Francis Lee

• Alana Munger
• Dieter Lindskog
• Gary Friedlaender
• Hyuk-Kwon Kwon
• Igor Latich
• JungHo Back
• Matthew D. Riedel
• Themis Kyriakides

Bone and Bones; Bone Diseases, Infectious; Bone Marrow; Fracture Fixation; Musculoskeletal Diseases; Orthopedics; Osteoarthritis; Osteoblasts; Osteoclasts; Stem Cells; Oncology Service, Hospital; Tissue Engineering

• Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains.Hao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon HK, Back J, Xu S, Lee FY. Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains. Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research 2021, 36:186-198.
• Locally delivered adjuvant biofilm-penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection.Cahill SV, Kwon HK, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Lee FY. Locally delivered adjuvant biofilm-penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2021, 39:402-414.
• Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases.Toombs C, Conway D, Munger AM, Alder KD, Latich I, Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases. Instructional Course Lectures 2021, 70:503-514.
• Biocompatibility of platinum-based bulk metallic glass in orthopedic applications.Loye A, Kwon HK, Dellal D, Ojeda Mota RM, Lee S, Davis R, Nagle N, Doukas P, Schroers J, Lee FY, Kyriakides TR. Biocompatibility of platinum-based bulk metallic glass in orthopedic applications. Biomedical Materials (Bristol, England) 2021, 16.
• Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis.Kwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis. Science Advances 2021, 7.
• Stem cell-directed therapies for osteoarthritis: The promise and the practice.Ng J, Little CB, Woods S, Whittle S, Lee FY, Gronthos S, Mukherjee S, Hunter DJ, Worthley DL. Stem cell-directed therapies for osteoarthritis: The promise and the practice. Stem Cells (Dayton, Ohio) 2020, 38:477-486.
• Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones.Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology : JVIR 2020, 31:649-658.e1.
• Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus.Alder KD, White AH, Chung YH, Lee I, Back J, Kwon HK, Cahill SV, Hao Z, Li L, Chen F, Lee S, Riedel MD, Lee FY. Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus. JBMR Plus 2020, 4:e10359.
• Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies.Yu K, Song L, Kang HP, Kwon HK, Back J, Lee FY. Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies. Bone & Joint Research 2020, 9:49-59.
• Avoiding Limb-Length Discrepancy with Reconstruction of a Massive Tibial Defect Using a Bone Allograft and a Minimally Invasive Lengthening System in a Pediatric Patient: A Case Report.Alder KD, Morris MT, Hao Z, Li L, Yu KE, Lee FY. Avoiding Limb-Length Discrepancy with Reconstruction of a Massive Tibial Defect Using a Bone Allograft and a Minimally Invasive Lengthening System in a Pediatric Patient: A Case Report. JBJS Case Connector 2020, 10:e0456.
• Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction.Alder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction. Bone 2020, 141:115568.
• Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43:e498-e502.
• Re-appraising the potential of naringin for natural, novel orthopedic biotherapies.Yu KE, Alder KD, Morris MT, Munger AM, Lee I, Cahill SV, Kwon HK, Back J, Lee FY. Re-appraising the potential of naringin for natural, novel orthopedic biotherapies. Therapeutic Advances In Musculoskeletal Disease 2020, 12:1759720X20966135.
• Excisional Curettage of Benign Cystic LesionsJournal of Bone Joint Surg Am. Essential Surgical Techniques: July-September 2019 - Volume 9 - Issue 3 - p e24 doi: 10.2106/JBJS.ST.18.00036
• Rotation Tibio-Pelvic Arthroplasty for a recalcitrant infectionSean Cahill, Kristin Yu, Christopher Dusik, Francis Y. Lee. Journal of Bone and Joint Surgery. Case Connector, 2019
• Section 8 – Orthopaedic Oncology. Section Editor: Francis Y. Lee, M.D., Ph.D.* Chapter 41: Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss. Izuchuku Ibe,,, Francis Y. Lee, M.D., Ph.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
• Chapter 42: Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss. Izuchuku Ibe,,, Francis Y. Lee, M.D., Ph.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
• Chapter 47: Femoral and Tibial Reconstruction for Skeletal Metastases and Pathological Fractures. Izuchuku Ibe,,, Francis Y. Lee, M.D., Ph.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
• Chapter 48: Bone Tumors and Reconstructive Options in Pediatric and Young Adult Patients. Izuchuku Ibe M.D., , Francis Y. Lee, M.D., Ph.D., Dieter Lindskog, M.D.*American Academy of Orthopaedic Surgeons, Instructional Course Lectures, Volume 68: ISBN/ISSN 9781975120863 Publication Date, February 27, 2019
• Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone: A 1 to 12-Year Follow-up Study.Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone: A 1 to 12-Year Follow-up Study. American Journal Of Clinical Oncology 2019, 42:231-237.
