Research & Publications
Dr. Wu’s lab is interested in the mechanisms and functions of chemoattractant and Wnt-activated signaling. Chemoattractants, including chemokines, play an important role in host defense. However, their unchecked activities contribute to may inflammation-related diseases, including atherosclerosis, arthritis, tumorigenesis, and various allergies. The Wnt family of secretory glycoproteins participates in a wide variety of developmental events including, control of cell growth, generation of cell polarity, and specification of cell fate. Wnt pathways have been also closely linked to tumorigenesis, glucose metabolism, and bone formation. We are using a combination of molecular and cell biological, biochemical, chemical biological, transgenic, functional genomic, and proteomic approaches to discover novel signaling mechanisms and functions for these signaling proteins.
Specialized Terms: Wnt; signal transduction; G protein, Chemotaxis;Cell migration; Cancer biology and therapeutics; Stem cell biology; Chemoattractant signaling; Inflammation
Extensive Research Description
2) Regulation of neutrophil migration
4) Wnt signaling in bone development and diseases
5) Wnt signaling and stem cell biology
Chemotaxis; Inflammation; Pharmacology; Stem Cells; Signal Transduction; GTP-Binding Proteins; Chemicals and Drugs