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Eduardo Groisman, PhD

Waldemar Von Zedtwitz Professor of Microbial Pathogenesis

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Eduardo Groisman, PhD

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Groisman Lab

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Research Summary

Molecular Mechanisms of Bacterial Signal Transduction

Summary: Eduardo Groisman is interested in understanding how pathogenic and symbiotic bacteria modulate their gene expression patterns in response to signals detected in host and in abiotic environments, as well as in how bacterial regulatory circuits evolve. Our laboratory investigates the mechanisms by which pathogenic and commensal bacteria modify their gene expression patterns so they can survive and proliferate within host tissues and in abiotic environments. We have focused on the mechanisms utilized by the gastroenteritis- and typhoid fever–causing Salmonella enterica, the bubonic plague agent Yersinia pestis, and the human gut commensal Escherichia coli. Our research program can be divided into three general areas: (1) the signal transduction pathways by which bacteria detect and integrate multiple signals into a cellular response, (2) the molecular mechanisms by which a regulatory protein or signal elicits distinct responses from coregulated targets, and (3) the genetic basis for the phenotypic differences that distinguish closely related bacterial species.

Specialized Terms: Bacterial genetics; Signal transduction; Infectious diseases; Gene regulation; Bacteria-host interactions; Gut commensal bacteria; Microbiome

Extensive Research Description

Our research seeks answers to a fundamental biological question: How does an organism know when, where and for long to turn a gene on or off? We address this question by investigating bacterial species that establish intimate interactions with animal hosts.

All organisms respond to a change in their environment by modifying their behavior. We are interested in identifying the specific signals that denote a given environment, the nature of the sensors that detect such signals, and how the sensors transmit this information to the regulators implementing a response that enables the organism to survive and prosper in the new condition.

We investigate the gastroenteritis- and typhoid fever-causing Salmonella entericaand the gut symbiotic bacteria Escherichia coli and Bacteroides thetaiotaomicron.

We have been examining protein sensors that detect extracellular signals and RNA sensors that monitor cellular metabolites and ions. These investigations led both to the discovery of the first signal transduction systems that sense extracytoplasmic magnesium and ferric iron and to the first mRNAs that respond to cytoplasmic magnesium and ATP.

Our research focuses on understanding:

  • how bacteria integrate multiple signals into a cellular response,
  • the mechanisms by which a given signal elicits distinct responses from co-regulated targets,
  • how bacteria from the gut microbiome compete for resources,
  • the genetic basis for phenotypic differences that distinguish closely related bacterial species, such as a pathogen and a symbiont,
  • the biochemical function of novel proteins and
  • the genetic control of virulence factors.

Coauthors

Research Interests

Ecology; Biological Evolution; Genetics; Signal Transduction; Infectious Disease Medicine; Microbiota

Public Health Interests

Genetics, Genomics, Epigenetics; Infectious Diseases; Microbial Ecology

Selected Publications

  • How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues.Blanc-Potard AB, Groisman EA. How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues. Trends In Microbiology 2021, 29: 98-106. PMID: 32807623, PMCID: PMC7855738, DOI: 10.1016/j.tim.2020.07.003.
  • Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state.Yeom J, Groisman EA. Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state. Science Signaling 2021, 14 PMID: 33500334, PMCID: PMC8378506, DOI: 10.1126/scisignal.abc4235.
  • Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis.Bruna RE, Kendra CG, Groisman EA, Pontes MH. Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118 PMID: 33707210, PMCID: PMC7980370, DOI: 10.1073/pnas.2021370118.
  • Low Cytoplasmic Magnesium Increases the Specificity of the Lon and ClpAP Proteases.Yeom J, Groisman EA. Low Cytoplasmic Magnesium Increases the Specificity of the Lon and ClpAP Proteases. Journal Of Bacteriology 2021, 203: e0014321. PMID: 33941609, PMCID: PMC8223949, DOI: 10.1128/JB.00143-21.
  • How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution.Groisman EA, Duprey A, Choi J. How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution. Microbiology And Molecular Biology Reviews : MMBR 2021, 85: e0017620. PMID: 34191587, PMCID: PMC8483708, DOI: 10.1128/MMBR.00176-20.
  • The Practice of Science as the Pursuit of Knowledge.Groisman EA. The Practice of Science as the Pursuit of Knowledge. The Yale Journal Of Biology And Medicine 2021, 94: 379-380. PMID: 34211357, PMCID: PMC8223544.
  • The regulation of DNA supercoiling across evolution.Duprey A, Groisman EA. The regulation of DNA supercoiling across evolution. Protein Science : A Publication Of The Protein Society 2021, 30: 2042-2056. PMID: 34398513, PMCID: PMC8442966, DOI: 10.1002/pro.4171.
  • A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor.Townsend GE, Han W, Schwalm ND, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor. MBio 2020, 11 PMID: 31992627, PMCID: PMC6989115, DOI: 10.1128/mBio.03221-19.
  • Erratum for Townsend et al., "A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor".Townsend GE, Han W, Schwalm ND, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. Erratum for Townsend et al., "A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor". MBio 2020, 11 PMID: 32184244, PMCID: PMC7078473, DOI: 10.1128/mBio.00301-20.
  • Salmonella expresses foreign genes during infection by degrading their silencer.Choi J, Groisman EA. Salmonella expresses foreign genes during infection by degrading their silencer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 8074-8082. PMID: 32209674, PMCID: PMC7149492, DOI: 10.1073/pnas.1912808117.
  • The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica.Salvail H, Groisman EA. The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica. PLoS Genetics 2020, 16: e1008722. PMID: 32392214, PMCID: PMC7241856, DOI: 10.1371/journal.pgen.1008722.
  • A Physiological Basis for Nonheritable Antibiotic Resistance.Pontes MH, Groisman EA. A Physiological Basis for Nonheritable Antibiotic Resistance. MBio 2020, 11 PMID: 32546621, PMCID: PMC7298711, DOI: 10.1128/mBio.00817-20.
  • FEDS: a Novel Fluorescence-Based High-Throughput Method for Measuring DNA Supercoiling In Vivo.Duprey A, Groisman EA. FEDS: a Novel Fluorescence-Based High-Throughput Method for Measuring DNA Supercoiling In Vivo. MBio 2020, 11 PMID: 32723920, PMCID: PMC7387798, DOI: 10.1128/mBio.01053-20.
  • Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter.Yeom J, Shao Y, Groisman EA. Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20235-20243. PMID: 32753384, PMCID: PMC7443967, DOI: 10.1073/pnas.2006116117.
  • Horizontally acquired regulatory gene activates ancestral regulatory system to promote Salmonella virulence.Choi J, Groisman EA. Horizontally acquired regulatory gene activates ancestral regulatory system to promote Salmonella virulence. Nucleic Acids Research 2020, 48: 10832-10847. PMID: 33045730, PMCID: PMC7641745, DOI: 10.1093/nar/gkaa813.
  • DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.Duprey A, Groisman EA. DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines. PLoS Genetics 2020, 16: e1009085. PMID: 33125364, PMCID: PMC7598504, DOI: 10.1371/journal.pgen.1009085.
  • Dietary sugar silences a colonization factor in a mammalian gut symbiont.Townsend GE, Han W, Schwalm ND, Raghavan V, Barry NA, Goodman AL, Groisman EA. Dietary sugar silences a colonization factor in a mammalian gut symbiont. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 233-238. PMID: 30559205, PMCID: PMC6320540, DOI: 10.1073/pnas.1813780115.
  • Slow growth determines nonheritable antibiotic resistance in Salmonella enterica.Pontes MH, Groisman EA. Slow growth determines nonheritable antibiotic resistance in Salmonella enterica. Science Signaling 2019, 12 PMID: 31363068, PMCID: PMC7206539, DOI: 10.1126/scisignal.aax3938.
  • The expanded specificity and physiological role of a widespread N-degron recognin.Gao X, Yeom J, Groisman EA. The expanded specificity and physiological role of a widespread N-degron recognin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 18629-18637. PMID: 31451664, PMCID: PMC6744884, DOI: 10.1073/pnas.1821060116.
  • Activator of one protease transforms into inhibitor of another in response to nutritional signals.Yeom J, Groisman EA. Activator of one protease transforms into inhibitor of another in response to nutritional signals. Genes & Development 2019, 33: 1280-1292. PMID: 31371438, PMCID: PMC6719616, DOI: 10.1101/gad.325241.119.
  • Protein synthesis controls phosphate homeostasis.Pontes MH, Groisman EA. Protein synthesis controls phosphate homeostasis. Genes & Development 2018, 32: 79-92. PMID: 29437726, PMCID: PMC5828397, DOI: 10.1101/gad.309245.117.
  • Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira.Adhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI. Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira. Frontiers In Cellular And Infection Microbiology 2018, 8: 45. PMID: 29600195, PMCID: PMC5863495, DOI: 10.3389/fcimb.2018.00045.
  • Reduction in adaptor amounts establishes degradation hierarchy among protease substrates.Yeom J, Gao X, Groisman EA. Reduction in adaptor amounts establishes degradation hierarchy among protease substrates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: E4483-E4492. PMID: 29686082, PMCID: PMC5948988, DOI: 10.1073/pnas.1722246115.
  • Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.Hong X, Chen HD, Groisman EA. Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane. Science Signaling 2018, 11 PMID: 29739882, PMCID: PMC5967240, DOI: 10.1126/scisignal.aar7921.
  • A protein that controls the onset of a Salmonella virulence program.Yeom J, Pontes MH, Choi J, Groisman EA. A protein that controls the onset of a Salmonella virulence program. The EMBO Journal 2018, 37 PMID: 29858228, PMCID: PMC6043847, DOI: 10.15252/embj.201796977.
  • Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron.Schwalm ND, Townsend GE, Groisman EA. Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron. Molecular Microbiology 2017, 104: 32-45. PMID: 28009067, DOI: 10.1111/mmi.13609.
  • RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader.Kriner MA, Groisman EA. RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader. Nucleic Acids Research 2017, 45: 631-642. PMID: 28123036, PMCID: PMC5314796, DOI: 10.1093/nar/gkw889.
  • Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.Schwalm ND, Groisman EA. Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp. Trends In Microbiology 2017, 25: 1005-1015. PMID: 28733133, DOI: 10.1016/j.tim.2017.06.009.
  • Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL.Choi J, Groisman EA. Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL. Science Signaling 2017, 10 PMID: 28851823, PMCID: PMC5966036, DOI: 10.1126/scisignal.aan6284.
  • Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.Yeom J, Wayne KJ, Groisman EA. Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate. Molecular Cell 2017, 66: 234-246.e5. PMID: 28431231, PMCID: PMC5424706, DOI: 10.1016/j.molcel.2017.03.009.
  • Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence.Choi J, Groisman EA. Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence. Molecular Microbiology 2016, 101: 1024-38. PMID: 27282333, PMCID: PMC5015592, DOI: 10.1111/mmi.13439.
  • Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron.Schwalm ND, Townsend GE, Groisman EA. Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron. MBio 2016, 7 PMID: 27729509, PMCID: PMC5061871, DOI: 10.1128/mBio.01342-16.
  • Reducing Ribosome Biosynthesis Promotes Translation during Low Mg2+ Stress.Pontes MH, Yeom J, Groisman EA. Reducing Ribosome Biosynthesis Promotes Translation during Low Mg2+ Stress. Molecular Cell 2016, 64: 480-492. PMID: 27746019, PMCID: PMC5500012, DOI: 10.1016/j.molcel.2016.05.008.
  • Feedback Control of Two-Component Regulatory Systems.Groisman EA. Feedback Control of Two-Component Regulatory Systems. Annual Review Of Microbiology 2016, 70: 103-24. PMID: 27607549, PMCID: PMC8380452, DOI: 10.1146/annurev-micro-102215-095331.
  • Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho.Kriner MA, Sevostyanova A, Groisman EA. Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho. Trends In Biochemical Sciences 2016, 41: 690-699. PMID: 27325240, PMCID: PMC4967001, DOI: 10.1016/j.tibs.2016.05.012.
  • When Too Much ATP Is Bad for Protein Synthesis.Pontes MH, Sevostyanova A, Groisman EA. When Too Much ATP Is Bad for Protein Synthesis. Journal Of Molecular Biology 2015, 427: 2586-2594. PMID: 26150063, PMCID: PMC4531837, DOI: 10.1016/j.jmb.2015.06.021.
  • Salmonella promotes virulence by repressing cellulose production.Pontes MH, Lee EJ, Choi J, Groisman EA. Salmonella promotes virulence by repressing cellulose production. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 5183-8. PMID: 25848006, PMCID: PMC4413311, DOI: 10.1073/pnas.1500989112.
  • The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals.Kriner MA, Groisman EA. The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals. Journal Of Molecular Biology 2015, 427: 3834-49. PMID: 26523680, PMCID: PMC4964609, DOI: 10.1016/j.jmb.2015.10.020.
  • An RNA motif advances transcription by preventing Rho-dependent termination.Sevostyanova A, Groisman EA. An RNA motif advances transcription by preventing Rho-dependent termination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: E6835-43. PMID: 26630006, PMCID: PMC4687561, DOI: 10.1073/pnas.1515383112.
  • Flagella-independent surface motility in Salmonella enterica serovar Typhimurium.Park SY, Pontes MH, Groisman EA. Flagella-independent surface motility in Salmonella enterica serovar Typhimurium. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1850-5. PMID: 25624475, PMCID: PMC4330729, DOI: 10.1073/pnas.1422938112.
  • Species-specific dynamic responses of gut bacteria to a mammalian glycan.Raghavan V, Groisman EA. Species-specific dynamic responses of gut bacteria to a mammalian glycan. Journal Of Bacteriology 2015, 197: 1538-48. PMID: 25691527, PMCID: PMC4403648, DOI: 10.1128/JB.00010-15.
  • Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium.Raghavan V, Lowe EC, Townsend GE, Bolam DN, Groisman EA. Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium. Molecular Microbiology 2014, 93: 1010-25. PMID: 25041429, DOI: 10.1111/mmi.12714.
  • Bacterial nucleoid-associated protein uncouples transcription levels from transcription timing.Zwir I, Yeo WS, Shin D, Latifi T, Huang H, Groisman EA. Bacterial nucleoid-associated protein uncouples transcription levels from transcription timing. MBio 2014, 5: e01485-14. PMID: 25293763, PMCID: PMC4196223, DOI: 10.1128/mBio.01485-14.
  • Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system.Park SY, Groisman EA. Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system. Molecular Microbiology 2014, 91: 135-44. PMID: 24256574, PMCID: PMC3890429, DOI: 10.1111/mmi.12449.
  • Control of a Salmonella virulence operon by proline-charged tRNA(Pro).Lee EJ, Choi J, Groisman EA. Control of a Salmonella virulence operon by proline-charged tRNA(Pro). Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 3140-5. PMID: 24516160, PMCID: PMC3939920, DOI: 10.1073/pnas.1316209111.
  • Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator.Hollands K, Sevostiyanova A, Groisman EA. Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: E1999-2007. PMID: 24778260, PMCID: PMC4024889, DOI: 10.1073/pnas.1319193111.
  • The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa.Choi J, Groisman EA. The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 9499-504. PMID: 23690578, PMCID: PMC3677452, DOI: 10.1073/pnas.1303420110.
  • A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase.Lee EJ, Pontes MH, Groisman EA. A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase. Cell 2013, 154: 146-56. PMID: 23827679, PMCID: PMC3736803, DOI: 10.1016/j.cell.2013.06.004.
  • Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.Townsend GE, Raghavan V, Zwir I, Groisman EA. Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: E161-9. PMID: 23256153, PMCID: PMC3545799, DOI: 10.1073/pnas.1212102110.
  • Conflicting roles for a cell surface modification in Salmonella.May JF, Groisman EA. Conflicting roles for a cell surface modification in Salmonella. Molecular Microbiology 2013, 88: 970-83. PMID: 23646936, PMCID: PMC4081025, DOI: 10.1111/mmi.12236.
  • The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications.Chen HD, Groisman EA. The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications. Annual Review Of Microbiology 2013, 67: 83-112. PMID: 23799815, PMCID: PMC8381567, DOI: 10.1146/annurev-micro-092412-155751.
  • Bacterial Mg2+ homeostasis, transport, and virulence.Groisman EA, Hollands K, Kriner MA, Lee EJ, Park SY, Pontes MH. Bacterial Mg2+ homeostasis, transport, and virulence. Annual Review Of Genetics 2013, 47: 625-46. PMID: 24079267, PMCID: PMC4059682, DOI: 10.1146/annurev-genet-051313-051025.
  • Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA.Lee EJ, Groisman EA. Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA. Nature 2012, 486: 271-5. PMID: 22699622, PMCID: PMC3711680, DOI: 10.1038/nature11090.
  • An allele of an ancestral transcription factor dependent on a horizontally acquired gene product.Chen HD, Jewett MW, Groisman EA. An allele of an ancestral transcription factor dependent on a horizontally acquired gene product. PLoS Genetics 2012, 8: e1003060. PMID: 23300460, PMCID: PMC3531487, DOI: 10.1371/journal.pgen.1003060.