• A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice.Kwon HK, Patra MC, Shin HJ, Gui X, Achek A, Panneerselvam S, Kim DJ, Song SJ, Hong R, Kim KS, Kim YG, Lee FY, Hahm DH, Lee SH, Choi S. A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice. Experimental & Molecular Medicine 2019, 51:1-19.
• Defining preoperative imaging findings of sacral chordomas associated with decreased overall survival and local recurrence.Munger AM, Geddes BJ, Lee FY. Defining preoperative imaging findings of sacral chordomas associated with decreased overall survival and local recurrence. Journal Of Spine Surgery (Hong Kong) 2019, 5:171-173.
• Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. The Journal Of Bone And Joint Surgery. American Volume 2019, 101:1399-1410.
• Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report.Cahill SV, Yu KE, Dussik CM, Lee FY. Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report. JBJS Case Connector 2019, 9:e0404.
• Excisional Curettage of Benign Cystic Lesions.Ibe IK, Alder KD, Henderson SE, Yu KE, Lee FY. Excisional Curettage of Benign Cystic Lesions. JBJS Essential Surgical Techniques 2019, 9:e24.
• Excisional Curettage of Benign Cystic Lesions.Ibe IK, Alder KD, Henderson SE, Yu KE, Lee FY. Excisional Curettage of Benign Cystic Lesions. JBJS Essential Surgical Techniques 2019, 9:e24.
• Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss.Henderson SE, Dussik C, Brand J, Ibe IK, Lee FY. Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68:557-566.
• Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss.Ibe IK, Sahlstrom A, White A, Henderson SE, Lee FY. Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss. Instructional Course Lectures 2019, 68:547-556.
• Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures.Henderson SE, Yu K, Alder KD, Ibe IK, Lee FY, Lindskog DM. Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures. Instructional Course Lectures 2019, 68:607-612.
• Targeted Therapies in Sarcomas6. Ibe, Izuchukwu; Haynes, Monique; Koo, Andrew; Lindskog, Dieter; Friedlaender, Gary E.; Lee, Francis Y. Techniques in Orthopaedics, 33(3):135-139, September, 2019.
• Immunooncology in SarcomaIbe, Izuchukwu; Sahlstrom, Adam; Nguyen, Minh N.; Lindskog, Dieter; Friedlaender, Gary E.; Lee, Francis Y. Techniques in Orthopaedics, 33(3):140-147, September, 2019.
• Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice.Mirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. The Journal Of Nutritional Biochemistry 2018, 52:54-61.
• Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices.Sau Yin Chin, Yukkee Cheung Poh, Anne-Céline Kohler, Jocelyn T. Compton, Lauren L. Hsu, Kathryn M. Lau, Sohyun Kim, Benjamin W. Lee, Francis Y. Lee, Samuel K. Science Robotics. 04 Jan 2017: Vol. 2, Issue 2, eaah645.
• Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor.Journal of Functional Foods, Volume 35: 458-465, 2017
• Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling.Tarafder S, Chen E, Jun Y, Kao K, Sim KH, Back J, Lee FY, Lee CH. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2017, 31:3991-3998.
• Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.Fischer CR, Mikami M, Minematsu H, Nizami S, Goo Lee H, Stamer D, Patel N, Yu Soung D, Back JH, Song L, Drissi H, Lee FY. Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2017, 35:2658-2666.
• Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices.Yin Chin S, Cheung Poh Y, Kohler AC, Compton JT, Hsu LL, Lau KM, Kim S, Lee BW, Lee FY, Sia SK. Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices. Science Robotics 2017, 2.
