Jason Johannesen, PhD

• Bruce E Wexler
• Deepak Cyril Dsouza
• Godfrey Pearlson
• John Krystal
• Morris Bell
• Ralitza Gueorguieva
• Toral Surti

Behavior and Behavior Mechanisms; Mental Disorders; Psychological Phenomena; Psychiatry and Psychology

Aging; Biomarkers; Clinical Trials; Mental Health

• Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophreniaSurti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.
• Validation of a suite of ERP and QEEG biomarkers in a pre-competitive, industry-led study in subjects with schizophrenia and healthy volunteers.Cecchi M, Adachi M, Basile A, Buhl DL, Chadchankar H, Christensen S, Christian E, Doherty J, Fadem KC, Farley B, Forman MS, Honda S, Johannesen J, Kinon BJ, Klamer D, Marino MJ, Missling C, O'Donnell P, Piser T, Puryear CB, Quirk MC, Rotte M, Sanchez C, Smith DG, Uslaner JM, Javitt DC, Keefe RSE, Mathalon D, Potter WZ, Walling DP, Ereshefsky L. Validation of a suite of ERP and QEEG biomarkers in a pre-competitive, industry-led study in subjects with schizophrenia and healthy volunteers. Schizophr Res 2023, 254: 178-189. PMID: 36921403, DOI: 10.1016/j.schres.2023.02.018.
• Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjectsTolin D, O'Bryan E, Davies C, Diefenbach G, Johannesen J. Central and peripheral nervous system responses to chronic and paced hyperventilation in anxious and healthy subjects. Biological Psychology 2022, 176: 108472. PMID: 36481266, PMCID: PMC9839632, DOI: 10.1016/j.biopsycho.2022.108472.
• O10.2. DEFICIENT VISUAL ODDBALL STIMULUS PROCESSING PREDICTS PSYCHOSIS ONSET: RESULTS FROM THE NORTH AMERICAN PRODROME LONGITUDINAL STUDYHamilton H, Roach B, Bachman P, Belger A, Carrion R, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. O10.2. DEFICIENT VISUAL ODDBALL STIMULUS PROCESSING PREDICTS PSYCHOSIS ONSET: RESULTS FROM THE NORTH AMERICAN PRODROME LONGITUDINAL STUDY. Schizophrenia Bulletin 2020, 46: s24-s25. PMCID: PMC7234016, DOI: 10.1093/schbul/sbaa028.056.
• Deficits in Auditory Predictive Coding in Individuals With the Psychosis Risk Syndrome: Prediction of Conversion to PsychosisFryer S, Roach B, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Mathalon D. Deficits in Auditory Predictive Coding in Individuals With the Psychosis Risk Syndrome: Prediction of Conversion to Psychosis. Biological Psychiatry 2020, 87: s117-s118. DOI: 10.1016/j.biopsych.2020.02.321.
• Gamma Oscillations and Excitation/Inhibition Imbalance: Parallel Effects of NMDA Receptor Antagonism and the Psychosis Risk SyndromeMathalon D, Roach B, Ford J, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S. Gamma Oscillations and Excitation/Inhibition Imbalance: Parallel Effects of NMDA Receptor Antagonism and the Psychosis Risk Syndrome. Biological Psychiatry 2020, 87: s97-s98. DOI: 10.1016/j.biopsych.2020.02.270.
• Individual Alpha Peak Frequency Moderates Transfer of Learning in Cognitive Remediation of SchizophreniaCastelluccio B, Kenney J, Johannesen J. Individual Alpha Peak Frequency Moderates Transfer of Learning in Cognitive Remediation of Schizophrenia. Journal Of The International Neuropsychological Society 2020, 26: 19-30. PMID: 31983373, PMCID: PMC7000127, DOI: 10.1017/s1355617719001243.
• O33. EEG Alpha Event-Related Desynchronization Deficits Predict Conversion to Psychosis in Individuals With the Psychosis Risk SyndromeRamyead A, Roach B, Hamilton H, Addington J, Bachman P, Bearden C, Belger A, Cadenhead K, Cannon T, Carrion R, Cornblatt B, Duncan E, Johannesen J, Light G, McGlashan T, Niznikiewicz M, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Mathalon D. O33. EEG Alpha Event-Related Desynchronization Deficits Predict Conversion to Psychosis in Individuals With the Psychosis Risk Syndrome. Biological Psychiatry 2019, 85: s119. DOI: 10.1016/j.biopsych.2019.03.298.
