306. PMID: 29057331, PMCID: PMC5644713, DOI: 10.1021/acsenergylett.7b00750.
- Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1Chase AR, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1. Molecular Biology Of The Cell 2017, 28: 2765-2772. PMID: 28814508, PMCID: PMC5638581, DOI: 10.1091/mbc.e17-05-0281.
- Chlorophyll a with a farnesyl tail in thermophilic cyanobacteriaWiwczar JM, LaFountain AM, Wang J, Frank HA, Brudvig GW. Chlorophyll a with a farnesyl tail in thermophilic cyanobacteria. Photosynthesis Research 2017, 134: 175-182. PMID: 28741056, PMCID: PMC5832022, DOI: 10.1007/s11120-017-0425-4.
- Effects of aligned α‐helix peptide dipoles on experimental electrostatic potentialsWang J, Videla PE, Batista VS. Effects of aligned α‐helix peptide dipoles on experimental electrostatic potentials. Protein Science 2017, 26: 1692-1697. PMID: 28556371, PMCID: PMC5563131, DOI: 10.1002/pro.3204.
- Experimental charge density from electron microscopic mapsWang J. Experimental charge density from electron microscopic maps. Protein Science 2017, 26: 1619-1626. PMID: 28543856, PMCID: PMC5521614, DOI: 10.1002/pro.3198.
- On contribution of known atomic partial charges of protein backbone in electrostatic potential density mapsWang J. On contribution of known atomic partial charges of protein backbone in electrostatic potential density maps. Protein Science 2017, 26: 1098-1104. PMID: 28370507, PMCID: PMC5441424, DOI: 10.1002/pro.3169.
- Systematic analysis of residual density suggests that a major limitation in well‐refined X‐ray structures of proteins is the omission of ordered solventWang J. Systematic analysis of residual density suggests that a major limitation in well‐refined X‐ray structures of proteins is the omission of ordered solvent. Protein Science 2017, 26: 1012-1023. PMID: 28244185, PMCID: PMC5405434, DOI: 10.1002/pro.3145.
- Insights into Photosystem II from Isomorphous Difference Fourier Maps of Femtosecond X‑ray Diffraction Data and Quantum Mechanics/Molecular Mechanics Structural ModelsWang J, Askerka M, Brudvig GW, Batista VS. Insights into Photosystem II from Isomorphous Difference Fourier Maps of Femtosecond X‑ray Diffraction Data and Quantum Mechanics/Molecular Mechanics Structural Models. ACS Energy Letters 2017, 2: 397-407. PMID: 28217747, PMCID: PMC5307371, DOI: 10.1021/acsenergylett.6b00626.
- Crystal structure of Pistol, a class of self-cleaving ribozymeNguyen LA, Wang J, Steitz TA. Crystal structure of Pistol, a class of self-cleaving ribozyme. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1021-1026. PMID: 28096403, PMCID: PMC5293083, DOI: 10.1073/pnas.1611191114.
- On the appearance of carboxylates in electrostatic potential mapsWang J. On the appearance of carboxylates in electrostatic potential maps. Protein Science 2016, 26: 396-402. PMID: 27977901, PMCID: PMC5326552, DOI: 10.1002/pro.3093.
- On the interpretation of electron microscopic maps of biological macromoleculesWang J, Moore PB. On the interpretation of electron microscopic maps of biological macromolecules. Protein Science 2016, 26: 122-129. PMID: 27706888, PMCID: PMC5192980, DOI: 10.1002/pro.3060.
- Oxygen additions in serial femtosecond crystallographic protein structuresWang J. Oxygen additions in serial femtosecond crystallographic protein structures. Protein Science 2016, 25: 1797-1802. PMID: 27438534, PMCID: PMC5029527, DOI: 10.1002/pro.2987.
- Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases*Vashishtha AK, Wang J, Konigsberg WH. Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases*. Journal Of Biological Chemistry 2016, 291: 20869-20875. PMID: 27462081, PMCID: PMC5076500, DOI: 10.1074/jbc.r116.742494.
- X‐ray radiation‐induced addition of oxygen atoms to protein residuesWang J. X‐ray radiation‐induced addition of oxygen atoms to protein residues. Protein Science 2016, 25: 1407-1419. PMID: 27074249, PMCID: PMC4989999, DOI: 10.1002/pro.2934.
- Destruction‐and‐diffraction by X‐ray free‐electron laserWang J. Destruction‐and‐diffraction by X‐ray free‐electron laser. Protein Science 2016, 25: 1585-1592. PMID: 27262052, PMCID: PMC5338243, DOI: 10.1002/pro.2959.
- S3 State of the O2‑Evolving Complex of Photosystem II: Insights from QM/MM, EXAFS, and Femtosecond X‑ray DiffractionAskerka M, Wang J, Vinyard DJ, Brudvig GW, Batista VS. S3 State of the O2‑Evolving Complex of Photosystem II: Insights from QM/MM, EXAFS, and Femtosecond X‑ray Diffraction. Biochemistry 2016, 55: 981-984. PMID: 26849148, DOI: 10.1021/acs.biochem.6b00041.
- Crystallographic study of a MATE transporter presents a difficult case in structure determination with low‐resolution, anisotropic data and crystal twinningSymersky J, Guo Y, Wang J, Lu M. Crystallographic study of a MATE transporter presents a difficult case in structure determination with low‐resolution, anisotropic data and crystal twinning. Acta Crystallographica Section D, Structural Biology 2015, 71: 2287-2296. PMID: 26527145, PMCID: PMC4631480, DOI: 10.1107/s1399004715016995.