• Please see NIH Format Biosketches (Selected out of 110 Publications)JBJS, JCI, Cell, JOR, and others
• Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response.Tascau L, Gardner T, Anan H, Yongpravat C, Cardozo CP, Bauman WA, Lee FY, Oh DS, Tawfeek HA. Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response. Endocrinology 2016, 157:112-26.
• Tissue engineering advances in spine surgery.Makhni MC, Caldwell JM, Saifi C, Fischer CR, Lehman RA, Lenke LG, Lee FY. Tissue engineering advances in spine surgery. Regenerative Medicine 2016, 11:211-22.
• 3D printing for regenerative medicine: From bench to bedside.Juan Li, Ling He, Chen Zhou, Yue Zhou, Hanying Bai, Francis Y. Lee, Jeremy Mao. Materials Research Society Bulletin, 2015 Feb, Vol. 40: 145-154.
• CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways.Patel N, Nizami S, Song L, Mikami M, Hsu A, Hickernell T, Chandhanayingyong C, Rho S, Compton JT, Caldwell JM, Kaiser PB, Bai H, Lee HG, Fischer CR, Lee FY. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2015, 33:1474-86.
• Harnessing endogenous stem/progenitor cells for tendon regeneration.Lee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration. The Journal Of Clinical Investigation 2015, 125:2690-701.
• Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 2015, 160:269-84.
• Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones.Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics (Bristol, Avon) 2015, 30:1114-8.
• Tumor-Induced Osteomalacia Secondary to a Fibroblast Growth Factor 23-Secreting Phosphaturic Mesenchymal Tumor in the Foot.Kim Y, Stein E, Remotti F, Lee FY. Tumor-Induced Osteomalacia Secondary to a Fibroblast Growth Factor 23-Secreting Phosphaturic Mesenchymal Tumor in the Foot. JBJS Case Connector 2014, 4:e22.
• Effects of biomechanical forces on signaling in the cortical collecting duct (CCD).Carrisoza-Gaytan R, Liu Y, Flores D, Else C, Lee HG, Rhodes G, Sandoval RM, Kleyman TR, Lee FY, Molitoris B, Satlin LM, Rohatgi R. Effects of biomechanical forces on signaling in the cortical collecting duct (CCD). American Journal Of Physiology. Renal Physiology 2014, 307:F195-204.
• Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition.Lee JH, Kim HK, Chandhanayingyong C, Lee FY, Hielscher AH. Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition. Biomedical Optics Express 2014, 5:2301-16.
• Proteomic identification of 14-3-3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells.Kim KO, Hsu AC, Lee HG, Patel N, Chandhanayingyong C, Hickernell T, Lee FY. Proteomic identification of 14-3-3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2014, 32:848-54.
• A review of osteocyte function and the emerging importance of sclerostin.Compton JT, Lee FY. A review of osteocyte function and the emerging importance of sclerostin. The Journal Of Bone And Joint Surgery. American Volume 2014, 96:1659-68.
• Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells.Guzzo RM, Gibson J, Xu RH, Lee FY, Drissi H. Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells. Journal Of Cellular Biochemistry 2013, 114:480-90.
• Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells.Lee HG, Hsu A, Goto H, Nizami S, Lee JH, Cadet ER, Tang P, Shaji R, Chandhanayinyong C, Kweon SH, Oh DS, Tawfeek H, Lee FY. Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells. American Journal Of Physiology. Cell Physiology 2013, 304:C431-9.
• Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study.Amorosa LF, Lee CH, Aydemir AB, Nizami S, Hsu A, Patel NR, Gardner TR, Navalgund A, Kim DG, Park SH, Mao JJ, Lee FY. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal Of Nanomedicine 2013, 8:1637-43.
• MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions.Chandhanayingyong C, Kim Y, Staples JR, Hahn C, Lee FY. MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Sarcoma 2012, 2012:404810.
• Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor.Kim Y, Nizami S, Goto H, Lee FY. Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. Clinics In Orthopedic Surgery 2012, 4:107-16.
