Skip to Main Content


Jack Zhang, PhD

Assistant Professor of Molecular Biophysics and Biochemistry

Contact Information

Jack Zhang, PhD

Mailing Address

  • Molecular Biophysics and Biochemistry

    260 Whitney Avenue, Yale Science Building

    New Haven, CT 06511

    United States

Research Summary

Our lab focuses on the structural mechanisms of motor proteins and cryo-electron microscopy (cryo-EM) methods. The long-term goal is to reveal the mechanisms of high-level cellular activities driven by motor proteins from a structure perspective at the atomic level. We are particularly interested in dyneins and many related protein complexes for their fascinating roles in intracellular/intraflagellar transport, cell division, organelle positioning, cell motility, neurodevelopment, neurodegeneration, viral infection and the mechanisms of dynein activity regulation during these processes. In addition to dynein mechanisms, we are also passionate about cryo-EM/ET methodology development and interdisciplinary researches in depth to enable the visualization of atomic details of large, dynamic protein complexes in vitro and in situ.


Research Interests

Biochemistry; Biophysics; Cilia; Cytoskeleton; Dyneins; Flagella; Image Processing, Computer-Assisted; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Molecular Biology; Nervous System Diseases; Protein Conformation; Signal Processing, Computer-Assisted; Tomography; Protein Structure, Tertiary; Cryoelectron Microscopy; Imaging, Three-Dimensional; Axoneme; Axonemal Dyneins; Machine Learning

Research Image

Selected Publications