Gang-Qing Yao, MD
Research Scientist in Medicine (Endocrinology); Director, Vector Design and Engineering Service
Research & Publications
Biography
Research Summary
Dr. Yao’s research interest focuses on cellular and molecular mechanisms of Colony Stimulating Factor-1 isoforms in bone. Selective deletion of the isoform in vivo is being pursued to better define their separate roles. The lab also provides a complete vector design and construction for knockout and knockin mice, as well as transgenic mice.
Specialized Terms: Molecular Biology of Bone Metabolism; Bone Metabolism; Endocrine effects on bone loss
Coauthors
Research Interests
Bone and Bones
Selected Publications
- AgRP Neurons Regulate Bone Mass.Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL. AgRP Neurons Regulate Bone Mass. Cell Reports 2015, 13:8-14.
- Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss.Yao GQ, Wu JJ, Troiano N, Zhu ML, Xiao XY, Insogna K. Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss. Journal Of Bone And Mineral Metabolism 2012, 30:408-18.
- Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.Yao GQ, Wu JJ, Troiano N, Insogna K. Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice. Journal Of Bone And Mineral Metabolism 2011, 29:141-8.
- Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice.Yao GQ, Wu JJ, Ovadia S, Troiano N, Sun BH, Insogna K. Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice. American Journal Of Physiology. Endocrinology And Metabolism 2009, 296:E714-20.
- The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice.Ovadia S, Insogna K, Yao GQ. The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice. Biology Of Reproduction 2006, 74:331-6.
- CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts.Yao GQ, Itokawa T, Paliwal I, Insogna K. CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts. Calcified Tissue International 2005, 76:371-8.
- The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo.Yao GQ, Wu JJ, Sun BH, Troiano N, Mitnick MA, Insogna K. The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo. Endocrinology 2003, 144:3677-82.
- A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis.Yao GQ, Sun BH, Weir EC, Insogna KL. A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis. Calcified Tissue International 2002, 70:339-46.