• Osteoid osteoma is an osteocalcinoma affecting glucose metabolism.Confavreux CB, Borel O, Lee F, Vaz G, Guyard M, Fadat C, Carlier MC, Chapurlat R, Karsenty G. Osteoid osteoma is an osteocalcinoma affecting glucose metabolism. Osteoporosis International : A Journal Established As Result Of Cooperation Between The European Foundation For Osteoporosis And The National Osteoporosis Foundation Of The USA 2012, 23:1645-50.
• Atrial Myxoma with Disseminated Osteolytic Embolic Lesions: A Case Report.Chandhanayingyong C, Thompson SA, Remotti F, Young-In Lee F. Atrial Myxoma with Disseminated Osteolytic Embolic Lesions: A Case Report. JBJS Case Connector 2012, 2:e36.
• Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets.Onishi AC, Hincker AM, Lee FY. Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets. Sarcoma 2011, 2011:381564.
• Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas.Noh K, Kim KO, Patel NR, Staples JR, Minematsu H, Nair K, Lee FY. Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas. The Journal Of Bone And Joint Surgery. American Volume 2011, 93:723-32.
• Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages.Minematsu H, Shin MJ, Celil Aydemir AB, Kim KO, Nizami SA, Chung GJ, Lee FY. Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. Cellular Signalling 2011, 23:1785-93.
• Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells.Lee HG, Minematsu H, Kim KO, Celil Aydemir AB, Shin MJ, Nizami SA, Chung KJ, Hsu AC, Jacobs CR, Lee FY. Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials 2011, 32:9197-206.
• New application of optical agent to image angiogenesis in hindlimb ischemia.Tekabe Y, Klose A, Nizami S, Luma J, Lee FY, Johnson L. New application of optical agent to image angiogenesis in hindlimb ischemia. Journal Of Biophotonics 2011, 4:859-65.
• Bone regeneration of tibial segmental defect using isotropic-pore structures hydroxyapatite/alumina bi-layered scaffold: in vivo pilot study.Han M, Kim JM, Choi SH, Lee FY, Son JS, Oh D. Bone regeneration of tibial segmental defect using isotropic-pore structures hydroxyapatite/alumina bi-layered scaffold: in vivo pilot study. Journal Of Long-term Effects Of Medical Implants 2011, 21:159-67.
• Zoledronate reduces unwanted bone resorption in intercalary bone allografts.Seo SW, Cho SK, Storer SK, Lee FY. Zoledronate reduces unwanted bone resorption in intercalary bone allografts. International Orthopaedics 2010, 34:599-603.
• Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model.Cadet ER, Vorys GC, Rahman R, Park SH, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2010, 28:308-14.
• Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells.Celil Aydemir AB, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY. Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells. Bone 2010, 46:167-75.
• Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis.Seo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis. Bone 2010, 46:695-702.
• siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells.Kim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY. siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells. Molecular Cancer 2009, 8:28.
• Characterization and comparison of the properties of sarcoma cell lines in vitro and in vivo.Mills J, Matos T, Charytonowicz E, Hricik T, Castillo-Martin M, Remotti F, Lee FY, Matushansky I. Characterization and comparison of the properties of sarcoma cell lines in vitro and in vivo. Human Cell 2009, 22:85-93.
• Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite.Suratwala SJ, Cho SK, van Raalte JJ, Park SH, Seo SW, Chang SS, Gardner TR, Lee FY. Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite. The Journal Of Bone And Joint Surgery. American Volume 2008, 90:2189-96.
• What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?Tuan RS, Lee FY, T Konttinen Y, Wilkinson JM, Smith RL. What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? The Journal Of The American Academy Of Orthopaedic Surgeons 2008, 16 Suppl 1:S42-8.
• Orthopedic implant particle-induced tumor necrosis factor-alpha production in macrophage-monocyte lineage cells is mediated by nuclear factor of activated T cells.Minematsu H, Shin MJ, Celil Aydemir AB, Seo SW, Kim DW, Blaine TA, Macián F, Yang J, Lee FY. Orthopedic implant particle-induced tumor necrosis factor-alpha production in macrophage-monocyte lineage cells is mediated by nuclear factor of activated T cells. Annals Of The New York Academy Of Sciences 2007, 1117:143-50.
