Guadalupe Garcia-Tsao, MD, FRCP
Research & Publications
Biography
News
Research Summary
I am primarily involved in clinical research which focuses on cirrhosis and its complications. This includes the following:
a) diagnosis and staging of cirrhosis, including predictors of decompensation (in compensated cirrhosis) and predictors of death (in decompensated cirrhosis) as well as noninvasive tests in the identification of clinically significant portal hypertension
b) describing the natural history of cirrhosis and its complications but also the effect of etiological therapies on its reversibility
c) pathogenesis and treatment of portal hypertension and investigating the usefulness of portal-pressure reducing drugs and their impact in the prevention of poor outcomes in cirrhosis
d) development of diagnostic criteria and investigation of therapies for ascites and its complications (refractory ascites, acute kidney injury - including hepatorenal syndrome)
e) identification and treatment of infections in cirrhosis, particularly spontaneous bacterial peritonitis
Specialized Terms: Cirrhosis; Natural history of cirrhosis; Portal hypertension, Gastroesophageal varices; Variceal hemorrhage; Ascites; Spontaneous bacterial peritonitis; Hepatorenal syndrome
Research Interests
Ascites; Hepatorenal Syndrome; Liver; Liver Cirrhosis; Liver Diseases; Veterans
Research Image
Pathogenesis of the complications of cirrhosis
Selected Publications
- Cirrhotic ascites: pathogenesis and management.Garcia-Tsao G. Cirrhotic ascites: pathogenesis and management. The Gastroenterologist 1995, 3: 41-54 PubMed ID: 7743121.
- Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites.Garcia-Tsao G, Lee FY, Barden GE, Cartun R, West AB. Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites. Gastroenterology 1995, 108: 1835-41 PubMed ID: 7768390, DOI: 10.1016/0016-5085(95)90147-7.
- Treatment of spontaneous bacterial peritonitis with oral ofloxacin: inpatient or outpatient therapy?García-Tsao G. Treatment of spontaneous bacterial peritonitis with oral ofloxacin: inpatient or outpatient therapy? Gastroenterology 1996, 111: 1147-50 PubMed ID: 8831614.
- Portal hypertensionGarcia-Tsao, G. Portal hypertension. Curr Opinion Gastro 13:263-270, 1997.
- Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage.García-Tsao G. Further evidence in favor of pharmacological portal pressure reduction in the prevention of variceal hemorrhage. Gastroenterology 1997, 112: 1770-1 PubMed ID: 9136864.
- The portal pressure response to beta-blockade is greater in cirrhotic patients without varices than in those with varices.Escorsell A, Ferayorni L, Bosch J, García-Pagán JC, García-Tsao G, Grace ND, Rodés J, Groszmann RJ. The portal pressure response to beta-blockade is greater in cirrhotic patients without varices than in those with varices. Gastroenterology 1997, 112: 2012-6 PubMed ID: 9178694.