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Hitten Zaveri, PhD

Assistant Professor

Contact Information

Hitten Zaveri, PhD

Office Location

Mailing Address

  • Neurology

    PO Box 208018

    New Haven, CT 06520-8018

    United States

Computational Neurophysiology Laboratory

Related Links

Research Summary

The research efforts of the Computational Neurophysiology Laboratory (CNL) broadly involve functional neurosurgery, critical care and cognitive neuroscience. A major focus of our research is medically intractable epilepsy. In our work on medically intractable epilepsy we seek to:

  1. understand how seizures are generated,
  2. improve neurotechnology for monitoring, analyzing and controlling aberrant brain activity,
  3. employ our knowledge of seizure generation and the sensing, analysis and interventional technology we have developed in patients with partial epilepsy to: (1) accurately locate the seizure onset area, and (2) detect and predict the onset of seizures and intervene to terminate or abort seizures once they have been detected or predicted.

Our work is both interdisciplinary and translational. Projects in these various areas are being conducted by investigators, in CNL or at collaboration sites in academia and industry, with specialization in multiple disciplines including neurology, neurosurgery, neurobiology, neuroscience, laboratory medicine, pathology, physiology, bioengineering, computer engineering, electrical engineering, material science and mathematics.

Extensive Research Description

There are two aspects to our work on epilepsy. First, we seek to understand, through experiments and analysis, how seizures the seemingly random disruption of brain function, are generated and how they spread through the brain. Second, we are developing brain implantable devices to sense, analyze and control aberrant brain activity. These devices include a wireless, battery-free, multimodal intracranial sensor to continuously monitor brain neurochemistry and electrophysiology (see the image on this page) and devices to detect and predict the onset of a seizure and intervene to terminate a seizure once it has been detected or predicted. Further information on our research can be found in our publications. A few, recent, publications are listed below. A comprehensive listing of our publications can be found on the Yale CNL website.

  • Understand how seizures are generated
  • Develop implantable multimodal sensors for direct brain sensing
  • Accurately locate the seizure onset area
  • Detect and predict the onset of seizures in real-time
  • Develop interventional methods to terminate or abort seizures

Coauthors

Research Interests

Engineering; Epilepsy; Mathematics; Neurosciences

Research Image

Brain implantable 64 channel battery-free device for wireless measurement of cortical and subcortical activity and electrical stimulation developed in collaboration with ITN Energy Systems.