• Coronal and sagittal plane correction in adolescent idiopathic scoliosis: a comparison between all pedicle screw versus hybrid thoracic hook lumbar screw constructs.Lowenstein JE, Matsumoto H, Vitale MG, Weidenbaum M, Gomez JA, Lee FY, Hyman JE, Roye DP. Coronal and sagittal plane correction in adolescent idiopathic scoliosis: a comparison between all pedicle screw versus hybrid thoracic hook lumbar screw constructs. Spine 2007, 32:448-52.
• Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells.Kim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee SE, Block JA, Hei TK, Lee FY. Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2007, 25:820-8.
• Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction.Celil Aydemir AB, Lee S, Won Kim D, Gardner TR, Prince D, Mok Ahn J, Lee FY. Nuclear factor of activated T cell mediates proinflammatory gene expression in response to mechanotransduction. Annals Of The New York Academy Of Sciences 2007, 1117:138-42.
• ERK signaling regulates macrophage colony-stimulating factor expression induced by titanium particles in MC3T3.E1 murine calvarial preosteoblastic cells.Seo SW, Lee D, Cho SK, Kim AD, Minematsu H, Celil Aydemir AB, Geller JA, Macaulay W, Yang J, Lee FY. ERK signaling regulates macrophage colony-stimulating factor expression induced by titanium particles in MC3T3.E1 murine calvarial preosteoblastic cells. Annals Of The New York Academy Of Sciences 2007, 1117:151-8.
• The effect of limb length discrepancy on health-related quality of life: is the '2 cm rule' appropriate?Vitale MA, Choe JC, Sesko AM, Hyman JE, Lee FY, Roye DP, Vitale MG. The effect of limb length discrepancy on health-related quality of life: is the '2 cm rule' appropriate? Journal Of Pediatric Orthopedics. Part B 2006, 15:1-5.
• Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five cases.Lee FY, Sinicropi SM, Lee FS, Vitale MG, Roye DP, Choi IH. Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7). A report of five cases. The Journal Of Bone And Joint Surgery. American Volume 2006, 88:627-33.
• Mechanical loading differentially regulates membrane-bound and soluble RANKL availability in MC3T3-E1 cells.Kim DW, Lee HJ, Karmin JA, Lee SE, Chang SS, Tolchin B, Lin S, Cho SK, Kwon A, Ahn JM, Lee FY. Mechanical loading differentially regulates membrane-bound and soluble RANKL availability in MC3T3-E1 cells. Annals Of The New York Academy Of Sciences 2006, 1068:568-72.
• Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2005, 23:203-9.
• The molecular pathophysiology of subacromial bursitis in rotator cuff disease.Blaine TA, Kim YS, Voloshin I, Chen D, Murakami K, Chang SS, Winchester R, Lee FY, O'keefe RJ, Bigliani LU. The molecular pathophysiology of subacromial bursitis in rotator cuff disease. Journal Of Shoulder And Elbow Surgery / American Shoulder And Elbow Surgeons ... [et Al.] 2005, 14:84S-89S.
• Zoledronate induces apoptosis in cells from fibro-cellular membrane of unicameral bone cyst (UBC).Yu J, Chang SS, Suratwala S, Chung WS, Abdelmessieh P, Lee HJ, Yang J, Lee FY. Zoledronate induces apoptosis in cells from fibro-cellular membrane of unicameral bone cyst (UBC). Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2005, 23:1004-12.
• mu-Calpain regulates receptor activator of NF-kappaB ligand (RANKL)-supported osteoclastogenesis via NF-kappaB activation in RAW 264.7 cells.Lee FY, Kim DW, Karmin JA, Hong D, Chang SS, Fujisawa M, Takayanagi H, Bigliani LU, Blaine TA, Lee HJ. mu-Calpain regulates receptor activator of NF-kappaB ligand (RANKL)-supported osteoclastogenesis via NF-kappaB activation in RAW 264.7 cells. The Journal Of Biological Chemistry 2005, 280:29929-36.
• Correction of adolescent idiopathic scoliosis using thoracic pedicle screw fixation versus hook constructs.Storer SK, Vitale MG, Hyman JE, Lee FY, Choe JC, Roye DP. Correction of adolescent idiopathic scoliosis using thoracic pedicle screw fixation versus hook constructs. Journal Of Pediatric Orthopedics 2005, 25:415-9.
