Jaewoong Lee, PhD
Research Scientist, Internal Medicine (Hematology)
Research & Publications
Biography
Coauthors
Selected Publications
- PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis.Pan L, Hong C, Chan LN, Xiao G, Malvi P, Robinson ME, Geng H, Reddy ST, Lee J, Khairnar V, Cosgun KN, Xu L, Kume K, Sadras T, Wang S, Wajapeyee N, Müschen M. PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118 PMID: 33531346, PMCID: PMC7896313, DOI: 10.1073/pnas.2016553118.
- Signalling input from divergent pathways subverts B cell transformation.Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. Signalling input from divergent pathways subverts B cell transformation. Nature 2020, 583: 845-851. PMID: 32699415, PMCID: PMC7394729, DOI: 10.1038/s41586-020-2513-4.
- IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature 2020, 588: 491-497. PMID: 33149299, PMCID: PMC8087162, DOI: 10.1038/s41586-020-2884-6.
- B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell 2018, 173: 470-484.e18. PMID: 29551267, PMCID: PMC6284818, DOI: 10.1016/j.cell.2018.02.048.
- Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.Sullivan-Reed K, Bolton-Gillespie E, Dasgupta Y, Langer S, Siciliano M, Nieborowska-Skorska M, Hanamshet K, Belyaeva EA, Bernhardy AJ, Lee J, Moore M, Zhao H, Valent P, Matlawska-Wasowska K, Müschen M, Bhatia S, Bhatia R, Johnson N, Wasik MA, Mazin AV, Skorski T. Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Reports 2018, 23: 3127-3136. PMID: 29898385, PMCID: PMC6082171, DOI: 10.1016/j.celrep.2018.05.034.
- Metabolic gatekeeper function of B-lymphoid transcription factors.Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 2017, 542: 479-483. PMID: 28192788, PMCID: PMC5621518, DOI: 10.1038/nature21076.
- Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell 2015, 27: 409-25. PMID: 25759025, PMCID: PMC4618684, DOI: 10.1016/j.ccell.2015.02.003.
- Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature 2015, 521: 357-61. PMID: 25799995, PMCID: PMC4441554, DOI: 10.1038/nature14231.
- Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Cramer-Morales K, Nieborowska-Skorska M, Scheibner K, Padget M, Irvine DA, Sliwinski T, Haas K, Lee J, Geng H, Roy D, Slupianek A, Rassool FV, Wasik MA, Childers W, Copland M, Müschen M, Civin CI, Skorski T. Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood 2013, 122: 1293-304. PMID: 23836560, PMCID: PMC3744994, DOI: 10.1182/blood-2013-05-501072.
- DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1.Lee JW, Kim HS, Kim S, Hwang J, Kim YH, Lim GY, Sohn WJ, Yoon SR, Kim JY, Park TS, Park KM, Ryoo ZY, Lee S. DACH1 regulates cell cycle progression of myeloid cells through the control of cyclin D, Cdk 4/6 and p21Cip1. Biochemical And Biophysical Research Communications 2012, 420: 91-5. PMID: 22405764, DOI: 10.1016/j.bbrc.2012.02.120.
- Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9.Lee JW, Kim HS, Hwang J, Kim YH, Lim GY, Sohn WJ, Yoon SR, Kim JY, Park TS, Oh SH, Park KM, Choi SU, Ryoo ZY, Lee S. Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9. Biochemical And Biophysical Research Communications 2012, 426: 299-305. PMID: 22902925, DOI: 10.1016/j.bbrc.2012.08.048.
- Processing and subcellular localization of ADAM2 in the Macaca fascicularis testis and sperm.Kim E, Lee JW, Baek DC, Lee SR, Kim MS, Kim SH, Kim CS, Ryoo ZY, Kang HS, Chang KT. Processing and subcellular localization of ADAM2 in the Macaca fascicularis testis and sperm. Animal Reproduction Science 2010, 117: 155-9. PMID: 19443142, DOI: 10.1016/j.anireprosci.2009.04.002.
- Importance of the porcine ADAM3 disintegrin domain in sperm-egg interaction.Kim E, Park KE, Kim JS, Baek DC, Lee JW, Lee SR, Kim MS, Kim SH, Kim CS, Koo DB, Kang HS, Ryoo ZY, Chang KT. Importance of the porcine ADAM3 disintegrin domain in sperm-egg interaction. The Journal Of Reproduction And Development 2009, 55: 156-62. PMID: 19106482, DOI: 10.1262/jrd.20134.
- Detection of low-abundant novel transcripts in mouse hematopoietic stem cells.Kim HS, Hwang J, Kim YH, Kim S, Lee JW, Kang HS, Kim KS, Ha JH, Chung JW, Chang KT, Ryoo ZY, Lee S. Detection of low-abundant novel transcripts in mouse hematopoietic stem cells. Molecular Genetics And Genomics : MGG 2009, 282: 363-70. PMID: 19585147, DOI: 10.1007/s00438-009-0469-z.
- Identification of novel retromer complexes in the mouse testis.Kim E, Lee JW, Baek DC, Lee SR, Kim MS, Kim SH, Imakawa K, Chang KT. Identification of novel retromer complexes in the mouse testis. Biochemical And Biophysical Research Communications 2008, 375: 16-21. PMID: 18656452, DOI: 10.1016/j.bbrc.2008.07.067.