Selected Publications

  • Measuring the coherence of intracranial electroencephalograms.Zaveri HP, Williams WJ, Sackellares JC, Beydoun A, Duckrow RB, Spencer SS. Measuring the coherence of intracranial electroencephalograms. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 1999, 110: 1717-25. PMID: 10574287, DOI: 10.1016/s1388-2457(99)00136-4.
  • The effect of a scalp reference signal on coherence measurements of intracranial electroencephalograms.Zaveri HP, Duckrow RB, Spencer SS. The effect of a scalp reference signal on coherence measurements of intracranial electroencephalograms. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2000, 111: 1293-9. PMID: 10880805, DOI: 10.1016/s1388-2457(00)00321-7.
  • Distinguishing subtypes of temporal lobe epilepsy with background hippocampal activity.Zaveri HP, Duckrow RB, de Lanerolle NC, Spencer SS. Distinguishing subtypes of temporal lobe epilepsy with background hippocampal activity. Epilepsia 2001, 42: 725-30. PMID: 11422326, DOI: 10.1046/j.1528-1157.2001.00500.x.
  • A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategories.de Lanerolle NC, Kim JH, Williamson A, Spencer SS, Zaveri HP, Eid T, Spencer DD. A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategories. Epilepsia 2003, 44: 677-87. PMID: 12752467, DOI: 10.1046/j.1528-1157.2003.32701.x.
  • Coherence of the electroencephalogram during the first sleep cycle.Duckrow RB, Zaveri HP. Coherence of the electroencephalogram during the first sleep cycle. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2005, 116: 1088-95. PMID: 15826849, DOI: 10.1016/j.clinph.2004.12.002.
  • On the use of bipolar montages for time-series analysis of intracranial electroencephalograms.Zaveri HP, Duckrow RB, Spencer SS. On the use of bipolar montages for time-series analysis of intracranial electroencephalograms. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2006, 117: 2102-8. PMID: 16887380, DOI: 10.1016/j.clinph.2006.05.032.
  • Neocortical and thalamic spread of amygdala kindled seizures.Blumenfeld H, Rivera M, Vasquez JG, Shah A, Ismail D, Enev M, Zaveri HP. Neocortical and thalamic spread of amygdala kindled seizures. Epilepsia 2007, 48: 254-62. PMID: 17295618, DOI: 10.1111/j.1528-1167.2006.00934.x.
  • Neurometabolism in human epilepsy.Pan JW, Williamson A, Cavus I, Hetherington HP, Zaveri H, Petroff OA, Spencer DD. Neurometabolism in human epilepsy. Epilepsia 2008, 49 Suppl 3: 31-41. PMID: 18304254, PMCID: PMC3657747, DOI: 10.1111/j.1528-1167.2008.01508.x.
  • Temporal distributions of seizure occurrence from various epileptogenic regions.Durazzo TS, Spencer SS, Duckrow RB, Novotny EJ, Spencer DD, Zaveri HP. Temporal distributions of seizure occurrence from various epileptogenic regions. Neurology 2008, 70: 1265-71. PMID: 18391158, DOI: 10.1212/01.wnl.0000308938.84918.3f.
  • Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients.Cavus I, Pan JW, Hetherington HP, Abi-Saab W, Zaveri HP, Vives KP, Krystal JH, Spencer SS, Spencer DD. Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients. Epilepsia 2008, 49: 1358-66. PMID: 18410365, DOI: 10.1111/j.1528-1167.2008.01603.x.
  • Interictal spikes on intracranial recording: behavior, physiology, and implications.Spencer SS, Goncharova II, Duckrow RB, Novotny EJ, Zaveri HP. Interictal spikes on intracranial recording: behavior, physiology, and implications. Epilepsia 2008, 49: 1881-92. PMID: 18479398, DOI: 10.1111/j.1528-1167.2008.01641.x.
  • Local spatial effect of 50 Hz cortical stimulation in humans.Gwinn RP, Spencer DD, Spencer SS, Duckrow RB, Vives K, Wu K, Tkeshelashvili D, Zaveri HP. Local spatial effect of 50 Hz cortical stimulation in humans. Epilepsia 2008, 49: 1602-10. PMID: 18435750, DOI: 10.1111/j.1528-1167.2008.01628.x.
  • Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats.Eid T, Ghosh A, Wang Y, Beckström H, Zaveri HP, Lee TS, Lai JC, Malthankar-Phatak GH, de Lanerolle NC. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats. Brain : A Journal Of Neurology 2008, 131: 2061-70. PMID: 18669513, PMCID: PMC2724901, DOI: 10.1093/brain/awn133.
  • Effects of working memory load on oscillatory power in human intracranial EEG.Meltzer JA, Zaveri HP, Goncharova II, Distasio MM, Papademetris X, Spencer SS, Spencer DD, Constable RT. Effects of working memory load on oscillatory power in human intracranial EEG. Cerebral Cortex (New York, N.Y. : 1991) 2008, 18: 1843-55. PMID: 18056698, PMCID: PMC2474453, DOI: 10.1093/cercor/bhm213.
  • Intracranial EEG power and metabolism in human epilepsy.Pan JW, Zaveri HP, Spencer DD, Hetherington HP, Spencer SS. Intracranial EEG power and metabolism in human epilepsy. Epilepsy Research 2009, 87: 18-24. PMID: 19699059, PMCID: PMC2783857, DOI: 10.1016/j.eplepsyres.2009.07.006.
