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Edward Manning, MD, PhD

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Edward Manning, MD, PhD

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Yale Medicine

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Research Summary

Dr. Manning’s research focuses on the physiology of the pulmonary artery with an emphasis on the effects of aging and hypoxia. He uses a multi-disciplinary functional genetics approach to investigate the structure, function, and transcriptomics of the pulmonary artery in health and disease.

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Selected Publications

  • Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissection.Manning EP, Mishall PL, Weidmann MD, Flax H, Lan S, Erlich M, Burton WB, Olson TR, Downie SA. Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissection. Anatomical Sciences Education 2018, 11: 605-612 PubMed ID: 29603672, PMCID: PMC6165707, DOI: 10.1002/ase.1785.
  • Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures.Manning EP. Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures. Aerospace Medicine And Human Performance 2016, 87: 477-86 PubMed ID: 27099087, PMCID: PMC7092644, DOI: 10.3357/AMHP.4463.2016.
  • PhytobezoarInduced Small Bowel Obstruction in a Young Male with Virgin Abdomen.Manning EP, Vattipallly V, Niazi M, Shah A. PhytobezoarInduced Small Bowel Obstruction in a Young Male with Virgin Abdomen. Journal Of Gastrointestinal & Digestive System 2015, 5 PubMed ID: 29795770, PMCID: PMC5962263, DOI: 10.4172/2161-069X.1000266.
  • Images in emergency medicine. Young woman with epigastric pain and vomiting. Ingestion of 35% hydrogen peroxide.Manning EP, Laskowski LK, Nelson LS, Touger M. Images in emergency medicine. Young woman with epigastric pain and vomiting. Ingestion of 35% hydrogen peroxide. Annals Of Emergency Medicine 2014, 64: 330, 333 PubMed ID: 25149968, PMCID: PMC4203436, DOI: 10.1016/j.annemergmed.2013.12.022.
  • Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT.Manning EP, Tardiff JC, Schwartz SD. Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT. Journal Of Molecular Biology 2012, 421: 54-66 PubMed ID: 22579624, PMCID: PMC3545441, DOI: 10.1016/j.jmb.2012.05.008.
  • Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach.Manning EP, Guinto PJ, Tardiff JC. Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach. The Journal Of Biological Chemistry 2012, 287: 14515-23 PubMed ID: 22334656, PMCID: PMC3340284, DOI: 10.1074/jbc.M111.257436.
  • A model of calcium activation of the cardiac thin filament.Manning EP, Tardiff JC, Schwartz SD. A model of calcium activation of the cardiac thin filament. Biochemistry 2011, 50: 7405-13 PubMed ID: 21797264, PMCID: PMC3165030, DOI: 10.1021/bi200506k.
  • Dehydration in extreme temperatures while conducting stability and support operations in a combat zone.Manning EP, Wilson B. Dehydration in extreme temperatures while conducting stability and support operations in a combat zone. Military Medicine 2007, 172: 972-6 PubMed ID: 17937362, DOI: 10.7205/milmed.172.9.972.
  • Computational Characterization of Mutations in Cardiac Troponin T Known to Cause Familial Hypertrophic Cardiomyopathy.Guinto PJ, Manning EP, Schwartz SD, Tardiff JC. Computational Characterization of Mutations in Cardiac Troponin T Known to Cause Familial Hypertrophic Cardiomyopathy. Journal Of Theoretical & Computational Chemistry 2007, 6: 413 PubMed ID: 26500385, PMCID: PMC4617307, DOI: 10.1142/S0219633607003271.
  • Room Temperature Synthesis of Ferroelectric Barium Titanate Nanoparticles Using Peptide Nanorings as Templates.Nuraje N, Su K, Haboosheh A, Samson J, Manning EP, Yang NL, Matsui H. Room Temperature Synthesis of Ferroelectric Barium Titanate Nanoparticles Using Peptide Nanorings as Templates. Advanced Materials (Deerfield Beach, Fla.) 2006, 18: 807-811 PubMed ID: 31031545, PMCID: PMC6482853, DOI: 10.1002/adma.200501340.
  • A Veteran-Centric Model of Care: Crossing the Cultural Divide.Manning EP. A Veteran-Centric Model of Care: Crossing the Cultural Divide. Annals Of Internal Medicine 2019, 171: 843-844 PubMed ID: 31658471, PMCID: PMC7188555, DOI: 10.7326/M19-1264.
  • Web Exclusive. Annals On Call - Are VA Patients Different?Centor RM, Manning EP. Web Exclusive. Annals On Call - Are VA Patients Different? Annals Of Internal Medicine 2020, 172: OC1 PubMed ID: 32066167, DOI: 10.7326/A19-0024.
  • Is Repeating Direct-Fluorescent Antibody Testing for Influenza Beneficial?Manning EP, Moskowitz CS. Connecticut Medicine 2018; 82:487-488.
  • Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report.Hakim A, Bazan IS, Sanogo ML, Manning EP, Pollak JS, Chupp GL. Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report. BMC Pulmonary Medicine 2019, 19: 34 PubMed ID: 30736787, PMCID: PMC6368789, DOI: 10.1186/s12890-019-0797-7.
  • New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone.Manning EP, Losier A, Emeagwali N, Ryu C, Honiden S. New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1561-1563 PubMed ID: 30822095, PMCID: PMC7051474, DOI: 10.1164/rccm.201809-1700RR.
  • Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis.Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. The European Respiratory Journal 2019, 54 PubMed ID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.
  • Disinfection of Pseudomonas aeruginosa from N95 respirators with ozone: a pilot study.Manning EP, Stephens MD, Dufresne S, Silver B, Gerbarg P, Gerbarg Z, Dela Cruz CS, Sharma L. Disinfection of Pseudomonas aeruginosa from N95 respirators with ozone: a pilot study. BMJ Open Respiratory Research 2021, 8 PubMed ID: 33431507, PMCID: PMC7802653, DOI: 10.1136/bmjresp-2020-000781.
  • Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302 PubMed ID: 34030460, PMCID: PMC8300155, DOI: 10.1161/CIRCULATIONAHA.120.052318.
  • Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data.Manning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253 PubMed ID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.
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