Hanming Zhang, PhD
Postdoctoral Associate
Research & Publications
Biography
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Selected Publications
- Increased complement activation is a distinctive feature of severe SARS-CoV-2 infectionMa L, Sahu S, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish M, Goshua G, Chang C, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo A, Goss C, O’Halloran J, Presti R, Kim A, Gelman A, Dela Cruz C, Lee A, Mudd P, Chun H, Atkinson J, Kulkarni H. Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Science Immunology 2021, 6: eabh2259. PMID: 34446527, PMCID: PMC8158979, DOI: 10.1126/sciimmunol.abh2259.
- PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19Wang S, Pine A, Mankbadi M, Chang C, Madeeva D, Zhang H, Dajani A, Crandall I, Sugeng L, Lee A, Chun H. PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19. Journal Of The American College Of Cardiology 2021, 77: 3193. PMID: 34167644, PMCID: PMC8091195, DOI: 10.1016/s0735-1097(21)04548-4.
- A neutrophil activation signature predicts critical illness and mortality in COVID-19Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.
- Circulating markers of angiogenesis and endotheliopathy in COVID‐19Pine AB, Meizlish ML, Goshua G, Chang C, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Circulating markers of angiogenesis and endotheliopathy in COVID‐19. Pulmonary Circulation 2020, 10: 1-4. PMID: 33282193, PMCID: PMC7691906, DOI: 10.1177/2045894020966547.
- Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional studyGoshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.
- Abstract 100: Dual Activation of PKA and PKG by PDE1 Inhibition Facilitates Proteasomal Degradation of Misfolded Proteins and Protects Against Proteinopathy-Based HFpEFZhang H, Pan B, Wu P, Rekhter M, Goldberg A, Wang X. Abstract 100: Dual Activation of PKA and PKG by PDE1 Inhibition Facilitates Proteasomal Degradation of Misfolded Proteins and Protects Against Proteinopathy-Based HFpEF. Circulation Research 2019, 125 DOI: 10.1161/res.125.suppl_1.100.
- PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathyZhang H, Pan B, Wu P, Parajuli N, Rekhter MD, Goldberg AL, Wang X. PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Science Advances 2019, 5: eaaw5870. PMID: 31131329, PMCID: PMC6531002, DOI: 10.1126/sciadv.aaw5870.
- Inhibition of Type 1 Phosphodiesterse Confers Therapeutic Benefit to Proteinopathy‐based HFpEF in MiceZhang H, Rekhter M, Wang X. Inhibition of Type 1 Phosphodiesterse Confers Therapeutic Benefit to Proteinopathy‐based HFpEF in Mice. The FASEB Journal 2018, 32: 903.14-903.14. DOI: 10.1096/fasebj.2018.32.1_supplement.903.14.
- TFEB activation protects against cardiac proteotoxicity via increasing autophagic fluxPan B, Zhang H, Cui T, Wang X. TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux. Journal Of Molecular And Cellular Cardiology 2017, 113: 51-62. PMID: 28993153, PMCID: PMC5656243, DOI: 10.1016/j.yjmcc.2017.10.003.
- Abstract 222: Inhibition of Phosphodiesterase 1 Confers Striking Therapeutic Benefit to HFpEF in MiceZhang H, Wang X. Abstract 222: Inhibition of Phosphodiesterase 1 Confers Striking Therapeutic Benefit to HFpEF in Mice. Circulation Research 2017, 121 DOI: 10.1161/res.121.suppl_1.222.
- Abstract 131: PDE1 Inhibition Improves Cardiac Protein Quality ControlZhang H, Wang X. Abstract 131: PDE1 Inhibition Improves Cardiac Protein Quality Control. Circulation Research 2016, 119 DOI: 10.1161/res.119.suppl_1.131.
- COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac ProteotoxicitySu H, Li J, Zhang H, Ma W, Wei N, Liu J, Wang X. COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac Proteotoxicity. Circulation Research 2015, 117: 956-966. PMID: 26383969, PMCID: PMC4636927, DOI: 10.1161/circresaha.115.306783.
- Abstract 423: Proteasome Priming by Protein Kinase G Protects Against Myocardial Ischemia-reperfusion InjuryWang X, Terpstra E, Callegari E, Hu C, Zhang H, Wang X. Abstract 423: Proteasome Priming by Protein Kinase G Protects Against Myocardial Ischemia-reperfusion Injury. Circulation Research 2015, 117 DOI: 10.1161/res.117.suppl_1.423.
- Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafilZhang H, Wang X. Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil. Future Cardiology 2015, 11: 177-189. PMID: 25760877, PMCID: PMC4370174, DOI: 10.2217/fca.15.3.
- Expression and Functional Analysis of Storage Protein 2 in the Silkworm, Bombyx moriYu W, Wang M, Zhang H, Quan Y, Zhang Y. Expression and Functional Analysis of Storage Protein 2 in the Silkworm, Bombyx mori. International Journal Of Genomics 2013, 2013: 145450. PMID: 23671839, PMCID: PMC3647547, DOI: 10.1155/2013/145450.