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Diane Krause, MD, PhD

Professor of Laboratory Medicine, of Cell Biology and of Pathology; Vice Chair for Research Affairs, Laboratory Medicine; Assoc. Director, Yale Stem Cell Center; Assoc. Director, Transfusion Medicine Service; Medical Director, Clinical Cell Processing Laboratory; Medical Director, Advanced Cell Therapy Laboratory

Contact Information

Diane Krause, MD, PhD

Mailing Address

  • Yale Stem Cell Center

    PO Box 208073, 10 Amistad Street

    New Haven, CT 06509

    United States

Krause lab website
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Research Summary

The overall goals of my research are to characterize bone marrow (BM) derived stem/progenitor cells, and to define the mechanisms that regulate the self-renewal and differentiation of these cells with the goal of improving therapeutic approaches to hematological diseases including leukemia. We have 2 major foci. The first is the molecular mechanism(s) regulating gene expression during normal and malignant hematopoiesis. We are using hematopoietic stem cells and human embryonic stem cells to better understand Acute Megakaryoblastic Leukemia. In vitro and in vivo cell and molecular approaches will help us to better understand hematopoiesis and leukemogenesis. The second focus is the differentiation of pluripotent stem cells to produce function parathyroid epithelial cells in order to develop effective cellular therapy for patients with hypoparathyroidism. We welcome graduate students to join the lab.

Link to laboratory website: https://krauselab.net/

Specialized Terms: Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia

Extensive Research Description

Hematopoiesis and leukemogenesis using bone marrow derived stem and progenitor cells Projects in the lab focus on molecular mechanisms that regulate early hematopoiesis and may be dysfunctional in leukemogenesis. Specifically, we are using primary cells as well as murine and human embryonic stem cells to study RBM15 and MKL1, two genes that are fused in the t(1;22) translocation associated with Acute Megakaryoblastic Leukemia AMKL). We are studying the roles of RBM15 and MKL1 in normal myelopoiesis and leukemogenesis. We have shown that RBM15 is downregulated as hematopoietic stem cells differentiate down the myeloid lineage such that megakaryoblasts express low levels of RBM15. When RBM15 is overexpressed, it prevents myeloid differentiation, and when RBM15 is inhibited or deleted, myeloid differentiation is enhanced, and there is a loss of hematopoietic stem and progenitor cell self-renewal. RBM15 can affect Notch signaling; RBM15 represses Notch induced Hes1 promoter activity. In addition, RBM15 is required for m6A RNA modification, and we are studying th role of this epitranscriptomic modification in normal hematopoiesis and leukemogenesis.

MKL1, identified at the C-terminus of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). The Krause laboratory has shown that MKL1 expression is upregulated during murine and human megakaryocytic differentiation, and that enforced overexpression of MKL1 enhances megakaryocytic differentiation. When the Human Erythroleukemia (HEL) cell line is induced to differentiate with TPA, overexpression of MKL1 results in an increased number of megakaryocytes with a concurrent increase in ploidy. MKL1 overexpression also promotes thrombopoietin-induced megakaryocytic differentiation of primary human CD34+ cells. The effect of MKL1 is abrogated when SRF is knocked down, suggesting that MKL1 acts through SRF. Consistent with these findings in human cells, knock out of MKL1 in mice leads to reduced platelet counts, and reduced ploidy in bone marrow megakaryocytes. Thus, MKL1 promotes physiological maturation of human and murine megakaryocytes.

Link to laboratory website: https://krauselab.net/

Coauthors

Research Interests

Cell Biology; Hematology; Leukemia; Pathology; Stem Cells; Gene Expression; Bone Marrow Transplantation

