Haseena Rajeevan, PhD
Research Scientist in Biomedical Informatics
Research & Publications
Biography
News
Research Summary
Advances in technology have increased the availability of genomic and clinical data.However, capacity to analyze genomic data in a biomedical setting needs meaningful integration of the different data sets from various sources.I have been involved in the design, development, and implementation of university-wide and community-wide genetic variation and clinical database applications. I have been collaborating with physicians and researchers at Yale Center for Asthma and Airway Diseases (YCAAD) and atmospheric scientists to better understand the relationship between asthma and other respiratory diseases and fluctuations in atmospheric and environmental parameters the patient is exposed to. I am interested in integrating diverse data sources to study the impacts of climate change on human health.
Extensive Research Description
Ongoing Projects:
- Allele Frequency Database (ALFRED) is designed to make allele frequency data on human population samples readily available for use by the scientific and educational communities. Designed and implemented under the direction of Kenneth Kidd, PhD (Population Genetics)
- Forensic Resource & Reference On Genetics knowledge base (FROG-kb) seeks to make allele frequency data for SNPs and other genetic polymorphisms more useful in a forensic setting. The primary objective of FROG-kb is to provide a web interface that, from a forensic perspective, is useful for teaching and research and can serve as a tool facilitating forensic practice. Designed and implemented under the direction of Kenneth Kidd, PhD (Population Genetics)
- Yale Center for Asthma and Airway Diseases (YCAAD) is a database application designed and implemented under the direction of Geoffrey Chupp, MD; YCAAD is the data repository for ongoing clinical research in airway diseases.
- Electronic Medical Management of Asthma (EMMA) is a web based tool that seeks to provide cutting edge care to patients with asthma.
- PainEASE is an application designed to assist Veterans with learning pain self-management skills
- Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) - clinical trial to test individually tailored interventions to prevent fall-related injuries.
Coauthors
Research Interests
Asthma; Genetics, Population; Medical Informatics Applications; Medical Informatics Computing; Database; Climate Change
Selected Publications
- Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.
- Machine Learning Prediction of Severe Asthma and COPD Hospital ReadmissionLi H, Lopez K, Lipkin-Moore Z, Kay S, Rajeevan H, Davis J, Wilson F, Rochester C, Gomez J. Machine Learning Prediction of Severe Asthma and COPD Hospital Readmission. 2023, a4831-a4831. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4831.
- User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trialMelnick ER, Nath B, Dziura JD, Casey MF, Jeffery MM, Paek H, Soares WE, Hoppe JA, Rajeevan H, Li F, Skains RM, Walter LA, Patel MD, Chari SV, Platts-Mills TF, Hess EP, D'Onofrio G. User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trial. The BMJ 2022, 377: e069271. PMID: 35760423, PMCID: PMC9231533, DOI: 10.1136/bmj-2021-069271.
- If you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management programReuman L, Solar C, MacLean RR, Halat AM, Rajeevan H, Williams DA, Heapy AA, Bair MJ, Krein SL, Kerns RD, Higgins DM. If you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program. Translational Behavioral Medicine 2022, 12: 693-701. PMID: 35192703, PMCID: PMC9154266, DOI: 10.1093/tbm/ibab165.
- A fast likelihood approach for estimation of large phylogenies from continuous trait dataPeng J, Rajeevan H, Kubatko L, RoyChoudhury A. A fast likelihood approach for estimation of large phylogenies from continuous trait data. Molecular Phylogenetics And Evolution 2021, 161: 107142. PMID: 33713799, DOI: 10.1016/j.ympev.2021.107142.
- Predictors of engagement in an internet-based cognitive behavioral therapy program for veterans with chronic low back painSolar C, Halat AM, MacLean RR, Rajeevan H, Williams DA, Krein SL, Heapy AA, Bair MJ, Kerns RD, Higgins DM. Predictors of engagement in an internet-based cognitive behavioral therapy program for veterans with chronic low back pain. Translational Behavioral Medicine 2020, 11: 1274-1282. PMID: 33098304, DOI: 10.1093/tbm/ibaa098.
- A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall InjuriesBhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.
