Gregory Michael Ouellet, MD, MHS
Research & Publications
Biography
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Extensive Research Description
My ultimate goal is to impact the lives of older adults by optimizing complex decision-making, that is, finding which treatments maximize benefits to each individual patient, minimize harms, and avoid treatment burden. I have recently completed work to understand whether the benefits of multiple antihypertensives seen in clinical trials extends to complex older adults and have worked with my mentor, Dr. Mary Tinetti, on her national effort to transform decision-making for persons with multiple chronic conditions, Patient Priorities Care. My current work focuses on extending the science of complex decision-making to older adults with dementia, another vulnerable group in whom the benefits and harms of chronic disease treatments are unclear. As a first step, I am studying an exemplar of chronic disease decision-making for persons with dementia, i.e., whether or not to treat persons with dementia and atrial fibrillation with anticoagulants. To do so, I am investigating the benefits and harms of anticoagulants in this population and what factors surrogate decision-makers and clinicians consider important when facing this decision.
Coauthors
Research Interests
Decision Making; Dementia; Geriatrics
Selected Publications
- Abstract 12707: The Association Between Beta-Blockers and Outcomes in Patients With Heart Failure and Alzheimer's Disease and Related DementiasGilstrap L, Cohen A, Ouellet G, Goyal P, Gladders B, Flint D, Skinner J. Abstract 12707: The Association Between Beta-Blockers and Outcomes in Patients With Heart Failure and Alzheimer's Disease and Related Dementias Circulation 2022, 146: a12707-a12707. DOI: 10.1161/circ.146.suppl_1.12707.
- Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementiaOuellet GM, O'Leary JR, Leggett CG, Skinner J, Tinetti ME, Cohen AB. Benefits and harms of oral anticoagulants for atrial fibrillation in nursing home residents with advanced dementia Journal Of The American Geriatrics Society 2022 PMID: 36310367, DOI: 10.1111/jgs.18108.
- The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementiasGilstrap L, Cohen A, Ouellet GM, Goyal P, Gladders B, Flint D, Skinner J. The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias Journal Of The American Geriatrics Society 2022 PMID: 36240493, DOI: 10.1111/jgs.18086.
- Abstract 10654: Prevalence and Outcomes of Patients with HFrEF and Alzheimer's Disease and Related Dementias (ADRD)Gilstrap L, Ouellet G, Cohen A, Flint D, Gladders B, Austin A, Skinner J. Abstract 10654: Prevalence and Outcomes of Patients with HFrEF and Alzheimer's Disease and Related Dementias (ADRD) Circulation 2021, 144: a10654-a10654. DOI: 10.1161/circ.144.suppl_1.10654.
- Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of LifeOuellet GM, Fried TR, Gilstrap LG, O’Leary J, Austin AM, Skinner JS, Cohen AB. Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life JAMA Internal Medicine 2021, 181: 1121-1123. PMID: 33970197, PMCID: PMC8111560, DOI: 10.1001/jamainternmed.2021.1819.
- Presentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI StudyHajduk AM, Saczynski JS, Tsang S, Geda ME, Dodson JA, Ouellet GM, Goldberg RJ, Chaudhry SI. Presentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI Study The American Journal Of Medicine 2021, 134: 910-917. PMID: 33737057, PMCID: PMC8243828, DOI: 10.1016/j.amjmed.2021.03.003.
- 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI studyDodson JA, Hajduk AM, Murphy TE, Geda M, Krumholz HM, Tsang S, Nanna MG, Tinetti ME, Ouellet G, Sybrant D, Gill TM, Chaudhry SI. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study Open Heart 2021, 8: e001442. PMID: 33452007, PMCID: PMC7813425, DOI: 10.1136/openhrt-2020-001442.
- Clinician Perspectives on Incorporating Patients' Values‐Based Health Priorities in Decision‐MakingOuellet GM, Kiwak E, Costello DM, Green AR, Geda M, Naik AD, Tinetti ME. Clinician Perspectives on Incorporating Patients' Values‐Based Health Priorities in Decision‐Making Journal Of The American Geriatrics Society 2020, 69: 267-269. PMID: 33165913, PMCID: PMC7839399, DOI: 10.1111/jgs.16914.
- Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI StudyHajduk AM, Dodson JA, Murphy TE, Tsang S, Geda M, Ouellet GM, Gill TM, Brush JE, Chaudhry SI. Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study Journal Of The American Heart Association 2020, 9: e015555. PMID: 33000681, PMCID: PMC7792390, DOI: 10.1161/jaha.119.015555.