  • Concerning the observation of an electrical potential at a distance from an intracranial electrode contact.Zaveri HP, Duckrow RB, Spencer SS. Concerning the observation of an electrical potential at a distance from an intracranial electrode contact. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2009, 120: 1873-5. PMID: 19748311, DOI: 10.1016/j.clinph.2009.08.001.
  • Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies.Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Epilepsia 2009, 50: 2575-85. PMID: 19674048, DOI: 10.1111/j.1528-1167.2009.02258.x.
  • The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study.Wang Y, Zaveri HP, Lee TS, Eid T. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study. Experimental Neurology 2009, 220: 293-302. PMID: 19747915, PMCID: PMC2989153, DOI: 10.1016/j.expneurol.2009.08.034.
  • A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoring.Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Spencer SS. A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoring. Epilepsy Research 2009, 86: 153-62. PMID: 19632096, DOI: 10.1016/j.eplepsyres.2009.06.002.
  • Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area.Zaveri HP, Pincus SM, Goncharova II, Duckrow RB, Spencer DD, Spencer SS. Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area. Neuroreport 2009, 20: 891-5. PMID: 19424095, DOI: 10.1097/WNR.0b013e32832c78e0.
  • Background intracranial EEG spectral changes with anti-epileptic drug taper.Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Blumenfeld H, Spencer SS. Background intracranial EEG spectral changes with anti-epileptic drug taper. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2010, 121: 311-7. PMID: 20075002, DOI: 10.1016/j.clinph.2009.11.081.
  • Impaired consciousness in temporal lobe seizures: role of cortical slow activity.Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain : A Journal Of Neurology 2010, 133: 3764-77. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.
  • Controversies in epilepsy: debates held during the Fourth International Workshop on Seizure Prediction.Frei MG, Zaveri HP, Arthurs S, Bergey GK, Jouny CC, Lehnertz K, Gotman J, Osorio I, Netoff TI, Freeman WJ, Jefferys J, Worrell G, Quyen Mle V, Schiff SJ, Mormann F. Controversies in epilepsy: debates held during the Fourth International Workshop on Seizure Prediction. Epilepsy & Behavior : E&B 2010, 19: 4-16. PMID: 20708976, PMCID: PMC2943379, DOI: 10.1016/j.yebeh.2010.06.009.
  • Patient and caregiver perspectives on seizure prediction.Arthurs S, Zaveri HP, Frei MG, Osorio I. Patient and caregiver perspectives on seizure prediction. Epilepsy & Behavior : E&B 2010, 19: 474-7. PMID: 20851054, DOI: 10.1016/j.yebeh.2010.08.010.
  • Seizure prediction: the Fourth International Workshop.Zaveri HP, Frei MG, Arthurs S, Osorio I. Seizure prediction: the Fourth International Workshop. Epilepsy & Behavior : E&B 2010, 19: 1-3. PMID: 20674508, PMCID: PMC2996270, DOI: 10.1016/j.yebeh.2010.06.008.
  • Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering and Physics.Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering and Physics, Editors: Osorio I, Zaveri HP, Frei MG, Arthurs S, CRC Press, 2011
  • Reconfigurable fault-tolerant multielectrode array for dependable monitoring of the human brain.Acharya I, Joshi B, Lanning B, Zaveri H. Reconfigurable fault-tolerant multielectrode array for dependable monitoring of the human brain. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2011, 2011: 652-5. PMID: 22254393, DOI: 10.1109/IEMBS.2011.6090145.
  • Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats.Kanak DJ, Jones RT, Tokhi A, Willingham AL, Zaveri HP, Rose GM, Patrylo PR. Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats. Aging And Disease 2011, 2: 318-31. PMID: 22396884, PMCID: PMC3295070.
  • Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy.Perez EL, Lauritzen F, Wang Y, Lee TS, Kang D, Zaveri HP, Chaudhry FA, Ottersen OP, Bergersen LH, Eid T. Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy. Neurobiology Of Disease 2012, 47: 331-7. PMID: 22659305, PMCID: PMC3392431, DOI: 10.1016/j.nbd.2012.05.010.
  • Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.Lauritzen F, Perez EL, Melillo ER, Roh JM, Zaveri HP, Lee TS, Wang Y, Bergersen LH, Eid T. Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy. Neurobiology Of Disease 2012, 45: 165-76. PMID: 21856423, PMCID: PMC3351090, DOI: 10.1016/j.nbd.2011.08.001.
  • Estimating correlation for a real-time measure of connectivity.Arunkumar A, Panday A, Joshi B, Ravindran A, Zaveri HP. Estimating correlation for a real-time measure of connectivity. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2012, 2012: 5190-3. PMID: 23367098, DOI: 10.1109/EMBC.2012.6347163.
