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Haifan Lin, PhD

Eugene Higgins Professor of Cell Biology, and Professor of Genetics, of Obstetrics, Gynecology & Reproductive Sciences, and of Dermatology; Director, Yale Stem Cell Center

Contact Information

Haifan Lin, PhD

Mailing Address

  • Stem Cell Center, Yale

    PO Box 208073, 10 Amistad St.

    New Haven, CT 06520-8073

    United States

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Research Summary

We study molecular mechanisms underlying the self-renewing division of stem cells. Currently, we focus on small RNA-mediated epigenetic programming and post-transcriptional regulation that are required for the self-renewal of germline and embryonic stem cells. Meanwhile, we are studying these mechanisms in cancer and germline development. Stem cells are characterized by their abilities to self-renew and to produce numerous differentiated daughter cells. These special properties enable stem cells to play a central role in generating and maintaining most tissues in higher organisms. Over-proliferation of stem cells can cause cancer, whereas under-proliferation of stem cells leads to tissue dystrophy, anemia, immuno-deficiency, or infertility. Drosophila and the mouse represent two powerful systems for studying stem cells since they allow easy access to combined genetic, cell biological, and molecular analyses. We use Drosophila as a pilot model to explore molecular mechanisms underlying stem cell division, and the mouse as an advanced model to expand what we learn from Drosophila to mammalian systems. Previously, we identified germline stem cells in the Drosophila ovary and revealed their self-renewing asymmetric division. We and others showed that the asymmetric division of these stem cells is controlled by both niche signaling and intracellular mechanisms. Using systematic genetic screens, we have identified key genes involved in both niche signaling and intracellular regulation of stem cell division. Among them, the argonaute/piwi gene family represent the only known gene family required for stem cell self-renewal in both animal and plant kingdoms. Currently, our research is focused on epigenetic programming and post-transcriptional regulation of germline stem cell self-renewal mediated by the Piwi proteins and a novel class of non-coding small RNAs called piwi-Interacting RNAs (piRNAs) that we and others discovered in 2006. Meanwhile, we have been studying post-transcriptional regulation of embryonic stem cells mediated by the Pumilio proteins.

Specialized Terms: Stem cell, small RNA, epigenetic programming, post-transcriptional regulation

Coauthors

Research Interests

Cell Biology; Genetics; Gynecology; RNA Processing, Post-Transcriptional; Stem Cells; Embryonic Stem Cells; Argonaute Proteins

