Janice Jin Hwang, MD
Assistant Professor of Medicine (Endocrinology)
Research & Publications
Biography
News
Research Summary
Dr. Hwang's research seeks to understand how obesity and diabetes impact the human brain particularly related to neuronal function and cognition. To do this, Dr. Hwang's group uses classic methods to investigate human physiology coupled with state of the art neuroimaging modalities such as functional magnetic resonance imaging and magnetic resonance spectroscopy.
Coauthors
Research Interests
Brain Diseases, Metabolic; Clinical Trials as Topic; Cognition Disorders; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Endocrinology; Metabolism; Neurosciences; Obesity; Translational Medical Research; Neuroimaging; Functional Neuroimaging; Cognitive Neuroscience
Selected Publications
- Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia.Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. The Journal Of Clinical Investigation 2018, 128: 1485-1495. PMID: 29381484, PMCID: PMC5873861, DOI: 10.1172/JCI97696.
- Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM.Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2017, 2 PMID: 29046482, PMCID: PMC5846903, DOI: 10.1172/jci.insight.95913.
- The human brain produces fructose from glucose.Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight 2017, 2: e90508. PMID: 28239653, PMCID: PMC5313070, DOI: 10.1172/jci.insight.90508.
- Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women.Hwang JJ, Johnson A, Cline G, Belfort-DeAguiar R, Snegovskikh D, Khokhar B, Han CS, Sherwin RS. Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women. PloS One 2015, 10: e0128582. PMID: 26035307, PMCID: PMC4452737, DOI: 10.1371/journal.pone.0128582.
- Verapamil is a potential therapy for hypoglycaemic brain injury.Hwang JJ, Sherwin RS. Verapamil is a potential therapy for hypoglycaemic brain injury. Nature Reviews. Endocrinology 2018, 14: 443-444. PMID: 29967401, DOI: 10.1038/s41574-018-0056-7.
- Treatment of endocrine disorders in the neuroscience intensive care unit.Hwang JJ, Hwang DY. Treatment of endocrine disorders in the neuroscience intensive care unit. Current Treatment Options In Neurology 2014, 16: 271. PMID: 24390813, DOI: 10.1007/s11940-013-0271-4.
- Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women.Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. American Journal Of Perinatology 2020, 37: 1094-1101. PMID: 32120424, DOI: 10.1055/s-0040-1702988.
- Glycemic Variability and CNS Inflammation: Reviewing the Connection.Watt C, Sanchez-Rangel E, Hwang JJ. Glycemic Variability and CNS Inflammation: Reviewing the Connection. Nutrients 2020, 12 PMID: 33371247, PMCID: PMC7766608, DOI: 10.3390/nu12123906.
- Food for Thought.Hwang JJ. Food for Thought. The Journal Of Nutrition 2021, 151: 2089-2091. PMID: 34195820, DOI: 10.1093/jn/nxab210.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diabetes Mellitus - Type 2; Diseases of the Endocrine System | Reversibility of Brain Glucose Transport and Metabolism in T2DM: an Intervention Study |
| Diseases of the Endocrine System; Obesity & Weight Control | Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism |
| Diseases of the Endocrine System; Women's Health; Pregnancy, Childbirth and the Puerperium | The effect of lactation on insulin sensitivity and lipolysis in women |
| Diseases of the Blood; COVID-19 Inpatient; COVID-19 Outpatient | Mechanisms for restoration of hypoglycemia awareness |
| Diabetes Mellitus - Type 1; Diabetes Mellitus - Type 2; Diseases of the Endocrine System | Restoring brain metabolism and function in older adult T1DM patients using an AP system |
| Diabetes Mellitus - Type 1; Diseases of the Endocrine System; Diseases of the Nervous System | Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM |