Imran Quraishi, MD, PhD
Assistant Professor
Research & Publications
Biography
News
Research Summary
I am an epileptologist interested in the use of neurostimulation in epilepsy, the use of implanted brain stimulators to gather long-term ambulatory EEG, as well as epilepsy neurogenetics and particularly channelopathies.
Extensive Research Description
Clinical projects
- Long-term ambulatory recordings from the responsive neurostimulation system (RNS) and thalamic deep brain stimulation (DBS) devices, which are implanted into the brain to treat epilepsy.
- Clinical trials of brain stimulation to treat epilepsy.
- Use of intracranial EEG from surgical epilepsy patients and from RNS to study cognitive neuroscience of language and memory.
- Seizure forecasting based on intracranial EEG biomarkers.
- Electric and magnetic source localization, including magnetoencephalography (MEG) to understand epilepsy networks.
- PET imaging with novel tracers to visualize the effects of brain stimulation and brain dysfunction in epilepsy.
Laboratory projects
- Cellular and animal models of KCNT1 potassium channelopathies
- Anti-sense oligonucleotides and new medications to treat epilepsy due to KCNT1 mutations
Coauthors
Research Interests
Biomedical Engineering; Electric Stimulation; Electroencephalography; Epilepsy; Ion Channels; Neurosciences; Seizures; Computational Biology; Channelopathies; Cognitive Neuroscience
Selected Publications
- Patient-detectable responsive neurostimulation as a seizure warning system.Quraishi IH, Hirsch LJ. Patient-detectable responsive neurostimulation as a seizure warning system. Epilepsia 2021, 62: e110-e116. PMID: 34018182, PMCID: PMC8629031, DOI: 10.1111/epi.16933.
- Gerstmann Syndrome Deconstructed by Cortical Stimulation.Vaddiparti A, McGrath H, Benjamin CF, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, DOI: 10.1212/WNL.0000000000012441.
- Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidationGraves KN, Sherman BE, Huberdeau D, Damisah E, Quraishi IH, Turk-Browne NB. Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation. BioRxiv 2021.10.18.464818
- Temporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortexSherman BE, Graves KN, Huberdeau DM, Quraishi IH, Damisah EC, Turk-Browne NB. Temporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortex. BioRxiv 2022.03.14.484293
- Miglustat Therapy for SCARB2-Associated Action Myoclonus-Renal Failure Syndrome.Quraishi IH, Szekely AM, Shirali AC, Mistry PK, Hirsch LJ. Miglustat Therapy for SCARB2-Associated Action Myoclonus-Renal Failure Syndrome. Neurology. Genetics 2021, 7: e614. PMID: 34337151, PMCID: PMC8320328, DOI: 10.1212/NXG.0000000000000614.
- Low-voltage-activated K currents in vestibular hair cells and calyceal afferent terminals mediate nonquantal transmission by modulating electrical and K+ potentials in the synaptic cleftGovindaraju AC, Quraishi IH, Lysakowski A, Eatock RA, Raphael RM. Low-voltage-activated K currents in vestibular hair cells and calyceal afferent terminals mediate nonquantal transmission by modulating electrical and K+ potentials in the synaptic cleft. BioRxiv 2021.11.18.469197v1
- Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.Zhang Y, Quraishi IH, McClure H, Williams LA, Cheng Y, Kale S, Dempsey GT, Agrawal S, Gerber DJ, McManus OB, Kaczmarek LK. Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2021, 35: e22053. PMID: 34820911, PMCID: PMC8630780, DOI: 10.1096/fj.202101356R.
- Electrical cortical stimulation can impair production of the alphabet without impairing counting.Rojas PH, Sivaraju A, Quraishi IH, Vanderlind M, Rofes A, Połczynska-Bletsos MM, Spencer DD, Hirsch LJ, Benjamin CFA. Electrical cortical stimulation can impair production of the alphabet without impairing counting. Epilepsy & Behavior Reports 2021, 15: 100433. PMID: 33778464, PMCID: PMC7985277, DOI: 10.1016/j.ebr.2021.100433.
- Early detection rate changes from a brain-responsive neurostimulation system predict efficacy of newly added antiseizure drugs.Quraishi IH, Mercier MR, Skarpaas TL, Hirsch LJ. Early detection rate changes from a brain-responsive neurostimulation system predict efficacy of newly added antiseizure drugs. Epilepsia 2020, 61: 138-148. PMID: 31849045, PMCID: PMC7003822, DOI: 10.1111/epi.16412.
- Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels.Quraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK. Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels. Scientific Reports 2020, 10: 3213. PMID: 32081855, PMCID: PMC7035262, DOI: 10.1038/s41598-020-60028-z.
- An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents.Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2019, 39: 7438-7449. PMID: 31350261, PMCID: PMC6759030, DOI: 10.1523/JNEUROSCI.1628-18.2019.
- Responsive NeurostimulationGummadavelli A, Quraishi IH, Gerrard JL. Responsive Neurostimulation. In: Stereotactic and Functional Neurosurgery, Nader Pouratian and Sameer Sheth (Eds). 2020. Springer, Cham
- Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity.Quraishi IH, Benjamin CF, Spencer DD, Blumenfeld H, Alkawadri R. Impairment of consciousness induced by bilateral electrical stimulation of the frontal convexity. Epilepsy & Behavior Case Reports 2017, 8: 117-122. PMID: 29204347, PMCID: PMC5707211, DOI: 10.1016/j.ebcr.2017.09.006.
- Hypothermia associated with clobazam use in adult epilepsy.Gauthier AC, Quraishi IH, Mattson RH. Hypothermia associated with clobazam use in adult epilepsy. Epilepsy & Behavior Case Reports 2016, 5: 17-8. PMID: 26870662, PMCID: PMC4739151, DOI: 10.1016/j.ebcr.2016.01.002.
- Human slack potassium channel mutations increase positive cooperativity between individual channels.Kim GE, Kronengold J, Barcia G, Quraishi IH, Martin HC, Blair E, Taylor JC, Dulac O, Colleaux L, Nabbout R, Kaczmarek LK. Human slack potassium channel mutations increase positive cooperativity between individual channels. Cell Reports 2014, 9: 1661-1672. PMID: 25482562, PMCID: PMC4294418, DOI: 10.1016/j.celrep.2014.11.015.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Nervous System; Mental Health & Behavioral Research | SV2A PET Imaging in Healthy Subjects and Epilepsy Patients |