Selected Publications

  • MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA.Hsieh CL, Xia J, Lin H. MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA. The EMBO Journal 2020, 39: e103614. PMID: 32677148, PMCID: PMC7429737, DOI: 10.15252/embj.2019103614.
  • Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis.Uyhazi KE, Yang Y, Liu N, Qi H, Huang XA, Mak W, Weatherbee SD, de Prisco N, Gennarino VA, Song X, Lin H. Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7851-7862. PMID: 32198202, PMCID: PMC7148564, DOI: 10.1073/pnas.1916471117.
  • PIWIL1 promotes gastric cancer via a piRNA-independent mechanism.Shi S, Yang ZZ, Liu S, Yang F, Lin H. PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 22390-22401. PMID: 32848063, PMCID: PMC7486755, DOI: 10.1073/pnas.2008724117.
  • PIWI-piRNA pathway-mediated transposable element repression in Hydra somatic stem cells.Teefy BB, Siebert S, Cazet JF, Lin H, Juliano CE. PIWI-piRNA pathway-mediated transposable element repression in Hydra somatic stem cells. RNA (New York, N.Y.) 2020, 26: 550-563. PMID: 32075940, PMCID: PMC7161359, DOI: 10.1261/rna.072835.119.
  • Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance.Sun N, Ren C, Kong Y, Zhong H, Chen J, Li Y, Zhang J, Zhou Y, Qiu X, Lin H, Song X, Yang X, Jiang B. Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance. European Journal Of Medicinal Chemistry 2020, 193: 112190. PMID: 32179332, DOI: 10.1016/j.ejmech.2020.112190.
  • The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production.Park AR, Liu N, Neuenkirchen N, Guo Q, Lin H. The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production. Genetics 2019, 211: 201-217. PMID: 30442760, PMCID: PMC6325692, DOI: 10.1534/genetics.118.301704.
  • Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea.Wang C, Yang ZZ, Guo FH, Shi S, Han XS, Zeng A, Lin H, Jing Q. Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea. The Journal Of Biological Chemistry 2019, 294: 9873-9887. PMID: 31076507, PMCID: PMC6597837, DOI: 10.1074/jbc.RA118.004445.
  • MIWI2 targets RNAs transcribed from piRNA-dependent regions to drive DNA methylation in mouse prospermatogonia.Watanabe T, Cui X, Yuan Z, Qi H, Lin H. MIWI2 targets RNAs transcribed from piRNA-dependent regions to drive DNA methylation in mouse prospermatogonia. The EMBO Journal 2018, 37 PMID: 30108053, PMCID: PMC6138435, DOI: 10.15252/embj.201695329.
  • A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila.Parikh RY, Lin H, Gangaraju VK. A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila. The Journal Of Biological Chemistry 2018, 293: 9140-9147. PMID: 29735528, PMCID: PMC6005430, DOI: 10.1074/jbc.AC118.003264.
  • A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis.Mak W, Xia J, Cheng EC, Lowther K, Lin H. A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis. Cell & Bioscience 2018, 8: 54. PMID: 30364263, PMCID: PMC6194604, DOI: 10.1186/s13578-018-0251-1.
  • miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer.Liu S, Wang Z, Liu Z, Shi S, Zhang Z, Zhang J, Lin H. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer. Journal Of Molecular Cell Biology 2018, 10: 302-315. PMID: 30053090, DOI: 10.1093/jmcb/mjy041.
  • Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins.Zhang M, Chen D, Xia J, Han W, Cui X, Neuenkirchen N, Hermes G, Sestan N, Lin H. Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins. Genes & Development 2017, 31: 1354-1369. PMID: 28794184, PMCID: PMC5580656, DOI: 10.1101/gad.298752.117.
  • Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins.Peng JC, Valouev A, Liu N, Lin H. Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins. Nature Genetics 2016, 48: 283-91. PMID: 26780607, PMCID: PMC4767590, DOI: 10.1038/ng.3486.
  • PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses.Jacobs DI, Qin Q, Lerro MC, Fu AN, Dubrow R, Claus EB, DeWan AT, Wang G, Lin H, Zhu Y. PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses. Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology 2016, 25: 1073-80. PMID: 27197292, DOI: 10.1158/1055-9965.EPI-16-0047.
  • The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer.Wang Z, Liu N, Shi S, Liu S, Lin H. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. The Journal Of Biological Chemistry 2016, 291: 10646-58. PMID: 26957540, PMCID: PMC4865913, DOI: 10.1074/jbc.M116.723239.
