Endothelial mechanosensing: A forgotten target to treat vascular remodeling in hypertension?
Tiezzi M, Deng H, Baeyens N. Endothelial mechanosensing: A forgotten target to treat vascular remodeling in hypertension? Biochemical Pharmacology 2022, 206: 115290. PMID: 36241094, DOI: 10.1016/j.bcp.2022.115290.Peer-Reviewed Original ResearchConceptsFuture drug development strategiesMechanistic cuesVascular remodelingNew potential therapeutic approachReceptor complexIon channelsPulmonary arterial hypertensionMechanosensitive organMesenchymal transitionPotential therapeutic approachDrug development strategiesCommon mechanismPleiotropic actionsArterial hypertensionEssential hypertensionEndothelial inflammationTherapeutic approachesBlood flowTissue perfusionVascular integrityHypertensionDistinct diseasesCrucial roleRecent studiesRemodelingHigh Fluid Shear Stress Inhibits Cytokine‐Driven Smad2/3 Activation in Vascular Endothelial Cells
Deng H, Schwartz MA. High Fluid Shear Stress Inhibits Cytokine‐Driven Smad2/3 Activation in Vascular Endothelial Cells. Journal Of The American Heart Association 2022, 11: e025337. PMID: 35861829, PMCID: PMC9707828, DOI: 10.1161/jaha.121.025337.Peer-Reviewed Original ResearchConceptsInflammatory cytokinesSmad2/3 activationEndothelial cellsNuclear translocationInflammatory cytokine treatmentGrowth factor betaVascular endothelial cellsQuantitative polymerase chain reactionSmad2/3 nuclear translocationTarget gene expressionBackground AtherosclerosisInflammatory mediatorsInflammatory pathwaysPolymerase chain reactionResult of inhibitionCytokine treatmentInhibits CytokineFactor betaMesenchymal transitionHigh fluid shear stressCytokinesEndMTGene expressionLaminar fluid shear stressFluid shear stress