Fengshan Liang, PhD
Research Scientist
Research & Publications
Biography
Research Summary
Investigating the DNA damage repair regulation and its connection to Fanconi anemia (FA) and cancer.
Coauthors
Selected Publications
- The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA exportOlazabal-Herrero A, He B, Kwon Y, Gupta A, Dutta A, Huang Y, Boddu P, Liang Z, Liang F, Teng Y, Lan L, Chen X, Pei H, Pillai M, Sung P, Kupfer G. The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export. Cell Reports 2024, 43: 113610. PMID: 38165804, PMCID: PMC10865995, DOI: 10.1016/j.celrep.2023.113610.
- Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongationTakasugi T, Gu P, Liang F, Staco I, Chang S. Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation. Nucleic Acids Research 2023, 51: 9227-9247. PMID: 37560909, PMCID: PMC10516629, DOI: 10.1093/nar/gkad648.
- Abstract 6100: The Fanconi Anemia pathway protein complex FANCI/FANCD2 couples the DNA damage response to R-loop regulation through SRSF1-mediated mRNA exportOlazabal-Herrero A, Liang F, Dutta A, Huang Y, Liang Z, Gupta A, Teng Y, Lan L, Chen X, Pei H, Pillai M, Sung P, Kupfer G. Abstract 6100: The Fanconi Anemia pathway protein complex FANCI/FANCD2 couples the DNA damage response to R-loop regulation through SRSF1-mediated mRNA export. Cancer Research 2023, 83: 6100-6100. DOI: 10.1158/1538-7445.am2023-6100.
- Complex Formation between FANCD2 and the Splicing Factor SRSF1 Helps Prevent R-Loop Accumulation through mRNA Export RegulationHerrero A, Liang F, Dutta A, Huang Y, Liang Z, Gupta A, Lan L, Pillai M, Sung P, Kupfer G. Complex Formation between FANCD2 and the Splicing Factor SRSF1 Helps Prevent R-Loop Accumulation through mRNA Export Regulation. Blood 2022, 140: 5828-5829. DOI: 10.1182/blood-2022-166798.
- Fanci-FANCD2 Promotes Genome Stability and DNA Repair By Down-Regulating BLM Helicase ActivityLiang F, Nagarajan A, Pillai M, Sung P, Kupfer G. Fanci-FANCD2 Promotes Genome Stability and DNA Repair By Down-Regulating BLM Helicase Activity. Blood 2021, 138: 1113. DOI: 10.1182/blood-2021-152218.
- The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repairLiang F, Miller AS, Tang C, Maranon D, Williamson EA, Hromas R, Wiese C, Zhao W, Sung P, Kupfer GM. The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair. Journal Of Biological Chemistry 2020, 295: 8186-8194. PMID: 32350107, PMCID: PMC7294083, DOI: 10.1074/jbc.ra120.013714.
- UAF1 DNA Binding Activity Is Critical for RAD51-Mediated Homologous DNA PairingLiang F, Miller A, Tang C, Sung P, Kupfer G. UAF1 DNA Binding Activity Is Critical for RAD51-Mediated Homologous DNA Pairing. Blood 2019, 134: 2497. DOI: 10.1182/blood-2019-130435.
- Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell deathJiang H, Xue X, Panda S, Kawale A, Hooy RM, Liang F, Sohn J, Sung P, Gekara NO. Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. The EMBO Journal 2019, 38: e102718. PMID: 31544964, PMCID: PMC6826206, DOI: 10.15252/embj.2019102718.
- DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage responseLiang F, Miller AS, Longerich S, Tang C, Maranon D, Williamson EA, Hromas R, Wiese C, Kupfer GM, Sung P. DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response. Nature Communications 2019, 10: 2849. PMID: 31253762, PMCID: PMC6599204, DOI: 10.1038/s41467-019-10408-5.
- Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 MonoubiquitinationLiang Z, Liang F, Teng Y, Chen X, Liu J, Longerich S, Rao T, Green AM, Collins NB, Xiong Y, Lan L, Sung P, Kupfer GM. Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination. Cell Reports 2019, 26: 564-572.e5. PMID: 30650351, PMCID: PMC6350941, DOI: 10.1016/j.celrep.2018.12.084.
- BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairingZhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P. BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing. Nature 2017, 550: 360-365. PMID: 28976962, PMCID: PMC5800781, DOI: 10.1038/nature24060.
- The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome MaintenanceLiang F, Longerich S, Tang C, Buzovestsky O, Xiong Y, Maranon D, Wiese C, Miller A, Sung P, Kupfer G. The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance. Blood 2016, 128: 1041. DOI: 10.1182/blood.v128.22.1041.1041.
- Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin.Chuang KH, Liang F, Higgins R, Wang Y. Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin. Molecular Biology Of The Cell 2016, 27: 2025-36. PMID: 27170182, PMCID: PMC4927277, DOI: 10.1091/mbc.E16-01-0026.
- Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 ComplexLiang F, Longerich S, Miller AS, Tang C, Buzovetsky O, Xiong Y, Maranon DG, Wiese C, Kupfer GM, Sung P. Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. Cell Reports 2016, 15: 2118-2126. PMID: 27239033, PMCID: PMC5381662, DOI: 10.1016/j.celrep.2016.05.007.
- NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stabilityParplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG, Leung SG, Grundt K, Dray E, Idate R, Østvold AC, Schild D, Sung P, Wiese C. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Research 2015, 43: 9817-9834. PMID: 26323318, PMCID: PMC4787752, DOI: 10.1093/nar/gkv859.
- 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y. 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes. Journal Of Cell Science 2013, 126: 4173-86. PMID: 23843611, PMCID: PMC3772389, DOI: 10.1242/jcs.126102.
- Slk19 clusters kinetochores and facilitates chromosome bipolar attachment.Richmond D, Rizkallah R, Liang F, Hurt MM, Wang Y. Slk19 clusters kinetochores and facilitates chromosome bipolar attachment. Molecular Biology Of The Cell 2013, 24: 566-77. PMID: 23283988, PMCID: PMC3583661, DOI: 10.1091/mbc.E12-07-0552.
- Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs.Liang F, Richmond D, Wang Y. Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs. PLoS Genetics 2013, 9: e1003319. PMID: 23468650, PMCID: PMC3584997, DOI: 10.1371/journal.pgen.1003319.
- The Cik1/Kar3 motor complex is required for the proper kinetochore-microtubule interaction after stressful DNA replication.Liu H, Jin F, Liang F, Tian X, Wang Y. The Cik1/Kar3 motor complex is required for the proper kinetochore-microtubule interaction after stressful DNA replication. Genetics 2011, 187: 397-407. PMID: 21135072, PMCID: PMC3030485, DOI: 10.1534/genetics.110.125468.
- The molecular function of the yeast polo-like kinase Cdc5 in Cdc14 release during early anaphase.Liang F, Jin F, Liu H, Wang Y. The molecular function of the yeast polo-like kinase Cdc5 in Cdc14 release during early anaphase. Molecular Biology Of The Cell 2009, 20: 3671-9. PMID: 19570916, PMCID: PMC2777927, DOI: 10.1091/mbc.e08-10-1049.
- The coordination of centromere replication, spindle formation, and kinetochore-microtubule interaction in budding yeast.Liu H, Liang F, Jin F, Wang Y. The coordination of centromere replication, spindle formation, and kinetochore-microtubule interaction in budding yeast. PLoS Genetics 2008, 4: e1000262. PMID: 19023403, PMCID: PMC2577889, DOI: 10.1371/journal.pgen.1000262.
- Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.Jin F, Liu H, Liang F, Rizkallah R, Hurt MM, Wang Y. Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 16177-82. PMID: 18845678, PMCID: PMC2570984, DOI: 10.1073/pnas.0808719105.
- DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast.Li Y, Liang F, Jiang W, Yu F, Cao R, Ma Q, Dai X, Jiang J, Wang Y, Si S. DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biology & Therapy 2007, 6: 1193-9. PMID: 17622795.
- DNA damage checkpoints inhibit mitotic exit by two different mechanisms.Liang F, Wang Y. DNA damage checkpoints inhibit mitotic exit by two different mechanisms. Molecular And Cellular Biology 2007, 27: 5067-78. PMID: 17485442, PMCID: PMC1951953, DOI: 10.1128/MCB.00095-07.