• Patient-based outcomes following clubfoot surgery: a 16-year follow-up study.Vitale MG, Choe JC, Vitale MA, Lee FY, Hyman JE, Roye DP. Patient-based outcomes following clubfoot surgery: a 16-year follow-up study. Journal Of Pediatric Orthopedics 2005, 25:533-8.
• Operative lengthening of the humerus: indications, benefits, and complications.Lee FY, Schoeb JS, Yu J, Christiansen BD, Dick HM. Operative lengthening of the humerus: indications, benefits, and complications. Journal Of Pediatric Orthopedics 2005, 25:613-6.
• Assessment of health status in patients with cerebral palsy: what is the role of quality-of-life measures?Vitale MG, Roye EA, Choe JC, Hyman JE, Lee FY, Roye DP. Assessment of health status in patients with cerebral palsy: what is the role of quality-of-life measures? Journal Of Pediatric Orthopedics 2005, 25:792-7.
• Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis.Yoon AJ, Parisien M, Feldman F, Young-In Lee F. Extranodal Rosai-Dorfman disease of bone, subcutaneous tissue and paranasal sinus mucosa with a review of its pathogenesis. Skeletal Radiology 2005, 34:653-7.
• Orthopaedic manifestations of Brachmann-de Lange syndrome: a report of 34 patients.Roposch A, Bhaskar AR, Lee F, Adedapo S, Mousny M, Alman BA. Orthopaedic manifestations of Brachmann-de Lange syndrome: a report of 34 patients. Journal Of Pediatric Orthopedics. Part B 2004, 13:118-22.
• Effect of bracing on the quality of life of adolescents with idiopathic scoliosis.Ugwonali OF, Lomas G, Choe JC, Hyman JE, Lee FY, Vitale MG, Roye DP. Effect of bracing on the quality of life of adolescents with idiopathic scoliosis. The Spine Journal : Official Journal Of The North American Spine Society 2004, 4:254-60.
• Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis.Chang SS, Suratwala SJ, Jung KM, Doppelt JD, Zhang HZ, Blaine TA, Kim TW, Winchester RJ, Lee FY. Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. Clinical Orthopaedics And Related Research 2004, 103-9.
• Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone.Lee FY, Yu J, Chang SS, Fawwaz R, Parisien MV. Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. The Journal Of Bone And Joint Surgery. American Volume 2004, 86:2677-85.
• Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP).Delloye C, Suratwala SJ, Cornu O, Lee FY. Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP). Acta Orthopaedica Belgica 2004, 70:591-7.
• Synovial chondromatosis of the foot.Young-In Lee F, Hornicek FJ, Dick HM, Mankin HJ. Synovial chondromatosis of the foot. Clinical Orthopaedics And Related Research 2004, 186-90.
• In situ pinning of hip for stable slipped capital femoral epiphysis on a radiolucent operating table.Lee FY, Chapman CB. In situ pinning of hip for stable slipped capital femoral epiphysis on a radiolucent operating table. Journal Of Pediatric Orthopedics 2003, 23:27-9.
• Use of ketorolac tromethamine in children undergoing scoliosis surgery. an analysis of complications.Vitale MG, Choe JC, Hwang MW, Bauer RM, Hyman JE, Lee FY, Roye DP. Use of ketorolac tromethamine in children undergoing scoliosis surgery. an analysis of complications. The Spine Journal : Official Journal Of The North American Spine Society 2003, 3:55-62.
• Novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis.Lee FY, Zawadsky M, Parisien M, Ho M, Murty VV, Jayaraman T, Dick HM. Novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis. Cancer Genetics And Cytogenetics 2002, 132:68-70.
• Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correction.Osgood GM, Lee FY, Parisien MV, Ruzal-Shapiro C. Magnetic resonance imaging depiction of tight iliotibial band in melorheostosis associated with severe external rotation deformity, limb shortening and patellar dislocation in planning surgical correction. Skeletal Radiology 2002, 31:49-52.