- Comment on “Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism”Wang J. Comment on “Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism”. Science 2015, 350: 519-519. PMID: 26516276, DOI: 10.1126/science.aab1432.
- A Ubl/ubiquitin switch in the activation of Parkin.Sauvé V, Lilov A, Seirafi M, Vranas M, Rasool S, Kozlov G, Sprules T, Wang J, Trempe JF, Gehring K. A Ubl/ubiquitin switch in the activation of Parkin. The EMBO Journal 2015, 34: 2492-505. PMID: 26254305, PMCID: PMC4609182, DOI: 10.15252/embj.201592237.
- Structure and function of the N‐terminal domain of the human mitochondrial calcium uniporterLee Y, Min CK, Kim TG, Song HK, Lim Y, Kim D, Shin K, Kang M, Kang JY, Youn HS, Lee JG, An JY, Park KR, Lim JJ, Kim JH, Kim JH, Park ZY, Kim YS, Wang J, Kim DH, Eom SH. Structure and function of the N‐terminal domain of the human mitochondrial calcium uniporter. EMBO Reports 2015, 16: 1318-1333. PMID: 26341627, PMCID: PMC4662854, DOI: 10.15252/embr.201540436.
- Estimation of the quality of refined protein crystal structuresWang J. Estimation of the quality of refined protein crystal structures. Protein Science 2015, 24: 661-669. PMID: 25581292, PMCID: PMC4420517, DOI: 10.1002/pro.2639.
- Analysis of the Radiation-Damage-Free X‑ray Structure of Photosystem II in Light of EXAFS and QM/MM DataAskerka M, Vinyard DJ, Wang J, Brudvig GW, Batista VS. Analysis of the Radiation-Damage-Free X‑ray Structure of Photosystem II in Light of EXAFS and QM/MM Data. Biochemistry 2015, 54: 1713-1716. PMID: 25710258, DOI: 10.1021/acs.biochem.5b00089.
- On the validation of crystallographic symmetry and the quality of structuresWang J. On the validation of crystallographic symmetry and the quality of structures. Protein Science 2014, 24: 621-632. PMID: 25352397, PMCID: PMC4420513, DOI: 10.1002/pro.2595.
- Structural Changes in the Oxygen-Evolving Complex of Photosystem II Induced by the S1 to S2 Transition: A Combined XRD and QM/MM StudyAskerka M, Wang J, Brudvig GW, Batista VS. Structural Changes in the Oxygen-Evolving Complex of Photosystem II Induced by the S1 to S2 Transition: A Combined XRD and QM/MM Study. Biochemistry 2014, 53: 6860-6862. PMID: 25347729, PMCID: PMC4230327, DOI: 10.1021/bi5011915.
- The mechanism of Torsin ATPase activationBrown RS, Zhao C, Chase AR, Wang J, Schlieker C. The mechanism of Torsin ATPase activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e4822-e4831. PMID: 25352667, PMCID: PMC4234599, DOI: 10.1073/pnas.1415271111.
- Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozymeEiler D, Wang J, Steitz TA. Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 13028-13033. PMID: 25157168, PMCID: PMC4246988, DOI: 10.1073/pnas.1414571111.
- Exploiting subtle structural differences in heavy‐atom derivatives for experimental phasingWang J, Li Y, Modis Y. Exploiting subtle structural differences in heavy‐atom derivatives for experimental phasing. Acta Crystallographica Section D, Structural Biology 2014, 70: 1873-1883. PMID: 25004964, PMCID: PMC4089484, DOI: 10.1107/s1399004714008943.
- Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helixBrown JA, Bulkley D, Wang J, Valenstein ML, Yario TA, Steitz TA, Steitz JA. Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix. Nature Structural & Molecular Biology 2014, 21: 633-640. PMID: 24952594, PMCID: PMC4096706, DOI: 10.1038/nsmb.2844.
- Diamonds in the rough: a strong case for the inclusion of weak‐intensity X‐ray diffraction dataWang J, Wing RA. Diamonds in the rough: a strong case for the inclusion of weak‐intensity X‐ray diffraction data. Acta Crystallographica Section D, Structural Biology 2014, 70: 1491-1497. PMID: 24816117, PMCID: PMC4014128, DOI: 10.1107/s1399004714005318.
- Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestivirusesWang J, Li Y, Modis Y. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses. Virology 2014, 454: 93-101. PMID: 24725935, PMCID: PMC3986810, DOI: 10.1016/j.virol.2014.02.015.
- Exploiting large non‐isomorphous differences for phase determination of a G‐segment invertase–DNA complexRitacco CJ, Steitz TA, Wang J. Exploiting large non‐isomorphous differences for phase determination of a G‐segment invertase–DNA complex. Acta Crystallographica Section D, Structural Biology 2014, 70: 685-693. PMID: 24598738, PMCID: PMC3949525, DOI: 10.1107/s1399004713032392.
- Crystal structure of glycoprotein E2 from bovine viral diarrhea virusLi Y, Wang J, Kanai R, Modis Y. Crystal structure of glycoprotein E2 from bovine viral diarrhea virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 6805-6810. PMID: 23569276, PMCID: PMC3637714, DOI: 10.1073/pnas.1300524110.
- DNA mismatch synthesis complexes provide insights into base selectivityXia S, Wang J, Konigsberg W. DNA mismatch synthesis complexes provide insights into base selectivity. The FASEB Journal 2013, 27: 540.1-540.1. DOI: 10.1096/fasebj.27.1_supplement.540.1.
- Calcium-dependent conformational transition of calmodulin determined by Fourier transform infrared spectroscopyYu T, Wu G, Yang H, Wang J, Yu S. Calcium-dependent conformational transition of calmodulin determined by Fourier transform infrared spectroscopy. International Journal Of Biological Macromolecules 2013, 56: 57-61. PMID: 23403030, DOI: 10.1016/j.ijbiomac.2013.02.004.
- Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertaseRitacco CJ, Kamtekar S, Wang J, Steitz TA. Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase. Nucleic Acids Research 2012, 41: 2673-2682. PMID: 23275567, PMCID: PMC3575834, DOI: 10.1093/nar/gks1303.
- DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA PolymeraseXia S, Wang J, Konigsberg WH. DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase. Journal Of The American Chemical Society 2012, 135: 193-202. PMID: 23214497, PMCID: PMC3760218, DOI: 10.1021/ja3079048.
- The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during TranslocationItsathitphaisarn O, Wing RA, Eliason WK, Wang J, Steitz TA. The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation. Cell 2012, 151: 267-277. PMID: 23022319, PMCID: PMC3597440, DOI: 10.1016/j.cell.2012.09.014.
- Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3′-terminal phosphate and 5′-OHEnglert M, Xia S, Okada C, Nakamura A, Tanavde V, Yao M, Eom SH, Konigsberg WH, Söll D, Wang J. Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3′-terminal phosphate and 5′-OH. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 15235-15240. PMID: 22949672, PMCID: PMC3458315, DOI: 10.1073/pnas.1213795109.
- Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNAXia S, Vashishtha A, Bulkley D, Eom SH, Wang J, Konigsberg WH. Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA. Biochemistry 2012, 51: 4922-4931. PMID: 22630605, PMCID: PMC3426629, DOI: 10.1021/bi300296q.
- Using a Fluorescent Cytosine Analogue tCo To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA PolymeraseXia S, Beckman J, Wang J, Konigsberg WH. Using a Fluorescent Cytosine Analogue tCo To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase. Biochemistry 2012, 51: 4609-4617. PMID: 22616982, PMCID: PMC3437246, DOI: 10.1021/bi300241m.
- Probing Minor Groove Hydrogen Bonding Interactions between RB69 DNA Polymerase and DNAXia S, Christian TD, Wang J, Konigsberg WH. Probing Minor Groove Hydrogen Bonding Interactions between RB69 DNA Polymerase and DNA. Biochemistry 2012, 51: 4343-4353. PMID: 22571765, PMCID: PMC3374494, DOI: 10.1021/bi300416z.
- Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide ResidueXia S, Eom SH, Konigsberg WH, Wang J. Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue. Biochemistry 2012, 51: 1476-1485. PMID: 22304682, PMCID: PMC3292180, DOI: 10.1021/bi2016487.
- Bidentate and tridentate metal‐ion coordination states within ternary complexes of RB69 DNA polymeraseXia S, Eom SH, Konigsberg WH, Wang J. Bidentate and tridentate metal‐ion coordination states within ternary complexes of RB69 DNA polymerase. Protein Science 2012, 21: 447-451. PMID: 22238207, PMCID: PMC3375444, DOI: 10.1002/pro.2026.
- Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA PolymeraseXia S, Wang M, Blaha G, Konigsberg WH, Wang J. Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase. Biochemistry 2011, 50: 9114-9124. PMID: 21923197, PMCID: PMC3760225, DOI: 10.1021/bi201260h.
- Hydrogen-Bonding Capability of a Templating Difluorotoluene Nucleotide Residue in an RB69 DNA Polymerase Ternary ComplexXia S, Konigsberg WH, Wang J. Hydrogen-Bonding Capability of a Templating Difluorotoluene Nucleotide Residue in an RB69 DNA Polymerase Ternary Complex. Journal Of The American Chemical Society 2011, 133: 10003-10005. PMID: 21667997, PMCID: PMC3139434, DOI: 10.1021/ja2021735.
- Hydrogen‐Bonding Capability of Nonpolar Difluorotoluene Nucleoside in Replication ComplexesXia S, Wang J, Konigsberg W. Hydrogen‐Bonding Capability of Nonpolar Difluorotoluene Nucleoside in Replication Complexes. The FASEB Journal 2011, 25: 688.8-688.8. DOI: 10.1096/fasebj.25.1_supplement.688.8.
- Structural Basis of Cooperative Ligand Binding by the Glycine RiboswitchButler EB, Xiong Y, Wang J, Strobel SA. Structural Basis of Cooperative Ligand Binding by the Glycine Riboswitch. Cell Chemical Biology 2011, 18: 293-298. PMID: 21439473, PMCID: PMC3076126, DOI: 10.1016/j.chembiol.2011.01.013.
- Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal StructuresXia S, Wang M, Lee HR, Sinha A, Blaha G, Christian T, Wang J, Konigsberg W. Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures. Journal Of Molecular Biology 2011, 406: 558-570. PMID: 21216248, PMCID: PMC3059800, DOI: 10.1016/j.jmb.2010.12.033.