  • Tandem attenuators control expression of the Salmonella mgtCBR virulence operon.Lee EJ, Groisman EA. Tandem attenuators control expression of the Salmonella mgtCBR virulence operon. Molecular Microbiology 2012, 86: 212-24. PMID: 22857388, PMCID: PMC3641672, DOI: 10.1111/j.1365-2958.2012.08188.x.
  • Reciprocal control between a bacterium's regulatory system and the modification status of its lipopolysaccharide.Kato A, Chen HD, Latifi T, Groisman EA. Reciprocal control between a bacterium's regulatory system and the modification status of its lipopolysaccharide. Molecular Cell 2012, 47: 897-908. PMID: 22921935, PMCID: PMC3465083, DOI: 10.1016/j.molcel.2012.07.017.
  • Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence.Choi Y, Choi J, Groisman EA, Kang DH, Shin D, Ryu S. Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence. Infection And Immunity 2012, 80: 4291-7. PMID: 23006851, PMCID: PMC3497419, DOI: 10.1128/IAI.00880-12.
  • Intrinsic negative feedback governs activation surge in two-component regulatory systems.Yeo WS, Zwir I, Huang HV, Shin D, Kato A, Groisman EA. Intrinsic negative feedback governs activation surge in two-component regulatory systems. Molecular Cell 2012, 45: 409-21. PMID: 22325356, PMCID: PMC3713471, DOI: 10.1016/j.molcel.2011.12.027.
  • Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.Tang YT, Gao R, Havranek JJ, Groisman EA, Stock AM, Marshall GR. Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator. Chemical Biology & Drug Design 2012, 79: 1007-17. PMID: 22339993, PMCID: PMC3445336, DOI: 10.1111/j.1747-0285.2012.01362.x.
  • Riboswitch control of Rho-dependent transcription termination.Hollands K, Proshkin S, Sklyarova S, Epshtein V, Mironov A, Nudler E, Groisman EA. Riboswitch control of Rho-dependent transcription termination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 5376-81. PMID: 22431636, PMCID: PMC3325659, DOI: 10.1073/pnas.1112211109.
  • The promoter architectural landscape of the Salmonella PhoP regulon.Zwir I, Latifi T, Perez JC, Huang H, Groisman EA. The promoter architectural landscape of the Salmonella PhoP regulon. Molecular Microbiology 2012, 84: 463-85. PMID: 22435712, PMCID: PMC3335776, DOI: 10.1111/j.1365-2958.2012.08036.x.
  • Ancestral genes can control the ability of horizontally acquired loci to confer new traits.Chen HD, Jewett MW, Groisman EA. Ancestral genes can control the ability of horizontally acquired loci to confer new traits. PLoS Genetics 2011, 7: e1002184. PMID: 21811415, PMCID: PMC3140997, DOI: 10.1371/journal.pgen.1002184.
  • Genome-wide detection of novel regulatory RNAs in E. coli.Raghavan R, Groisman EA, Ochman H. Genome-wide detection of novel regulatory RNAs in E. coli. Genome Research 2011, 21: 1487-97. PMID: 21665928, PMCID: PMC3166833, DOI: 10.1101/gr.119370.110.
  • Orphan and hybrid two-component system proteins in health and disease.Raghavan V, Groisman EA. Orphan and hybrid two-component system proteins in health and disease. Current Opinion In Microbiology 2010, 13: 226-31. PMID: 20089442, PMCID: PMC2861427, DOI: 10.1016/j.mib.2009.12.010.
  • An antisense RNA that governs the expression kinetics of a multifunctional virulence gene.Lee EJ, Groisman EA. An antisense RNA that governs the expression kinetics of a multifunctional virulence gene. Molecular Microbiology 2010, 76: 1020-33. PMID: 20398218, PMCID: PMC2909850, DOI: 10.1111/j.1365-2958.2010.07161.x.
  • Positive autoregulation shapes response timing and intensity in two-component signal transduction systems.Mitrophanov AY, Hadley TJ, Groisman EA. Positive autoregulation shapes response timing and intensity in two-component signal transduction systems. Journal Of Molecular Biology 2010, 401: 671-80. PMID: 20600106, PMCID: PMC2942797, DOI: 10.1016/j.jmb.2010.06.051.
  • Defining the plasticity of transcription factor binding sites by Deconstructing DNA consensus sequences: the PhoP-binding sites among gamma/enterobacteria.Harari O, Park SY, Huang H, Groisman EA, Zwir I. Defining the plasticity of transcription factor binding sites by Deconstructing DNA consensus sequences: the PhoP-binding sites among gamma/enterobacteria. PLoS Computational Biology 2010, 6: e1000862. PMID: 20661307, PMCID: PMC2908699, DOI: 10.1371/journal.pcbi.1000862.
  • A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals.Park SY, Cromie MJ, Lee EJ, Groisman EA. A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals. Cell 2010, 142: 737-48. PMID: 20813261, PMCID: PMC2967377, DOI: 10.1016/j.cell.2010.07.046.
  • Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome.Jarvik T, Smillie C, Groisman EA, Ochman H. Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome. Journal Of Bacteriology 2010, 192: 560-7. PMID: 19897643, PMCID: PMC2805332, DOI: 10.1128/JB.01233-09.
  • Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica.Cromie MJ, Groisman EA. Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica. Journal Of Bacteriology 2010, 192: 604-7. PMID: 19897653, PMCID: PMC2805325, DOI: 10.1128/JB.01239-09.
  • Response acceleration in post-translationally regulated genetic circuits.Mitrophanov AY, Groisman EA. Response acceleration in post-translationally regulated genetic circuits. Journal Of Molecular Biology 2010, 396: 1398-409. PMID: 19932119, PMCID: PMC2861412, DOI: 10.1016/j.jmb.2009.11.043.
  • Evolution of transcriptional regulatory circuits in bacteria.Perez JC, Groisman EA. Evolution of transcriptional regulatory circuits in bacteria. Cell 2009, 138: 233-44. PMID: 19632175, PMCID: PMC2726713, DOI: 10.1016/j.cell.2009.07.002.
  • Evolution of a bacterial regulon controlling virulence and Mg(2+) homeostasis.Perez JC, Shin D, Zwir I, Latifi T, Hadley TJ, Groisman EA. Evolution of a bacterial regulon controlling virulence and Mg(2+) homeostasis. PLoS Genetics 2009, 5: e1000428. PMID: 19300486, PMCID: PMC2650801, DOI: 10.1371/journal.pgen.1000428.
  • Identifying promoter features of co-regulated genes with similar network motifs.Harari O, del Val C, Romero-Zaliz R, Shin D, Huang H, Groisman EA, Zwir I. Identifying promoter features of co-regulated genes with similar network motifs. BMC Bioinformatics 2009, 10 Suppl 4: S1. PMID: 19426448, PMCID: PMC2681069, DOI: 10.1186/1471-2105-10-S4-S1.
  • Transcription factor function and promoter architecture govern the evolution of bacterial regulons.Perez JC, Groisman EA. Transcription factor function and promoter architecture govern the evolution of bacterial regulons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 4319-24. PMID: 19251636, PMCID: PMC2649204, DOI: 10.1073/pnas.0810343106.
  • Control of Salmonella pathogenicity island-2 gene expression.Fass E, Groisman EA. Control of Salmonella pathogenicity island-2 gene expression. Current Opinion In Microbiology 2009, 12: 199-204. PMID: 19264535, PMCID: PMC2805070, DOI: 10.1016/j.mib.2009.01.004.
  • Activated by different signals, the PhoP/PhoQ two-component system differentially regulates metal uptake.Choi E, Groisman EA, Shin D. Activated by different signals, the PhoP/PhoQ two-component system differentially regulates metal uptake. Journal Of Bacteriology 2009, 191: 7174-81. PMID: 19801407, PMCID: PMC2786564, DOI: 10.1128/JB.00958-09.
  • Positive feedback in cellular control systems.Mitrophanov AY, Groisman EA. Positive feedback in cellular control systems. BioEssays : News And Reviews In Molecular, Cellular And Developmental Biology 2008, 30: 542-55. PMID: 18478531, PMCID: PMC2486260, DOI: 10.1002/bies.20769.
  • Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria.Mitrophanov AY, Jewett MW, Hadley TJ, Groisman EA. Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria. PLoS Genetics 2008, 4: e1000233. PMID: 18949034, PMCID: PMC2565834, DOI: 10.1371/journal.pgen.1000233.
  • Overcoming H-NS-mediated transcriptional silencing of horizontally acquired genes by the PhoP and SlyA proteins in Salmonella enterica.Perez JC, Latifi T, Groisman EA. Overcoming H-NS-mediated transcriptional silencing of horizontally acquired genes by the PhoP and SlyA proteins in Salmonella enterica. The Journal Of Biological Chemistry 2008, 283: 10773-83. PMID: 18270203, PMCID: PMC2447644, DOI: 10.1074/jbc.M709843200.
  • RstA-promoted expression of the ferrous iron transporter FeoB under iron-replete conditions enhances Fur activity in Salmonella enterica.Jeon J, Kim H, Yun J, Ryu S, Groisman EA, Shin D. RstA-promoted expression of the ferrous iron transporter FeoB under iron-replete conditions enhances Fur activity in Salmonella enterica. Journal Of Bacteriology 2008, 190: 7326-34. PMID: 18790861, PMCID: PMC2576650, DOI: 10.1128/JB.00903-08.
  • The PhoQ/PhoP regulatory network of Salmonella enterica.Kato A, Groisman EA. The PhoQ/PhoP regulatory network of Salmonella enterica. Advances In Experimental Medicine And Biology 2008, 631: 7-21. PMID: 18792679, DOI: 10.1007/978-0-387-78885-2_2.
  • Signal integration in bacterial two-component regulatory systems.Mitrophanov AY, Groisman EA. Signal integration in bacterial two-component regulatory systems. Genes & Development 2008, 22: 2601-11. PMID: 18832064, PMCID: PMC2751022, DOI: 10.1101/gad.1700308.
  • Gene promoter scan methodology for identifying and classifying coregulated promoters.Zwir I, Harari O, Groisman EA. Gene promoter scan methodology for identifying and classifying coregulated promoters. Methods In Enzymology 2007, 422: 361-85. PMID: 17628149, PMCID: PMC3755887, DOI: 10.1016/S0076-6879(06)22018-4.
  • A connector of two-component regulatory systems promotes signal amplification and persistence of expression.Kato A, Mitrophanov AY, Groisman EA. A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 12063-8. PMID: 17615238, PMCID: PMC1924540, DOI: 10.1073/pnas.0704462104.
  • The intricate world of riboswitches.Coppins RL, Hall KB, Groisman EA. The intricate world of riboswitches. Current Opinion In Microbiology 2007, 10: 176-81. PMID: 17383225, PMCID: PMC1894890, DOI: 10.1016/j.mib.2007.03.006.
  • Acid pH activation of the PmrA/PmrB two-component regulatory system of Salmonella enterica.Perez JC, Groisman EA. Acid pH activation of the PmrA/PmrB two-component regulatory system of Salmonella enterica. Molecular Microbiology 2007, 63: 283-93. PMID: 17229213, PMCID: PMC1804205, DOI: 10.1111/j.1365-2958.2006.05512.x.
  • The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica.Tu X, Latifi T, Bougdour A, Gottesman S, Groisman EA. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13503-8. PMID: 16938894, PMCID: PMC1557385, DOI: 10.1073/pnas.0606026103.
  • Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium.Nishino K, Latifi T, Groisman EA. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. Molecular Microbiology 2006, 59: 126-41. PMID: 16359323, DOI: 10.1111/j.1365-2958.2005.04940.x.
  • The PmrA/PmrB and RcsC/YojN/RcsB systems control expression of the Salmonella O-antigen chain length determinant.Delgado MA, Mouslim C, Groisman EA. The PmrA/PmrB and RcsC/YojN/RcsB systems control expression of the Salmonella O-antigen chain length determinant. Molecular Microbiology 2006, 60: 39-50. PMID: 16556219, DOI: 10.1111/j.1365-2958.2006.05069.x.
  • A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit.Shin D, Lee EJ, Huang H, Groisman EA. A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit. Science (New York, N.Y.) 2006, 314: 1607-9. PMID: 17158330, DOI: 10.1126/science.1134930.
  • Identification of the lipopolysaccharide modifications controlled by the Salmonella PmrA/PmrB system mediating resistance to Fe(III) and Al(III).Nishino K, Hsu FF, Turk J, Cromie MJ, Wösten MM, Groisman EA. Identification of the lipopolysaccharide modifications controlled by the Salmonella PmrA/PmrB system mediating resistance to Fe(III) and Al(III). Molecular Microbiology 2006, 61: 645-54. PMID: 16803591, PMCID: PMC1618816, DOI: 10.1111/j.1365-2958.2006.05273.x.
  • Sensing by bacterial regulatory systems in host and non-host environments.Groisman EA, Mouslim C. Sensing by bacterial regulatory systems in host and non-host environments. Nature Reviews. Microbiology 2006, 4: 705-9. PMID: 16894339, DOI: 10.1038/nrmicro1478.
  • An RNA sensor for intracellular Mg(2+).Cromie MJ, Shi Y, Latifi T, Groisman EA. An RNA sensor for intracellular Mg(2+). Cell 2006, 125: 71-84. PMID: 16615891, DOI: 10.1016/j.cell.2006.01.043.
  • Structural characterization of cardiolipin by tandem quadrupole and multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization.Hsu FF, Turk J, Rhoades ER, Russell DG, Shi Y, Groisman EA. Structural characterization of cardiolipin by tandem quadrupole and multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. Journal Of The American Society For Mass Spectrometry 2005, 16: 491-504. PMID: 15792718, DOI: 10.1016/j.jasms.2004.12.015.
  • The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica.Bijlsma JJ, Groisman EA. The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica. Molecular Microbiology 2005, 57: 85-96. PMID: 15948951, DOI: 10.1111/j.1365-2958.2005.04668.x.
  • Analysis of differentially-regulated genes within a regulatory network by GPS genome navigation.Zwir I, Huang H, Groisman EA. Analysis of differentially-regulated genes within a regulatory network by GPS genome navigation. Bioinformatics (Oxford, England) 2005, 21: 4073-83. PMID: 16159917, DOI: 10.1093/bioinformatics/bti672.
  • The origin and evolution of human pathogens.Groisman EA, Casadesús J. The origin and evolution of human pathogens. Molecular Microbiology 2005, 56: 1-7. PMID: 15773974, DOI: 10.1111/j.1365-2958.2005.04564.x.
  • Signal-dependent binding of the response regulators PhoP and PmrA to their target promoters in vivo.Shin D, Groisman EA. Signal-dependent binding of the response regulators PhoP and PmrA to their target promoters in vivo. The Journal Of Biological Chemistry 2005, 280: 4089-94. PMID: 15569664, DOI: 10.1074/jbc.M412741200.
  • Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica.Zwir I, Shin D, Kato A, Nishino K, Latifi T, Solomon F, Hare JM, Huang H, Groisman EA. Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 2862-7. PMID: 15703297, PMCID: PMC548500, DOI: 10.1073/pnas.0408238102.
  • Transcriptional regulation of the 4-amino-4-deoxy-L-arabinose biosynthetic genes in Yersinia pestis.Winfield MD, Latifi T, Groisman EA. Transcriptional regulation of the 4-amino-4-deoxy-L-arabinose biosynthetic genes in Yersinia pestis. The Journal Of Biological Chemistry 2005, 280: 14765-72. PMID: 15710615, DOI: 10.1074/jbc.M413900200.
  • Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor.Kato A, Groisman EA. Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor. Genes & Development 2004, 18: 2302-13. PMID: 15371344, PMCID: PMC517523, DOI: 10.1101/gad.1230804.
  • Activation of the RcsC/YojN/RcsB phosphorelay system attenuates Salmonella virulence.Mouslim C, Delgado M, Groisman EA. Activation of the RcsC/YojN/RcsB phosphorelay system attenuates Salmonella virulence. Molecular Microbiology 2004, 54: 386-95. PMID: 15469511, DOI: 10.1111/j.1365-2958.2004.04293.x.
  • Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes.Winfield MD, Groisman EA. Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17162-7. PMID: 15569938, PMCID: PMC534605, DOI: 10.1073/pnas.0406038101.
  • Characterization of acylphosphatidylglycerols from Salmonella typhimurium by tandem mass spectrometry with electrospray ionization.Hsu FF, Turk J, Shi Y, Groisman EA. Characterization of acylphosphatidylglycerols from Salmonella typhimurium by tandem mass spectrometry with electrospray ionization. Journal Of The American Society For Mass Spectrometry 2004, 15: 1-11. PMID: 14698549, DOI: 10.1016/j.jasms.2003.08.006.
  • The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica.Lee H, Hsu FF, Turk J, Groisman EA. The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica. Journal Of Bacteriology 2004, 186: 4124-33. PMID: 15205413, PMCID: PMC421605, DOI: 10.1128/JB.186.13.4124-4133.2004.
  • Transcriptional control of the antimicrobial peptide resistance ugtL gene by the Salmonella PhoP and SlyA regulatory proteins.Shi Y, Latifi T, Cromie MJ, Groisman EA. Transcriptional control of the antimicrobial peptide resistance ugtL gene by the Salmonella PhoP and SlyA regulatory proteins. The Journal Of Biological Chemistry 2004, 279: 38618-25. PMID: 15208313, DOI: 10.1074/jbc.M406149200.
  • PhoP-regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B.Shi Y, Cromie MJ, Hsu FF, Turk J, Groisman EA. PhoP-regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B. Molecular Microbiology 2004, 53: 229-41. PMID: 15225317, DOI: 10.1111/j.1365-2958.2004.04107.x.
  • Involvement of Salmonella pathogenicity island 2 in the up-regulation of interleukin-10 expression in macrophages: role of protein kinase A signal pathway.Uchiya K, Groisman EA, Nikai T. Involvement of Salmonella pathogenicity island 2 in the up-regulation of interleukin-10 expression in macrophages: role of protein kinase A signal pathway. Infection And Immunity 2004, 72: 1964-73. PMID: 15039316, PMCID: PMC375175, DOI: 10.1128/iai.72.4.1964-1973.2004.
  • Evolution and Ecology of Salmonella.Winfield MD, Groisman EA. Evolution and Ecology of Salmonella. EcoSal Plus 2004, 1 PMID: 26443365, DOI: 10.1128/ecosalplus.6.4.6.
  • Closing the loop: the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD.Kato A, Latifi T, Groisman EA. Closing the loop: the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 4706-11. PMID: 12676988, PMCID: PMC153620, DOI: 10.1073/pnas.0836837100.
  • Signal-dependent requirement for the co-activator protein RcsA in transcription of the RcsB-regulated ugd gene.Mouslim C, Latifi T, Groisman EA. Signal-dependent requirement for the co-activator protein RcsA in transcription of the RcsB-regulated ugd gene. The Journal Of Biological Chemistry 2003, 278: 50588-95. PMID: 14514676, DOI: 10.1074/jbc.M309433200.
  • The ShiA protein encoded by the Shigella flexneri SHI-2 pathogenicity island attenuates inflammation.Ingersoll MA, Moss JE, Weinrauch Y, Fisher PE, Groisman EA, Zychlinsky A. The ShiA protein encoded by the Shigella flexneri SHI-2 pathogenicity island attenuates inflammation. Cellular Microbiology 2003, 5: 797-807. PMID: 14531895, DOI: 10.1046/j.1462-5822.2003.00320.x.
  • Genomics. A global view of gene gain, loss, regulation and function.Groisman EA, Ehrlich SD. Genomics. A global view of gene gain, loss, regulation and function. Current Opinion In Microbiology 2003, 6: 479-81. PMID: 14572540, DOI: 10.1016/j.mib.2003.09.010.
  • Role of nonhost environments in the lifestyles of Salmonella and Escherichia coli.Winfield MD, Groisman EA. Role of nonhost environments in the lifestyles of Salmonella and Escherichia coli. Applied And Environmental Microbiology 2003, 69: 3687-94. PMID: 12839733, PMCID: PMC165204, DOI: 10.1128/aem.69.7.3687-3694.2003.
  • Mg2+ sensing by the Mg2+ sensor PhoQ of Salmonella enterica.Chamnongpol S, Cromie M, Groisman EA. Mg2+ sensing by the Mg2+ sensor PhoQ of Salmonella enterica. Journal Of Molecular Biology 2003, 325: 795-807. PMID: 12507481, DOI: 10.1016/s0022-2836(02)01268-8.
  • Control of the Salmonella ugd gene by three two-component regulatory systems.Mouslim C, Groisman EA. Control of the Salmonella ugd gene by three two-component regulatory systems. Molecular Microbiology 2003, 47: 335-44. PMID: 12519186, DOI: 10.1046/j.1365-2958.2003.03318.x.
  • Making informed decisions: regulatory interactions between two-component systems.Bijlsma JJ, Groisman EA. Making informed decisions: regulatory interactions between two-component systems. Trends In Microbiology 2003, 11: 359-66. PMID: 12915093, DOI: 10.1016/s0966-842x(03)00176-8.
  • The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking.Shotland Y, Krämer H, Groisman EA. The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. Molecular Microbiology 2003, 49: 1565-76. PMID: 12950921, DOI: 10.1046/j.1365-2958.2003.03668.x.
  • Mg2+ homeostasis and avoidance of metal toxicity.Chamnongpol S, Groisman EA. Mg2+ homeostasis and avoidance of metal toxicity. Molecular Microbiology 2002, 44: 561-71. PMID: 11972791, DOI: 10.1046/j.1365-2958.2002.02917.x.
  • Conflicting needs for a Salmonella hypervirulence gene in host and non-host environments.Mouslim C, Hilbert F, Huang H, Groisman EA. Conflicting needs for a Salmonella hypervirulence gene in host and non-host environments. Molecular Microbiology 2002, 45: 1019-27. PMID: 12180921, DOI: 10.1046/j.1365-2958.2002.03070.x.
  • Fe(III)-mediated cellular toxicity.Chamnongpol S, Dodson W, Cromie MJ, Harris ZL, Groisman EA. Fe(III)-mediated cellular toxicity. Molecular Microbiology 2002, 45: 711-9. PMID: 12139617, DOI: 10.1046/j.1365-2958.2002.03041.x.
  • Molecular mechanisms of Salmonella pathogenesis.Groisman EA, Mouslim C. Molecular mechanisms of Salmonella pathogenesis. Current Opinion In Infectious Diseases 2000, 13: 519-522. PMID: 11964823, DOI: 10.1097/00001432-200010000-00014.
  • Cellular Adaptations to Cytoplasmic Mg2+ Limitation.Groisman EA, Chan C. Cellular Adaptations to Cytoplasmic Mg2+ Limitation. Annual Review Of Microbiology 2021, 75: 649-672. PMID: 34623895, DOI: 10.1146/annurev-micro-020518-115606.
  • RNA chaperone activates Salmonella virulence program during infection.Choi J, Salvail H, Groisman EA. RNA chaperone activates Salmonella virulence program during infection. Nucleic Acids Research 2021, 49: 11614-11628. PMID: 34751407, PMCID: PMC8599858, DOI: 10.1093/nar/gkab992.
  • Bacterial responses to host-defense peptides.Groisman EA. Bacterial responses to host-defense peptides. Trends In Microbiology 1996, 4: 127-8; discussion 128-9. PMID: 8728603, DOI: 10.1016/0966-842x(96)30013-9.
  • How Salmonella became a pathogen.Groisman EA, Ochman H. How Salmonella became a pathogen. Trends In Microbiology 1997, 5: 343-9. PMID: 9294889, DOI: 10.1016/S0966-842X(97)01099-8.
  • Regulation of polymyxin resistance and adaptation to low-Mg2+ environments.Groisman EA, Kayser J, Soncini FC. Regulation of polymyxin resistance and adaptation to low-Mg2+ environments. Journal Of Bacteriology 1997, 179: 7040-5. PMID: 9371451, PMCID: PMC179645, DOI: 10.1128/jb.179.22.7040-7045.1997.
  • The ins and outs of virulence gene expression: Mg2+ as a regulatory signal.Groisman EA. The ins and outs of virulence gene expression: Mg2+ as a regulatory signal. BioEssays : News And Reviews In Molecular, Cellular And Developmental Biology 1998, 20: 96-101. PMID: 9504051, DOI: 10.1002/(SICI)1521-1878(199801)20:1<96::AID-BIES13>3.0.CO;2-3.
