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Henry J. Binder, MD

Professor Emeritus of Internal Medicine (Digestive Diseases)

Contact Information

Henry J. Binder, MD

Research Summary

Dr. Binder's research career has primarily been directed toward the regulation of colonic electrolyte transport and the pathophysiology of diarrhea and the basis for development of new approaches for treatment of diarrhea. These transport studies were primarily in vitro and dissected the cellular mechanisms of Na, C1, K, HCO3 and short-chain fatty acid transport and were supported by NIDDK for 37 years. During the past few years, Dr. Binder has focused his investigative activities toward the establishment of a major modification of oral rehydration solution (ORS) that is based on his prior laboratory studies that demonstrated butyrate-stimulated Na absorption in the colon was cyclic AMP-insensitive. These studies supported by Bill & Melinda Gates Foundation are designed to increase the uptake of ORS with the adaption of an improved formulation with resistant starch (starch that is relatively insensitive to amylase digestion).

Specialized Terms: ATPase; Colonic Electrolyte Transport; Epithelial Cell Function; Ion Transport; Short Chain Fatty Acids; Molecular Cellular Entities; Receptors; Regulation of colonic Na transport in apical and basolateral membranes.

Extensive Research Description

Dr. Binder's research career has primarily been directed toward the regulation of colonic electrolyte transport and the pathophysiology of diarrhea and the basis for development of new approaches for treatment of diarrhea. These transport studies were primarily in vitro and dissected the cellular mechanisms of Na, C1, K, HCO3 and short-chain fatty acid transport and were supported by NIDDK for 37 years. During the past few years, Dr. Binder has focused his investigative activities toward the establishment of a major modification of oral rehydration solution (ORS) that is based on his prior laboratory studies that demonstrated butyrate-stimulated Na absorption in the colon was cyclic AMP-insensitive. These studies supported by Bill & Melinda Gates Foundation are designed to increase the uptake of ORS with the adaption of an improved formulation with resistant starch (starch that is relatively insensitive to amylase digestion).

Coauthors

Research Interests

Adenosine Triphosphatases; Digestive System Diseases; Epithelial Cells; Fatty Acids, Volatile; Ion Transport

Selected Publications

  • Nutrient digestion and absorptionBinder, H.J.: Nutrient digestion and absorption. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 949-979, 2009.
  • Intestinal fluid and electrolyte movementBinder. H.J.: Intestinal fluid and electrolyte movement. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 933-948, 2009.
  • Gastric FunctionBinder, H.J.: Gastric Function. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 895-911, 2009.
  • Organization of the gastrointestinal systemBinder, H.J.: Organization of the gastrointestinal system. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 883-894, 2009.
  • Disorders of absorptionBinder, H.J.: Disorders of absorption. In: Harrison’s Principles of Internal Medicine. Ed. Fauci, A. Kasper, D.L., McGraw Hill, New York. 17th ed. (in press).