Hanieh Falahati, PhD
Postdoctoral Fellow
Research & Publications
Biography
Research Summary
I study the spine apparatus, which is a specialized compartment of the neuronal smooth endoplasmic reticulum (ER) located in a subset of dendritic spines. It consists of stacks of ER cisterns that are interconnected by an unknown dense matrix and are continuous with each other and with the ER of the dendritic shaft. While this organelle has been first observed over 60 years ago, the mechanism of its formation and function remains a mystery. The focus of my work is to take an interdisciplinary approach to address these longstanding questions and better understand the contributions of this enigmatic organelle in neuronal physiology and in disease.
Coauthors
Research Image
The Enigmatic Spine Apparatus of Neuronal Dendritic Spines
Spine Apparatus (orange) is a specialization of neuronal endoplasmic reticulum, which is located at dendritic spines.
Selected Publications
- Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses.Li S, Raychaudhuri S, Lee SA, Brockmann MM, Wang J, Kusick G, Prater C, Syed S, Falahati H, Ramos R, Bartol TM, Hosy E, Watanabe S. Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses. Nature Communications 2021, 12: 677. PMID: 33514725, PMCID: PMC7846561, DOI: 10.1038/s41467-021-21004-x.
- Temperature-Induced uncoupling of cell cycle regulators.Falahati H, Hur W, Di Talia S, Wieschaus E. Temperature-Induced uncoupling of cell cycle regulators. Developmental Biology 2021, 470: 147-153. PMID: 33278404, PMCID: PMC8106975, DOI: 10.1016/j.ydbio.2020.11.010.
- Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells.Benedetti L, Marvin JS, Falahati H, Guillén-Samander A, Looger LL, De Camilli P. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. ELife 2020, 9 PMID: 33174843, PMCID: PMC7735757, DOI: 10.7554/eLife.63230.
- Thermodynamically driven assemblies and liquid-liquid phase separations in biology.Falahati H, Haji-Akbari A. Thermodynamically driven assemblies and liquid-liquid phase separations in biology. Soft Matter 2019, 15: 1135-1154. PMID: 30672955, DOI: 10.1039/c8sm02285b.
- Independent active and thermodynamic processes govern the nucleolus assembly in vivo.Falahati H, Wieschaus E. Independent active and thermodynamic processes govern the nucleolus assembly in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1335-1340. PMID: 28115706, PMCID: PMC5307486, DOI: 10.1073/pnas.1615395114.
- Nucleation by rRNA Dictates the Precision of Nucleolus Assembly.Falahati H, Pelham-Webb B, Blythe S, Wieschaus E. Nucleation by rRNA Dictates the Precision of Nucleolus Assembly. Current Biology : CB 2016, 26: 277-85. PMID: 26776729, PMCID: PMC5866055, DOI: 10.1016/j.cub.2015.11.065.
- Mitosis-associated repression in development.Esposito E, Lim B, Guessous G, Falahati H, Levine M. Mitosis-associated repression in development. Genes & Development 2016, 30: 1503-8. PMID: 27401553, PMCID: PMC4949323, DOI: 10.1101/gad.281188.116.
- Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents.Pazhang M, Mehrnejad F, Pazhang Y, Falahati H, Chaparzadeh N. Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents. Biotechnology And Applied Biochemistry 2016, 63: 206-13. PMID: 25757511, DOI: 10.1002/bab.1366.
- Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of Iran.Doustdar F, Pazhang M, Mehrnejad F, Safarzadeh M, Rabiei D, Chaparzadeh N, Falahati H, Mir-Derikvand M. Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of Iran. The Protein Journal 2015, 34: 181-92. PMID: 25972249, DOI: 10.1007/s10930-015-9610-5.
- Transmitting the allosteric signal in methylglyoxal synthase.Falahati H, Pazhang M, Zareian S, Ghaemi N, Rofougaran R, Hofer A, Rezaie AR, Khajeh K. Transmitting the allosteric signal in methylglyoxal synthase. Protein Engineering, Design & Selection : PEDS 2013, 26: 445-52. PMID: 23592737, DOI: 10.1093/protein/gzt014.
- Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquidsDabirmanesh, Bahareh, Khosro Khajeh, Jafar Akbari, Hanieh Falahati, Somayeh Daneshjoo, and Akbar Heydari. Journal of Molecular Liquids 161, no. 3 (2011): 139-143.
- Cloning, expression, and characterization of a novel methylglyoxal synthase from Thermus sp. strain GH5.Pazhang M, Khajeh K, Asghari SM, Falahati H, Naderi-Manesh H. Cloning, expression, and characterization of a novel methylglyoxal synthase from Thermus sp. strain GH5. Applied Biochemistry And Biotechnology 2010, 162: 1519-28. PMID: 20419481, DOI: 10.1007/s12010-010-8933-0.