Selected Publications

  • Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis.Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.
  • Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants.Kwon N, Thompson EN, Mayday MY, Scanlon V, Lu YC, Krause DS. Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants. Current Opinion In Hematology 2021, 28: 28-35. PMID: 33186151, PMCID: PMC7737300, DOI: 10.1097/MOH.0000000000000625.
  • Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews. Cardiology 2021, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
  • Single cell epigenetic visualization assay.Kint S, Van Criekinge W, Vandekerckhove L, De Vos WH, Bomsztyk K, Krause DS, Denisenko O. Single cell epigenetic visualization assay. Nucleic Acids Research 2021, 49: e43. PMID: 33511400, PMCID: PMC8096246, DOI: 10.1093/nar/gkab009.
  • Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells. Science (New York, N.Y.) 2021, 371: 1019-1025. PMID: 33674488, PMCID: PMC8292008, DOI: 10.1126/science.abe2485.
  • MRTFA: A critical protein in normal and malignant hematopoiesis and beyond.Reed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS. MRTFA: A critical protein in normal and malignant hematopoiesis and beyond. The Journal Of Biological Chemistry 2021, 296: 100543. PMID: 33722605, PMCID: PMC8079280, DOI: 10.1016/j.jbc.2021.100543.
  • Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury.Ciechanowicz AK, Sielatycka K, Cymer M, Skoda M, Suszyńska M, Bujko K, Ratajczak MZ, Krause DS, Kucia M. Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury. Cells 2021, 10 PMID: 34206516, PMCID: PMC8303224, DOI: 10.3390/cells10071570.
  • Methylation of dual-specificity phosphatase 4 controls cell differentiation.Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, Sun CW, Zhu Y, Zhao Q, Chen Y, Cable L, Shen Y, Liu J, Qu CK, Han X, Klug CA, Bhatia R, Chen Y, Nimer SD, Zheng YG, Iancu-Rubin C, Jin J, Deng H, Krause DS, Xiang J, Verma A, Luo M, Zhao X. Methylation of dual-specificity phosphatase 4 controls cell differentiation. Cell Reports 2021, 36: 109421. PMID: 34320342, PMCID: PMC9110119, DOI: 10.1016/j.celrep.2021.109421.
  • Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells.Lawton BR, Martineau C, Sosa JA, Roman S, Gibson CE, Levine MA, Krause DS. Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells. Endocrinology 2020, 161 PMID: 32810225, PMCID: PMC7505176, DOI: 10.1210/endocr/bqaa141.
  • Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation.Wang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucio J, Lu YC, Zhang M, Roden C, Cheng J, Krause DS, Ding Y, Fan R, Lu J. Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation. Nature Communications 2019, 10: 95. PMID: 30626865, PMCID: PMC6327095, DOI: 10.1038/s41467-018-07981-6.
  • Promoters to Study Vascular Smooth Muscle.Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis, Thrombosis, And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/ATVBAHA.119.312449.
  • Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability.Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS. Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability. Thrombosis And Haemostasis 2019, 119: 744-757. PMID: 30861547, PMCID: PMC6599679, DOI: 10.1055/s-0039-1679908.
  • MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation.Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nature Communications 2019, 10: 1695. PMID: 30979898, PMCID: PMC6461646, DOI: 10.1038/s41467-019-09636-6.
  • IFN-γ binds TPO to inhibit hematopoiesis.Krause DS. IFN-γ binds TPO to inhibit hematopoiesis. Blood 2019, 133: 2004-2005. PMID: 31072961, DOI: 10.1182/blood-2019-03-900977.
  • Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit.He L, Cohen EB, Edwards APB, Xavier-Ferrucio J, Bugge K, Federman RS, Absher D, Myers RM, Kragelund BB, Krause DS, DiMaio D. Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit. IScience 2019, 17: 167-181. PMID: 31279934, PMCID: PMC6614117, DOI: 10.1016/j.isci.2019.06.027.
  • Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N, Tebaldi T, Halene S, Cao C, Fleming MD, Finberg KE, Krause DS. Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice. Blood 2019, 134: 1547-1557. PMID: 31439541, PMCID: PMC6839952, DOI: 10.1182/blood.2019002039.
  • A versatile flow-based assay for immunocyte-mediated cytotoxicity.Rabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG. A versatile flow-based assay for immunocyte-mediated cytotoxicity. Journal Of Immunological Methods 2019, 474: 112668. PMID: 31525367, PMCID: PMC6891822, DOI: 10.1016/j.jim.2019.112668.
  • Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy.Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLoS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.
  • Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2018, 314: L882-L892. PMID: 29345196, PMCID: PMC6008135, DOI: 10.1152/ajplung.00418.2017.
  • Hematopoietic defects in response to reduced Arhgap21.Xavier-Ferrucio J, Ricon L, Vieira K, Longhini AL, Lazarini M, Bigarella CL, Franchi G, Krause DS, Saad STO. Hematopoietic defects in response to reduced Arhgap21. Stem Cell Research 2018, 26: 17-27. PMID: 29212046, PMCID: PMC6084430, DOI: 10.1016/j.scr.2017.11.014.
  • Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies.Xavier-Ferrucio J, Krause DS. Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies. Stem Cells (Dayton, Ohio) 2018, 36: 1138-1145. PMID: 29658164, PMCID: PMC6105498, DOI: 10.1002/stem.2834.
  • MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis.Rahman NT, Schulz VP, Wang L, Gallagher PG, Denisenko O, Gualdrini F, Esnault C, Krause DS. MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis. Blood Advances 2018, 2: 2691-2703. PMID: 30337297, PMCID: PMC6199649, DOI: 10.1182/bloodadvances.2018019448.
