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Imran Quraishi, MD, PhD

Assistant Professor

Contact Information

Imran Quraishi, MD, PhD

Mailing Address

  • Neurology

    P.O. Box 208018, Yale Epilepsy Center

    New Haven, CT 06520-8018

    United States

Research Summary

I am an epileptologist interested in ion channels in epilepsy. I use a combination of cellular electrophysiology, animal models, and computational simulations to study epilepsy-associated potassium channels. I am also interested in applications of technology such as medical devices to epilepsy care.

Extensive Research Description

Potassium channels in epilepsy

  • Recordings of mutant and wild type Slack (KCNT1) neuronal potassium currents in different types of neurons and induced pluripotent stem cells.
  • EEG and behavioral tests in animal models derived from patients with epilepsy-associated potassium channel mutations to characterize seizures, learning abnormalities, and the response to new drugs.
  • Computational models of epilepsy to determine the effects of changes in ion channel function on seizure initiation and dynamics.

Clinical projects

  • Analysis of data from the NeuroPace responsive neurostimulator (RNS), a pacemaker-like device that is implanted into the brain to treat epilepsy.
  • Use of intracranial EEG from surgical epilepsy patients and from RNS to study cognitive neuroscience of language and memory.
  • NeuroNext fellowship to use ambulatory intracranial EEG biomarkers for seizure forecasting.
  • Setting up magnetoencephalography (MEG) to understand epilepsy networks.

Coauthors

Research Interests

Biomedical Engineering; Electroencephalography; Epilepsy; Ion Channels; Neurosciences; Seizures; Computational Biology; Channelopathies; Cognitive Neuroscience

Selected Publications

Clinical Trials

ConditionsStudy Title
Diseases of the Nervous System; Mental Health & Behavioral ResearchSV2A PET Imaging in Healthy Subjects and Epilepsy Patients