- Interrupted Time Series of User‐centered Clinical Decision Support Implementation for Emergency Department–initiated Buprenorphine for Opioid Use DisorderHolland WC, Nath B, Li F, Maciejewski K, Paek H, Dziura J, Rajeevan H, Lu CC, Katsovich L, D'Onofrio G, Melnick ER. Interrupted Time Series of User‐centered Clinical Decision Support Implementation for Emergency Department–initiated Buprenorphine for Opioid Use Disorder. Academic Emergency Medicine 2020, 27: 753-763. PMID: 32352206, PMCID: PMC7496559, DOI: 10.1111/acem.14002.
- Internet‐Based Pain Self‐Management for Veterans: Feasibility and Preliminary Efficacy of the Pain EASE ProgramHiggins DM, Buta E, Williams DA, Halat A, Bair MJ, Heapy AA, Krein SL, Rajeevan H, Rosen MI, Kerns RD. Internet‐Based Pain Self‐Management for Veterans: Feasibility and Preliminary Efficacy of the Pain EASE Program. Pain Practice 2020, 20: 357-370. PMID: 31778281, DOI: 10.1111/papr.12861.
- FrogAncestryCalc: A standalone batch likelihood computation tool for ancestry inference panels catalogued in FROG-kbRajeevan H, Soundararajan U, Pakstis AJ, Kidd KK. FrogAncestryCalc: A standalone batch likelihood computation tool for ancestry inference panels catalogued in FROG-kb. Forensic Science International Genetics 2020, 46: 102237. PMID: 31991337, DOI: 10.1016/j.fsigen.2020.102237.
- Population relationships based on 170 ancestry SNPs from the combined Kidd and Seldin panelsPakstis AJ, Speed WC, Soundararajan U, Rajeevan H, Kidd JR, Li H, Kidd KK. Population relationships based on 170 ancestry SNPs from the combined Kidd and Seldin panels. Scientific Reports 2019, 9: 18874. PMID: 31827153, PMCID: PMC6906462, DOI: 10.1038/s41598-019-55175-x.
- Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPsPakstis AJ, Gurkan C, Dogan M, Balkaya HE, Dogan S, Neophytou PI, Cherni L, Boussetta S, Khodjet-El-Khil H, Ben Ammar ElGaaied A, Salvo NM, Janssen K, Olsen GH, Hadi S, Almohammed EK, Pereira V, Truelsen DM, Bulbul O, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs. European Journal Of Human Genetics 2019, 27: 1885-1893. PMID: 31285530, PMCID: PMC6871633, DOI: 10.1038/s41431-019-0466-6.
- Improving ancestry distinctions among Southwest Asian populationsBulbul O, Speed WC, Gurkan C, Soundararajan U, Rajeevan H, Pakstis AJ, Kidd KK. Improving ancestry distinctions among Southwest Asian populations. Forensic Science International Genetics 2018, 35: 14-20. PMID: 29625264, DOI: 10.1016/j.fsigen.2018.03.010.
- The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kbKidd KK, Soundararajan U, Rajeevan H, Pakstis AJ, Moore KN, Ropero-Miller JD. The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb. Forensic Science International Genetics 2017, 33: 33-37. PMID: 29175726, DOI: 10.1016/j.fsigen.2017.11.009.
- Increasing the reference populations for the 55 AISNP panel: the need and benefitsPakstis AJ, Kang L, Liu L, Zhang Z, Jin T, Grigorenko EL, Wendt FR, Budowle B, Hadi S, Al Qahtani MS, Morling N, Mogensen HS, Themudo GE, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. Increasing the reference populations for the 55 AISNP panel: the need and benefits. International Journal Of Legal Medicine 2017, 131: 913-917. PMID: 28070634, PMCID: PMC5491587, DOI: 10.1007/s00414-016-1524-z.
- Evaluating a subset of ancestry informative SNPs for discriminating among Southwest Asian and circum-Mediterranean populationsBulbul O, Cherni L, Khodjet-el-khil H, Rajeevan H, Kidd KK. Evaluating a subset of ancestry informative SNPs for discriminating among Southwest Asian and circum-Mediterranean populations. Forensic Science International Genetics 2016, 23: 153-158. PMID: 27160361, DOI: 10.1016/j.fsigen.2016.04.010.