  • CHANGE POINT ANALYSIS OF HISTONE MODIFICATIONS REVEALS EPIGENETIC BLOCKS LINKING TO PHYSICAL DOMAINS.Chen M, Lin H, Zhao H. CHANGE POINT ANALYSIS OF HISTONE MODIFICATIONS REVEALS EPIGENETIC BLOCKS LINKING TO PHYSICAL DOMAINS. The Annals Of Applied Statistics 2016, 10: 506-526. PMID: 27231496, PMCID: PMC4876974, DOI: 10.1214/16-AOAS905.
  • Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila.Ku HY, Gangaraju VK, Qi H, Liu N, Lin H. Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila. PLoS Genetics 2016, 12: e1005813. PMID: 26808625, PMCID: PMC4726654, DOI: 10.1371/journal.pgen.1005813.
  • An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.Mak W, Fang C, Holden T, Dratver MB, Lin H. An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biology Of Reproduction 2016, 94: 134. PMID: 27170441, PMCID: PMC4946805, DOI: 10.1095/biolreprod.115.137497.
  • Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress.Ge XQ, Han J, Cheng EC, Yamaguchi S, Shima N, Thomas JL, Lin H. Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress. Stem Cell Reports 2015, 5: 185-94. PMID: 26190528, PMCID: PMC4618655, DOI: 10.1016/j.stemcr.2015.06.002.
  • Poreless eggshells.Lin H, Matzuk MM. Poreless eggshells. The Journal Of Clinical Investigation 2015, 125: 4005-7. PMID: 26485282, PMCID: PMC4639988, DOI: 10.1172/JCI84692.
  • Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline.Watanabe T, Cheng EC, Zhong M, Lin H. Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline. Genome Research 2015, 25: 368-80. PMID: 25480952, PMCID: PMC4352877, DOI: 10.1101/gr.180802.114.
  • Piwi Is a Key Regulator of Both Somatic and Germline Stem Cells in the Drosophila Testis.Gonzalez J, Qi H, Liu N, Lin H. Piwi Is a Key Regulator of Both Somatic and Germline Stem Cells in the Drosophila Testis. Cell Reports 2015, 12: 150-161. PMID: 26119740, PMCID: PMC4497877, DOI: 10.1016/j.celrep.2015.06.004.
  • Reassessment of Piwi binding to the genome and Piwi impact on RNA polymerase II distribution.Lin H, Chen M, Kundaje A, Valouev A, Yin H, Liu N, Neuenkirchen N, Zhong M, Snyder M. Reassessment of Piwi binding to the genome and Piwi impact on RNA polymerase II distribution. Developmental Cell 2015, 32: 772-4. PMID: 25805139, PMCID: PMC4472434, DOI: 10.1016/j.devcel.2015.03.004.
  • PIWI proteins are dispensable for mouse somatic development and reprogramming of fibroblasts into pluripotent stem cells.Cheng EC, Kang D, Wang Z, Lin H. PIWI proteins are dispensable for mouse somatic development and reprogramming of fibroblasts into pluripotent stem cells. PloS One 2014, 9: e97821. PMID: 25238487, PMCID: PMC4169525, DOI: 10.1371/journal.pone.0097821.
  • PIWI proteins and PIWI-interacting RNAs in the soma.Ross RJ, Weiner MM, Lin H. PIWI proteins and PIWI-interacting RNAs in the soma. Nature 2014, 505: 353-359. PMID: 24429634, PMCID: PMC4265809, DOI: 10.1038/nature12987.
  • PIWI proteins and their interactors in piRNA biogenesis, germline development and gene expression.Ku HY, Lin H. PIWI proteins and their interactors in piRNA biogenesis, germline development and gene expression. National Science Review 2014, 1: 205-218. PMID: 25512877, PMCID: PMC4265212, DOI: 10.1093/nsr/nwu014.
  • PIWI proteins are essential for early Drosophila embryogenesis.Mani SR, Megosh H, Lin H. PIWI proteins are essential for early Drosophila embryogenesis. Developmental Biology 2014, 385: 340-9. PMID: 24184635, PMCID: PMC3915879, DOI: 10.1016/j.ydbio.2013.10.017.
  • Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs.Watanabe T, Lin H. Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs. Molecular Cell 2014, 56: 18-27. PMID: 25280102, PMCID: PMC4185416, DOI: 10.1016/j.molcel.2014.09.012.
  • Special Topic: Frontiers in RNA Research: The ever-expanding RNA world.Lin H. Special Topic: Frontiers in RNA Research: The ever-expanding RNA world. National Science Review 2014, 1: 182. PMID: 25520852, PMCID: PMC4266142, DOI: 10.1093/nsr/nwu010.
  • Noncoding RNAs in the regulation of DNA replication.Ge XQ, Lin H. Noncoding RNAs in the regulation of DNA replication. Trends In Biochemical Sciences 2014, 39: 341-3. PMID: 25027733, PMCID: PMC4265214, DOI: 10.1016/j.tibs.2014.06.003.
  • PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells.Juliano CE, Reich A, Liu N, Götzfried J, Zhong M, Uman S, Reenan RA, Wessel GM, Steele RE, Lin H. PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 337-42. PMID: 24367095, PMCID: PMC3890812, DOI: 10.1073/pnas.1320965111.
  • Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary.Ma X, Wang S, Do T, Song X, Inaba M, Nishimoto Y, Liu LP, Gao Y, Mao Y, Li H, McDowell W, Park J, Malanowski K, Peak A, Perera A, Li H, Gaudenz K, Haug J, Yamashita Y, Lin H, Ni JQ, Xie T. Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PloS One 2014, 9: e90267. PMID: 24658126, PMCID: PMC3962343, DOI: 10.1371/journal.pone.0090267.
  • Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism.Peng JC, Lin H. Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism. Current Opinion In Cell Biology 2013, 25: 190-4. PMID: 23465540, PMCID: PMC3651849, DOI: 10.1016/j.ceb.2013.01.010.
  • Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity.Darricarrère N, Liu N, Watanabe T, Lin H. Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 1297-302. PMID: 23297219, PMCID: PMC3557079, DOI: 10.1073/pnas.1213283110.
  • Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.Saxe JP, Chen M, Zhao H, Lin H. Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. The EMBO Journal 2013, 32: 1869-85. PMID: 23714778, PMCID: PMC3981179, DOI: 10.1038/emboj.2013.121.
  • Piwi genes are dispensable for normal hematopoiesis in mice.Nolde MJ, Cheng EC, Guo S, Lin H. Piwi genes are dispensable for normal hematopoiesis in mice. PloS One 2013, 8: e71950. PMID: 24058407, PMCID: PMC3751959, DOI: 10.1371/journal.pone.0071950.
  • A major epigenetic programming mechanism guided by piRNAs.Huang XA, Yin H, Sweeney S, Raha D, Snyder M, Lin H. A major epigenetic programming mechanism guided by piRNAs. Developmental Cell 2013, 24: 502-16. PMID: 23434410, PMCID: PMC3600162, DOI: 10.1016/j.devcel.2013.01.023.
  • Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.Cheng EC, Lin H. Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal. Developmental Cell 2013, 25: 1-2. PMID: 23597480, PMCID: PMC3906851, DOI: 10.1016/j.devcel.2013.03.020.
  • Capturing the cloud: UAP56 in nuage assembly and function.Lin H. Capturing the cloud: UAP56 in nuage assembly and function. Cell 2012, 151: 699-701. PMID: 23141532, PMCID: PMC4234066, DOI: 10.1016/j.cell.2012.10.026.
  • piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism.Beyret E, Liu N, Lin H. piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism. Cell Research 2012, 22: 1429-39. PMID: 22907665, PMCID: PMC3463270, DOI: 10.1038/cr.2012.120.
  • Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice.Wang J, Gu H, Lin H, Chi T. Essential roles of the chromatin remodeling factor BRG1 in spermatogenesis in mice. Biology Of Reproduction 2012, 86: 186. PMID: 22495890, PMCID: PMC3386149, DOI: 10.1095/biolreprod.111.097097.
  • High-efficiency transfection and siRNA-mediated gene knockdown in human pluripotent stem cells.Ma Y, Lin H, Qiu C. High-efficiency transfection and siRNA-mediated gene knockdown in human pluripotent stem cells. Current Protocols In Stem Cell Biology 2012, Chapter 2: Unit 5C.2. PMID: 22605647, DOI: 10.1002/9780470151808.sc05c02s21.
  • Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis.Chen D, Zheng W, Lin A, Uyhazi K, Zhao H, Lin H. Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Current Biology : CB 2012, 22: 420-5. PMID: 22342750, PMCID: PMC3449084, DOI: 10.1016/j.cub.2012.01.039.
  • The miRNA Regulation of Stem Cells.Huang XA, Lin H. The miRNA Regulation of Stem Cells. Wiley Interdisciplinary Reviews. Membrane Transport And Signaling 2012, 1: 83-95. PMID: 23024929, PMCID: PMC3459065, DOI: 10.1002/wdev.5.
  • The microRNA regulation of stem cells.Huang XA, Lin H. The microRNA regulation of stem cells. Wiley Interdisciplinary Reviews. Developmental Biology 2012, 1: 83-95. PMID: 23801669, DOI: 10.1002/wdev.5.
  • Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells.Peng S, Chen LL, Lei XX, Yang L, Lin H, Carmichael GG, Huang Y. Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells (Dayton, Ohio) 2011, 29: 496-504. PMID: 21425412, DOI: 10.1002/stem.591.
  • Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.Gangaraju VK, Yin H, Weiner MM, Wang J, Huang XA, Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nature Genetics 2011, 43: 153-8. PMID: 21186352, PMCID: PMC3443399, DOI: 10.1038/ng.743.
  • Small noncoding RNAs in the germline.Saxe JP, Lin H. Small noncoding RNAs in the germline. Cold Spring Harbor Perspectives In Biology 2011, 3: a002717. PMID: 21669983, PMCID: PMC3181032, DOI: 10.1101/cshperspect.a002717.
  • Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms.Juliano C, Wang J, Lin H. Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annual Review Of Genetics 2011, 45: 447-69. PMID: 21942366, PMCID: PMC3832951, DOI: 10.1146/annurev-genet-110410-132541.
  • PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition.Liu L, Qi H, Wang J, Lin H. PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Development (Cambridge, England) 2011, 138: 1863-73. PMID: 21447556, PMCID: PMC3074456, DOI: 10.1242/dev.059287.
  • The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells.Qi H, Watanabe T, Ku HY, Liu N, Zhong M, Lin H. The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cells. The Journal Of Biological Chemistry 2011, 286: 3789-97. PMID: 21106531, PMCID: PMC3030380, DOI: 10.1074/jbc.M110.193888.
  • Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S, Iida N, Hoki Y, Murphy PJ, Toyoda A, Gotoh K, Hiura H, Arima T, Fujiyama A, Sado T, Shibata T, Nakano T, Lin H, Ichiyanagi K, Soloway PD, Sasaki H. Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (New York, N.Y.) 2011, 332: 848-52. PMID: 21566194, PMCID: PMC3368507, DOI: 10.1126/science.1203919.
  • MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, Toyoda A, Hoki Y, Fujiyama A, Shibata T, Sado T, Noce T, Nakano T, Nakatsuji N, Lin H, Sasaki H. MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Developmental Cell 2011, 20: 364-75. PMID: 21397847, PMCID: PMC3062204, DOI: 10.1016/j.devcel.2011.01.005.
  • A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster.Yin H, Sweeney S, Raha D, Snyder M, Lin H. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. PLoS Genetics 2011, 7: e1002380. PMID: 22194694, PMCID: PMC3240582, DOI: 10.1371/journal.pgen.1002380.
  • Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse.Beyret E, Lin H. Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Developmental Biology 2011, 355: 215-26. PMID: 21539824, PMCID: PMC3443393, DOI: 10.1016/j.ydbio.2011.04.021.
  • Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing.Wu JQ, Habegger L, Noisa P, Szekely A, Qiu C, Hutchison S, Raha D, Egholm M, Lin H, Weissman S, Cui W, Gerstein M, Snyder M. Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 5254-9. PMID: 20194744, PMCID: PMC2841935, DOI: 10.1073/pnas.0914114107.
  • A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal.Smulders-Srinivasan TK, Szakmary A, Lin H. A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal. Genetics 2010, 186: 573-83. PMID: 20647505, PMCID: PMC2954472, DOI: 10.1534/genetics.110.119081.
  • Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis.Ye Y, Yin DT, Chen L, Zhou Q, Shen R, He G, Yan Q, Tong Z, Issekutz AC, Shapiro CL, Barsky SH, Lin H, Li JJ, Gao JX. Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis. PloS One 2010, 5: e13406. PMID: 20975993, PMCID: PMC2958115, DOI: 10.1371/journal.pone.0013406.
  • High-efficiency siRNA-based gene knockdown in human embryonic stem cells.Ma Y, Jin J, Dong C, Cheng EC, Lin H, Huang Y, Qiu C. High-efficiency siRNA-based gene knockdown in human embryonic stem cells. RNA (New York, N.Y.) 2010, 16: 2564-9. PMID: 20978109, PMCID: PMC2995416, DOI: 10.1261/rna.2350710.
  • MicroRNAs: key regulators of stem cells.Gangaraju VK, Lin H. MicroRNAs: key regulators of stem cells. Nature Reviews. Molecular Cell Biology 2009, 10: 116-25. PMID: 19165214, PMCID: PMC4118578, DOI: 10.1038/nrm2621.
  • The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster.Szakmary A, Reedy M, Qi H, Lin H. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. The Journal Of Cell Biology 2009, 185: 613-27. PMID: 19433453, PMCID: PMC2711570, DOI: 10.1083/jcb.200903034.
  • MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation.Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi-Miyagawa S, Nakano T, Lin H. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. The Journal Of Biological Chemistry 2009, 284: 6507-19. PMID: 19114715, PMCID: PMC2649106, DOI: 10.1074/jbc.M809104200.
  • The biogenesis and function of PIWI proteins and piRNAs: progress and prospect.Thomson T, Lin H. The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annual Review Of Cell And Developmental Biology 2009, 25: 355-76. PMID: 19575643, PMCID: PMC2780330, DOI: 10.1146/annurev.cellbio.24.110707.175327.
  • Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.Wang J, Saxe JP, Tanaka T, Chuma S, Lin H. Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Current Biology : CB 2009, 19: 640-4. PMID: 19345100, PMCID: PMC2704239, DOI: 10.1016/j.cub.2009.02.061.
  • Stem cells in 2009.McKay RD, van der Kooy D, Zwaka TP, Lin H. Stem cells in 2009. Cell Stem Cell 2009, 5: 483-9. PMID: 19896440, DOI: 10.1016/j.stem.2009.10.012.
  • Piecing together the mosaic of early mammalian development through microRNAs.Blakaj A, Lin H. Piecing together the mosaic of early mammalian development through microRNAs. The Journal Of Biological Chemistry 2008, 283: 9505-8. PMID: 18272516, PMCID: PMC2442291, DOI: 10.1074/jbc.R800002200.
  • Cell biology of stem cells: an enigma of asymmetry and self-renewal.Lin H. Cell biology of stem cells: an enigma of asymmetry and self-renewal. The Journal Of Cell Biology 2008, 180: 257-60. PMID: 18227277, PMCID: PMC2213586, DOI: 10.1083/jcb.200712159.
  • Precancerous stem cells have the potential for both benign and malignant differentiation.Chen L, Shen R, Ye Y, Pu XA, Liu X, Duan W, Wen J, Zimmerer J, Wang Y, Liu Y, Lasky LC, Heerema NA, Perrotti D, Ozato K, Kuramochi-Miyagawa S, Nakano T, Yates AJ, Carson WE, Lin H, Barsky SH, Gao JX. Precancerous stem cells have the potential for both benign and malignant differentiation. PloS One 2007, 2: e293. PMID: 17356702, PMCID: PMC1808425, DOI: 10.1371/journal.pone.0000293.
  • piRNAs in the germ line.Lin H. piRNAs in the germ line. Science (New York, N.Y.) 2007, 316: 397. PMID: 17446387, DOI: 10.1126/science.1137543.
  • Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis.Wang Z, Lin H. Sex-lethal is a target of Bruno-mediated translational repression in promoting the differentiation of stem cell progeny during Drosophila oogenesis. Developmental Biology 2007, 302: 160-8. PMID: 17067567, PMCID: PMC1904479, DOI: 10.1016/j.ydbio.2006.09.016.
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a.Brower-Toland B, Findley SD, Jiang L, Liu L, Yin H, Dus M, Zhou P, Elgin SC, Lin H. Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes & Development 2007, 21: 2300-11. PMID: 17875665, PMCID: PMC1973144, DOI: 10.1101/gad.1564307.
  • An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster.Yin H, Lin H. An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature 2007, 450: 304-8. PMID: 17952056, DOI: 10.1038/nature06263.
  • A novel class of small RNAs in mouse spermatogenic cells.Grivna ST, Beyret E, Wang Z, Lin H. A novel class of small RNAs in mouse spermatogenic cells. Genes & Development 2006, 20: 1709-14. PMID: 16766680, PMCID: PMC1522066, DOI: 10.1101/gad.1434406.
  • Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells.Kotaja N, Lin H, Parvinen M, Sassone-Corsi P. Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. Journal Of Cell Science 2006, 119: 2819-25. PMID: 16787948, DOI: 10.1242/jcs.03022.
  • MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis.Grivna ST, Pyhtila B, Lin H. MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13415-20. PMID: 16938833, PMCID: PMC1569178, DOI: 10.1073/pnas.0605506103.
  • The role of PIWI and the miRNA machinery in Drosophila germline determination.Megosh HB, Cox DN, Campbell C, Lin H. The role of PIWI and the miRNA machinery in Drosophila germline determination. Current Biology : CB 2006, 16: 1884-94. PMID: 16949822, DOI: 10.1016/j.cub.2006.08.051.
  • Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein.Lin H. Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein. The Yale Journal Of Biology And Medicine 2006, 79: 187-91. PMID: 17940631, PMCID: PMC1994806.
  • Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation.Szakmary A, Cox DN, Wang Z, Lin H. Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. Current Biology : CB 2005, 15: 171-8. PMID: 15668175, DOI: 10.1016/j.cub.2005.01.005.
  • The division of Drosophila germline stem cells and their precursors requires a specific cyclin.Wang Z, Lin H. The division of Drosophila germline stem cells and their precursors requires a specific cyclin. Current Biology : CB 2005, 15: 328-33. PMID: 15723793, DOI: 10.1016/j.cub.2005.02.016.
  • Nanos maintains germline stem cell self-renewal by preventing differentiation.Wang Z, Lin H. Nanos maintains germline stem cell self-renewal by preventing differentiation. Science (New York, N.Y.) 2004, 303: 2016-9. PMID: 14976263, DOI: 10.1126/science.1093983.
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