Elsio Wunder Jr

• Albert C Shaw
• Albert Ko
• Brett Lindenbach
• Craig B. Wilen
• David A. Hafler
• Jamie Childs
• Kimberley Gibson
• Lauren Pischel
• Mariam O. Fofana
• Onyema Ogbuagu
• Peiwen Lu
• Ruth R Montgomery
• Steven Kleinstein
• Wade Schulz

Leptospira; Leptospirosis; Vaccines, Attenuated; Host-Pathogen Interactions; Translational Research, Biomedical

Disease Transmission; Global Health; Infectious Diseases; Zoonotic Diseases

• Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study.Quintero-Vélez J, Rodas J, Rojas C, Ko A, Wunder E. Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study. American Journal Of Tropical Medicine And Hygiene 2022, 107: 1267-1277. PMID: 36375452, PMCID: PMC9768283, DOI: 10.4269/ajtmh.21-1103.
• Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagellaHolzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, d’Andon M, Bortolussi S, Fiette L, Goarant C, Wunder E, Picardeau M, Ko A, Werling D, Matsui M, Boneca I, Werts C. Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella Frontiers In Immunology 2022, 13: 932151. PMCID: PMC9682272, DOI: 10.3389/fimmu.2022.932151.
• Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagellaHolzapfel M, Bonhomme D, Cagliero J, Vernel-Pauillac F, d’Andon M, Bortolussi S, Fiette L, Goarant C, Wunder E, Picardeau M, Ko A, Werling D, Matsui M, Boneca I, Werts C. Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella Frontiers In Immunology 2022, 13: 932151. PMID: 36439189, PMCID: PMC9682272, DOI: 10.3389/fimmu.2022.932151.
• Rickettsial Infections Causing Acute Febrile Illness in Urban Slums, Brazil - Volume 28, Number 10—October 2022 - Emerging Infectious Diseases journal - CDCFournier JB, Blanton LS, Nery N, Wunder EA, Costa F, Reis MG, Ribeiro GS, Walker DH, Ko AI. Rickettsial Infections Causing Acute Febrile Illness in Urban Slums, Brazil - Volume 28, Number 10—October 2022 - Emerging Infectious Diseases journal - CDC Emerging Infectious Diseases 2022, 28: 2132-2134. PMID: 36148970, PMCID: PMC9514363, DOI: 10.3201/eid2810.220497.
• Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in BrazilEyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.
• Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional surveyFofana MO, Nery N, Ticona J, de Andrade Belitardo EMM, Victoriano R, Anjos RO, Portilho MM, de Santana MC, dos Santos LL, de Oliveira D, Cruz JS, Muenker MC, Khouri R, Wunder EA, Hitchings MDT, Johnson O, Reis MG, Ribeiro GS, Cummings DAT, Costa F, Ko AI. Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey PLOS Medicine 2022, 19: e1004093. PMID: 36074784, PMCID: PMC9499230, DOI: 10.1371/journal.pmed.1004093.
• Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC studyOzonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, Ozonoff A, Schaenman J, Jayavelu N, Milliren C, Calfee C, Cairns C, Kraft M, Baden L, Shaw A, Krammer F, van Bakel H, Esserman D, Liu S, Sesma A, Simon V, Hafler D, Montgomery R, Kleinstein S, Levy O, Bime C, Haddad E, Erle D, Pulendran B, Nadeau K, Davis M, Hough C, Messer W, Higuita N, Metcalf J, Atkinson M, Brakenridge S, Corry D, Kheradmand F, Ehrlich L, Melamed E, McComsey G, Sekaly R, Diray-Arce J, Peters B, Augustine A, Reed E, McEnaney K, Barton B, Lentucci C, Saluvan M, Chang A, Hoch A, Albert M, Shaheen T, Kho A, Thomas S, Chen J, Murphy M, Cooney M, Presnell S, Fragiadakis G, Patel R, Guan L, Gygi J, Pawar S, Brito A, Khalil