  • The pleiotropic two-component regulatory system PhoP-PhoQ.Groisman EA. The pleiotropic two-component regulatory system PhoP-PhoQ. Journal Of Bacteriology 2001, 183: 1835-42. PMID: 11222580, PMCID: PMC95077, DOI: 10.1128/JB.183.6.1835-1842.2001.
  • Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome.Groisman EA, Saier MH, Ochman H. Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome. The EMBO Journal 1992, 11: 1309-16. PMID: 1339343, PMCID: PMC556579, DOI: 10.1002/j.1460-2075.1992.tb05175.x.
  • Resistance to host antimicrobial peptides is necessary for Salmonella virulence.Groisman EA, Parra-Lopez C, Salcedo M, Lipps CJ, Heffron F. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 11939-43. PMID: 1465423, PMCID: PMC50673, DOI: 10.1073/pnas.89.24.11939.
  • Molecular genetic analysis of the Escherichia coli phoP locus.Groisman EA, Heffron F, Solomon F. Molecular genetic analysis of the Escherichia coli phoP locus. Journal Of Bacteriology 1992, 174: 486-91. PMID: 1530848, PMCID: PMC205741, DOI: 10.1128/jb.174.2.486-491.1992.
  • Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor functions which is homologous to the periplasmic ribose-binding protein.Vartak NB, Reizer J, Reizer A, Gripp JT, Groisman EA, Wu LF, Tomich JM, Saier MH. Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor functions which is homologous to the periplasmic ribose-binding protein. Research In Microbiology 1991, 142: 951-63. PMID: 1805309, DOI: 10.1016/0923-2508(91)90005-u.
  • Genome mapping and protein coding region identification using bacteriophage Mu.Groisman EA, Pagratis N, Casadaban MJ. Genome mapping and protein coding region identification using bacteriophage Mu. Gene 1991, 99: 1-7. PMID: 1827084, DOI: 10.1016/0378-1119(91)90026-8.
  • In vivo genetic engineering with bacteriophage Mu.Groisman EA. In vivo genetic engineering with bacteriophage Mu. Methods In Enzymology 1991, 204: 180-212. PMID: 1834917, DOI: 10.1016/0076-6879(91)04010-l.
  • Salmonella virulence: new clues to intramacrophage survival.Groisman EA, Saier MH. Salmonella virulence: new clues to intramacrophage survival. Trends In Biochemical Sciences 1990, 15: 30-3. PMID: 2180148, DOI: 10.1016/0968-0004(90)90128-x.
  • A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells.Fields PI, Groisman EA, Heffron F. A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. Science (New York, N.Y.) 1989, 243: 1059-62. PMID: 2646710, DOI: 10.1126/science.2646710.
  • Salmonella typhimurium phoP virulence gene is a transcriptional regulator.Groisman EA, Chiao E, Lipps CJ, Heffron F. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 7077-81. PMID: 2674945, PMCID: PMC297997, DOI: 10.1073/pnas.86.18.7077.
  • In vivo DNA cloning with a mini-Mu replicon cosmid and a helper lambda phage.Groisman EA, Casadaban MJ. In vivo DNA cloning with a mini-Mu replicon cosmid and a helper lambda phage. Gene 1987, 51: 77-84. PMID: 2954879, DOI: 10.1016/0378-1119(87)90476-8.
  • Mini-mu bacteriophage with plasmid replicons for in vivo cloning and lac gene fusing.Groisman EA, Casadaban MJ. Mini-mu bacteriophage with plasmid replicons for in vivo cloning and lac gene fusing. Journal Of Bacteriology 1986, 168: 357-64. PMID: 3020001, PMCID: PMC213459, DOI: 10.1128/jb.168.1.357-364.1986.
  • High frequency generalized transduction by miniMu plasmid phage.Wang BM, Liu L, Groisman EA, Casadaban MJ, Berg CM. High frequency generalized transduction by miniMu plasmid phage. Genetics 1987, 116: 201-6. PMID: 3301525, PMCID: PMC1203130, DOI: 10.1093/genetics/116.2.201.
  • crp genes of Shigella flexneri, Salmonella typhimurium, and Escherichia coli.Cossart P, Groisman EA, Serre MC, Casadaban MJ, Gicquel-Sanzey B. crp genes of Shigella flexneri, Salmonella typhimurium, and Escherichia coli. Journal Of Bacteriology 1986, 167: 639-46. PMID: 3525518, PMCID: PMC212937, DOI: 10.1128/jb.167.2.639-646.1986.
  • Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons.Groisman EA, Casadaban MJ. Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons. Journal Of Bacteriology 1987, 169: 687-93. PMID: 3542967, PMCID: PMC211834, DOI: 10.1128/jb.169.2.687-693.1987.
  • In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon.Groisman EA, Castilho BA, Casadaban MJ. In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 1480-3. PMID: 6324195, PMCID: PMC344860, DOI: 10.1073/pnas.81.5.1480.
  • Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon.Soncini FC, Véscovi EG, Groisman EA. Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon. Journal Of Bacteriology 1995, 177: 4364-71. PMID: 7543474, PMCID: PMC177185, DOI: 10.1128/jb.177.15.4364-4371.1995.
  • Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica.Li J, Ochman H, Groisman EA, Boyd EF, Solomon F, Nelson K, Selander RK. Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 7252-6. PMID: 7638176, PMCID: PMC41317, DOI: 10.1073/pnas.92.16.7252.
  • The evolution of invasion by enteric bacteria.Ochman H, Groisman EA. The evolution of invasion by enteric bacteria. Canadian Journal Of Microbiology 1995, 41: 555-61. PMID: 7641138, DOI: 10.1139/m95-074.
  • The role of the PhoP/PhoQ regulon in Salmonella virulence.Garcia Véscovi E, Soncini FC, Groisman EA. The role of the PhoP/PhoQ regulon in Salmonella virulence. Research In Microbiology 1994, 145: 473-80. PMID: 7855434, DOI: 10.1016/0923-2508(94)90096-5.
  • How bacteria resist killing by host-defense peptides.Groisman EA. How bacteria resist killing by host-defense peptides. Trends In Microbiology 1994, 2: 444-9. PMID: 7866702, DOI: 10.1016/0966-842x(94)90802-8.
  • How to become a pathogen.Groisman EA, Ochman H. How to become a pathogen. Trends In Microbiology 1994, 2: 289-94. PMID: 7981972, DOI: 10.1016/0966-842x(94)90006-x.
  • The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium.Ochman H, Groisman EA. The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium. EXS 1994, 69: 479-93. PMID: 7994120, DOI: 10.1007/978-3-0348-7527-1_27.
  • A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium.Parra-Lopez C, Lin R, Aspedon A, Groisman EA. A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium. The EMBO Journal 1994, 13: 3964-72. PMID: 8076592, PMCID: PMC395316, DOI: 10.1002/j.1460-2075.1994.tb06712.x.
  • Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium.Parra-Lopez C, Baer MT, Groisman EA. Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium. The EMBO Journal 1993, 12: 4053-62. PMID: 8223423, PMCID: PMC413698, DOI: 10.1002/j.1460-2075.1993.tb06089.x.
  • Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.Groisman EA, Ochman H. Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. The EMBO Journal 1993, 12: 3779-87. PMID: 8404849, PMCID: PMC413660, DOI: 10.1002/j.1460-2075.1993.tb06056.x.
  • Molecular, functional, and evolutionary analysis of sequences specific to Salmonella.Groisman EA, Sturmoski MA, Solomon FR, Lin R, Ochman H. Molecular, functional, and evolutionary analysis of sequences specific to Salmonella. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 1033-7. PMID: 8430070, PMCID: PMC45805, DOI: 10.1073/pnas.90.3.1033.
  • Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence.García Véscovi E, Soncini FC, Groisman EA. Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 1996, 84: 165-74. PMID: 8548821, DOI: 10.1016/s0092-8674(00)81003-x.
  • Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes.Soncini FC, García Véscovi E, Solomon F, Groisman EA. Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes. Journal Of Bacteriology 1996, 178: 5092-9. PMID: 8752324, PMCID: PMC178303, DOI: 10.1128/jb.178.17.5092-5099.1996.
  • Identification of a pathogenicity island required for Salmonella survival in host cells.Ochman H, Soncini FC, Solomon F, Groisman EA. Identification of a pathogenicity island required for Salmonella survival in host cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7800-4. PMID: 8755556, PMCID: PMC38828, DOI: 10.1073/pnas.93.15.7800.
  • Pathogenicity islands: bacterial evolution in quantum leaps.Groisman EA, Ochman H. Pathogenicity islands: bacterial evolution in quantum leaps. Cell 1996, 87: 791-4. PMID: 8945505, DOI: 10.1016/s0092-8674(00)81985-6.
  • Distribution of pathogenicity islands in Salmonella spp.Ochman H, Groisman EA. Distribution of pathogenicity islands in Salmonella spp. Infection And Immunity 1996, 64: 5410-2. PMID: 8945597, PMCID: PMC174539, DOI: 10.1128/iai.64.12.5410-5412.1996.
  • Two-component regulatory systems can interact to process multiple environmental signals.Soncini FC, Groisman EA. Two-component regulatory systems can interact to process multiple environmental signals. Journal Of Bacteriology 1996, 178: 6796-801. PMID: 8955299, PMCID: PMC178578, DOI: 10.1128/jb.178.23.6796-6801.1996.
  • Characterization of the bacterial sensor protein PhoQ. Evidence for distinct binding sites for Mg2+ and Ca2+.Véscovi EG, Ayala YM, Di Cera E, Groisman EA. Characterization of the bacterial sensor protein PhoQ. Evidence for distinct binding sites for Mg2+ and Ca2+. The Journal Of Biological Chemistry 1997, 272: 1440-3. PMID: 8999810, DOI: 10.1074/jbc.272.3.1440.
  • The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium.Aspedon A, Groisman EA. The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium. Microbiology (Reading, England) 1996, 142 ( Pt 12): 3389-97. PMID: 9004502, DOI: 10.1099/13500872-142-12-3389.
  • The genetic basis of microbial resistance to antimicrobial peptides.Groisman EA, Aspedon A. The genetic basis of microbial resistance to antimicrobial peptides. Methods In Molecular Biology (Clifton, N.J.) 1997, 78: 205-15. PMID: 9276306, DOI: 10.1385/0-89603-408-9:205.
  • The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival.Blanc-Potard AB, Groisman EA. The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival. The EMBO Journal 1997, 16: 5376-85. PMID: 9311997, PMCID: PMC1170169, DOI: 10.1093/emboj/16.17.5376.
  • A green light for virulence gene expression.Groisman EA. A green light for virulence gene expression. Nature Medicine 1997, 3: 1190-1. PMID: 9359685, DOI: 10.1038/nm1197-1190.
  • The SPI-3 pathogenicity island of Salmonella enterica.Blanc-Potard AB, Solomon F, Kayser J, Groisman EA. The SPI-3 pathogenicity island of Salmonella enterica. Journal Of Bacteriology 1999, 181: 998-1004. PMID: 9922266, PMCID: PMC93469, DOI: 10.1128/JB.181.3.998-1004.1999.
  • A periplasmic D-alanyl-D-alanine dipeptidase in the gram-negative bacterium Salmonella enterica.Hilbert F, García-del Portillo F, Groisman EA. A periplasmic D-alanyl-D-alanine dipeptidase in the gram-negative bacterium Salmonella enterica. Journal Of Bacteriology 1999, 181: 2158-65. PMID: 10094694, PMCID: PMC93629, DOI: 10.1128/JB.181.7.2158-2165.1999.
  • A Salmonella virulence protein that inhibits cellular trafficking.Uchiya K, Barbieri MA, Funato K, Shah AH, Stahl PD, Groisman EA. A Salmonella virulence protein that inhibits cellular trafficking. The EMBO Journal 1999, 18: 3924-33. PMID: 10406797, PMCID: PMC1171468, DOI: 10.1093/emboj/18.14.3924.
  • The selC-associated SHI-2 pathogenicity island of Shigella flexneri.Moss JE, Cardozo TJ, Zychlinsky A, Groisman EA. The selC-associated SHI-2 pathogenicity island of Shigella flexneri. Molecular Microbiology 1999, 33: 74-83. PMID: 10411725, DOI: 10.1046/j.1365-2958.1999.01449.x.
  • Molecular characterization of the PmrA regulon.Wösten MM, Groisman EA. Molecular characterization of the PmrA regulon. The Journal Of Biological Chemistry 1999, 274: 27185-90. PMID: 10480935, DOI: 10.1074/jbc.274.38.27185.
  • A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica.Buchmeier N, Blanc-Potard A, Ehrt S, Piddington D, Riley L, Groisman EA. A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica. Molecular Microbiology 2000, 35: 1375-82. PMID: 10760138, DOI: 10.1046/j.1365-2958.2000.01797.x.
  • A small protein that mediates the activation of a two-component system by another two-component system.Kox LF, Wösten MM, Groisman EA. A small protein that mediates the activation of a two-component system by another two-component system. The EMBO Journal 2000, 19: 1861-72. PMID: 10775270, PMCID: PMC302009, DOI: 10.1093/emboj/19.8.1861.
  • Lateral gene transfer and the nature of bacterial innovation.Ochman H, Lawrence JG, Groisman EA. Lateral gene transfer and the nature of bacterial innovation. Nature 2000, 405: 299-304. PMID: 10830951, DOI: 10.1038/35012500.
  • Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase.Chamnongpol S, Groisman EA. Acetyl phosphate-dependent activation of a mutant PhoP response regulator that functions independently of its cognate sensor kinase. Journal Of Molecular Biology 2000, 300: 291-305. PMID: 10873466, DOI: 10.1006/jmbi.2000.3848.
  • A signal transduction system that responds to extracellular iron.Wösten MM, Kox LF, Chamnongpol S, Soncini FC, Groisman EA. A signal transduction system that responds to extracellular iron. Cell 2000, 103: 113-25. PMID: 11051552, DOI: 10.1016/s0092-8674(00)00092-1.
  • The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri.Moss JE, Fisher PE, Vick B, Groisman EA, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular Microbiology 2000, 2: 443-52. PMID: 11207599, DOI: 10.1046/j.1462-5822.2000.00065.x.
  • Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation.Cano DA, Martínez-Moya M, Pucciarelli MG, Groisman EA, Casadesús J, García-Del Portillo F. Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation. Infection And Immunity 2001, 69: 6463-74. PMID: 11553591, PMCID: PMC98782, DOI: 10.1128/IAI.69.10.6463-6474.2001.
  • Pathogenicity islands of Shigella.Ingersoll M, Groisman EA, Zychlinsky A. Pathogenicity islands of Shigella. Current Topics In Microbiology And Immunology 2002, 264: 49-65. PMID: 12014181.
  • Type III secretion system genes in clinical Aeromonas isolates.Chacón MR, Soler L, Groisman EA, Guarro J, Figueras MJ. Type III secretion system genes in clinical Aeromonas isolates. Journal Of Clinical Microbiology 2004, 42: 1285-7. PMID: 15004096, PMCID: PMC356863, DOI: 10.1128/JCM.42.3.1285-1287.2004.
  • A Mg2+-responding RNA that controls the expression of a Mg2+ transporter.Groisman EA, Cromie MJ, Shi Y, Latifi T. A Mg2+-responding RNA that controls the expression of a Mg2+ transporter. Cold Spring Harbor Symposia On Quantitative Biology 2006, 71: 251-8. PMID: 17381304, DOI: 10.1101/sqb.2006.71.005.
  • Differential synthesis of novel small protein times Salmonella virulence program.Salvail H, Choi J, Groisman EA. Differential synthesis of novel small protein times Salmonella virulence program. PLoS Genetics 2022, 18: e1010074. PMID: 35245279, PMCID: PMC8896665, DOI: 10.1371/journal.pgen.1010074.
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