- Insights into Base Selectivity from the 1.8 Å Resolution Structure of an RB69 DNA Polymerase Ternary ComplexWang M, Xia S, Blaha G, Steitz TA, Konigsberg WH, Wang J. Insights into Base Selectivity from the 1.8 Å Resolution Structure of an RB69 DNA Polymerase Ternary Complex. Biochemistry 2010, 50: 581-590. PMID: 21158418, PMCID: PMC3036992, DOI: 10.1021/bi101192f.
- Poly(A) Tail Recognition by a Viral RNA Element Through Assembly of a Triple HelixMitton-Fry RM, DeGregorio SJ, Wang J, Steitz TA, Steitz JA. Poly(A) Tail Recognition by a Viral RNA Element Through Assembly of a Triple Helix. Science 2010, 330: 1244-1247. PMID: 21109672, PMCID: PMC3074936, DOI: 10.1126/science.1195858.
- Structural insight into the mechanisms of enveloped virus tethering by tetherinYang H, Wang J, Jia X, McNatt MW, Zang T, Pan B, Meng W, Wang HW, Bieniasz PD, Xiong Y. Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 18428-18432. PMID: 20940320, PMCID: PMC2972963, DOI: 10.1073/pnas.1011485107.
- Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin,Beckman J, Wang M, Blaha G, Wang J, Konigsberg WH. Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin,. Biochemistry 2010, 49: 8554-8563. PMID: 20795733, PMCID: PMC3755731, DOI: 10.1021/bi100913v.
- Inclusion of weak high-resolution X-ray data for improvement of a group II intron structure.Wang J. Inclusion of weak high-resolution X-ray data for improvement of a group II intron structure. Acta Crystallographica. Section D, Biological Crystallography 2010, 66: 988-1000. PMID: 20823550, DOI: 10.1107/S0907444910029938.
- Heterohexameric Ring Arrangement of the Eukaryotic Proteasomal ATPases: Implications for Proteasome Structure and AssemblyTomko RJ, Funakoshi M, Schneider K, Wang J, Hochstrasser M. Heterohexameric Ring Arrangement of the Eukaryotic Proteasomal ATPases: Implications for Proteasome Structure and Assembly. Molecular Cell 2010, 38: 393-403. PMID: 20471945, PMCID: PMC2879271, DOI: 10.1016/j.molcel.2010.02.035.
- Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP To Be Inserted opposite 7,8-Dihydro-8-oxoguanine,Beckman J, Wang M, Blaha G, Wang J, Konigsberg WH. Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP To Be Inserted opposite 7,8-Dihydro-8-oxoguanine,. Biochemistry 2010, 49: 4116-4125. PMID: 20411947, PMCID: PMC2882254, DOI: 10.1021/bi100102s.
- Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligandCortajarena AL, Wang J, Regan L. Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand. The FEBS Journal 2010, 277: 1058-1066. PMID: 20089039, DOI: 10.1111/j.1742-4658.2009.07549.x.
- Tertiary architecture of the Oceanobacillus iheyensis group II intronToor N, Keating KS, Fedorova O, Rajashankar K, Wang J, Pyle AM. Tertiary architecture of the Oceanobacillus iheyensis group II intron. RNA 2009, 16: 57-69. PMID: 19952115, PMCID: PMC2802037, DOI: 10.1261/rna.1844010.
- Structural basis of ligand binding by a c-di-GMP riboswitchSmith KD, Lipchock SV, Ames TD, Wang J, Breaker RR, Strobel SA. Structural basis of ligand binding by a c-di-GMP riboswitch. Nature Structural & Molecular Biology 2009, 16: 1218-1223. PMID: 19898477, PMCID: PMC2850612, DOI: 10.1038/nsmb.1702.
- Structure of apo-CAP reveals that large conformational changes are necessary for DNA bindingSharma H, Yu S, Kong J, Wang J, Steitz TA. Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16604-16609. PMID: 19805344, PMCID: PMC2745332, DOI: 10.1073/pnas.0908380106.
- Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4′-Ethynylthymidine Analog Resistance Profile▿Yang G, Paintsil E, Dutschman GE, Grill SP, Wang CJ, Wang J, Tanaka H, Hamasaki T, Baba M, Cheng YC. Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4′-Ethynylthymidine Analog Resistance Profile▿. Antimicrobial Agents And Chemotherapy 2009, 53: 4640-4646. PMID: 19704131, PMCID: PMC2772322, DOI: 10.1128/aac.00686-09.
- Application of general formulas for the correction of a lattice‐translocation defect in crystals of a lentiviral integrase in complex with LEDGFHare S, Cherepanov P, Wang J. Application of general formulas for the correction of a lattice‐translocation defect in crystals of a lentiviral integrase in complex with LEDGF. Acta Crystallographica Section D, Structural Biology 2009, 65: 966-973. PMID: 19690374, DOI: 10.1107/s0907444909023695.
- Structural Basis for Functional Tetramerization of Lentiviral IntegraseHare S, Di Nunzio F, Labeja A, Wang J, Engelman A, Cherepanov P. Structural Basis for Functional Tetramerization of Lentiviral Integrase. PLOS Pathogens 2009, 5: e1000515. PMID: 19609359, PMCID: PMC2705190, DOI: 10.1371/journal.ppat.1000515.
- RB69 DNA Polymerase Mutants with Expanded Nascent Base-Pair-Binding Pockets Are Highly Efficient but Have Reduced Base SelectivityZhang H, Beckman J, Wang J, Konigsberg W. RB69 DNA Polymerase Mutants with Expanded Nascent Base-Pair-Binding Pockets Are Highly Efficient but Have Reduced Base Selectivity. Biochemistry 2009, 48: 6940-6950. PMID: 19522539, PMCID: PMC2847438, DOI: 10.1021/bi900422b.
- Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channelClayton GM, Aller SG, Wang J, Unger V, Morais-Cabral JH. Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channel. Journal Of Structural Biology 2009, 167: 220-226. PMID: 19545635, PMCID: PMC2922748, DOI: 10.1016/j.jsb.2009.06.012.
- Structures of RB69 DNA polymerase ternary complexes reveal multiple modes of metal ion coordination to correct incoming dNTPsWang M, Konigsberg W, Steitz T, Wang J. Structures of RB69 DNA polymerase ternary complexes reveal multiple modes of metal ion coordination to correct incoming dNTPs. The FASEB Journal 2009, 23: 482.1-482.1. DOI: 10.1096/fasebj.23.1_supplement.482.1.
- A regulatable switch mediates self-association in an immunoglobulin foldCalabrese MF, Eakin CM, Wang JM, Miranker AD. A regulatable switch mediates self-association in an immunoglobulin fold. Nature Structural & Molecular Biology 2008, 15: 965-971. PMID: 19172750, PMCID: PMC2680708, DOI: 10.1038/nsmb.1483.
- Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4′-Ethynyl Stavudine Triphosphate▿Yang G, Wang J, Cheng Y, Dutschman GE, Tanaka H, Baba M, Cheng YC. Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4′-Ethynyl Stavudine Triphosphate▿. Antimicrobial Agents And Chemotherapy 2008, 52: 2035-2042. PMID: 18391035, PMCID: PMC2415781, DOI: 10.1128/aac.00083-08.
- Structural basis for base discrimination by RB69 DNA polymeraseWang M, Klimenko D, Steitz T, Wang J. Structural basis for base discrimination by RB69 DNA polymerase. The FASEB Journal 2008, 22: 593.2-593.2. DOI: 10.1096/fasebj.22.1_supplement.593.2.
- Crystal structure of Bacillus subtilis CodW, a noncanonical HslV‐like peptidase with an impaired catalytic apparatusRho S, Park HH, Kang GB, Im YJ, Kang MS, Lim BK, Seong IS, Seol J, Chung CH, Wang J, Eom SH. Crystal structure of Bacillus subtilis CodW, a noncanonical HslV‐like peptidase with an impaired catalytic apparatus. Proteins Structure Function And Bioinformatics 2007, 71: 1020-1026. PMID: 17979190, DOI: 10.1002/prot.21758.
- Structural Metals in the Group I Intron: A Ribozyme with a Multiple Metal Ion CoreStahley MR, Adams PL, Wang J, Strobel SA. Structural Metals in the Group I Intron: A Ribozyme with a Multiple Metal Ion Core. Journal Of Molecular Biology 2007, 372: 89-102. PMID: 17612557, PMCID: PMC2071931, DOI: 10.1016/j.jmb.2007.06.026.
- The ϕ29 DNA polymerase:protein‐primer structure suggests a model for the initiation to elongation transitionKamtekar S, Berman AJ, Wang J, Lázaro JM, de Vega M, Blanco L, Salas M, Steitz TA. The ϕ29 DNA polymerase:protein‐primer structure suggests a model for the initiation to elongation transition. The EMBO Journal 2006, 25: 1335-1343. PMID: 16511564, PMCID: PMC1422159, DOI: 10.1038/sj.emboj.7601027.
- The L561A Substitution in the Nascent Base-Pair Binding Pocket of RB69 DNA Polymerase Reduces Base Discrimination †Zhang H, Rhee C, Bebenek A, Drake JW, Wang J, Konigsberg W. The L561A Substitution in the Nascent Base-Pair Binding Pocket of RB69 DNA Polymerase Reduces Base Discrimination †. Biochemistry 2006, 45: 2211-2220. PMID: 16475809, PMCID: PMC3373012, DOI: 10.1021/bi052099y.
- Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpATalavera MA, Matthews EE, Eliason WK, Sagi I, Wang J, Henn A, De La Cruz EM. Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA. Journal Of Molecular Biology 2005, 355: 697-707. PMID: 16325852, DOI: 10.1016/j.jmb.2005.10.058.
- Hoogsteen base-pairing in DNA replication?Wang J. Hoogsteen base-pairing in DNA replication? Nature 2005, 437: e6-e7. PMID: 16163299, DOI: 10.1038/nature04199.
- A Twisted Four-Sheeted Model for an Amyloid FibrilWang J, Gülich S, Bradford C, Ramirez-Alvarado M, Regan L. A Twisted Four-Sheeted Model for an Amyloid Fibril. Structure 2005, 13: 1279-1288. PMID: 16154085, DOI: 10.1016/j.str.2005.06.010.
- Correction of X‐ray intensities from an HslV–HslU co‐crystal containing lattice‐translocation defectsWang J, Rho SH, Park HH, Eom SH. Correction of X‐ray intensities from an HslV–HslU co‐crystal containing lattice‐translocation defects. Acta Crystallographica Section D, Structural Biology 2005, 61: 932-941. PMID: 15983416, DOI: 10.1107/s0907444905009546.
- Recent Cyanobacterial Kai Protein Structures Suggest a Rotary ClockWang J. Recent Cyanobacterial Kai Protein Structures Suggest a Rotary Clock. Structure 2005, 13: 735-741. PMID: 15893664, DOI: 10.1016/j.str.2005.02.011.