Z, Maguire C, Fourati S, Overton J, Vita R, Westendorf K, Salehi-Rad R, Leligdowicz A, Matthay M, Singer J, Kangelaris K, Hendrickson C, Krummel M, Langelier C, Woodruff P, Powell D, Kim J, Simmons B, Goonewardene I, Smith C, Martens M, Mosier J, Kimura H, Sherman A, Walsh S, Issa N, Dela Cruz C, Farhadian S, Iwasaki A, Ko A, Chinthrajah S, Ahuja N, Rogers A, Artandi M, Siegel S, Lu Z, Drevets D, Brown B, Anderson M, Guirgis F, Thyagarajan R, Rousseau J, Wylie D, Busch J, Gandhi S, Triplett T, Yendewa G, Giddings O, Anderson E, Mehta A, Sevransky J, Khor B, Rahman A, Stadlbauer D, Dutta J, Xie H, Kim-Schulze S, Gonzalez-Reiche A, van de Guchte A, Farrugia K, Khan Z, Maecker H, Elashoff D, Brook J, Ramires-Sanchez E, Llamas M, Rivera A, Perdomo C, Ward D, Magyar C, Fulcher J, Abe-Jones Y, Asthana S, Beagle A, Bhide S, Carrillo S, Chak S, Fragiadakis G, Ghale R, Gonzalez A, Jauregui A, Jones N, Lea T, Lee D, Lota R, Milush J, Nguyen V, Pierce L, Prasad P, Rao A, Samad B, Shaw C, Sigman A, Sinha P, Ward A, Willmore A, Zhan J, Rashid S, Rodriguez N, Tang K, Altamirano L, Betancourt L, Curiel C, Sutter N, Paz M, Tietje-Ulrich G, Leroux C, Connors J, Bernui M, Kutzler M, Edwards C, Lee E, Lin E, Croen B, Semenza N, Rogowski B, Melnyk N, Woloszczuk K, Cusimano G, Bell M, Furukawa S, McLin R, Marrero P, Sheidy J, Tegos G, Nagle C, Mege N, Ulring K, Seyfert-Margolis V, Conway M, Francisco D, Molzahn A, Erickson H, Wilson C, Schunk R, Sierra B, Hughes T, Smolen K, Desjardins M, van Haren S, Mitre X, Cauley J, Li X, Tong A, Evans B, Montesano C, Licona J, Krauss J, Chang J, Izaguirre N, Chaudhary O, Coppi A, Fournier J, Mohanty S, Muenker M, Nelson A, Raddassi K, Rainone M, Ruff W, Salahuddin S, Schulz W, Vijayakumar P, Wang H, Wunder E, Young H, Zhao Y, Saksena M, Altman D, Kojic E, Srivastava K, Eaker L, Bermúdez-González M, Beach K, Sominsky L, Azad A, Carreño J, Singh G, Raskin A, Tcheou J, Bielak D, Kawabata H, Mulder L, Kleiner G, Lee A, E, Fernandes A, Manohar M, Hagan T, Blish C, Din H, Roque J, Yang S, Brunton A, Sullivan P, Strnad M, Lyski Z, Coulter F, Booth J, Sinko L, Moldawer L, Borresen B, Roth-Manning B, Song L, Nelson E, Lewis-Smith M, Smith J, Tipan P, Siles N, Bazzi S, Geltman J, Hurley K, Gabriele G, Sieg S, Vaysman T, Bristow L, Hussaini L, Hellmeister K, Samaha H, Cheng A, Spainhour C, Scherer E, Johnson B, Bechnak A, Ciric C, Hewitt L, Carter E, Mcnair N, Panganiban B, Huerta C, Usher J, Ribeiro S, Altman M, Becker P, Rouphael N. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study EBioMedicine 2022, 83: 104208. PMID: 35952496, PMCID: PMC9359694, DOI: 10.1016/j.ebiom.2022.104208.
• Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, BrazilCruz J, Nery N, Sacramento G, Victoriano R, Montenegro A, Santana J, Costa F, Ko A, Reis M, Wunder E. Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil Frontiers In Medicine 2022, 9: 862378. PMID: 35492362, PMCID: PMC9048256, DOI: 10.3389/fmed.2022.862378.
• Rainfall and other meteorological factors as drivers of urban transmission of leptospirosisCunha M, Costa F, Ribeiro GS, Carvalho MS, Reis RB, Nery N, Pischel L, Gouveia EL, Santos AC, Queiroz A, Wunder EA, Reis MG, Diggle PJ, Ko AI. Rainfall and other meteorological factors as drivers of urban transmission of leptospirosis PLOS Neglected Tropical Diseases 2022, 16: e0007507. PMID: 35404948, PMCID: PMC9022820, DOI: 10.1371/journal.pntd.0007507.