• Repair of bone allograft fracture using bone morphogenetic protein-2.Lee FY, Storer S, Hazan EJ, Gebhardt MC, Mankin HJ. Repair of bone allograft fracture using bone morphogenetic protein-2. Clinical Orthopaedics And Related Research 2002, 119-26.
• Intra-articular lipoma with osteochondroid metaplasia in the knee joint.Lee F, Keel SB, Gebhardt MC, Rosenthal DI. Intra-articular lipoma with osteochondroid metaplasia in the knee joint. Skeletal Radiology 2001, 30:230-3.
• Coronal split fracture of the proximal tibia epiphysis through a partially closed physis: a new fracture pattern.Patari SK, Lee FY, Behrens FF. Coronal split fracture of the proximal tibia epiphysis through a partially closed physis: a new fracture pattern. Journal Of Pediatric Orthopedics 2001, 21:451-5.
• An all-arthroscopic soft-tissue balancing technique for lateral patellar instability.Ahmad CS, Lee FY. An all-arthroscopic soft-tissue balancing technique for lateral patellar instability. Arthroscopy : The Journal Of Arthroscopic & Related Surgery : Official Publication Of The Arthroscopy Association Of North America And The International Arthroscopy Association 2001, 17:555-7.
• Experimental model for allograft incorporation and allograft fracture repair.Lee FY, Hazan EJ, Gebhardt MC, Mankin HJ. Experimental model for allograft incorporation and allograft fracture repair. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2000, 18:303-6.
• Chondroblastoma of bone.Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ. Chondroblastoma of bone. The Journal Of Bone And Joint Surgery. American Volume 2000, 82:1140-5.
• Chondrosarcoma of bone: an assessment of outcome.Lee FY, Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Rosenberg AE, Jennings LC. Chondrosarcoma of bone: an assessment of outcome. The Journal Of Bone And Joint Surgery. American Volume 1999, 81:326-38.
• Recurrent giant-cell tumor presenting as a soft-tissue mass. A report of four cases.Lee FY, Montgomery M, Hazan EJ, Keel SB, Mankin HJ, Kattapuram S. Recurrent giant-cell tumor presenting as a soft-tissue mass. A report of four cases. The Journal Of Bone And Joint Surgery. American Volume 1999, 81:703-7.
• Reconstruction of the shoulder joint using an acetabular allograft. A report of two cases.Lee FY, Hornicek FJ, Hazan EJ, Kloen P, Wolfe MA, Mankin HJ. Reconstruction of the shoulder joint using an acetabular allograft. A report of two cases. Clinical Orthopaedics And Related Research 1998, 116-21.
• A discrete soft tissue mass in the distal thigh of a 29-year-old man.Lee FY, Gebhardt MC, Keel SB, Rosenthal DI. A discrete soft tissue mass in the distal thigh of a 29-year-old man. Clinical Orthopaedics And Related Research 1998, 247-50, 255-6.
• Programmed removal of chondrocytes during endochondral fracture healing.Lee FY, Choi YW, Behrens FF, DeFouw DO, Einhorn TA. Programmed removal of chondrocytes during endochondral fracture healing. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 1998, 16:144-50.
• Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement.Benevenia J, Lee FY, Buechel F, Parsons JR. Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement. Journal Of Biomedical Materials Research 1998, 43:473-7.
• Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing.Harten RD, Lee FY, Zimmerman MC, Hurowitz E, Arakal R, Behrens FF. Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 1997, 15:570-6.
• Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture.Seong SC, Matsumura T, Lee FY, Whelan MC, Li XQ, Trippel SB. Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture. Experimental Cell Research 1994, 211:238-44.
• Morphologic and biomechanical study of avascular necrosis of the femoral head.Kim YM, Lee SH, Lee FY, Koo KH, Cho KH. Morphologic and biomechanical study of avascular necrosis of the femoral head. Orthopedics 1991, 14:1111-6.
• Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction.Back J, Nguyen MN, Li L, Lee S, Lee I, Chen F, Gillinov L, Chung YH, Alder KD, Kwon HK, Yu KE, Dussik CM, Hao Z, Flores MJ, Kim Y, Ibe IK, Munger AM, Seo SW, Lee FY. Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction. Bone Research 2021, 9:43.