Research & Publications
Around 20% of the US population suffers from a mood disorder. Depression is one of the most common psychiatric disorders, however we still don’t know its exact cause and antidepressants only work in approximately half the population. Bipolar disorder is a severe mood disorder that is associated with a high risk of suicide: between 20-50% attempt suicide. Current treatments for BD are only partially effective. We are using PET, fMRI, EEG, and MRS to further our understanding of the receptors and neural mechanisms underlying these disorders so that we can develop more effective treatments and reduce the suffering.
Extensive Research Description
Examination of the beta2-nAChR system in bipolar depression and relevance to the persistent tobacco smoking.
Imaging glutamatergic system in depression via PET and MRS to determine role of glutamate and mGluR5 in depression and associated cognitive difficulties.
Imaging ACh changes in the brain in living humans.
Psychiatry; Radiology; Tobacco; Mood Disorders; Molecular Imaging; Chemicals and Drugs