Hyuk-Kwon Kwon, PhD

• Alana Munger
• Francis Lee
• Irvin Oh
• Pete Doukas
• Sang-Hun Kim
• Themis Kyriakides

Bacterial Infections; Cell Survival; DNA Damage; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation; Necrosis; Staphylococcus aureus; Toxicology; Cytokines; Chemotherapy, Adjuvant; Apoptosis; Chemokines; Toll-Like Receptors; Methicillin-Resistant Staphylococcus aureus; Inflammasomes

• Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive InflammationKwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.
• Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destructionBack J, Nguyen MN, Li L, Lee S, Lee I, Chen F, Gillinov L, Chung YH, Alder KD, Kwon HK, Yu KE, Dussik CM, Hao Z, Flores MJ, Kim Y, Ibe IK, Munger AM, Seo SW, Lee FY. Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction Bone Research 2021, 9: 43. PMID: 34588427, PMCID: PMC8481290, DOI: 10.1038/s41413-021-00158-w.
• Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritisKwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.
• Biocompatibility of platinum-based bulk metallic glass in orthopedic applicationsLoye AM, Kwon HK, Dellal D, Ojeda R, Lee S, Davis R, Nagle N, Doukas PG, Schroers J, Lee FY, Kyriakides TR. Biocompatibility of platinum-based bulk metallic glass in orthopedic applications Biomedical Materials 2021, 16: 045018. PMID: 33873168, DOI: 10.1088/1748-605x/abf981.
• Intracellular Staphylococcus aureus in Bone and Joint Infections: A Mechanism of Disease Recurrence, Inflammation, and Bone and Cartilage DestructionAlder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in Bone and Joint Infections: A Mechanism of Disease Recurrence, Inflammation, and Bone and Cartilage Destruction Bone 2020, 141: 115568. PMID: 32745687, DOI: 10.1016/j.bone.2020.115568.
• Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategiesYu K, Song L, Kang HP, Kwon HK, Back J, Lee FY. Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies Bone And Joint Research 2020, 9: 49-59. PMID: 32435455, PMCID: PMC7229311, DOI: 10.1302/2046-3758.92.bjr-2019-0131.r1.
• A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models.Achek A, Kwon HK, Patra MC, Shah M, Hong R, Lee WH, Baek WY, Choi YS, Kim GY, Pham TLH, Suh CH, Kim W, Hahm DH, Choi S. A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models. EBioMedicine 2020, 52: 102645. PMID: 32014819, PMCID: PMC6997517, DOI: 10.1016/j.ebiom.2020.102645.
• Re-appraising the potential of naringin for natural, novel orthopedic biotherapiesYu KE, Alder KD, Morris MT, Munger AM, Lee I, Cahill SV, Kwon HK, Back J, Lee FY. Re-appraising the potential of naringin for natural, novel orthopedic biotherapies Therapeutic Advances In Musculoskeletal Disease 2020, 12: 1759720x20966135. PMID: 33343723, PMCID: PMC7727086, DOI: 10.1177/1759720x20966135.
• Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model.Achek A, Shah M, Seo JY, Kwon HK, Gui X, Shin HJ, Cho EY, Lee BS, Kim DJ, Lee SH, Yoo TH, Kim MS, Choi S. Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model. Journal Of Medicinal Chemistry 2019, 62: 6495-6511. PMID: 31283217, DOI: 10.1021/acs.jmedchem.9b00061.
• A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in miceKwon HK, Patra MC, Shin HJ, Gui X, Achek A, Panneerselvam S, Kim DJ, Song SJ, Hong R, Kim KS, Kim YG, Lee FY, Hahm DH, Lee SH, Choi S. A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice Experimental & Molecular Medicine 2019, 51: 1-19. PMID: 31028244, PMCID: PMC6486608, DOI: 10.1038/s12276-019-0244-0.
• Quasi-Stem Cells Derived from Human Somatic Cells by Chemically Modified Carbon Nanotubes.Lee JH, Kwon HK, Shin HJ, Nam GH, Kim JH, Choi S. Quasi-Stem Cells Derived from Human Somatic Cells by Chemically Modified Carbon Nanotubes. ACS Applied Materials & Interfaces 2018, 10: 8417-8425. PMID: 29286621, DOI: 10.1021/acsami.7b12914.
• Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer.Patra MC, Kwon HK, Batool M, Choi S. Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer. Frontiers In Immunology 2018, 9: 489. PMID: 29593733, PMCID: PMC5857566, DOI: 10.3389/fimmu.2018.00489.
