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Jack Zhang, PhD

Assistant Professor of Molecular Biophysics and Biochemistry

Contact Information

Jack Zhang, PhD

Mailing Address

  • Molecular Biophysics and Biochemistry

    260 Whitney Avenue, Yale Science Building

    New Haven, CT 06511

    United States

Research Summary

Our laboratory is at the forefront of exploring the fascinating cellular processes governing intracellular cargo transport, cell motility, and the mechanisms of cellular energy production, distribution, and utilization. Our goal is to dissect the atomic details of molecular mechanism by which the cytoskeletal motor proteins, in particular dyneins, convert biochemical energy into mechanical work, facilitating ciliary beating and cellular cargo transport along microtubules. Additionally, we are committed to deciphering how mitochondria produce energy molecules in a precise spatiotemporal manner and to revealing the mechanisms by which motor proteins influence mitochondrial positioning and the distribution in various types of cells.


Research Interests

Biochemistry; Biophysics; Cell Membrane; Cilia; Cytoskeleton; Diagnostic Imaging; Dyneins; Energy Metabolism; Flagella; Image Processing, Computer-Assisted; Intracellular Membranes; Microscopy, Electron; Microscopy, Fluorescence; Microtubules; Mitochondria; Molecular Biology; Nervous System Diseases; Protein Conformation; Signal Processing, Computer-Assisted; Tomography; Protein Structure, Tertiary; Cryoelectron Microscopy; Molecular Motor Proteins; Imaging, Three-Dimensional; Cell Membrane Structures; Cellular Structures; Electron Transport Chain Complex Proteins; Axoneme; Electron Microscope Tomography; Axonemal Dyneins; Cytoplasmic Dyneins; Molecular Imaging; Machine Learning; Dynactin Complex

Research Images

Selected Publications