• De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case reportGandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.
• Structural factors contributing to SARS-CoV-2 infection risk in the urban slum setting.Fofana MO, Nery N, Aguilar Ticona JP, Belitardo EMMA, Victoriano R, Anjos RO, Portilho MM, de Santana MC, Dos Santos LL, de Oliveira D, Cruz JS, Muencker MC, Khouri R, Wunder EA, Hitchings MDT, Johnson O, Reis MG, Ribeiro GS, Cummings DAT, Costa F, Ko AI. Structural factors contributing to SARS-CoV-2 infection risk in the urban slum setting. MedRxiv : The Preprint Server For Health Sciences 2022 PMID: 35194620, PMCID: PMC8863166, DOI: 10.1101/2022.02.13.22270856.
• De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report.Gandhi S, Klein J, Robertson A, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SA, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 34909781, PMCID: PMC8669848, DOI: 10.1101/2021.11.08.21266069.
• Sero-prevalence of anti-Leptospira antibodies and associated risk factors in rural Rwanda: A cross-sectional studyNtabanganyimana E, Giraneza R, Dusabejambo V, Bizimana A, Hamond C, Iyamuremye A, Nshizirungu P, Uzabakiriho R, Munyengabe M, Wunder EA, Page C. Sero-prevalence of anti-Leptospira antibodies and associated risk factors in rural Rwanda: A cross-sectional study PLOS Neglected Tropical Diseases 2021, 15: e0009708. PMID: 34874936, PMCID: PMC8683035, DOI: 10.1371/journal.pntd.0009708.
• High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19Haynes WA, Kamath K, Bozekowski J, Baum-Jones E, Campbell M, Casanovas-Massana A, Daugherty PS, Dela Cruz CS, Dhal A, Farhadian SF, Fitzgibbons L, Fournier J, Jhatro M, Jordan G, Klein J, Lucas C, Kessler D, Luchsinger LL, Martinez B, Catherine Muenker M, Pischel L, Reifert J, Sawyer JR, Waitz R, Wunder EA, Zhang M, Iwasaki A, Ko A, Shon J. High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19 Communications Biology 2021, 4: 1317. PMID: 34811480, PMCID: PMC8608966, DOI: 10.1038/s42003-021-02835-2.
• Effect of Sewerage on the Contamination of Soil with Pathogenic Leptospira in Urban SlumsCasanovas-Massana A, Souza F, Curry M, de Oliveira D, de Oliveira AS, Eyre MT, Santiago D, Santos M, Serra RMR, Lopes E, Xavier BI, Diggle PJ, Wunder EA, Reis MG, Ko AI, Costa F. Effect of Sewerage on the Contamination of Soil with Pathogenic Leptospira in Urban Slums Environmental Science And Technology 2021, 55: 15882-15890. PMID: 34767339, PMCID: PMC9302045, DOI: 10.1021/acs.est.1c04916.
• Heterogeneous development of children with Congenital Zika Syndrome-associated microcephalyTicona J, Nery N, Doss-Gollin S, Gambrah C, Lessa M, Rastely-Júnior V, Matos A, de Paula Freitas B, Borja A, Wunder EA, Ballalai V, Vieira C, Cruz JS, de Oliveira D, Araujo DB, Oliveira DB, Maeda D, Mendes EA, Soares C, Durigon EL, de Souza Ferreira LC, Belfort R, Almeida A, Oliveira-Filho J, Reis MG, Ko AI, Costa F. Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly PLOS ONE 2021, 16: e0256444. PMID: 34525107, PMCID: PMC8443077, DOI: 10.1371/journal.pone.0256444.
• An asymmetric structure of the filament is key to inducing flagellar curvature and enabling motility in the Leptospira spirocheteSan Martin F, San Martin F, Gibson K, Trajtenberg F, Trajtenberg F, Brady M, Brady M, Wunder E, Picardeau M, Picardeau M, Mechaly A, Mechaly A, Ko A, Sindelar C, Buschiazzo A, Buschiazzo A. An asymmetric structure of the filament is key to inducing flagellar curvature and enabling motility in the Leptospira spirochete Acta Crystallographica Section A: Foundations And Advances 2021, 77: c291-c291. DOI: 10.1107/s0108767321093910.