  • The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification.Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS. The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification. Cell Reports 2018, 25: 3229. PMID: 30540953, PMCID: PMC6357951, DOI: 10.1016/j.celrep.2018.11.075.
  • Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages.Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Scientific Reports 2017, 7: 10882. PMID: 28883468, PMCID: PMC5589856, DOI: 10.1038/s41598-017-11012-7.
  • Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA. Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nature Genetics 2017, 49: 451-456. PMID: 28112737, PMCID: PMC5687824, DOI: 10.1038/ng.3772.
  • SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PloS One 2017, 12: e0178095. PMID: 28542600, PMCID: PMC5441597, DOI: 10.1371/journal.pone.0178095.
  • ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction.Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1 PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.
  • Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction.Sanada C, Xavier-Ferrucio J, Lu YC, Min E, Zhang PX, Zou S, Kang E, Zhang M, Zerafati G, Gallagher PG, Krause DS. Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction. Blood 2016, 128: 923-33. PMID: 27268089, PMCID: PMC4990855, DOI: 10.1182/blood-2016-01-693705.
  • An oxidase road to platelet adhesion.Krause DS. An oxidase road to platelet adhesion. Blood 2016, 127: 1386. PMID: 26989190, DOI: 10.1182/blood-2016-01-694935.
  • Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.Zou S, Teixeira AM, Yin M, Xiang Y, Xavier-Ferruccio J, Zhang PX, Hwa J, Min W, Krause DS. Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation. Thrombosis And Haemostasis 2016, 116: 506-16. PMID: 27345948, PMCID: PMC5845781, DOI: 10.1160/TH15-11-0848.
  • In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications 2016, 7: 13304. PMID: 27782131, PMCID: PMC5095181, DOI: 10.1038/ncomms13304.
  • Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling.Bruscia E, Zhang PX, Barone C, Scholte BJ, Homer RJ, Krause D, Egan ME. Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. American Journal Of Physiology. Lung Cellular And Molecular Physiology 2016, 310: L711-9. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
  • The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation.Chae WJ, Ehrlich AK, Chan PY, Teixeira AM, Henegariu O, Hao L, Shin JH, Park JH, Tang WH, Kim ST, Maher SE, Goldsmith-Pestana K, Shan P, Hwa J, Lee PJ, Krause DS, Rothlin CV, McMahon-Pratt D, Bothwell AL. The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation. Immunity 2016, 44: 246-58. PMID: 26872695, PMCID: PMC4758884, DOI: 10.1016/j.immuni.2016.01.008.
  • Stem cell maintenance: aMPLe splicing choices.Halene S, Krause DS. Stem cell maintenance: aMPLe splicing choices. Blood 2015, 125: 891-2. PMID: 25655452, DOI: 10.1182/blood-2014-12-616326.
  • Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation.Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nature Communications 2015, 6: 6221. PMID: 25665524, PMCID: PMC4324503, DOI: 10.1038/ncomms7221.
  • Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.Sui Z, Nowak RB, Sanada C, Halene S, Krause DS, Fowler VM. Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis. Blood 2015, 126: 520-30. PMID: 25964668, PMCID: PMC4513252, DOI: 10.1182/blood-2014-09-601484.
  • Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.Kim Y, Schulz VP, Satake N, Gruber TA, Teixeira AM, Halene S, Gallagher PG, Krause DS. Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia. Leukemia 2014, 28: 945-8. PMID: 24157583, PMCID: PMC3981934, DOI: 10.1038/leu.2013.314.
  • Engineering human peripheral blood stem cell grafts that are depleted of naïve T cells and retain functional pathogen-specific memory T cells.Bleakley M, Heimfeld S, Jones LA, Turtle C, Krause D, Riddell SR, Shlomchik W. Engineering human peripheral blood stem cell grafts that are depleted of naïve T cells and retain functional pathogen-specific memory T cells. Biology Of Blood And Marrow Transplantation : Journal Of The American Society For Blood And Marrow Transplantation 2014, 20: 705-16. PMID: 24525279, PMCID: PMC3985542, DOI: 10.1016/j.bbmt.2014.01.032.
  • Nonstochastic reprogramming from a privileged somatic cell state.Guo S, Zi X, Schulz VP, Cheng J, Zhong M, Koochaki SH, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J. Nonstochastic reprogramming from a privileged somatic cell state. Cell 2014, 156: 649-62. PMID: 24486105, PMCID: PMC4318260, DOI: 10.1016/j.cell.2014.01.020.
  • Very small embryonic-like cells: biology and function of these potential endogenous pluripotent stem cells in adult tissues.Kassmer SH, Krause DS. Very small embryonic-like cells: biology and function of these potential endogenous pluripotent stem cells in adult tissues. Molecular Reproduction And Development 2013, 80: 677-90. PMID: 23440892, PMCID: PMC3740022, DOI: 10.1002/mrd.22168.
  • Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung.Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS. Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Stem Cells (Dayton, Ohio) 2013, 31: 2759-66. PMID: 23681901, PMCID: PMC4536826, DOI: 10.1002/stem.1413.
  • Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia.Krause DS, Crispino JD. Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research 2013, 19: 6084-8. PMID: 23963861, PMCID: PMC3836832, DOI: 10.1158/1078-0432.CCR-12-2604.
