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Jiankan Guo

Research Scientist

Contact Information

Jiankan Guo

Mailing Address

  • Nephrology

    PO Box 208029

    New Haven, CT 06520-8029

    United States

Research Summary

Life originates from a stem cell. Proper control of cell type, mass, and cell-cell contact and communication makes functional tissues, organs, and body. The mystery behind any biological event is a combined effort of genetic, epigenetic, and environmental factors. We take kidney as a model organ to study its formation, function, repair, and possible regeneration.

Extensive Research Description

The metanephos (the permanent kidney in mammals) develops as a result of the interplay between metanephric mesenchyme (a clump of embryonic renal stem cells that root from intermediate mesoderm) and ureter bud (epithelial structure that derives from Wolffian duct). One of our long term goals is to understand the molecular events that govern kidney formation and functional maintenance by analyzing genetic or epigenetic factors. One of our other goals is to delineate pathways or to devise new methods that can induce embryonic stem cells toward renal lineage, which may eventually pave the way for repair/regeneration of renal epithelium.

Coauthors

Research Interests

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; WAGR Syndrome

Selected Publications