- Role of the GYVG Pore Motif of HslU ATPase in Protein Unfolding and Translocation for Degradation by HslV Peptidase*Park E, Rho YM, Koh OJ, Ahn SW, Seong IS, Song JJ, Bang O, Seol JH, Wang J, Eom SH, Chung CH. Role of the GYVG Pore Motif of HslU ATPase in Protein Unfolding and Translocation for Degradation by HslV Peptidase*. Journal Of Biological Chemistry 2005, 280: 22892-22898. PMID: 15849200, DOI: 10.1074/jbc.m500035200.
- A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacityRodríguez I, Lázaro JM, Blanco L, Kamtekar S, Berman AJ, Wang J, Steitz TA, Salas M, de Vega M. A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 6407-6412. PMID: 15845765, PMCID: PMC1088371, DOI: 10.1073/pnas.0500597102.
- Base Selectivity Is Impaired by Mutants that Perturb Hydrogen Bonding Networks in the RB69 DNA Polymerase Active Site †Yang G, Wang J, Konigsberg W. Base Selectivity Is Impaired by Mutants that Perturb Hydrogen Bonding Networks in the RB69 DNA Polymerase Active Site †. Biochemistry 2005, 44: 3338-3346. PMID: 15736944, DOI: 10.1021/bi047921x.
- Correction of X‐ray intensities from single crystals containing lattice‐translocation defectsWang J, Kamtekar S, Berman AJ, Steitz TA. Correction of X‐ray intensities from single crystals containing lattice‐translocation defects. Acta Crystallographica Section D, Structural Biology 2004, 61: 67-74. PMID: 15608377, DOI: 10.1107/s0907444904026721.
- Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage φ29Kamtekar S, Berman A, Wang J, Lázaro J, de Vega M, Blanco L, Salas M, Steitz T. Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage φ29. Molecular Cell 2004, 16: 1035-1036. DOI: 10.1016/j.molcel.2004.12.006.
- Nucleotide-dependent domain motions within rings of the RecA/AAA+ superfamilyWang J. Nucleotide-dependent domain motions within rings of the RecA/AAA+ superfamily. Journal Of Structural Biology 2004, 148: 259-267. PMID: 15522774, DOI: 10.1016/j.jsb.2004.07.003.
- Crystal structure of a group I intron splicing intermediateAdams PL, Stahley MR, Gill ML, Kosek AB, Wang J, Strobel SA. Crystal structure of a group I intron splicing intermediate. RNA 2004, 10: 1867-1887. PMID: 15547134, PMCID: PMC1370676, DOI: 10.1261/rna.7140504.
- RNA kink turns to the left and to the rightStrobel SA, Adams PL, Stahley MR, Wang J. RNA kink turns to the left and to the right. RNA 2004, 10: 1852-1854. PMID: 15547133, PMCID: PMC1370673, DOI: 10.1261/rna.7141504.
- Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage φ29Kamtekar S, Berman AJ, Wang J, Lázaro JM, de Vega M, Blanco L, Salas M, Steitz TA. Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage φ29. Molecular Cell 2004, 16: 609-618. PMID: 15546620, DOI: 10.1016/j.molcel.2004.10.019.
- Visualizing a Circadian Clock Protein Crystal Structure of KaiC and Functional InsightsPattanayek R, Wang J, Mori T, Xu Y, Johnson C, Egli M. Visualizing a Circadian Clock Protein Crystal Structure of KaiC and Functional Insights. Molecular Cell 2004, 15: 841. DOI: 10.1016/j.molcel.2004.08.027.
- Visualizing a Circadian Clock Protein Crystal Structure of KaiC and Functional InsightsPattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M. Visualizing a Circadian Clock Protein Crystal Structure of KaiC and Functional Insights. Molecular Cell 2004, 15: 375-388. PMID: 15304218, DOI: 10.1016/j.molcel.2004.07.013.
- Crystal structure of a self-splicing group I intron with both exonsAdams PL, Stahley MR, Kosek AB, Wang J, Strobel SA. Crystal structure of a self-splicing group I intron with both exons. Nature 2004, 430: 45-50. PMID: 15175762, DOI: 10.1038/nature02642.
- The structure of a ribosomal protein S8/spc operon mRNA complexMerianos HJ, Wang J, Moore PB. The structure of a ribosomal protein S8/spc operon mRNA complex. RNA 2004, 10: 954-964. PMID: 15146079, PMCID: PMC1370587, DOI: 10.1261/rna.7030704.
- The Activity of Selected RB69 DNA Polymerase Mutants Can Be Restored by Manganese Ions: The Existence of Alternative Metal Ion Ligands Used during the Polymerization Cycle †Zakharova E, Wang J, Konigsberg W. The Activity of Selected RB69 DNA Polymerase Mutants Can Be Restored by Manganese Ions: The Existence of Alternative Metal Ion Ligands Used during the Polymerization Cycle †. Biochemistry 2004, 43: 6587-6595. PMID: 15157091, DOI: 10.1021/bi049615p.
- Pre-Steady-State Kinetics of RB69 DNA Polymerase and Its Exo Domain Mutants: Effect of pH and Thiophosphoryl Linkages on 3‘−5‘ Exonuclease Activity †Wang C, Zakharova E, Li J, Joyce C, Wang J, Konigsberg W. Pre-Steady-State Kinetics of RB69 DNA Polymerase and Its Exo Domain Mutants: Effect of pH and Thiophosphoryl Linkages on 3‘−5‘ Exonuclease Activity †. Biochemistry 2004, 43: 3853-3861. PMID: 15049692, DOI: 10.1021/bi0302292.
- Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide ComplexesXiong Y, Li F, Wang J, Weiner AM, Steitz TA. Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide Complexes. Molecular Cell 2003, 12: 1165-1172. PMID: 14636575, DOI: 10.1016/s1097-2765(03)00440-4.
- Domain Motions in GroEL upon Binding of an OligopeptideWang J, Chen L. Domain Motions in GroEL upon Binding of an Oligopeptide. Journal Of Molecular Biology 2003, 334: 489-499. PMID: 14623189, DOI: 10.1016/j.jmb.2003.09.074.
- Modifying the oligomeric state of cyclic amidase and its effect on enzymatic catalysisYoon J, Oh B, Kim K, Park JE, Wang J, Kim HS, Kim Y. Modifying the oligomeric state of cyclic amidase and its effect on enzymatic catalysis. Biochemical And Biophysical Research Communications 2003, 310: 651-659. PMID: 14521961, DOI: 10.1016/j.bbrc.2003.09.056.
- Crystal structure of a transcription factor IIIB core interface ternary complexJuo ZS, Kassavetis GA, Wang J, Geiduschek EP, Sigler PB. Crystal structure of a transcription factor IIIB core interface ternary complex. Nature 2003, 422: 534-539. PMID: 12660736, DOI: 10.1038/nature01534.
- The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetasesKamtekar S, Kennedy WD, Wang J, Stathopoulos C, Söll D, Steitz TA. The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 1673-1678. PMID: 12578991, PMCID: PMC149891, DOI: 10.1073/pnas.0437911100.
- A second response in correcting the HslV–HslU quaternary structureWang J. A second response in correcting the HslV–HslU quaternary structure. Journal Of Structural Biology 2003, 141: 7-8. PMID: 12576015, DOI: 10.1016/s1047-8477(02)00629-9.
- The crystal structure of a 26-nucleotide RNA containing a hook-turn.Szép S, Wang J, Moore PB. The crystal structure of a 26-nucleotide RNA containing a hook-turn. RNA (New York, N.Y.) 2003, 9: 44-51. PMID: 12554875, PMCID: PMC1370369, DOI: 10.1261/rna.2107303.
- Crystal Structures of the Bacillus stearothermophilus CCA-Adding Enzyme and Its Complexes with ATP or CTPLi F, Xiong Y, Wang J, Cho HD, Tomita K, Weiner AM, Steitz TA. Crystal Structures of the Bacillus stearothermophilus CCA-Adding Enzyme and Its Complexes with ATP or CTP. Cell 2002, 111: 815-824. PMID: 12526808, DOI: 10.1016/s0092-8674(02)01115-7.
- Crystal Structure of d-Hydantoinase from Bacillus stearothermophilus: Insight into the Stereochemistry of Enantioselectivity † , ‡Cheon YH, Kim HS, Han KH, Abendroth J, Niefind K, Schomburg D, Wang J, Kim Y. Crystal Structure of d-Hydantoinase from Bacillus stearothermophilus: Insight into the Stereochemistry of Enantioselectivity † , ‡. Biochemistry 2002, 41: 9410-9417. PMID: 12135362, DOI: 10.1021/bi0201567.
- The C-terminal Tails of HslU ATPase Act as a Molecular Switch for Activation of HslV Peptidase*Seong IS, Kang MS, Choi MK, Lee JW, Koh OJ, Wang J, Eom SH, Chung CH. The C-terminal Tails of HslU ATPase Act as a Molecular Switch for Activation of HslV Peptidase*. Journal Of Biological Chemistry 2002, 277: 25976-25982. PMID: 12011053, DOI: 10.1074/jbc.m202793200.
- Structure of the Replicating Complex of a Pol α Family DNA PolymeraseFranklin M, Wang J, Steitz T. Structure of the Replicating Complex of a Pol α Family DNA Polymerase. Cell 2001, 105: 657-667. PMID: 11389835, DOI: 10.1016/s0092-8674(01)00367-1.
- Unraveling the means to the end in ATP-dependent proteasesHochstrasser M, Wang J. Unraveling the means to the end in ATP-dependent proteases. Nature Structural & Molecular Biology 2001, 8: 294-296. PMID: 11276243, DOI: 10.1038/86153.
- A Corrected Quaternary Arrangement of the Peptidase HslV and ATPase HslU in a Cocrystal StructureWang J. A Corrected Quaternary Arrangement of the Peptidase HslV and ATPase HslU in a Cocrystal Structure. Journal Of Structural Biology 2001, 134: 15-24. PMID: 11469873, DOI: 10.1006/jsbi.2001.4347.
- Sulfolobus shibatae CCA-adding enzyme forms a tetramer upon binding two tRNA molecules: a scrunching-shuttling model of CCA specificity1 1Edited by T. RichmondLi F, Wang J, Steitz T. Sulfolobus shibatae CCA-adding enzyme forms a tetramer upon binding two tRNA molecules: a scrunching-shuttling model of CCA specificity1 1Edited by T. Richmond. Journal Of Molecular Biology 2000, 304: 483-492. PMID: 11090289, DOI: 10.1006/jmbi.2000.4189.