• Diabetes Aggravates Post-ischaemic Renal Fibrosis through Persistent Activation of TGF-β1 and Shh Signalling.Kim DJ, Kang JM, Park SH, Kwon HK, Song SJ, Moon H, Kim SM, Seo JW, Lee YH, Kim YG, Moon JY, Lee SY, Son Y, Lee SH. Diabetes Aggravates Post-ischaemic Renal Fibrosis through Persistent Activation of TGF-β1 and Shh Signalling. Scientific Reports 2017, 7: 16782. PMID: 29196746, PMCID: PMC5711892, DOI: 10.1038/s41598-017-16977-z.
• Toll-like receptor 2 antagonists identified through virtual screening and experimental validation.Durai P, Shin HJ, Achek A, Kwon HK, Govindaraj RG, Panneerselvam S, Yesudhas D, Choi J, No KT, Choi S. Toll-like receptor 2 antagonists identified through virtual screening and experimental validation. The FEBS Journal 2017, 284: 2264-2283. PMID: 28570013, DOI: 10.1111/febs.14124.
• TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation.Park S, Shin HJ, Shah M, Cho HY, Anwar MA, Achek A, Kwon HK, Lee B, Yoo TH, Choi S. TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation. Biomaterials 2017, 126: 49-60. PMID: 28254693, DOI: 10.1016/j.biomaterials.2017.02.023.
• Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells.Shin HJ, Kwon HK, Lee JH, Anwar MA, Choi S. Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells. Scientific Reports 2016, 6: 34064. PMID: 27666530, PMCID: PMC5036097, DOI: 10.1038/srep34064.
• Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53.Shin HJ, Kwon HK, Lee JH, Gui X, Achek A, Kim JH, Choi S. Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53. Scientific Reports 2015, 5: 15798. PMID: 26522181, PMCID: PMC4629133, DOI: 10.1038/srep15798.
• Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells.Kwon HK, Shin HJ, Lee JH, Park SH, Kwon MC, Panneerselvam S, Lee CG, Kim SG, Kim JH, Choi S. Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2015, 148: 204-19. PMID: 26259609, DOI: 10.1093/toxsci/kfv182.
• Structural and functional analysis of cell adhesion and nuclear envelope nano-topography in cell death.Kwon HK, Lee JH, Shin HJ, Kim JH, Choi S. Structural and functional analysis of cell adhesion and nuclear envelope nano-topography in cell death. Scientific Reports 2015, 5: 15623. PMID: 26490051, PMCID: PMC4614995, DOI: 10.1038/srep15623.
• Activating transcription factor 3 represses inflammatory responses by binding to the p65 subunit of NF-κB.Kwon JW, Kwon HK, Shin HJ, Choi YM, Anwar MA, Choi S. Activating transcription factor 3 represses inflammatory responses by binding to the p65 subunit of NF-κB. Scientific Reports 2015, 5: 14470. PMID: 26412238, PMCID: PMC4585983, DOI: 10.1038/srep14470.
• Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation.Choi YM, Kim HK, Shim W, Anwar MA, Kwon JW, Kwon HK, Kim HJ, Jeong H, Kim HM, Hwang D, Kim HS, Choi S. Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation. PloS One 2015, 10: e0135083. PMID: 26247588, PMCID: PMC4527592, DOI: 10.1371/journal.pone.0135083.
• Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury.Lee CG, Kim JG, Kim HJ, Kwon HK, Cho IJ, Choi DW, Lee WH, Kim WD, Hwang SJ, Choi S, Kim SG. Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury. Kidney International 2014, 86: 943-53. PMID: 24759152, DOI: 10.1038/ki.2014.117.
• Doxorubicin induces cytotoxicity through upregulation of pERK-dependent ATF3.Park EJ, Kwon HK, Choi YM, Shin HJ, Choi S. Doxorubicin induces cytotoxicity through upregulation of pERK-dependent ATF3. PloS One 2012, 7: e44990. PMID: 23028726, PMCID: PMC3441731, DOI: 10.1371/journal.pone.0044990.
• Capric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis.Park EJ, Kim SA, Choi YM, Kwon HK, Shim W, Lee G, Choi S. Capric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis. PloS One 2011, 6: e27739. PMID: 22110749, PMCID: PMC3218024, DOI: 10.1371/journal.pone.0027739.
• ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-κB activation.Kim EY, Shin HY, Kim JY, Kim DG, Choi YM, Kwon HK, Rhee DK, Kim YS, Choi S. ATF3 plays a key role in Kdo2-lipid A-induced TLR4-dependent gene expression via NF-κB activation. PloS One 2010, 5: e14181. PMID: 21152039, PMCID: PMC2996292, DOI: 10.1371/journal.pone.0014181.