Irene Chernova, MD, PhD
Assistant Professor of Medicine (Nephrology)
Research & Publications
Biography
News
Coauthors
Selected Publications
- Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody depositionChernova I, Craft J. Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition. Cell Reports Medicine 2021, 2: 100479. PMID: 35028618, PMCID: PMC8714907, DOI: 10.1016/j.xcrm.2021.100479.
- The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritisChernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.
- Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.Song W, Sanchez G, Mayer D, Blackburn H, Chernova I, Flavell R, Weinstein J, Craft J. Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection. The Journal Of Immunology 2023, 210: 1861-1865. PMID: 37133336, PMCID: PMC10247523, DOI: 10.4049/jimmunol.2300027.
- Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centersSong W, Antao OQ, Condiff E, Sanchez GM, Chernova I, Zembrzuski K, Steach H, Rubtsova K, Angeletti D, Lemenze A, Laidlaw BJ, Craft J, Weinstein JS. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity 2022, 55: 290-307.e5. PMID: 35090581, PMCID: PMC8965751, DOI: 10.1016/j.immuni.2022.01.002.
- Resistant Hypertension Updated GuidelinesChernova I, Krishnan N. Resistant Hypertension Updated Guidelines. Current Cardiology Reports 2019, 21: 117. PMID: 31471727, DOI: 10.1007/s11886-019-1209-6.
- No strict requirement for eosinophils for bone marrow plasma cell survivalBortnick A, Chernova I, Spencer SP, Allman D. No strict requirement for eosinophils for bone marrow plasma cell survival. European Journal Of Immunology 2018, 48: 815-821. PMID: 29442367, DOI: 10.1002/eji.201747229.
- mTOR has distinct functions in generating versus sustaining humoral immunityJones DD, Gaudette BT, Wilmore JR, Chernova I, Bortnick A, Weiss BM, Allman D. mTOR has distinct functions in generating versus sustaining humoral immunity. Journal Of Clinical Investigation 2016, 126: 4250-4261. PMID: 27760048, PMCID: PMC5096901, DOI: 10.1172/jci86504.
- Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct PrecursorsChernova I, Jones DD, Wilmore JR, Bortnick A, Yucel M, Hershberg U, Allman D. Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors. The Journal Of Immunology 2014, 193: 4971-4979. PMID: 25326027, PMCID: PMC4234148, DOI: 10.4049/jimmunol.1401264.
- Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent AntigensBortnick A, Chernova I, Quinn WJ, Mugnier M, Cancro MP, Allman D. Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens. The Journal Of Immunology 2012, 188: 5389-5396. PMID: 22529295, PMCID: PMC4341991, DOI: 10.4049/jimmunol.1102808.
- TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic CellsKobayashi N, Karisola P, Peña-Cruz V, Dorfman D, Jinushi M, Umetsu S, Butte M, Nagumo H, Chernova I, Zhu B, Sharpe A, Ito S, Dranoff G, Kaplan G, Casasnovas J, Umetsu D, DeKruyff R, Freeman G. TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells. Immunity 2007, 27: 927-940. PMID: 18082433, PMCID: PMC2757006, DOI: 10.1016/j.immuni.2007.11.011.
- PD-L2 is a second ligand for PD-1 and inhibits T cell activationLatchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long A, Brown J, Nunes R, Greenfield E, Bourque K, Boussiotis V, Carter L, Carreno B, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe A, Freeman G. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology 2001, 2: 261-268. PMID: 11224527, DOI: 10.1038/85330.