  • Effect of a matrigel sandwich on endodermal differentiation of human embryonic stem cells.Lawton BR, Sosa JA, Roman S, Krause DS. Effect of a matrigel sandwich on endodermal differentiation of human embryonic stem cells. Stem Cell Reviews And Reports 2013, 9: 578-85. PMID: 23719997, DOI: 10.1007/s12015-013-9447-2.
  • Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Molecular Therapy : The Journal Of The American Society Of Gene Therapy 2013, 21: 42-8. PMID: 23011031, PMCID: PMC3538311, DOI: 10.1038/mt.2012.203.
  • Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging.Megyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng EC, Nottoli T, Krause DS, Lu J, Guo S. Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Stem Cells (Dayton, Ohio) 2013, 31: 895-905. PMID: 23335078, PMCID: PMC4309553, DOI: 10.1002/stem.1323.
  • Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator.Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator. Journal Of Immunology (Baltimore, Md. : 1950) 2013, 190: 5196-206. PMID: 23606537, PMCID: PMC3711148, DOI: 10.4049/jimmunol.1201607.
  • Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation.Smith EC, Teixeira AM, Chen RC, Wang L, Gao Y, Hahn KL, Krause DS. Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation. Blood 2013, 121: 1094-101. PMID: 23243284, PMCID: PMC3575755, DOI: 10.1182/blood-2012-05-429993.
  • Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.Gao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Developmental Cell 2012, 22: 573-84. PMID: 22387001, PMCID: PMC3306542, DOI: 10.1016/j.devcel.2011.12.019.
  • Successful collection and engraftment of autologous peripheral blood progenitor cells in poorly mobilized patients receiving high-dose granulocyte colony-stimulating factor.Cooper DL, Proytcheva M, Medoff E, Seropian SE, Snyder EL, Krause DS, Wu Y. Successful collection and engraftment of autologous peripheral blood progenitor cells in poorly mobilized patients receiving high-dose granulocyte colony-stimulating factor. Journal Of Clinical Apheresis 2012, 27: 235-41. PMID: 22566214, DOI: 10.1002/jca.21232.
  • Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells.Kassmer SH, Bruscia EM, Zhang PX, Krause DS. Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells. Stem Cells (Dayton, Ohio) 2012, 30: 491-9. PMID: 22162244, PMCID: PMC3725285, DOI: 10.1002/stem.1003.
  • MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE, Krause DS. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood 2012, 120: 2317-29. PMID: 22806889, PMCID: PMC3447785, DOI: 10.1182/blood-2012-04-420828.
  • Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J. Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16636-41. PMID: 23012470, PMCID: PMC3478612, DOI: 10.1073/pnas.1213196109.
  • Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate.Rogers FA, Lin SS, Hegan DC, Krause DS, Glazer PM. Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate. Molecular Therapy : The Journal Of The American Society Of Gene Therapy 2012, 20: 109-18. PMID: 21829173, PMCID: PMC3255600, DOI: 10.1038/mt.2011.163.
  • Enhanced growth and hepatic differentiation of fetal liver epithelial cells through combinational and temporal adjustment of soluble factors.Qian L, Krause DS, Saltzman WM. Enhanced growth and hepatic differentiation of fetal liver epithelial cells through combinational and temporal adjustment of soluble factors. Biotechnology Journal 2012, 7: 440-8. PMID: 21922669, PMCID: PMC3532892, DOI: 10.1002/biot.201100184.
  • Increased tubular proliferation as an adaptive response to glomerular albuminuria.Guo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased tubular proliferation as an adaptive response to glomerular albuminuria. Journal Of The American Society Of Nephrology : JASN 2012, 23: 429-37. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/ASN.2011040396.
  • ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets.Truman LA, Bentley KL, Smith EC, Massaro SA, Gonzalez DG, Haberman AM, Hill M, Jones D, Min W, Krause DS, Ruddle NH. ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets. The American Journal Of Pathology 2012, 180: 1715-25. PMID: 22310467, PMCID: PMC3349900, DOI: 10.1016/j.ajpath.2011.12.026.
  • Bi-allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia.Massaro SA, Bajaj R, Pashankar FD, Ornstein D, Gallagher PG, Krause DS, Li P. Bi-allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia. Pediatric Blood & Cancer 2011, 57: 516-9. PMID: 21538823, PMCID: PMC4517576, DOI: 10.1002/pbc.23156.
  • Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel.Hibino N, Villalona G, Pietris N, Duncan DR, Schoffner A, Roh JD, Yi T, Dobrucki LW, Mejias D, Sawh-Martinez R, Harrington JK, Sinusas A, Krause DS, Kyriakides T, Saltzman WM, Pober JS, Shin'oka T, Breuer CK. Tissue-engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2011, 25: 2731-9. PMID: 21566209, PMCID: PMC3136337, DOI: 10.1096/fj.11-182246.
  • Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. Journal Of Immunology (Baltimore, Md. : 1950) 2011, 186: 6990-8. PMID: 21593379, PMCID: PMC3111054, DOI: 10.4049/jimmunol.1100396.
  • Activation of autophagy in mesenchymal stem cells provides tumor stromal support.Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 2011, 32: 964-72. PMID: 21317300, PMCID: PMC3128555, DOI: 10.1093/carcin/bgr029.
  • Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells.Mohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells. Hepatology (Baltimore, Md.) 2010, 51: 963-73. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.
