2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2022
A 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlas
2009
Baseline brain energy supports the state of consciousness
Shulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.Peer-Reviewed Original ResearchConceptsLoss of consciousnessBrain energyConscious stateHigh-frequency neuronal activityCerebral energy consumptionBrain energy consumptionCerebral energyEnsembles of neuronsRat brainSomatosensory responsesNeuronal activityGamma-band rangeNeuronal propertiesFiring rateSensory stimulationNeuronal signalingPET measurementsAnesthesiaFMRI patternsFMRI activity patternsOxygen consumptionState of consciousnessStimulationBehavioral abilitiesMagnetic resonance spectroscopy
2000
Meeting Report: Transcranial Magnetic Stimulation and Studies of Human Cognition
Fitzpatrick S, Rothman D. Meeting Report: Transcranial Magnetic Stimulation and Studies of Human Cognition. Journal Of Cognitive Neuroscience 2000, 12: 704-709. PMID: 10936921, DOI: 10.1162/089892900562327.Peer-Reviewed Original ResearchProton MRS: GABA and glutamate.
Petroff O, Mattson R, Rothman D. Proton MRS: GABA and glutamate. Advances In Neurology 2000, 83: 261-71. PMID: 10999208.Peer-Reviewed Original Research
1999
Linear projection method for automatic slice shimming
Shen J, Rothman D, Hetherington H, Pan J. Linear projection method for automatic slice shimming. Magnetic Resonance In Medicine 1999, 42: 1082-1088. PMID: 10571929, DOI: 10.1002/(sici)1522-2594(199912)42:6<1082::aid-mrm12>3.0.co;2-g.Peer-Reviewed Original ResearchBrainHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPhantoms, ImagingNew Approaches to Functional Neuroenergetics
Fitzpatrick S, Rothman D. New Approaches to Functional Neuroenergetics. Journal Of Cognitive Neuroscience 1999, 11: 467-471. PMID: 10507889, DOI: 10.1162/089892999563454.Peer-Reviewed Original ResearchAnimalsBrainBrain MappingEnergy MetabolismHumansMagnetic Resonance ImagingNeuronsTomography, Emission-ComputedEnergy on demand.
Magistretti P, Pellerin L, Rothman D, Shulman R. Energy on demand. Science 1999, 283: 496-7. PMID: 9988650, DOI: 10.1126/science.283.5401.496.Peer-Reviewed Original Research
1998
Interpreting functional imaging studies in terms of neurotransmitter cycling
Shulman R, Rothman D. Interpreting functional imaging studies in terms of neurotransmitter cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11993-11998. PMID: 9751778, PMCID: PMC21753, DOI: 10.1073/pnas.95.20.11993.Peer-Reviewed Original ResearchConceptsFunctional imaging experimentsNeurobiological processesFunctional magnetic resonance imagingBasis of neuroscienceSpecific mental processesFunctional imaging studiesFunctional imaging dataVivo 13C NMR measurementsCognitive psychologyCognitive tasksMental processesPsychological termsPsychological interpretationImaging experimentsNeuroscientific interpretationSensory stimulationPsychological designHuman brainFunctional imaging signalsNeurotransmitter cyclingParticular positron emission tomographyNeurotransmitter fluxBrain energy consumptionImaging studiesImaging data
1997
Adiabatic Slice-Selective Excitation for Surface Coils
Shen J, Rothman D. Adiabatic Slice-Selective Excitation for Surface Coils. Journal Of Magnetic Resonance 1997, 124: 72-79. PMID: 9169211, DOI: 10.1006/jmre.1996.7483.Peer-Reviewed Original Research
1996
Dynamic shim updating: A new approach towards optimized whole brain shimming
Blamire A, Rothman D, Nixon T. Dynamic shim updating: A new approach towards optimized whole brain shimming. Magnetic Resonance In Medicine 1996, 36: 159-165. PMID: 8795035, DOI: 10.1002/mrm.1910360125.Peer-Reviewed Original ResearchShort echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain
Hwang J, Graham G, Behar K, Alger J, Prichard J, Rothman D. Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magnetic Resonance In Medicine 1996, 35: 633-639. PMID: 8722812, DOI: 10.1002/mrm.1910350502.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCerebrovascular DisordersFemaleHumansMacromolecular SubstancesMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedReproducibility of ResultsConceptsSubacute stroke patientsProton magnetic resonance spectroscopicProton magnetic resonance spectroscopic imagingMagnetic resonance spectroscopic imagingStroke patientsHealthy subjectsMagnetic resonance spectroscopicMetabolite signal intensitiesBrain regionsPathological conditionsMacromolecule resonancesHuman brainBrainSignal intensitySubjectsRecovery timeSpectroscopic imagingPatients
1994
Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS
Blamire A, Graham G, Rothman D, Prichard J. Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS. Magnetic Resonance Imaging 1994, 12: 1227-1235. PMID: 7854028, DOI: 10.1016/0730-725x(94)90087-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAspartic AcidBrain ChemistryCerebrovascular DisordersCholineCreatineFemaleHumansLactatesLactic AcidMagnetic Resonance ImagingMaleMiddle AgedModels, StructuralConceptsStroke patientsAge-matched normal subjectsHuman strokeSpin-echo MRINormal subjectsNormal brainPatientsInfarcted tissueProton T2 relaxation timesInverse correlationHigh inverse correlationT2 relaxation timesCholine resonanceSignificant differencesProton spectroscopyPercentage volumeT2 valuesT. SpectraPartial volume effectsPeak amplitudeSTEAM sequence
1993
Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study.
Graham G, Blamire A, Rothman D, Brass L, Fayad P, Petroff O, Prichard J. Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study. Stroke 1993, 24: 1891-1896. PMID: 8248973, DOI: 10.1161/01.str.24.12.1891.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedBrainCerebral InfarctionFemaleHumansLactatesMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedTime FactorsConceptsAcetyl-aspartate signalProton magnetic resonance spectroscopyCerebral infarctionProton magnetic resonance spectroscopy studyLactate signalAbundant leukocyte infiltrationAcetyl-aspartate peakNonhemorrhagic cerebral infarctionAcute cerebral infarctionDays of strokeMagnetic resonance spectroscopy studyContralateral normal brainClearance of lactateCreatine/phosphocreatineMagnetic resonance spectroscopyLong-term elevationLate deathsHuman strokeSubacute stageLeukocyte infiltrationChronic periodLesion volumeCerebral metabolitesInfarct zoneSecond examinationNuclear magnetic resonance imaging and spectroscopy of human brain function.
Shulman R, Blamire A, Rothman D, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 3127-3133. PMID: 8475050, PMCID: PMC46253, DOI: 10.1073/pnas.90.8.3127.Peer-Reviewed Original ResearchMeSH KeywordsBrainContrast MediaGlucoseHemoglobinsHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyTomography, Emission-ComputedConceptsRegional cerebral blood volumeMagnetic resonance imagingMR spectroscopyResonance imagingBrain functionHuman brain functionCerebral glutamate poolPositron emission tomography studyBrain glucose concentrationsEmission tomography studiesCerebral blood volumeBlood oxygenation levelVivo magnetic resonance imagingConcentration of lactateBrain metabolismMotor cortexCerebral vasculatureSubsequent glucose metabolismBlood flowGlucose metabolismBlood volumeFrontal lobeVisual cortexBrain tissueTomography study
1988
Surface coil localization of 31P NMR signals from orthotopic human kidney and liver.
Jue T, Rothman D, Lohman J, Hughes E, Hanstock C, Shulman R. Surface coil localization of 31P NMR signals from orthotopic human kidney and liver. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 971-974. PMID: 3422493, PMCID: PMC279682, DOI: 10.1073/pnas.85.4.971.Peer-Reviewed Original Research