  • Intracranial EEG evaluation of relationship within a resting state network.Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2013, 124: 1943-51. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.
  • Seizure localization using three-dimensional surface projections of intracranial EEG power.Lee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H. Seizure localization using three-dimensional surface projections of intracranial EEG power. NeuroImage 2013, 83: 616-26. PMID: 23850575, PMCID: PMC3815983, DOI: 10.1016/j.neuroimage.2013.07.010.
  • Intracranially recorded interictal spikes: relation to seizure onset area and effect of medication and time of day.Goncharova II, Spencer SS, Duckrow RB, Hirsch LJ, Spencer DD, Zaveri HP. Intracranially recorded interictal spikes: relation to seizure onset area and effect of medication and time of day. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2013, 124: 2119-28. PMID: 23856192, DOI: 10.1016/j.clinph.2013.05.027.
  • Identifying preseizure state in intracranial EEG data using diffusion kernels.Duncan D, Talmon R, Zaveri HP, Coifman RR. Identifying preseizure state in intracranial EEG data using diffusion kernels. Mathematical Biosciences And Engineering : MBE 2013, 10: 579-90. PMID: 23906137, DOI: 10.3934/mbe.2013.10.579.
  • Altered network timing in the CA3-CA1 circuit of hippocampal slices from aged mice.Kanak DJ, Rose GM, Zaveri HP, Patrylo PR. Altered network timing in the CA3-CA1 circuit of hippocampal slices from aged mice. PloS One 2013, 8: e61364. PMID: 23593474, PMCID: PMC3620228, DOI: 10.1371/journal.pone.0061364.
  • The spatial and signal characteristics of physiologic high frequency oscillations.Alkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-95. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.
  • Automatic detection of prominent interictal spikes in intracranial EEG: validation of an algorithm and relationsip to the seizure onset zone.Gaspard N, Alkawadri R, Farooque P, Goncharova II, Zaveri HP. Automatic detection of prominent interictal spikes in intracranial EEG: validation of an algorithm and relationsip to the seizure onset zone. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2014, 125: 1095-103. PMID: 24269092, PMCID: PMC5123744, DOI: 10.1016/j.clinph.2013.10.021.
  • Ictal spread of medial temporal lobe seizures with and without secondary generalization: an intracranial electroencephalography analysis.Yoo JY, Farooque P, Chen WC, Youngblood MW, Zaveri HP, Gerrard JL, Spencer DD, Hirsch LJ, Blumenfeld H. Ictal spread of medial temporal lobe seizures with and without secondary generalization: an intracranial electroencephalography analysis. Epilepsia 2014, 55: 289-95. PMID: 24417694, PMCID: PMC4103687, DOI: 10.1111/epi.12505.
  • Reply to about the electrophysiological basis of resting state networks.Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Reply to about the electrophysiological basis of resting state networks. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2014, 125: 1713-4. PMID: 24440225, DOI: 10.1016/j.clinph.2013.12.098.
  • 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy.Dhaher R, Damisah EC, Wang H, Gruenbaum SE, Ong C, Zaveri HP, Gruenbaum BF, Eid T. 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiology Of Disease 2014, 67: 18-23. PMID: 24632421, PMCID: PMC4035438, DOI: 10.1016/j.nbd.2014.03.006.
  • Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.Gruenbaum SE, Wang H, Zaveri HP, Tang AB, Lee TS, Eid T, Dhaher R. Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy & Behavior : E&B 2015, 51: 96-103. PMID: 26262937, PMCID: PMC4663049, DOI: 10.1016/j.yebeh.2015.07.015.
  • Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy.Dhaher R, Wang H, Gruenbaum SE, Tu N, Lee TS, Zaveri HP, Eid T. Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy Research 2015, 115: 45-54. PMID: 26220375, PMCID: PMC4677790, DOI: 10.1016/j.eplepsyres.2015.05.005.
  • Delta rhythm in wakefulness: evidence from intracranial recordings in human beings.Sachdev RN, Gaspard N, Gerrard JL, Hirsch LJ, Spencer DD, Zaveri HP. Delta rhythm in wakefulness: evidence from intracranial recordings in human beings. Journal Of Neurophysiology 2015, 114: 1248-54. PMID: 26084904, PMCID: PMC4725112, DOI: 10.1152/jn.00249.2015.
  • Progressive change in sleep over multiple nights of intracranial EEG monitoring.Joshi RB, Gaspard N, Goncharova II, Pavlova M, Duckrow RB, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Progressive change in sleep over multiple nights of intracranial EEG monitoring. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2016, 127: 2302-7. PMID: 27072103, DOI: 10.1016/j.clinph.2016.02.018.