  • Serum response factor is an essential transcription factor in megakaryocytic maturation.Halene S, Gao Y, Hahn K, Massaro S, Italiano JE, Schulz V, Lin S, Kupfer GM, Krause DS. Serum response factor is an essential transcription factor in megakaryocytic maturation. Blood 2010, 116: 1942-50. PMID: 20525922, PMCID: PMC3173990, DOI: 10.1182/blood-2010-01-261743.
  • C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.Halene S, Gaines P, Sun H, Zibello T, Lin S, Khanna-Gupta A, Williams SC, Perkins A, Krause D, Berliner N. C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx. Experimental Hematology 2010, 38: 90-103. PMID: 19925846, PMCID: PMC2827304, DOI: 10.1016/j.exphem.2009.11.004.
  • SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng EC, Chen H, Krause DS, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. The Journal Of Experimental Medicine 2010, 207: 1183-95. PMID: 20457756, PMCID: PMC2882842, DOI: 10.1084/jem.20092215.
  • Discovery that polyploid cells can undergo mitosis.Gao Y, Krause D. Discovery that polyploid cells can undergo mitosis. Cell Cycle (Georgetown, Tex.) 2010, 9: 2500. PMID: 20647753.
  • Detection of bone marrow-derived lung epithelial cells.Kassmer SH, Krause DS. Detection of bone marrow-derived lung epithelial cells. Experimental Hematology 2010, 38: 564-73. PMID: 20447442, PMCID: PMC2909593, DOI: 10.1016/j.exphem.2010.04.011.
  • Influence of culture medium on smooth muscle cell differentiation from human bone marrow-derived mesenchymal stem cells.Gong Z, Calkins G, Cheng EC, Krause D, Niklason LE. Influence of culture medium on smooth muscle cell differentiation from human bone marrow-derived mesenchymal stem cells. Tissue Engineering. Part A 2009, 15: 319-30. PMID: 19115826, PMCID: PMC2716410, DOI: 10.1089/ten.tea.2008.0161.
  • Role for MKL1 in megakaryocytic maturation.Cheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS. Role for MKL1 in megakaryocytic maturation. Blood 2009, 113: 2826-34. PMID: 19136660, PMCID: PMC2661865, DOI: 10.1182/blood-2008-09-180596.
  • Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice.Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Krause DS, Egan ME. Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice. American Journal Of Respiratory Cell And Molecular Biology 2009, 40: 295-304. PMID: 18776130, PMCID: PMC2645527, DOI: 10.1165/rcmb.2008-0170OC.
  • Chimeric mice reveal clonal development of pancreatic acini, but not islets.Swenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets. Biochemical And Biophysical Research Communications 2009, 379: 526-31. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.
  • Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.Zhi G, Wilson JB, Chen X, Krause DS, Xiao Y, Jones NJ, Kupfer GM. Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. Cancer Research 2009, 69: 8775-83. PMID: 19861535, PMCID: PMC5912675, DOI: 10.1158/0008-5472.CAN-09-2312.
  • Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture.Mahajan MC, Karmakar S, Newburger PE, Krause DS, Weissman SM. Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture. Experimental Hematology 2009, 37: 1143-1156.e3. PMID: 19607874, PMCID: PMC2997688, DOI: 10.1016/j.exphem.2009.07.001.
  • Regeneration and repair: new findings in stem cell research and aging.Friedman RS, Krause DS. Regeneration and repair: new findings in stem cell research and aging. Annals Of The New York Academy Of Sciences 2009, 1172: 88-94. PMID: 19735242, DOI: 10.1111/j.1749-6632.2009.04411.x.
  • Understanding the mysteries of iPS cells.Cohen JB, Krause DS. Understanding the mysteries of iPS cells. The Yale Journal Of Biology And Medicine 2009, 82: 105-7. PMID: 19774121, PMCID: PMC2744933.
  • Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models.Weiner SA, Caputo C, Bruscia E, Ferreira EC, Price JE, Krause DS, Egan ME. Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models. Pediatric Research 2008, 63: 73-8. PMID: 18043508, DOI: 10.1203/PDR.0b013e31815b4bc6.
  • Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration.Swenson ES, Kuwahara R, Krause DS, Theise ND. Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration. Liver International : Official Journal Of The International Association For The Study Of The Liver 2008, 28: 308-18. PMID: 18290773, PMCID: PMC2846401, DOI: 10.1111/j.1478-3231.2007.01659.x.
  • Hepatocyte nuclear factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice.Swenson ES, Guest I, Ilic Z, Mazzeo-Helgevold M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte nuclear factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice. Stem Cells (Dayton, Ohio) 2008, 26: 1768-77. PMID: 18467658, PMCID: PMC2846397, DOI: 10.1634/stemcells.2008-0148.
  • Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids.Chin JY, Kuan JY, Lonkar PS, Krause DS, Seidman MM, Peterson KR, Nielsen PE, Kole R, Glazer PM. Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 13514-9. PMID: 18757759, PMCID: PMC2533221, DOI: 10.1073/pnas.0711793105.
  • Bone marrow-derived lung epithelial cells.Krause DS. Bone marrow-derived lung epithelial cells. Proceedings Of The American Thoracic Society 2008, 5: 699-702. PMID: 18684720, PMCID: PMC2645262, DOI: 10.1513/pats.200803-031AW.
  • Bone marrow-derived cells and stem cells in lung repair.Krause DS. Bone marrow-derived cells and stem cells in lung repair. Proceedings Of The American Thoracic Society 2008, 5: 323-7. PMID: 18403327, PMCID: PMC2645242, DOI: 10.1513/pats.200712-169DR.
  • Limitations of green fluorescent protein as a cell lineage marker.Swenson ES, Price JG, Brazelton T, Krause DS. Limitations of green fluorescent protein as a cell lineage marker. Stem Cells (Dayton, Ohio) 2007, 25: 2593-600. PMID: 17615263, DOI: 10.1634/stemcells.2007-0241.
  • Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation.Ma X, Renda MJ, Wang L, Cheng EC, Niu C, Morris SW, Chi AS, Krause DS. Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation. Molecular And Cellular Biology 2007, 27: 3056-64. PMID: 17283045, PMCID: PMC1899951, DOI: 10.1128/MCB.01339-06.
  • Circulating stem cells in extremely preterm neonates.Bizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates. Acta Paediatrica (Oslo, Norway : 1992) 2007, 96: 521-5. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.
  • Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation.Herzog EL, Van Arnam J, Hu B, Zhang J, Chen Q, Haberman AM, Krause DS. Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2007, 21: 2592-601. PMID: 17449722, DOI: 10.1096/fj.06-7861com.
  • The commonly used beta-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis.Guo JK, Cheng EC, Wang L, Swenson ES, Ardito TA, Kashgarian M, Cantley LG, Krause DS. The commonly used beta-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis. Transgenic Research 2007, 16: 829-34. PMID: 17594530, DOI: 10.1007/s11248-007-9107-x.
  • Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry.Cogle CR, Theise ND, Fu D, Ucar D, Lee S, Guthrie SM, Lonergan J, Rybka W, Krause DS, Scott EW. Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. Stem Cells (Dayton, Ohio) 2007, 25: 1881-7. PMID: 17478582, DOI: 10.1634/stemcells.2007-0163.
  • Threshold of lung injury required for the appearance of marrow-derived lung epithelia.Herzog EL, Van Arnam J, Hu B, Krause DS. Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells (Dayton, Ohio) 2006, 24: 1986-92. PMID: 16868209, DOI: 10.1634/stemcells.2005-0579.
  • Engraftment of marrow-derived epithelial cells: the role of fusion.Herzog EL, Krause DS. Engraftment of marrow-derived epithelial cells: the role of fusion. Proceedings Of The American Thoracic Society 2006, 3: 691-5. PMID: 17065375, PMCID: PMC2647654, DOI: 10.1513/pats.200605-109SF.
  • Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation.Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2965-70. PMID: 16481627, PMCID: PMC1413802, DOI: 10.1073/pnas.0510758103.
  • Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice.Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells (Dayton, Ohio) 2006, 24: 2299-308. PMID: 16794262, DOI: 10.1634/stemcells.2006-0166.
  • Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells.Tolar J, O'shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood 2006, 107: 4182-8. PMID: 16410448, PMCID: PMC1895284, DOI: 10.1182/blood-2005-08-3289.
  • Bone marrow transplantation can attenuate the progression of mesangial sclerosis.Guo JK, Schedl A, Krause DS. Bone marrow transplantation can attenuate the progression of mesangial sclerosis. Stem Cells (Dayton, Ohio) 2006, 24: 406-15. PMID: 16150922, DOI: 10.1634/stemcells.2005-0139.
  • SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 2006, 108: 2726-35. PMID: 16763212, PMCID: PMC1895586, DOI: 10.1182/blood-2006-02-001594.
  • Prevention of mesangial sclerosis by bone marrow transplantation.Guo JK, Ardito TA, Kashgarian M, Krause DS. Prevention of mesangial sclerosis by bone marrow transplantation. Kidney International 2006, 70: 910-3. PMID: 16850025, DOI: 10.1038/sj.ki.5001698.
  • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8: 315-7. PMID: 16923606, DOI: 10.1080/14653240600855905.
  • Engraftment of bone marrow-derived epithelial cells.Van Arnam JS, Herzog E, Grove J, Bruscia E, Ziegler E, Swenson S, Krause DS. Engraftment of bone marrow-derived epithelial cells. Stem Cell Reviews 2005, 1: 21-7. PMID: 17132871, DOI: 10.1385/SCR:1:1:021.
  • Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons.Radtke C, Akiyama Y, Lankford KL, Vogt PM, Krause DS, Kocsis JD. Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons. Neuroscience Letters 2005, 387: 85-9. PMID: 16084645, PMCID: PMC2605373, DOI: 10.1016/j.neulet.2005.06.073.
  • Engraftment of bone marrow-derived epithelial cells.Krause DS. Engraftment of bone marrow-derived epithelial cells. Annals Of The New York Academy Of Sciences 2005, 1044: 117-24. PMID: 15958704, DOI: 10.1196/annals.1349.015.
  • Bone marrow plasticity revisited: protection or differentiation in the kidney tubule?Krause D, Cantley LG. Bone marrow plasticity revisited: protection or differentiation in the kidney tubule? The Journal Of Clinical Investigation 2005, 115: 1705-8. PMID: 16007248, PMCID: PMC1159151, DOI: 10.1172/JCI25540.
  • The importance of National Blood Foundation funding.Krause DS. The importance of National Blood Foundation funding. Transfusion 2005, 45: 67S-71S. PMID: 16086791, DOI: 10.1111/j.1537-2995.2005.00541.x.
  • Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement.Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005, 7: 393-5. PMID: 16236628, DOI: 10.1080/14653240500319234.
  • Bone marrow-derived cells contribute to epithelial engraftment during wound healing.Borue X, Lee S, Grove J, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise ND, Krause DS. Bone marrow-derived cells contribute to epithelial engraftment during wound healing. The American Journal Of Pathology 2004, 165: 1767-72. PMID: 15509544, PMCID: PMC1618655, DOI: 10.1016/S0002-9440(10)63431-1.
  • Lack of a fusion requirement for development of bone marrow-derived epithelia.Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science (New York, N.Y.) 2004, 305: 90-3. PMID: 15232107, DOI: 10.1126/science.1098925.
  • Lineage specificity of gene expression patterns.Kluger Y, Tuck DP, Chang JT, Nakayama Y, Poddar R, Kohya N, Lian Z, Ben Nasr A, Halaban HR, Krause DS, Zhang X, Newburger PE, Weissman SM. Lineage specificity of gene expression patterns. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6508-13. PMID: 15096607, PMCID: PMC404075, DOI: 10.1073/pnas.0401136101.