• S57. Does the Acquisition of Social Cognitive Skills Over Adolescence Coincide With Neurophysiological Metric of Brain Maturation? A Cross-Sectional Analysis of the NAPLS-II Consortium SampleSutcliff J, Dixon H, Johannesen J, Davidson C, Roach B, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Mathalon D. S57. Does the Acquisition of Social Cognitive Skills Over Adolescence Coincide With Neurophysiological Metric of Brain Maturation? A Cross-Sectional Analysis of the NAPLS-II Consortium Sample. Biological Psychiatry 2019, 85: s318-s319. DOI: 10.1016/j.biopsych.2019.03.808.
• S190. Does Cannabis Use Interact With Neurophysiological Vulnerability in the Early Expression of Psychosis and Conversion Status in Clinical High-Risk (CHR) Individuals?Martin A, Johannesen J, Roach B, Hamilton H, Bachman P, Belger A, Carrión R, Duncan E, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Mathalon D. S190. Does Cannabis Use Interact With Neurophysiological Vulnerability in the Early Expression of Psychosis and Conversion Status in Clinical High-Risk (CHR) Individuals? Biological Psychiatry 2019, 85: s370-s371. DOI: 10.1016/j.biopsych.2019.03.941.
• 16.3 ARE VISUAL MOTION PERCEPTION AND DETECTION OF ANIMACY CRITICAL TO HIGHER-ORDER SOCIAL COGNITIVE FUNCTION IN SCHIZOPHRENIA?Johannesen J, Lysaker P, James A, Kenney J, Bell M. 16.3 ARE VISUAL MOTION PERCEPTION AND DETECTION OF ANIMACY CRITICAL TO HIGHER-ORDER SOCIAL COGNITIVE FUNCTION IN SCHIZOPHRENIA? Schizophrenia Bulletin 2019, 45: s114-s114. PMCID: PMC6455344, DOI: 10.1093/schbul/sbz022.062.
• F254. Social Processing Subtyping and Functional Neural Architecture Across Autism Spectrum Disorder, Schizophrenia and Non-Clinical SampleAssaf M, Corbera S, Rabany L, Brocke S, Pitman B, Johannesen J, Bell M, Calhoun V, Wexler B, Pearlson G. F254. Social Processing Subtyping and Functional Neural Architecture Across Autism Spectrum Disorder, Schizophrenia and Non-Clinical Sample. Biological Psychiatry 2018, 83: s337-s338. DOI: 10.1016/j.biopsych.2018.02.868.
• F202. Atypical P300 Amplitude Differentiates Conversion Patterns in Psychosis Prodrome When Autism Spectrum Disorder is ComorbidGuillory S, Velthorst E, Hamilton H, Roach B, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Bearden C, Foss-Feig J, Mathalon D. F202. Atypical P300 Amplitude Differentiates Conversion Patterns in Psychosis Prodrome When Autism Spectrum Disorder is Comorbid. Biological Psychiatry 2018, 83: s317-s318. DOI: 10.1016/j.biopsych.2018.02.816.
• F118. ARCHITECTURE OF PSYCHOSIS SYMPTOMS AND NEURAL PREDICTORS OF CONVERSION AMONG CLINICAL HIGH RISK INDIVIDUALS WITH AUTISM SPECTRUM DISORDERFoss-Feig J, Velthorst E, Guillory S, Hamilton H, Roach B, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Bearden C, Mathalon D. F118. ARCHITECTURE OF PSYCHOSIS SYMPTOMS AND NEURAL PREDICTORS OF CONVERSION AMONG CLINICAL HIGH RISK INDIVIDUALS WITH AUTISM SPECTRUM DISORDER. Schizophrenia Bulletin 2018, 44: s266-s266. PMCID: PMC5888346, DOI: 10.1093/schbul/sby017.649.
• 80. Auditory Target Processing Deficits in Individuals at Clinical High Risk for PsychosisHamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Roach B, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Woods S, Mathalon D. 80. Auditory Target Processing Deficits in Individuals at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2017, 43: s45-s45. PMCID: PMC5475574, DOI: 10.1093/schbul/sbx021.119.
• 192. Different Age-Related Trajectories of Social Cognition in Youths at Clinical High Risk of PsychosisDavidson C, Piskulic D, Addington J, Cadenhead K, Cannon T, Cornblatt B, McGlashan T, Perkins D, Seidman L, Tsuang M, Walker E, Bearden C, Mathalon D, Woods S, Johannesen J. 192. Different Age-Related Trajectories of Social Cognition in Youths at Clinical High Risk of Psychosis. Schizophrenia Bulletin 2017, 43: s100-s101. PMCID: PMC5475730, DOI: 10.1093/schbul/sbx021.270.