- 52 additional reference population samples for the 55 AISNP panelPakstis AJ, Haigh E, Cherni L, ElGaaied AB, Barton A, Evsanaa B, Togtokh A, Brissenden J, Roscoe J, Bulbul O, Filoglu G, Gurkan C, Meiklejohn KA, Robertson JM, Li CX, Wei YL, Li H, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. 52 additional reference population samples for the 55 AISNP panel. Forensic Science International Genetics 2015, 19: 269-271. PMID: 26355664, DOI: 10.1016/j.fsigen.2015.08.003.
- Proceedings of the American Thoracic Society International Conference:2015Rajeevan, H., et al., Effect of atmospheric conditions on asthma control and gene expression in the airway [abstract]. In: Proceedings of the American Thoracic Society International Conference; 2015 May 15–20; Denver: ATS; 2015. Abstract nr D107.
- Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populationsYun L, Gu Y, Rajeevan H, Kidd KK. Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations. International Journal Of Legal Medicine 2014, 128: 447-453. PMID: 24395150, DOI: 10.1007/s00414-013-0953-1.
- Proceedings of the 20th International Congress of BiometeorologyRajeevan, H., et al., Effect of atmospheric conditions on clinical, physiological, and biologic parameters of asthma [abstract]. In: Proceedings of the 20th International Congress of Biometeorology; 2014 September 28–October 01; Cleveland, Ohio: International Society of Biometeorology; Poster Abstract nr 48.
- Introducing the Forensic Research/Reference on Genetics knowledge base, FROG-kbRajeevan H, Soundararajan U, Pakstis AJ, Kidd KK. Introducing the Forensic Research/Reference on Genetics knowledge base, FROG-kb. Investigative Genetics 2012, 3: 18. PMID: 22938150, PMCID: PMC3488007, DOI: 10.1186/2041-2223-3-18.
- ALFRED: an allele frequency resource for research and teachingRajeevan H, Soundararajan U, Kidd JR, Pakstis AJ, Kidd KK. ALFRED: an allele frequency resource for research and teaching. Nucleic Acids Research 2011, 40: d1010-d1015. PMID: 22039151, PMCID: PMC3245092, DOI: 10.1093/nar/gkr924.
- The phenotype and genotype experiment object model (PaGE‐OM): a robust data structure for information related to DNA variationBrookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I, Kuroda M, Mizushima H, Thorisson GA, Dash D, Rajeevan H, Darlison MW, Woon M, Fredman D, Smith AV, Senger M, Naito K, Sugawara H. The phenotype and genotype experiment object model (PaGE‐OM): a robust data structure for information related to DNA variation. Human Mutation 2009, 30: 968-977. PMID: 19479963, DOI: 10.1002/humu.20973.
- Semantic Web-Based Integration of Cancer Pathways and Allele Frequency DataHolford ME, Rajeevan H, Zhao H, Kidd KK, Cheung KH. Semantic Web-Based Integration of Cancer Pathways and Allele Frequency Data. Cancer Informatics 2009, 8: cin.s1006. PMID: 19458791, PMCID: PMC2664696, DOI: 10.4137/cin.s1006.
- ALFRED: an allele frequency database for microevolutionary studies.Rajeevan H, Cheung KH, Gadagkar R, Stein S, Soundararajan U, Kidd JR, Pakstis AJ, Miller PL, Kidd KK. ALFRED: an allele frequency database for microevolutionary studies. Evolutionary Bioinformatics 2007, 1: 1-10. PMID: 19325849, PMCID: PMC2658869.
- ALFRED: An Allele Frequency Database for Microevolutionary StudiesRajeevan H, Cheung K, Gadagkar R, Stein S, Soundararajan U, Kidd J, Pakstis A, Miller P, Kidd K. ALFRED: An Allele Frequency Database for Microevolutionary Studies. Evolutionary Bioinformatics 2005, 1: 117693430500100006. DOI: 10.1177/117693430500100006.
- ALFRED: the ALelle FREquency Database. UpdateRajeevan H, Osier MV, Cheung KH, Deng H, Druskin L, Heinzen R, Kidd JR, Stein S, Pakstis AJ, Tosches NP, Yeh CC, Miller PL, Kidd KK. ALFRED: the ALelle FREquency Database. Update. Nucleic Acids Research 2003, 31: 270-271. PMID: 12519999, PMCID: PMC165490, DOI: 10.1093/nar/gkg043.