  • A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment.Angelopoulou MK, Rinder H, Wang C, Burtness B, Cooper DL, Krause DS. A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment. Transfusion 2004, 44: 555-66. PMID: 15043572, DOI: 10.1111/j.1537-2995.2004.03285.x.
  • Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury.Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004, 110: 3300-5. PMID: 15533866, DOI: 10.1161/01.CIR.0000147780.30124.CF.
  • Plasticity of bone marrow-derived stem cells.Grove JE, Bruscia E, Krause DS. Plasticity of bone marrow-derived stem cells. Stem Cells (Dayton, Ohio) 2004, 22: 487-500. PMID: 15277695, DOI: 10.1634/stemcells.22-4-487.
  • Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice.Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, Krause DS. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Experimental Hematology 2003, 31: 413-20. PMID: 12763140, DOI: 10.1016/s0301-472x(03)00042-0.
  • Plasticity of marrow-derived stem cells.Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003, 102: 3483-93. PMID: 12893756, DOI: 10.1182/blood-2003-05-1664.
  • Bone marrow stem cells contribute to repair of the ischemically injured renal tubule.Kale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. The Journal Of Clinical Investigation 2003, 112: 42-9. PMID: 12824456, PMCID: PMC162291, DOI: 10.1172/JCI17856.
  • Comment on "Little evidence for developmental plasticity of adult hematopoietic stem cells".Theise ND, Krause DS, Sharkis S. Comment on "Little evidence for developmental plasticity of adult hematopoietic stem cells". Science (New York, N.Y.) 2003, 299: 1317; author reply 1317. PMID: 12610282, DOI: 10.1126/science.1078412.
  • A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agents.Lerro KA, Medoff E, Wu Y, Seropian SE, Snyder E, Krause D, Cooper DL. A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agents. Bone Marrow Transplantation 2003, 32: 1113-7. PMID: 14647264, DOI: 10.1038/sj.bmt.1704286.
  • Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library.Ma X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, Perkins AS. Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library. Blood 2002, 100: 833-44. PMID: 12130493, DOI: 10.1182/blood.v100.3.833.
  • Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow.Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Experimental Hematology 2002, 30: 1333-8. PMID: 12423687, DOI: 10.1016/s0301-472x(02)00931-1.
  • Regulation of hematopoietic stem cell fate.Krause DS. Regulation of hematopoietic stem cell fate. Oncogene 2002, 21: 3262-9. PMID: 12032767, DOI: 10.1038/sj.onc.1205316.
  • Bone marrow to liver: the blood of Prometheus.Theise ND, Krause DS. Bone marrow to liver: the blood of Prometheus. Seminars In Cell & Developmental Biology 2002, 13: 411-7. PMID: 12468241, DOI: 10.1016/s1084952102001283.
  • Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium.Grove JE, Lutzko C, Priller J, Henegariu O, Theise ND, Kohn DB, Krause DS. Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 645-51. PMID: 12444022, DOI: 10.1165/rcmb.2002-0056RC.
  • Toward a new paradigm of cell plasticity.Theise ND, Krause DS. Toward a new paradigm of cell plasticity. Leukemia 2002, 16: 542-8. PMID: 11960330, DOI: 10.1038/sj.leu.2402445.
  • Plasticity of marrow-derived stem cells.Krause DS. Plasticity of marrow-derived stem cells. Gene Therapy 2002, 9: 754-8. PMID: 12032704, DOI: 10.1038/sj.gt.3301760.
  • BM-derived stem cells for the treatment of nonhematopoietic diseases.Krause DS. BM-derived stem cells for the treatment of nonhematopoietic diseases. Cytotherapy 2002, 4: 503-6. PMID: 12568982, DOI: 10.1080/146532402761624629.
  • Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001, 105: 369-77. PMID: 11348593, DOI: 10.1016/s0092-8674(01)00328-2.
  • Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production.Perez LE, Rinder HM, Wang C, Tracey JB, Maun N, Krause DS. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood 2001, 97: 1635-43. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.
  • Hematopoietic stem cells can be CD34+ or CD34-.Donnelly DS, Krause DS. Hematopoietic stem cells can be CD34+ or CD34-. Leukemia & Lymphoma 2001, 40: 221-34. PMID: 11426544, DOI: 10.3109/10428190109057921.
  • Suggestions for a new paradigm of cell differentiative potential.Theise ND, Krause DS. Suggestions for a new paradigm of cell differentiative potential. Blood Cells, Molecules & Diseases 2001, 27: 625-31. PMID: 11482876, DOI: 10.1006/bcmd.2001.0425.
  • Breast tumor contamination of PBSC harvests: tumor depletion by positive selection of CD34(+) cells.Burgess J, Mills B, Griffith M, Mansour V, Weaver CH, Schwartzberg LS, Snyder EL, Krause DS, Yanovich S, Prilutskaya M, Umiel T, Moss TJ. Breast tumor contamination of PBSC harvests: tumor depletion by positive selection of CD34(+) cells. Cytotherapy 2001, 3: 285-94. PMID: 12171717, DOI: 10.1080/146532401317070925.
  • Isolation and flow cytometric analysis of T-cell-depleted CD34+ PBPCs.Debelak J, Shlomchik MJ, Snyder EL, Cooper D, Seropian S, McGuirk J, Smith B, Krause DS. Isolation and flow cytometric analysis of T-cell-depleted CD34+ PBPCs. Transfusion 2000, 40: 1475-81. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.
  • Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation.Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology (Baltimore, Md.) 2000, 31: 235-40. PMID: 10613752, DOI: 10.1002/hep.510310135.
  • Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trial.Yanovich S, Mitsky P, Cornetta K, Maziarz RT, Rosenfeld C, Krause DS, Lotz JP, Bitran JD, Williams S, Preti R, Somlo G, Burtness B, Mills B. Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trial. Bone Marrow Transplantation 2000, 25: 1165-74. PMID: 10849529, DOI: 10.1038/sj.bmt.1702415.
  • Liver from bone marrow in humans.Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS. Liver from bone marrow in humans. Hepatology (Baltimore, Md.) 2000, 32: 11-6. PMID: 10869283, DOI: 10.1053/jhep.2000.9124.
  • Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start site.Taranenko N, Krause DS. Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start site. Experimental Hematology 2000, 28: 974-84. PMID: 10989198, DOI: 10.1016/s0301-472x(00)00492-6.
  • Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation.Marshall NA, Howe JG, Formica R, Krause D, Wagner JE, Berliner N, Crouch J, Pilip I, Cooper D, Blazar BR, Seropian S, Pamer EG. Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation. Blood 2000, 96: 2814-21. PMID: 11023516.
  • A phase I study of paclitaxel for mobilization of peripheral blood progenitor cells.Burtness BA, Psyrri A, Rose M, D'Andrea E, Staugaard-Hahn C, Henderson-Bakas M, Clark MB, Mechanic S, Krause D, Snyder E, Cooper RB, Abrantes J, Corringham R, Deisseroth A, Cooper DL. A phase I study of paclitaxel for mobilization of peripheral blood progenitor cells. Bone Marrow Transplantation 1999, 23: 311-5. PMID: 10100573, DOI: 10.1038/sj.bmt.1701589.
  • Functional activity of murine CD34+ and CD34- hematopoietic stem cell populations.Donnelly DS, Zelterman D, Sharkis S, Krause DS. Functional activity of murine CD34+ and CD34- hematopoietic stem cell populations. Experimental Hematology 1999, 27: 788-96. PMID: 10340393, DOI: 10.1016/s0301-472x(99)00032-6.
  • A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.Radomska HS, Satterthwaite AB, Taranenko N, Narravula S, Krause DS, Tenen DG. A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene. Blood 1999, 94: 3772-80. PMID: 10572091.
  • Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation.Garcia-Sanchez F, Pizzorno G, Fu SQ, Nanakorn T, Krause DS, Liang J, Adams E, Leffert JJ, Yin LH, Cooperberg MR, Hanania E, Wang WL, Won JH, Peng XY, Cote R, Brown R, Burtness B, Giles R, Crystal R, Deisseroth AB. Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation. Blood 1998, 92: 672-82. PMID: 9657770.
  • High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study.Chabannon C, Cornetta K, Lotz JP, Rosenfeld C, Shlomchik M, Yanovitch S, Marolleau JP, Sledge G, Novakovitch G, Srour EF, Burtness B, Camerlo J, Gravis G, Lee-Fischer J, Faucher C, Chabbert I, Krause D, Maraninchi D, Mills B, Kunkel L, Oldham F, Blaise D, Viens P. High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study. British Journal Of Cancer 1998, 78: 913-21. PMID: 9764583, PMCID: PMC2063121, DOI: 10.1038/bjc.1998.601.
  • CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb.Krause DS, Mucenski ML, Lawler AM, May WS. CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb. Experimental Hematology 1998, 26: 1086-92. PMID: 9766450.
  • Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.Lawson ND, Krause DS, Berliner N. Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines. Experimental Hematology 1998, 26: 1178-85. PMID: 9808058.
  • Multilineage gene expression precedes commitment in the hemopoietic system.Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes & Development 1997, 11: 774-85. PMID: 9087431, DOI: 10.1101/gad.11.6.774.
  • Gotta find GATA a friend.Krause DS, Perkins AS. Gotta find GATA a friend. Nature Medicine 1997, 3: 960-1. PMID: 9288719, DOI: 10.1038/nm0997-960.
  • Regulation of CD34 expression in differentiating M1 cells.Krause DS, Kapadia SU, Raj NB, May WS. Regulation of CD34 expression in differentiating M1 cells. Experimental Hematology 1997, 25: 1051-61. PMID: 9293902.
  • CD34: structure, biology, and clinical utility.Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood 1996, 87: 1-13. PMID: 8547630.
  • Full-length but not truncated CD34 inhibits hematopoietic cell differentiation of M1 cells.Fackler MJ, Krause DS, Smith OM, Civin CI, May WS. Full-length but not truncated CD34 inhibits hematopoietic cell differentiation of M1 cells. Blood 1995, 85: 3040-7. PMID: 7538813.
  • Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells.Krause DS, Ito T, Fackler MJ, Smith OM, Collector MI, Sharkis SJ, May WS. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells. Blood 1994, 84: 691-701. PMID: 7519070.
  • Acute aspirin overdose: mechanisms of toxicity.Krause DS, Wolf BA, Shaw LM. Acute aspirin overdose: mechanisms of toxicity. Therapeutic Drug Monitoring 1992, 14: 441-51. PMID: 1485363, DOI: 10.1097/00007691-199212000-00001.
  • Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected.Krause DS, Deutsch C. Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected. Journal Of Immunology (Baltimore, Md. : 1950) 1991, 146: 2285-96. PMID: 1848580.
  • Forskolin effects on the voltage-gated K+ conductance of human T cells.Krause D, Lee SC, Deutsch C. Forskolin effects on the voltage-gated K+ conductance of human T cells. Pflügers Archiv : European Journal Of Physiology 1988, 412: 133-40. PMID: 2845353.
  • Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester.Deutsch C, Krause D, Lee SC. Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester. The Journal Of Physiology 1986, 372: 405-23. PMID: 3487642, PMCID: PMC1192770, DOI: 10.1113/jphysiol.1986.sp016016.
  • Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559, DOI: 10.3324/haematol.2022.280499.
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