  • A comparison of the power spectral density of scalp EEG and subjacent electrocorticograms.Petroff OA, Spencer DD, Goncharova II, Zaveri HP. A comparison of the power spectral density of scalp EEG and subjacent electrocorticograms. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2016, 127: 1108-1112. PMID: 26386645, DOI: 10.1016/j.clinph.2015.08.004.
  • The relationship between seizures, interictal spikes and antiepileptic drugs.Goncharova II, Alkawadri R, Gaspard N, Duckrow RB, Spencer DD, Hirsch LJ, Spencer SS, Zaveri HP. The relationship between seizures, interictal spikes and antiepileptic drugs. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2016, 127: 3180-3186. PMID: 27292227, DOI: 10.1016/j.clinph.2016.05.014.
  • Regional and network relationship in the intracranial EEG second spectrum.Joshi RB, Gaspard N, Goncharova II, Duckrow RB, Duncan D, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Regional and network relationship in the intracranial EEG second spectrum. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2016, 127: 3485-3491. PMID: 27692590, DOI: 10.1016/j.clinph.2016.09.003.
  • 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate.Cavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-97. PMID: 26749134, DOI: 10.1111/epi.13269.
  • Disruption of Brain-Heart Coupling in Sepsis.Admiraal MM, Gilmore EJ, Van Putten MJAM, Zaveri HP, Hirsch LJ, Gaspard N. Disruption of Brain-Heart Coupling in Sepsis. Journal Of Clinical Neurophysiology : Official Publication Of The American Electroencephalographic Society 2017, 34: 413-420. PMID: 28520632, DOI: 10.1097/WNP.0000000000000381.
  • Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging.Wang H, Huang Y, Coman D, Munbodh R, Dhaher R, Zaveri HP, Hyder F, Eid T. Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging. Epilepsia 2017, 58: 824-834. PMID: 28378878, PMCID: PMC5429866, DOI: 10.1111/epi.13731.
  • Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.Albright B, Dhaher R, Wang H, Harb R, Lee TW, Zaveri H, Eid T. Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition. Experimental Neurology 2017, 288: 122-133. PMID: 27769717, PMCID: PMC5547560, DOI: 10.1016/j.expneurol.2016.10.007.
  • The roles of surgery and technology in understanding focal epilepsy and its comorbidities.Spencer DD, Gerrard JL, Zaveri HP. The roles of surgery and technology in understanding focal epilepsy and its comorbidities. The Lancet. Neurology 2018, 17: 373-382. PMID: 29553383, DOI: 10.1016/S1474-4422(18)30031-0.
  • Expanding Brain-Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy.Gummadavelli A, Zaveri HP, Spencer DD, Gerrard JL. Expanding Brain-Computer Interfaces for Controlling Epilepsy Networks: Novel Thalamic Responsive Neurostimulation in Refractory Epilepsy. Frontiers In Neuroscience 2018, 12: 474. PMID: 30108472, PMCID: PMC6079216, DOI: 10.3389/fnins.2018.00474.
  • Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram.Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.
  • Seizure prediction - ready for a new era.Kuhlmann L, Lehnertz K, Richardson MP, Schelter B, Zaveri HP. Seizure prediction - ready for a new era. Nature Reviews. Neurology 2018, 14: 618-630. PMID: 30131521, DOI: 10.1038/s41582-018-0055-2.
  • A Review of Cerebral Shunts, Current Technologies, and Future Endeavors.Soler GJ, Bao M, Jaiswal D, Zaveri HP, DiLuna ML, Grant RA, Hoshino K. A Review of Cerebral Shunts, Current Technologies, and Future Endeavors. The Yale Journal Of Biology And Medicine 2018, 91: 313-321. PMID: 30258318, PMCID: PMC6153620.
  • Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy.Gruenbaum SE, Dhaher R, Rapuano A, Zaveri HP, Tang A, de Lanerolle N, Eid T. Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy. Journal Of Neurosurgical Anesthesiology 2019, 31: 247-256. PMID: 29620688, PMCID: PMC6170745, DOI: 10.1097/ANA.0000000000000499.
  • Astrocytes and Glutamine Synthetase in Epileptogenesis.Eid T, Lee TW, Patrylo P, Zaveri HP. Astrocytes and Glutamine Synthetase in Epileptogenesis. Journal Of Neuroscience Research 2019, 97: 1345-1362. PMID: 30022509, PMCID: PMC6338538, DOI: 10.1002/jnr.24267.
  • Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker.Marino AC, Yang GJ, Tyrtova E, Wu K, Zaveri HP, Farooque P, Spencer DD, Bandt SK. Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker. Clinical Neurophysiology : Official Journal Of The International Federation Of Clinical Neurophysiology 2019, 130: 280-288. PMID: 30605890, DOI: 10.1016/j.clinph.2018.11.016.