- Insights into Editing from an Ile-tRNA Synthetase Structure with tRNAIle and MupirocinSilvian L, Wang J, Steitz T. Insights into Editing from an Ile-tRNA Synthetase Structure with tRNAIle and Mupirocin. Science 1999, 285: 1074-1077. PMID: 10446055, DOI: 10.1126/science.285.5430.1074.
- New insights into the ATP‐dependent Clp protease: Escherichia coli and beyondPorankiewicz J, Wang J, Clarke A. New insights into the ATP‐dependent Clp protease: Escherichia coli and beyond. Molecular Microbiology 1999, 32: 449-458. PMID: 10320569, DOI: 10.1046/j.1365-2958.1999.01357.x.
- Crystal Structure Determination ofEscherichia coliClpP Starting from an EM-Derived MaskWang J, Hartling J, Flanagan J. Crystal Structure Determination ofEscherichia coliClpP Starting from an EM-Derived Mask. Journal Of Structural Biology 1998, 124: 151-163. PMID: 10049803, DOI: 10.1006/jsbi.1998.4058.
- The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent ProteolysisWang J, Hartling J, Flanagan J. The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent Proteolysis. Cell 1997, 91: 447-456. PMID: 9390554, DOI: 10.1016/s0092-8674(00)80431-6.
- Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69Wang J, Sattar A, Wang C, Karam J, Konigsberg W, Steitz T. Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69. Cell 1997, 89: 1087-1099. PMID: 9215631, DOI: 10.1016/s0092-8674(00)80296-2.
- Structure of Taq polymerase with DNA at the polymerase active siteEom S, Wang J, Steitz T. Structure of Taq polymerase with DNA at the polymerase active site. Nature 1996, 382: 278-281. PMID: 8717047, DOI: 10.1038/382278a0.
- The 2.4 Å crystal structure of the bacterial chaperonin GroEL complexed with ATPγSBoisvert D, Wang J, Otwinowski Z, Norwich A, Sigler P. The 2.4 Å crystal structure of the bacterial chaperonin GroEL complexed with ATPγS. Nature Structural & Molecular Biology 1996, 3: 170-177. PMID: 8564544, DOI: 10.1038/nsb0296-170.
- Crystal Structures of an NH2-Terminal Fragment of T4 DNA Polymerase and Its Complexes with Single-Stranded DNA and with Divalent Metal Ions †Wang J, Yu P, Lin T, Konigsberg W, Steitz T. Crystal Structures of an NH2-Terminal Fragment of T4 DNA Polymerase and Its Complexes with Single-Stranded DNA and with Divalent Metal Ions †. Biochemistry 1996, 35: 8110-8119. PMID: 8679562, DOI: 10.1021/bi960178r.
- Crystal structure of Thermus aquaticus DNA polymeraseKim Y, Eom S, Wang J, Lee D, Suh S, Steitz T. Crystal structure of Thermus aquaticus DNA polymerase. Nature 1995, 376: 612-616. PMID: 7637814, DOI: 10.1038/376612a0.
- Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motionJäger J, Smerdon S, Wang J, Boisvert D, Steitz T. Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion. Structure 1994, 2: 869-876. PMID: 7529124, DOI: 10.1016/s0969-2126(94)00087-5.
- The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution.Czworkowski J, Wang J, Steitz T, Moore P. The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution. The EMBO Journal 1994, 13: 3661-3668. PMID: 8070396, PMCID: PMC395276, DOI: 10.1002/j.1460-2075.1994.tb06675.x.
- Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer.Wang J, Smerdon S, Jäger J, Kohlstaedt L, Rice P, Friedman J, Steitz T. Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 7242-7246. PMID: 7518928, PMCID: PMC44375, DOI: 10.1073/pnas.91.15.7242.
- Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.Smerdon S, Jäger J, Wang J, Kohlstaedt L, Chirino A, Friedman J, Rice P, Steitz T. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3911-3915. PMID: 7513427, PMCID: PMC43692, DOI: 10.1073/pnas.91.9.3911.
- AddendumSteitz T, Kohlstaedt L, Wang J, Friedman J, Rice P. Addendum. Science 1993, 259: 295-295. DOI: 10.1126/science.259.5093.295.
- AddendumSteitz T, Kohlstaedt L, Wang J, Friedman J, Rice P. Addendum. Science 1993, 259: 295-295. PMID: 17832331, DOI: 10.1126/science.259.5093.295-a.
- AddendumSteitz T, Kohlstaedt L, Wang J, Friedman J, Rice P. Addendum. Science 1993, 259: 295-295. DOI: 10.1126/science.259.5093.295.a.
- Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I.Steitz T, Smerdon S, Jäger J, Wang J, Kohlstaedt L, Friedman J, Beese L, Rice P. Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. Cold Spring Harbor Symposia On Quantitative Biology 1993, 58: 495-504. PMID: 7525146, DOI: 10.1101/sqb.1993.058.01.056.
- Hiv Reverse Transcriptase: Structure and Specificity for tRNAsteitz T, Kohlstaedt L, Wang J, Rice P, Boisvert D, Friedman J. Hiv Reverse Transcriptase: Structure and Specificity for tRNA. Protein Engineering Design And Selection 1993, 6: 108-108. DOI: 10.1093/protein/6.supplement.108.
- Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an InhibitorKohlstaedt L, Wang J, Friedman J, Rice P, Steitz T. Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor. Science 1992, 256: 1783-1790. PMID: 1377403, DOI: 10.1126/science.1377403.