- Combating Heightened Social Isolation of Nursing Home Elders: The Telephone Outreach in the COVID-19 Outbreak Programvan Dyck LI, Wilkins KM, Ouellet J, Ouellet GM, Conroy ML. Combating Heightened Social Isolation of Nursing Home Elders: The Telephone Outreach in the COVID-19 Outbreak Program American Journal Of Geriatric Psychiatry 2020, 28: 989-992. PMID: 32593495, PMCID: PMC7274114, DOI: 10.1016/j.jagp.2020.05.026.
- Association of Patient Priorities–Aligned Decision-Making With Patient Outcomes and Ambulatory Health Care Burden Among Older Adults With Multiple Chronic ConditionsTinetti ME, Naik AD, Dindo L, Costello DM, Esterson J, Geda M, Rosen J, Hernandez-Bigos K, Smith CD, Ouellet GM, Kang G, Lee Y, Blaum C. Association of Patient Priorities–Aligned Decision-Making With Patient Outcomes and Ambulatory Health Care Burden Among Older Adults With Multiple Chronic Conditions JAMA Internal Medicine 2019, 179: 1688-1697. PMID: 31589281, PMCID: PMC6784811, DOI: 10.1001/jamainternmed.2019.4235.
- Challenges and strategies in patients’ health priorities-aligned decision-making for older adults with multiple chronic conditionsTinetti M, Dindo L, Smith CD, Blaum C, Costello D, Ouellet G, Rosen J, Hernandez-Bigos K, Geda M, Naik A. Challenges and strategies in patients’ health priorities-aligned decision-making for older adults with multiple chronic conditions PLOS ONE 2019, 14: e0218249. PMID: 31181117, PMCID: PMC6557523, DOI: 10.1371/journal.pone.0218249.
- Hospital Readmission From Skilled Nursing Facilities (SNFs): Perspectives of Hospital and SNF ProvidersMinges KE, Campbell Britton M, Clark BW, Ouellet GM, Hodshon B, Chaudhry SI. Hospital Readmission From Skilled Nursing Facilities (SNFs): Perspectives of Hospital and SNF Providers Journal Of The American Medical Directors Association 2019, 20: 1050-1051. PMID: 31043356, DOI: 10.1016/j.jamda.2019.03.005.
- Functional Outcomes After Hip Fracture in Independent Community‐Dwelling PatientsOuellet JA, Ouellet GM, Romegialli AM, Hirsch M, Berardi L, Ramsey CM, Cooney LM, Walke LM. Functional Outcomes After Hip Fracture in Independent Community‐Dwelling Patients Journal Of The American Geriatrics Society 2019, 67: 1386-1392. PMID: 30964203, PMCID: PMC6941577, DOI: 10.1111/jgs.15870.
- Treatment of Hypertension in Complex Older Adults: How Many Medications Are Needed?Ouellet GM, McAvay G, Murphy TE, Tinetti ME. Treatment of Hypertension in Complex Older Adults: How Many Medications Are Needed? Gerontology And Geriatric Medicine 2019, 5: 2333721419856436. PMID: 31245434, PMCID: PMC6580710, DOI: 10.1177/2333721419856436.
- COGNITIVE IMPAIRMENT AND SIX-MONTH OUTCOMES AMONG OLDER ADULTS WITH MYOCARDIAL INFARCTION: THE SILVER-AMI STUDYHajduk A, Saczynski J, Tsang S, Geda M, Dodson J, Ouellet G, Goldberg R, Chaudhry S. COGNITIVE IMPAIRMENT AND SIX-MONTH OUTCOMES AMONG OLDER ADULTS WITH MYOCARDIAL INFARCTION: THE SILVER-AMI STUDY Innovation In Aging 2018, 2: 772-772. PMCID: PMC6228403, DOI: 10.1093/geroni/igy023.2857.
- Principle of rational prescribing and deprescribing in older adults with multiple chronic conditionsOuellet GM, Ouellet JA, Tinetti ME. Principle of rational prescribing and deprescribing in older adults with multiple chronic conditions Therapeutic Advances In Drug Safety 2018, 9: 639-652. PMID: 30479739, PMCID: PMC6243421, DOI: 10.1177/2042098618791371.
- National Prescribing Trends for High‐Risk Anticholinergic Medications in Older AdultsRhee TG, Choi YC, Ouellet GM, Ross JS. National Prescribing Trends for High‐Risk Anticholinergic Medications in Older Adults Journal Of The American Geriatrics Society 2018, 66: 1382-1387. PMID: 29582410, PMCID: PMC6097908, DOI: 10.1111/jgs.15357.
- Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction StudyOuellet GM, Geda M, Murphy TE, Tsang S, Tinetti ME, Chaudhry SI. Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study Journal Of The American Geriatrics Society 2017, 65: 2391-2396. PMID: 29044463, PMCID: PMC5681402, DOI: 10.1111/jgs.15102.
- Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving ProvidersBritton MC, Ouellet GM, Minges KE, Gawel M, Hodshon B, Chaudhry SI. Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers The Joint Commission Journal On Quality And Patient Safety 2017, 43: 565-572. PMID: 29056176, PMCID: PMC5693352, DOI: 10.1016/j.jcjq.2017.06.004.
- Prostate Cancer in Elderly Men Screening, Active Surveillance, and Definitive TherapyRoussel B, Ouellet GM, Mohile SG, Dale W. Prostate Cancer in Elderly Men Screening, Active Surveillance, and Definitive Therapy Clinics In Geriatric Medicine 2015, 31: 615-629. PMID: 26476120, DOI: 10.1016/j.cger.2015.07.004.
- Effect of Cardiac Resynchronization Therapy on the Risk of First and Recurrent Ventricular Tachyarrhythmic Events in MADIT-CRTOuellet G, Huang DT, Moss AJ, Hall WJ, Barsheshet A, McNitt S, Klein H, Zareba W, Goldenberg I. Effect of Cardiac Resynchronization Therapy on the Risk of First and Recurrent Ventricular Tachyarrhythmic Events in MADIT-CRT Journal Of The American College Of Cardiology 2012, 60: 1809-1816. PMID: 23040580, DOI: 10.1016/j.jacc.2012.05.057.
- Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndromeCosta J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome Heart Rhythm 2012, 9: 892-898. PMID: 22293141, PMCID: PMC3358462, DOI: 10.1016/j.hrthm.2012.01.020.
- Effectiveness of Cardiac Resynchronization Therapy in Diabetic Patients with Ischemic and Nonischemic CardiomyopathyGeorge J, Barsheshet A, Moss AJ, Martin D, Ouellet G, McNitt S, Goldenberg I. Effectiveness of Cardiac Resynchronization Therapy in Diabetic Patients with Ischemic and Nonischemic Cardiomyopathy Annals Of Noninvasive Electrocardiology 2012, 17: 14-21. PMID: 22276624, PMCID: PMC6932461, DOI: 10.1111/j.1542-474x.2011.00476.x.
- RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY AMONG PATIENTS WITH DIABETES MELLITUS AND ISCHEMIC AND NON-ISCHEMIC ETIOLOGY OF CARDIOMYOPATHYGeorge J, Ouellet G, Moss A, Martin D, Barsheshet A, McNitt S, Goldenberg I. RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY AMONG PATIENTS WITH DIABETES MELLITUS AND ISCHEMIC AND NON-ISCHEMIC ETIOLOGY OF CARDIOMYOPATHY Journal Of The American College Of Cardiology 2011, 57: e95. DOI: 10.1016/s0735-1097(11)60095-8.
- Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndromeMigdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome Heart Rhythm 2011, 8: 1537-1543. PMID: 21440677, PMCID: PMC4028036, DOI: 10.1016/j.hrthm.2011.03.049.
- Long QT Syndrome in African‐AmericansFugate T, Moss AJ, Jons C, McNitt S, Mullally J, Ouellet G, Goldenberg I, Zareba W, Robinson JL, Investigators F. Long QT Syndrome in African‐Americans Annals Of Noninvasive Electrocardiology 2010, 15: 73-76. PMID: 20146785, PMCID: PMC4028024, DOI: 10.1111/j.1542-474x.2009.00342.x.
- Influence of Diabetes Mellitus on Outcome in Patients Over 40 Years of Age With the Long QT SyndromeOuellet G, Moss AJ, Jons C, McNitt S, Mullally J, Fugate T, Goldenberg I, Zareba W, Robinson JL, Registry I. Influence of Diabetes Mellitus on Outcome in Patients Over 40 Years of Age With the Long QT Syndrome The American Journal Of Cardiology 2009, 105: 87-89. PMID: 20102896, PMCID: PMC2813216, DOI: 10.1016/j.amjcard.2009.08.657.
- Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During InfancySpazzolini C, Mullally J, Moss AJ, Schwartz PJ, McNitt S, Ouellet G, Fugate T, Goldenberg I, Jons C, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Crotti L, Kaufman ES, Locati EH, Qi M, Napolitano C, Priori SG, Towbin JA, Vincent GM. Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy Journal Of The American College Of Cardiology 2009, 54: 832-837. PMID: 19695463, PMCID: PMC3517782, DOI: 10.1016/j.jacc.2009.05.029.
- Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell ApoptosisRogers R, Ouellet G, Brown C, Moyer B, Rasoulpour T, Hixon M. Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis Toxicological Sciences 2008, 106: 497-508. PMID: 18755736, PMCID: PMC2581679, DOI: 10.1093/toxsci/kfn186.