• Social determinants associated with Zika virus infection in pregnant womenNery N, Ticona J, Gambrah C, Doss-Gollin S, Aromolaran A, Rastely-Júnior V, Lessa M, Sacramento GA, Cruz JS, de Oliveira D, dos Santos LL, da Silva CG, Botosso VF, Soares CP, Araujo DB, Oliveira DB, dos Santos Alves RP, Andreata-Santos R, Durigon EL, de Souza Ferreira LC, Wunder EA, Khouri R, Oliveira-Filho J, de Siqueira IC, Almeida ARP, Reis MG, Ko AI, Costa F. Social determinants associated with Zika virus infection in pregnant women PLOS Neglected Tropical Diseases 2021, 15: e0009612. PMID: 34329305, PMCID: PMC8323902, DOI: 10.1371/journal.pntd.0009612.
• Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis.Casanovas-Massana A, de Oliveira D, Schneider AG, Begon M, Childs JE, Costa F, Reis MG, Ko AI, Wunder EA. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal Of Infectious Diseases 2021, 225: 130-134. PMID: 34139761, PMCID: PMC8730487, DOI: 10.1093/infdis/jiab323.
• Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort studyTicona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.
• A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genusWunder EA, Adhikarla H, Hamond C, Bonner K, Liang L, Rodrigues CB, Bisht V, Nally JE, Alt DP, Reis MG, Diggle PJ, Felgner PL, Ko A. A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus ELife 2021, 10: e64166. PMID: 33496263, PMCID: PMC7837694, DOI: 10.7554/elife.64166.
• Spatial and Simultaneous Seroprevalence of Anti-Leptospira Antibodies in Owners and Their Domiciled Dogs in a Major City of Southern Brazildo Nascimento Benitez A, Monica T, Miura A, Romanelli M, Giordano L, Freire R, Mitsuka-Breganó R, Martins C, Biondo A, Serrano I, Lopes T, Reis R, Gomes J, Costa F, Wunder E, Ko A, Navarro I. Spatial and Simultaneous Seroprevalence of Anti-Leptospira Antibodies in Owners and Their Domiciled Dogs in a Major City of Southern Brazil Frontiers In Veterinary Science 2021, 7: 580400. PMID: 33490126, PMCID: PMC7820180, DOI: 10.3389/fvets.2020.580400.
• Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents.Aguilar Ticona JP, Baig H, Nery N, Doss-Gollin S, Sacramento GA, Adhikarla H, Muenker MC, Wunder EA, Nascimento EJM, Marques ETA, Reis MG, Ko AI, Costa F. Risk of Sexually Transmitted Zika Virus in a Cohort of Economically Disadvantaged Urban Residents. The Journal Of Infectious Diseases 2021, 224: 860-864. PMID: 33395487, PMCID: PMC8522079, DOI: 10.1093/infdis/jiab001.
• Inactivation of the antimicrobial peptide LL-37 by pathogenic LeptospiraOliveira PN, Courrol DS, Chura-Chambi RM, Morganti L, Souza GO, Franzolin MR, Wunder EA, Heinemann MB, Barbosa AS. Inactivation of the antimicrobial peptide LL-37 by pathogenic Leptospira Microbial Pathogenesis 2020, 150: 104704. PMID: 33347965, DOI: 10.1016/j.micpath.2020.104704.
• Novel Architecture and Composition of a Bacterial Flagellum in the Spirochete Leptospira biflexaGibson K, Wunder E, Liu J, Liu J, Trajtenberg F, Trajtenberg F, Buschiazzo A, Buschiazzo A, Ko A, Sindelar C. Novel Architecture and Composition of a Bacterial Flagellum in the Spirochete Leptospira biflexa Biophysical Journal 2018, 114: 371a. DOI: 10.1016/j.bpj.2017.11.2056.
• Mastitis with systemic lesions due to Staphylococus aureus subesp. aureus in rabbitsTraverso S, da Cunha L, Fernandes J, Loretti A, Rhoden A, Wunder E, Driemeier D. Mastitis with systemic lesions due to Staphylococus aureus subesp. aureus in rabbits Ciência Rural 2003, 33: 373-376. DOI: 10.1590/s0103-84782003000200031.