Jie Gong, MD, PhD
Associate Research Scientist of Ophthalmology and Visual Science
Research & Publications
Biography
Research Summary
Projects focus on the identification and use of extracellular matrix (ECM) to direct stem cell differentiation into retinal neurons or RPE cell lineage. . I am also engaged in determining the effects of age-related changes within BM on the biology of the RPE cells (RPE cell survival, reattachment, phagocytosis effect and retinal retinoid metabolism) through the use of organ culture of post-mortem donor retinas. Development of techniques and tools that direct stem cell differentiation can improve the outcome of cell-based therapy for the treatment of AMD.
Coauthors
Selected Publications
- Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epitheliumCai H, Gong J, Team N, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epithelium. Experimental Eye Research 2021, 207: 108576. PMID: 33895162, DOI: 10.1016/j.exer.2021.108576.
- Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactionsGong J, Cai H, Team N, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions. Stem Cells Translational Medicine 2019, 9: 364-376. PMID: 31840941, PMCID: PMC7031648, DOI: 10.1002/sctm.19-0321.
- High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMDCai H, Gong J, Abriola L, Hoyer D, Team N, Noggle S, Paull D, Del Priore LV, Fields MA. High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD. Experimental Eye Research 2019, 185: 107641. PMID: 30980814, DOI: 10.1016/j.exer.2019.04.009.
- Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's MembraneCai H, Gong J, Del Priore LV, Tezel TH, Fields MA. Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane. Journal Of Visualized Experiments 2018, 57084. PMID: 29708536, PMCID: PMC5933494, DOI: 10.3791/57084.
- Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's MembraneCai H, Gong J, Del Priore L, Tezel T, Fields M. Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane. Journal Of Visualized Experiments 2018 DOI: 10.3791/57084-v.
- Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cellsFields MA, Bowrey HE, Gong J, Moreira EF, Cai H, Del Priore LV. Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells. PLOS ONE 2017, 12: e0177763. PMID: 28505174, PMCID: PMC5432172, DOI: 10.1371/journal.pone.0177763.
- Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD)Fields M, Cai H, Gong J, Del Priore L. Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD). Cells 2016, 5: 44. PMID: 27941641, PMCID: PMC5187528, DOI: 10.3390/cells5040044.
- Differentiation of Human Protein-Induced Pluripotent Stem Cells toward a Retinal Pigment Epithelial Cell FateGong J, Fields MA, Moreira EF, Bowrey HE, Gooz M, Ablonczy Z, Del Priore LV. Differentiation of Human Protein-Induced Pluripotent Stem Cells toward a Retinal Pigment Epithelial Cell Fate. PLOS ONE 2015, 10: e0143272. PMID: 26606685, PMCID: PMC4659559, DOI: 10.1371/journal.pone.0143272.
- Chapter Twenty-Eight Retinoid Processing in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium CulturesFields MA, Bowrey HE, Gong J, Ablonczy Z, Del Priore LV. Chapter Twenty-Eight Retinoid Processing in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cultures. 2015, 134: 477-490. PMID: 26310172, PMCID: PMC8680204, DOI: 10.1016/bs.pmbts.2015.06.004.
- Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment EpitheliumNitrite-Modified ECM Alters CD46 and VEGF In VitroFields MA, Cai H, Bowrey HE, Moreira EF, Gooz M, Kunchithapautham K, Gong J, Vought E, Del Priore LV. Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment EpitheliumNitrite-Modified ECM Alters CD46 and VEGF In Vitro. Investigative Ophthalmology & Visual Science 2015, 56: 4231-4238. PMID: 26161984, PMCID: PMC4703405, DOI: 10.1167/iovs.15-16438.
- The Eye as a Target Organ for Stem Cell TherapyFields M, Hwang J, Gong J, Cai H, Del Priore L. The Eye as a Target Organ for Stem Cell Therapy. 2012, 1-29. DOI: 10.1007/978-1-4614-5493-9_1.
- Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitorsGong J, Sagiv O, Cai H, Tsang SH, Del Priore LV. Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. Experimental Eye Research 2008, 86: 957-965. PMID: 18472095, PMCID: PMC4405535, DOI: 10.1016/j.exer.2008.03.014.