• M121. Relatively More Intact Levels of Social Cognition Predict Fewer Impairments in Neurocognition, Metacognition, and Healthier Personality Functioning in a Sample With Prolonged SchizophreniaJames A, Johannesen J, Buck K, Lysaker P. M121. Relatively More Intact Levels of Social Cognition Predict Fewer Impairments in Neurocognition, Metacognition, and Healthier Personality Functioning in a Sample With Prolonged Schizophrenia. Schizophrenia Bulletin 2017, 43: s254-s255. PMCID: PMC5475865, DOI: 10.1093/schbul/sbx022.115.
• Mismatch Negativity and Repetition Positivity Predict Transition to Psychosis in Clinical High Risk IndividualsMathalon D, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Niznikiewicz M, Cadenhead K, NAPLS C. Mismatch Negativity and Repetition Positivity Predict Transition to Psychosis in Clinical High Risk Individuals. International Journal Of Psychophysiology 2016, 108: 37. DOI: 10.1016/j.ijpsycho.2016.07.122.
• Diagnostic Specificity of Neurophysiological Endophenotypes in Schizophrenia and Bipolar DisorderJohannesen JK, O’Donnell B, Shekhar A, McGrew JH, Hetrick WP. Diagnostic Specificity of Neurophysiological Endophenotypes in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin 2012, 39: 1219-1229. PMID: 22927673, PMCID: PMC3796068, DOI: 10.1093/schbul/sbs093.
• Comparison of computational methods for the evaluation of learning potential in schizophreniaFISZDON JM, JOHANNESEN JK. Comparison of computational methods for the evaluation of learning potential in schizophrenia. Journal Of The International Neuropsychological Society 2010, 16: 613-620. PMID: 20374673, DOI: 10.1017/s1355617710000317.
• MEMORY PROFILES IN SCHIZOPHRENIA: CATEGORIZATION VALIDITY AND STABILITYBell M, Johannesen J, Greig T, Wexler B. MEMORY PROFILES IN SCHIZOPHRENIA: CATEGORIZATION VALIDITY AND STABILITY. Schizophrenia Research 2010, 117: 207. DOI: 10.1016/j.schres.2010.02.286.
• Functional significance of preserved affect recognition in schizophreniaFiszdon JM, Johannesen JK. Functional significance of preserved affect recognition in schizophrenia. Psychiatry Research 2010, 176: 120-125. PMID: 20202689, PMCID: PMC2844467, DOI: 10.1016/j.psychres.2009.08.006.
• Change in Self-Perceived Barriers to Employment as a Predictor of Vocational Rehabilitation OutcomeJOHANNESEN J, McGREW J, GRISS M, BO D. Change in Self-Perceived Barriers to Employment as a Predictor of Vocational Rehabilitation Outcome. American Journal Of Psychiatric Rehabilitation 2009, 12: 295-316. DOI: 10.1080/15487760903248358.
• Secretin Effects on Cerebellar-Dependent Motor Learning in SchizophreniaBolbecker AR, Hetrick WP, Johannesen JK, O'Donnell BF, Steinmetz JE, Shekhar AS. Secretin Effects on Cerebellar-Dependent Motor Learning in Schizophrenia. American Journal Of Psychiatry 2009, 166: 460-466. PMID: 19223439, DOI: 10.1176/appi.ajp.2008.08040597.
• Perceptual Anomalies in Schizophrenia Co-Occur With Selective Impairments in the Gamma Frequency Component of Midlatency Auditory ERPsJohannesen JK, Bodkins M, O'Donnell BF, Shekhar A, Hetrick WP. Perceptual Anomalies in Schizophrenia Co-Occur With Selective Impairments in the Gamma Frequency Component of Midlatency Auditory ERPs. Journal Of Psychopathology And Clinical Science 2008, 117: 106-118. PMID: 18266489, DOI: 10.1037/0021-843x.117.1.106.
• Schizophrenia and the experience of intersubjectivity as threatLysaker P, Johannesen J, Lysaker J. Schizophrenia and the experience of intersubjectivity as threat. Phenomenology And The Cognitive Sciences 2005, 4: 335-352. DOI: 10.1007/s11097-005-4067-1.
• Contributions of subtype and spectral frequency analyses to the study of P50 ERP amplitude and suppression in schizophreniaJohannesen JK, Kieffaber PD, O'Donnell BF, Shekhar A, Evans JD, Hetrick WP. Contributions of subtype and spectral frequency analyses to the study of P50 ERP amplitude and suppression in schizophrenia. Schizophrenia Research 2005, 78: 269-284. PMID: 16002265, DOI: 10.1016/j.schres.2005.05.022.
• Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of lifeLysaker P, Carcione A, Dimaggio G, Johannesen J, Nicolò G, Procacci M, Semerari A. Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiatrica Scandinavica 2005, 112: 64-71. PMID: 15952947, DOI: 10.1111/j.1600-0447.2005.00514.x.