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Emanuela Bruscia, PhD

Associate Professor of Pediatrics (Respiratory)

Contact Information

Emanuela Bruscia, PhD

Mailing Address

  • Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine

    PO Box 208064

    New Haven, CT, 06520-8064

    United States

Research Summary

Our research aims to understand how CFTR--the gene that, when mutated, causes Cystic Fibrosis (CF)--affects innate immunity and how this will impact the progression of CF lung disease. We have performed pioneering studies demonstrating that CFTR expression is necessary for the normal function of an important player of the innate immune response: macrophages. Using in vitro and in vivo models, we are dissecting the molecular mechanisms by which CFTR affects these cells.

Specialized Terms: Cystic Fibrosis; Lung inflammation; Macrophages

Coauthors

Research Interests

Cystic Fibrosis; Lung; Macrophages; Pediatrics; Respiration Disorders; Cystic Fibrosis Transmembrane Conductance Regulator

Selected Publications