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Gary Cline, PhD

Professor Emeritus of Medicine (Endocrinology); Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine; Co-Director, Clinical Metabolism Core, Yale Diabetes Research Center

Contact Information

Gary Cline, PhD

Research Summary

Diabetes mellitus has a profound impact on hepatic and peripheral glucose metabolic fluxes. My studies on the biochemical mechanisms responsible for the pathophysiology of diabetes mellitus primarily employ nuclear magnetic resonance spectroscopy, mass spectroscopy, and stable isotopic techniques. Using these techniques, the flux and fate of key intermediates of carbohydrate and lipid metabolism can be determined in vitro and in vivo. These techniques are developed in cell systems and small animal models and when appropriate applied to studies of human physiology. New areas of research are the application and adaptation of these techniques to the study of pancreatic beta-cell metabolism and glucose-stimulated insulin release. In addition, we are developing PET imaging to evaluate whether loss of pancreatic beta-cell mass contributes to insufficient insulin secretion with T2DM.

Research Interests

Diabetes Mellitus; Endocrinology; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Lipid Metabolism

Clinical Trials

ConditionsStudy Title
Diseases of the Nervous SystemImaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
Children's Health; Diseases of the Digestive System - LiverThe Role of Hepatic De Novo Lipogenesis (DNL) in the Pathogenesis of Hepatic Steatosis