Ian Odell
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Research Summary
Fibrosis is an immune-mediated process that leads to abnormal collagen deposition in different organs and it contributes to almost half of all deaths as an end result of chronic inflammation in diseases such as atherosclerosis, chronic kidney disease, and inflammatory bowel disease. Scleroderma is the prototypic fibrotic disease and causes devastating fibrosis in the skin, lungs and other organs. In the skin, it leads to debilitating contractures and in the lung, it causes progressive asphyxiation and death. Its pathogenesis is poorly understood and there are few therapies that have significant impact.
A fundamental question that drives my work is how immune cells regulate tissue fibrosis. Although there are many studies of scleroderma fibroblasts, the disease is likely mediated by hematopoietic cells, as evidenced by the development of sclerotic graft vs host disease (GvHD) after stem cell transplant, which while not the same disorder, can mimic scleroderma both clinically and histologically. To understand which immune cells are important for fibrosis, I focus on patient-based translational studies as well as basic science approaches with mouse genetics and in vitro cell cultures. To bridge the advantages of mouse studies with the use of human tissue, I am developing a humanized mouse model of scleroderma. In this model, I engraft human skin and stem cells into mice that can support the development of a human immune system. This model allows us to ask questions that wouldn’t be possible with patients, such as making additional genetic alterations or use new compounds and antibodies. All together the purpose of these studies is to understand fundamental questions about scleroderma and chronic GvHD pathogenesis in order to develop new therapeutics.
Coauthors
Research Interests
Fibrosis; Graft vs Host Disease; Scleroderma, Systemic
Selected Publications
- Morphea after Borrelia-induced facial nerve palsyXie CB, Cowper S, Odell ID. Morphea after Borrelia-induced facial nerve palsy. Journal Of Scleroderma And Related Disorders 2020, 6: 111-113. PMID: 35382252, PMCID: PMC8922639, DOI: 10.1177/2397198320956892.
- Improvement of pterygium inversum unguis and Raynaud phenomenon with interdigital botulinum toxin injectionsKim DJ, Odell ID. Improvement of pterygium inversum unguis and Raynaud phenomenon with interdigital botulinum toxin injections. JAAD Case Reports 2022, 26: 79-81. PMID: 35942355, PMCID: PMC9356022, DOI: 10.1016/j.jdcr.2022.06.009.
- Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studiesOdell ID, Flavell RA, Silver FH. Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies. Journal Of The American Academy Of Dermatology 2020, 85: 780-782. PMID: 32860914, PMCID: PMC9793292, DOI: 10.1016/j.jaad.2020.08.091.
- Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosisOdell I, Steach H, Gauld S, Reinke-Breen L, Karman J, Carr T, Wetter J, Phillips L, Hinchcliff M, Flavell R. Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis. Science Immunology 2022, 7: eabq6691. PMID: 36490328, PMCID: PMC9840167, DOI: 10.1126/sciimmunol.abq6691.
- IL-6 trans-signaling in a humanized mouse model of sclerodermaOdell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.
- Amelanotic melanoma in a patient with Hermansky-Pudlak syndromeFan R, Johnston MS, Gowen MF, Damsky W, Odell I, Clune J, Vesely MD. Amelanotic melanoma in a patient with Hermansky-Pudlak syndrome. JAAD Case Reports 2022, 27: 61-63. PMID: 35990226, PMCID: PMC9388864, DOI: 10.1016/j.jdcr.2022.06.035.
- Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosisDamsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis. Nature Communications 2022, 13: 3140. PMID: 35668129, PMCID: PMC9170782, DOI: 10.1038/s41467-022-30615-x.
- Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graftXie CB, Ring N, Damsky W, McNiff JM, Olino K, Odell I. Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft. JAAD Case Reports 2021, 19: 90-93. PMID: 35024397, PMCID: PMC8724883, DOI: 10.1016/j.jdcr.2021.11.005.
- A novel NFkB1 mutation linking pyoderma gangrenosum and common variable immunodeficiencySun Q, Gehlhausen JR, Freudzon M, Kibbi N, Bale A, Choate K, Tomayko M, Odell I, Ramachandran S. A novel NFkB1 mutation linking pyoderma gangrenosum and common variable immunodeficiency. JAAD Case Reports 2021, 18: 61-63. PMID: 34825039, PMCID: PMC8605275, DOI: 10.1016/j.jdcr.2021.10.015.
- New bullous lesions in a 72-year-old womanMendoza H, Goodwin J, Gehlhausen J, Odell I, McNiff J, Gnanapandithan K. New bullous lesions in a 72-year-old woman. Cleveland Clinic Journal Of Medicine 2021, 88: 319-324. PMID: 34078615, DOI: 10.3949/ccjm.88a.20180.
- Skin puckering and edema during durvalumab therapyOlamiju B, Odell I, Panse G, Eder JP, Leventhal JS. Skin puckering and edema during durvalumab therapy. JAAD Case Reports 2020, 7: 110-112. PMID: 33364282, PMCID: PMC7750709, DOI: 10.1016/j.jdcr.2020.11.019.