  • Slowing less than 1 Hz is decreased near the seizure onset zone.Lundstrom BN, Boly M, Duckrow R, Zaveri HP, Blumenfeld H. Slowing less than 1 Hz is decreased near the seizure onset zone. Scientific Reports 2019, 9: 6218. PMID: 30996228, PMCID: PMC6470162, DOI: 10.1038/s41598-019-42347-y.
  • The connectivity index: an effective metric for grading epileptogenicity.Yan Q, Gaspard N, Zaveri HP, Blumenfeld H, Hirsch LJ, Spencer DD, Alkawadri R. The connectivity index: an effective metric for grading epileptogenicity. Journal Of Neurosurgery 2019, 1-8. PMID: 31561212, DOI: 10.3171/2019.4.JNS195.
  • Time-frequency representation of electrocorticograms in temporal lobe epilepsy.Zaveri HP, Williams WJ, Iasemidis LD, Sackellares JC. Time-frequency representation of electrocorticograms in temporal lobe epilepsy. IEEE Transactions On Bio-medical Engineering 1992, 39: 502-9. PMID: 1526640, DOI: 10.1109/10.135544.
  • Phase space topography and the Lyapunov exponent of electrocorticograms in partial seizures.Iasemidis LD, Sackellares JC, Zaveri HP, Williams WJ. Phase space topography and the Lyapunov exponent of electrocorticograms in partial seizures. Brain Topography 1990, 2: 187-201. PMID: 2116818, DOI: 10.1007/bf01140588.
  • Modelling of ECoG in temporal lobe epilepsy.Iasemidis LD, Zaveri HP, Sackellares JC, Williams WJ. Modelling of ECoG in temporal lobe epilepsy. Biomedical Sciences Instrumentation 1988, 24: 187-93. PMID: 3378094.
  • Analysis of event related potentials: time-frequency energy distribution.Choi HI, Williams WJ, Zaveri H. Analysis of event related potentials: time-frequency energy distribution. Biomedical Sciences Instrumentation 1987, 23: 251-8. PMID: 3607180.
  • Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy.Dhaher R, Chen EC, Perez E, Rapuano A, Sandhu MRS, Gruenbaum SE, Deshpande K, Dai F, Zaveri HP, Eid T. Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy. Nutritional Neuroscience 2020, 1-6. PMID: 31900092, DOI: 10.1080/1028415X.2019.1708568.
  • Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference.Zaveri HP, Schelter B, Schevon CA, Jiruska P, Jefferys JGR, Worrell G, Schulze-Bonhage A, Joshi RB, Jirsa V, Goodfellow M, Meisel C, Lehnertz K. Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference. Seizure 2020, 78: 78-85. PMID: 32272333, PMCID: PMC7952007, DOI: 10.1016/j.seizure.2020.03.010.
  • Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy.Sandhu MRS, Dhaher R, Gruenbaum SE, Raaisa R, Spencer DD, Pavlova MK, Zaveri HP, Eid T. Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy. Frontiers In Neurology 2020, 11: 398. PMID: 32499751, PMCID: PMC7242976, DOI: 10.3389/fneur.2020.00398.
  • Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions.Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior : E&B 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.
  • Graph-based risk assessment and error detection in radiation therapy.Munbodh R, Bowles JK, Zaveri HP. Graph-based risk assessment and error detection in radiation therapy. Medical Physics 2021, 48: 965-977. PMID: 33340128, DOI: 10.1002/mp.14666.
  • Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis.Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/WNL.0000000000011846.
  • Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy.Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy. Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.
  • Increased branched-chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain.Ong C, Damisah EC, Gruenbaum SE, Dhaher R, Deng Y, Sandhu MRS, Zaveri HP, Spencer DD, Eid T. Increased branched-chain amino acids at baseline and hours before a spontaneous seizure in the human epileptic brain. Epilepsia 2021, 62: e88-e97. PMID: 33949690, DOI: 10.1111/epi.16920.
  • Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy.Duckrow RB, Ceolini E, Zaveri HP, Brooks C, Ghosh A. Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy. IScience 2021, 24: 102538. PMID: 34308281, PMCID: PMC8257969, DOI: 10.1016/j.isci.2021.102538.
  • Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity.Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, DOI: 10.1111/epi.17072.
  • Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.Chen HY, Elmer J, Zafar SF, Ghanta M, Junior VM, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Neurology 2021 PMID: 34845057, DOI: 10.1212/WNL.0000000000013126.
  • International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke.Mishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Bhushan Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Epilepsy & Behavior : E&B 2021, 127: 108502. PMID: 34968775, DOI: 10.1016/j.yebeh.2021.108502.
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