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Henry J. Binder, MD

Professor Emeritus of Internal Medicine (Digestive Diseases)

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Henry J. Binder, MD

Research Summary

Dr. Binder's research career has primarily been directed toward the regulation of colonic electrolyte transport and the pathophysiology of diarrhea and the basis for development of new approaches for treatment of diarrhea. These transport studies were primarily in vitro and dissected the cellular mechanisms of Na, C1, K, HCO3 and short-chain fatty acid transport and were supported by NIDDK for 37 years. During the past few years, Dr. Binder has focused his investigative activities toward the establishment of a major modification of oral rehydration solution (ORS) that is based on his prior laboratory studies that demonstrated butyrate-stimulated Na absorption in the colon was cyclic AMP-insensitive. These studies supported by Bill & Melinda Gates Foundation are designed to increase the uptake of ORS with the adaption of an improved formulation with resistant starch (starch that is relatively insensitive to amylase digestion).

Specialized Terms: ATPase; Colonic Electrolyte Transport; Epithelial Cell Function; Ion Transport; Short Chain Fatty Acids; Molecular Cellular Entities; Receptors; Regulation of colonic Na transport in apical and basolateral membranes.

Extensive Research Description

Dr. Binder's research career has primarily been directed toward the regulation of colonic electrolyte transport and the pathophysiology of diarrhea and the basis for development of new approaches for treatment of diarrhea. These transport studies were primarily in vitro and dissected the cellular mechanisms of Na, C1, K, HCO3 and short-chain fatty acid transport and were supported by NIDDK for 37 years. During the past few years, Dr. Binder has focused his investigative activities toward the establishment of a major modification of oral rehydration solution (ORS) that is based on his prior laboratory studies that demonstrated butyrate-stimulated Na absorption in the colon was cyclic AMP-insensitive. These studies supported by Bill & Melinda Gates Foundation are designed to increase the uptake of ORS with the adaption of an improved formulation with resistant starch (starch that is relatively insensitive to amylase digestion).

Coauthors

Research Interests

Adenosine Triphosphatases; Digestive System Diseases; Epithelial Cells; Fatty Acids, Volatile; Ion Transport

Selected Publications

  • Radiation decreases murine small intestinal HCO3- secretion.Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3- secretion. International Journal Of Radiation Biology 2011, 87: 878-88. PMID: 21689053, DOI: 10.3109/09553002.2011.583314.
  • Identification of functionally distinct Na-HCO3 co-transporters in colon.Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of functionally distinct Na-HCO3 co-transporters in colon. PloS One 2013, 8: e62864. PMID: 23690961, PMCID: PMC3653958, DOI: 10.1371/journal.pone.0062864.
  • Preventive strategy against infectious diarrhea--a holistic approach.Motarjemi Y, Steffen R, Binder HJ. Preventive strategy against infectious diarrhea--a holistic approach. Gastroenterology 2012, 143: 516-519. PMID: 22925951, DOI: 10.1053/j.gastro.2012.07.021.
  • Role of colonic short-chain fatty acid transport in diarrhea.Binder HJ. Role of colonic short-chain fatty acid transport in diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.
  • Nutrient digestion and absorptionBinder, H.J.: Nutrient digestion and absorption. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 949-979, 2009.
  • Intestinal fluid and electrolyte movementBinder. H.J.: Intestinal fluid and electrolyte movement. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 933-948, 2009.
  • Gastric FunctionBinder, H.J.: Gastric Function. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 895-911, 2009.
  • Organization of the gastrointestinal systemBinder, H.J.: Organization of the gastrointestinal system. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 883-894, 2009.
  • A randomized controlled trial of glucose versus amylase resistant starch hypo-osmolar oral rehydration solution for adult acute dehydrating diarrhea.Ramakrishna BS, Subramanian V, Mohan V, Sebastian BK, Young GP, Farthing MJ, Binder HJ. A randomized controlled trial of glucose versus amylase resistant starch hypo-osmolar oral rehydration solution for adult acute dehydrating diarrhea. PloS One 2008, 3: e1587. PMID: 18270575, PMCID: PMC2217593, DOI: 10.1371/journal.pone.0001587.
  • Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum.Subramanya SB, Rajendran VM, Srinivasan P, Nanda Kumar NS, Ramakrishna BS, Binder HJ. Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2007, 293: G857-63. PMID: 17690171, DOI: 10.1152/ajpgi.00462.2006.
  • Evaluation of oral rehydration solution by whole-gut perfusion in rats: effect of osmolarity, sodium concentration and resistant starch.Subramanya S, Ramakrishna BS, Binder HJ, Farthing MJ, Young GP. Evaluation of oral rehydration solution by whole-gut perfusion in rats: effect of osmolarity, sodium concentration and resistant starch. Journal Of Pediatric Gastroenterology And Nutrition 2006, 43: 568-75. PMID: 17130730, DOI: 10.1097/01.mpg.0000239998.43141.b2.
  • Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrhea.Raghupathy P, Ramakrishna BS, Oommen SP, Ahmed MS, Priyaa G, Dziura J, Young GP, Binder HJ. Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrhea. Journal Of Pediatric Gastroenterology And Nutrition 2006, 42: 362-8. PMID: 16641573, DOI: 10.1097/01.mpg.0000214163.83316.41.
  • Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum.Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. American Journal Of Physiology. Gastrointestinal And Liver Physiology 2005, 288: G956-63. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.
  • Three distinct mechanisms of HCO3- secretion in rat distal colon.Vidyasagar S, Rajendran VM, Binder HJ. Three distinct mechanisms of HCO3- secretion in rat distal colon. American Journal Of Physiology. Cell Physiology 2004, 287: C612-21. PMID: 15308466, DOI: 10.1152/ajpcell.00474.2003.
  • Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon.Krishnan S, Rajendran VM, Binder HJ. Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon. American Journal Of Physiology. Cell Physiology 2003, 285: C1246-54. PMID: 12878493, DOI: 10.1152/ajpcell.00598.2002.
  • Amylase-resistant starch plus oral rehydration solution for cholera.Ramakrishna BS, Venkataraman S, Srinivasan P, Dash P, Young GP, Binder HJ. Amylase-resistant starch plus oral rehydration solution for cholera. The New England Journal Of Medicine 2000, 342: 308-13. PMID: 10655529, DOI: 10.1056/NEJM200002033420502.
  • Disorders of absorptionBinder, H.J.: Disorders of absorption. In: Harrison’s Principles of Internal Medicine. Ed. Fauci, A. Kasper, D.L., McGraw Hill, New York. 17th ed. (in press).
  • Causes of chronic diarrhea.Binder HJ. Causes of chronic diarrhea. The New England Journal Of Medicine 2006, 355: 236-9. PMID: 16855263, DOI: 10.1056/NEJMp068124.
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