Jeanne Hendrickson, MD
Research & Publications
Biography
News
Research Summary
The Hendrickson laboratory primarily studies complications of transfusion therapy, including the development of immune responses to antigens expressed on transfused blood products. Millions of blood products are transfused annually, and immune responses to transfused red blood cells or platelets or white blood cells may complicate future transfusions, pregnancies, or organ transplantation. Factors influencing alloimmunization, including those on the donor and recipient sides of the equation, are studied in the Hendrickson laboratory. Environmental and genetic variables that impact the intersections of innate and adaptive immunity are also studied. Some studies involve reductionist models with expression of authentic human blood group antigens, whereas others are more translational/patient focused. In addition to developing strategies to prevent alloimmunization in a transfusion setting, the Hendrickson laboratory is also working to develop strategies to prevent alloimmunization or to mitigate the dangers of existing maternal alloantibodies in a pregnancy setting.
Extensive Research Description
Please pubmed search Hendrickson JE to see the range of topics the Hendrickson lab is interested in. In general, the lab is interested in investigating clinically relevant issues in transfusion medicine using basic science models and translational research tools.
Cellular therapy; Red blood cell alloimmunization
Coauthors
Research Interests
Anemia, Sickle Cell; Blood Transfusion; Hematology; Immune Tolerance; Plasmapheresis; Pregnancy Complications, Hematologic; Immunity, Humoral; Transfusion Medicine
Selected Publications
- Factor V activity in apheresis platelets: Implications for management of FV deficiency.Gupta GK, Hendrickson JE, Bahel P, Siddon AJ, Rinder HM, Tormey CA. Factor V activity in apheresis platelets: Implications for management of FV deficiency. Transfusion 2021, 61:405-409.
- Parasite burden and red blood cell exchange transfusion for babesiosis.O'Bryan J, Gokhale A, Hendrickson JE, Krause PJ. Parasite burden and red blood cell exchange transfusion for babesiosis. Journal Of Clinical Apheresis 2021, 36:127-134.
- Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura.Goshua G, Sinha P, Hendrickson JE, Tormey CA, Bendapudi P, Lee AI. Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood 2021, 137:969-976.
- Pediatric Hemovigilance and Adverse Transfusion Reactions.Sostin N, Hendrickson JE. Pediatric Hemovigilance and Adverse Transfusion Reactions. Clinics In Laboratory Medicine 2021, 41:51-67.
- Optimization of repeat plerixafor dosing for autologous peripheral blood stem-cell collection.Gupta GK, Perreault S, Seropian SE, Tormey CA, Hendrickson JE. Optimization of repeat plerixafor dosing for autologous peripheral blood stem-cell collection. Transfusion And Apheresis Science : Official Journal Of The World Apheresis Association : Official Journal Of The European Society For Haemapheresis 2021, 60:103069.
- Red blood cell alloimmunization and sickle cell disease: a narrative review on antibody induction.Hendrickson JE. Red blood cell alloimmunization and sickle cell disease: a narrative review on antibody induction. Annals Of Blood 2020, 5.
- Variation in Neonatal Transfusion Practice.Patel RM, Hendrickson JE, Nellis ME, Birch R, Goel R, Karam O, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Sola-Visner M. Variation in Neonatal Transfusion Practice. The Journal Of Pediatrics 2021, 235:92-99.e4.
- Marginal Zone B Cells Mediate a CD4 T Cell Dependent Extrafollicular Antibody Response Following RBC Transfusion in Mice.Zerra PE, Patel SR, Jajosky RP, Arthur CM, McCoy JW, Allen JWL, Chonat S, Fasano RM, Roback J, Josephson CD, Hendrickson JE, Stowell SR. Marginal Zone B Cells Mediate a CD4 T Cell Dependent Extrafollicular Antibody Response Following RBC Transfusion in Mice. Blood 2021.
- Transfusion practices in a large cohort of hospitalized children.Nellis ME, Goel R, Hendrickson JE, Birch R, Patel RM, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Sola-Visner M, Josephson CD, Karam O. Transfusion practices in a large cohort of hospitalized children. Transfusion 2021, 61:2042-2053.
- The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids.Medved J, Knott BM, Tarrah SN, Li AN, Shah N, Moscovich TC, Boscia AR, Salazar JE, Santhanakrishnan M, Hendrickson JE, Fu X, Zimring JC, Luckey CJ. The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. Transfusion 2021, 61:2169-2178.
- Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice.Escamilla-Rivera V, Santhanakrishnan M, Liu J, Gibb DR, Forsmo JE, Foxman EF, Eisenbarth SC, Luckey CJ, Zimring JC, Hudson KE, Stowell SR, Hendrickson JE. Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. Frontiers In Immunology 2021, 12:704072.
- Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database.Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Nellis ME. Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. Pediatric Critical Care Medicine : A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies 2021.
- Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19.Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PloS One 2021, 16:e0254453.
- Potential Implications of a Type 1 Interferon Gene Signature on COVID-19 Severity and Chronic Inflammation in Sickle Cell Disease.Madany E, Okwan-Duodu D, Balbuena-Merle R, Hendrickson JE, Gibb DR. Potential Implications of a Type 1 Interferon Gene Signature on COVID-19 Severity and Chronic Inflammation in Sickle Cell Disease. Frontiers In Medicine 2021, 8:679030.
- Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola-Visner MC, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion 2021, 61:2589-2600.