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Hai Feng Zhang, PhD

Associate Research Scientist in Pathology

Contact Information

Hai Feng Zhang, PhD

Office Location

Mailing Address

  • Pathology

    310 Cedar Street, PO Box 208023

    New Haven, CT 06520-8023

    United States

Extensive Research Description

My main interestis heart and vascular diseases caused by inflammation. Excessive/chronicinflammatory responses (e.g., TNF) and increases in reactive oxygen species(ROS) represent common pathogenic mechanism for atherosclerosis. The vascularcell that primarily limits the inflammatory and atherosclerotic process is thevascular endothelial cells (EC). Inflammation/ROS induces EC dysfunction bydisturbing normal homeostasis, relaxation and survival. These defects in ECfunction are mediated by cytokine/redox-regulated signal transduction and genetranscription. My experiments are designed to dissect signal pathways duringinflammatory responses. We have identified that AIP1 plays important roles inTNF signaling pathways in EC by interacting with ASK1,TRAF2 and RIP1. AIP1'sother functions such as tumor suppression are under investigation.

Coauthors

Selected Publications