- A novel medical student initiative to enhance provision of teledermatology in a resident continuity clinic during the COVID‐19 pandemic: a pilot studyBelzer A, Olamiju B, Antaya RJ, Odell ID, Bia M, Perkins SH, Cohen JM. A novel medical student initiative to enhance provision of teledermatology in a resident continuity clinic during the COVID‐19 pandemic: a pilot study. International Journal Of Dermatology 2020, 60: 128-129. PMID: 33226121, PMCID: PMC7753449, DOI: 10.1111/ijd.15322.
- HER2 joins AKT to inhibit STING immunityOdell ID, Flavell RA. HER2 joins AKT to inhibit STING immunity. Nature Cell Biology 2019, 21: 917-918. PMID: 31371829, DOI: 10.1038/s41556-019-0368-4.
- A case of subungual tumors of incontinentia pigmenti: A rare manifestation and association with bipolar diseaseKibbi N, Totonchy M, Suozzi KC, Ko CJ, Odell ID. A case of subungual tumors of incontinentia pigmenti: A rare manifestation and association with bipolar disease. JAAD Case Reports 2018, 4: 737-741. PMID: 30167449, PMCID: PMC6113656, DOI: 10.1016/j.jdcr.2018.03.018.
- Microbiome: Ecology of eczemaOdell ID, Flavell RA. Microbiome: Ecology of eczema. Nature Microbiology 2016, 1: 16135. PMID: 27562264, PMCID: PMC6035744, DOI: 10.1038/nmicrobiol.2016.135.
- Well-Differentiated Syringofibrocarcinoma in a Patient With Clouston SyndromeOdell ID, Lilly E, Reeve K, Bosenberg MW, Milstone LM. Well-Differentiated Syringofibrocarcinoma in a Patient With Clouston Syndrome. JAMA Dermatology 2016, 152: 484. PMID: 26792110, DOI: 10.1001/jamadermatol.2015.4496.
- Treatment of melanoma in-transit metastases with combination intralesional interleukin-2, topical imiquimod, and tretinoin 0.1% creamLeventhal JS, Odell ID, Imaeda S, Maverakis E, King BA. Treatment of melanoma in-transit metastases with combination intralesional interleukin-2, topical imiquimod, and tretinoin 0.1% cream. JAAD Case Reports 2016, 2: 114-116. PMID: 27051847, PMCID: PMC4810288, DOI: 10.1016/j.jdcr.2016.01.004.
- Cutaneous Vasculopathy as an Adverse Effect of the Anti–Vascular Endothelial Growth Factor Agent AxitinibShi VJ, Galan A, Odell ID, Choi JN. Cutaneous Vasculopathy as an Adverse Effect of the Anti–Vascular Endothelial Growth Factor Agent Axitinib. JAMA Dermatology 2016, 152: 222. PMID: 26509864, DOI: 10.1001/jamadermatol.2015.3209.
- Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab TherapyLim YH, Odell ID, Ko CJ, Choate KA. Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy. JAMA Dermatology 2015, 151: 1240-1243. PMID: 26422291, DOI: 10.1001/jamadermatol.2015.1925.
- Leukaemic vasculitis with myelodysplastic syndromeOdell ID, Zeidan AM, Parker TL, Colegio OR, Subtil A. Leukaemic vasculitis with myelodysplastic syndrome. The Lancet 2015, 386: 501-502. PMID: 26251396, DOI: 10.1016/s0140-6736(15)61165-5.
- Optimizing Direct ImmunofluorescenceOdell ID, Cook D. Optimizing Direct Immunofluorescence. 2014, 1180: 111-117. PMID: 25015144, DOI: 10.1007/978-1-4939-1050-2_6.
- Immunofluorescence TechniquesOdell ID, Cook D. Immunofluorescence Techniques. Journal Of Investigative Dermatology 2013, 133: 1-4. PMID: 23299451, DOI: 10.1038/jid.2012.455.
- Rules of engagement for base excision repair in chromatinOdell ID, Wallace SS, Pederson DS. Rules of engagement for base excision repair in chromatin. Journal Of Cellular Physiology 2012, 228: 258-266. PMID: 22718094, PMCID: PMC3468691, DOI: 10.1002/jcp.24134.
- Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision RepairOdell ID, Barbour JE, Murphy DL, Della-Maria JA, Sweasy JB, Tomkinson AE, Wallace SS, Pederson DS. Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair. Molecular And Cellular Biology 2011, 31: 4623-4632. PMID: 21930793, PMCID: PMC3209256, DOI: 10.1128/mcb.05715-11.
- Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1Odell ID, Newick K, Heintz NH, Wallace SS, Pederson DS. Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1. DNA Repair 2009, 9: 134-143. PMID: 20005182, PMCID: PMC2829949, DOI: 10.1016/j.dnarep.2009.11.005.
- A systematic RNAi screen for longevity genes in C. elegansHamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development 2005, 19: 1544-1555. PMID: 15998808, PMCID: PMC1172061, DOI: 10.1101/gad.1308205.
- Rapid Species Identification Within the Mycobacterium chelonae–abscessus Group by High-Resolution Melting Analysis of hsp65 PCR ProductsOdell ID, Cloud JL, Seipp M, Wittwer CT. Rapid Species Identification Within the Mycobacterium chelonae–abscessus Group by High-Resolution Melting Analysis of hsp65 PCR Products. American Journal Of Clinical Pathology 2005, 123: 96-101. PMID: 15762284, DOI: 10.1309/wdr082x9ffjbqqgb.