2024
Review: Evidence-Based Psychosocial Treatments for Childhood Irritability and Aggressive Behavior
Kalvin C, Zhong J, Rutten M, Ibrahim K, Sukhodolsky D. Review: Evidence-Based Psychosocial Treatments for Childhood Irritability and Aggressive Behavior. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.01.009.Peer-Reviewed Original ResearchCognitive-behavioral therapyParent management trainingDialectical behavior therapyChildhood irritabilityChildhood aggressionMaladaptive aggressionPsychosocial treatmentsPsychosocial interventionsReview of evidence-based psychosocial treatmentsDisruptive mood dysregulation disorderEvidence-based psychosocial treatmentsCo-occurring psychopathologySevere mood dysregulationOutpatient mental health servicesChild psychiatric disordersChild mental healthMental health servicesMood dysregulationBehavioral therapyDysregulation disorderPsychiatric disordersDisruptive behaviorWell-powered randomized controlled trialsAggressive behaviorRelevant to clinical practiceAttention-Deficit/Hyperactivity Disorder Symptoms and Anger and Aggression in Russian Adolescents
Isaksson J, Sukhodolsky D, Koposov R, Stickley A, Ramklint M, Ruchkin V. Attention-Deficit/Hyperactivity Disorder Symptoms and Anger and Aggression in Russian Adolescents. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.01.006.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorder symptomsAttention-deficit/hyperactivity disorderLevels of ADHD symptomsComponents of aggressionTrait angerADHD symptomsConduct problemsAttention-deficit/hyperactivityComorbid problemsSocial aggressionHigher levels of trait angerLevels of trait angerTreat attention-deficit/hyperactivity disorderLevels of social aggressionClinically significant levelsAnger ruminationSelf-reported dataProactive aggressionLinear model analysisDisorder symptomsAggressive beliefsIndependent of comorbidityVerbal aggressionAggressive behaviorGeneral linear model analysis
2023
Depressive symptoms and anger and aggression in Russian adolescents
Ruchkin V, Stickley A, Koposov R, Sukhodolsky D, Isaksson J. Depressive symptoms and anger and aggression in Russian adolescents. Child And Adolescent Psychiatry And Mental Health 2023, 17: 130. PMID: 37974287, PMCID: PMC10652468, DOI: 10.1186/s13034-023-00677-w.Peer-Reviewed Original ResearchComorbid mental health problemsMental health problemsAnger ruminationComorbid problemsDepressive symptomsTypes of angerAggressive behaviorOvert aggressive behaviorLevel of depressionAggression variablesVerbal aggressionSocial aggressionRussian adolescentsAngerGeneral population sampleDepressive episodeAggressionInconsistent findingsAdolescentsHealth problemsCurrent major depressive episodeSubthreshold depressive symptomsRuminationMajor depressive episodeSignificant depressive episodeBulimia symptoms and anger and aggression among adolescents
Koposov R, Stickley A, Sukhodolsky D, Ruchkin V. Bulimia symptoms and anger and aggression among adolescents. BMC Public Health 2023, 23: 833. PMID: 37147644, PMCID: PMC10161674, DOI: 10.1186/s12889-023-15664-1.Peer-Reviewed Original ResearchConceptsAnger ruminationBulimia symptomsBN symptomsEating Disorder Diagnostic ScaleState-Trait Anger Expression InventoryAggressive behaviorTrait Anger Expression InventoryDisorder Diagnostic ScaleSelf-report scalesAnger Rumination ScaleCommunity-based adolescentsAnger Expression InventoryBulimia nervosa diagnosisTrait Anger ScaleSocial aggressionPhysical aggressionRumination ScaleHigh angerAngerAnger ScaleRuminationAggression scoresDiagnostic ScaleAggressionAdolescentsAggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety
Kalvin C, Jordan R, Rowley S, Weis A, Ibrahim K, Sukhodolsky D. Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety. Focus On Autism And Other Developmental Disabilities 2023, 38: 168-176. PMID: 38469453, PMCID: PMC10927274, DOI: 10.1177/10883576231165265.Peer-Reviewed Original ResearchAutism spectrum disorderSocial adaptive skillsAdaptive skillsSocial adaptiveAggressive behaviorSocial adaptive functioningSample of childrenAdaptive functioningASD diagnosisSpectrum disorderSocial functioningAge 8SkillsChildrenFunctioningAggressionAnxietyBehaviorParticipantsDisordersFindingsAdaptive
2022
Posttraumatic Stress and Perceived Interpersonal Provocation in Adolescents
Saunderson JM, Stickley A, Sturidsson K, Koposov R, Sukhodolsky DG, Ruchkin V. Posttraumatic Stress and Perceived Interpersonal Provocation in Adolescents. Journal Of Interpersonal Violence 2022, 38: 3191-3214. PMID: 35613735, PMCID: PMC9850389, DOI: 10.1177/08862605221104525.Peer-Reviewed Original ResearchConceptsPosttraumatic stress symptomsPosttraumatic stressStress symptomsProvocation scenariosPosttraumatic symptomsAggressive responsesPhysical aggressionAttribution of intentionalityInterpersonal provocationPeer provocationHostile intentionsChoice of responseAggressive reactionsAdolescent boysAggressive situationsConflict situationsOpposite patternHigh levelsAdolescentsAggressive behaviorAggressionGirlsDaily lifeBoysDifferent patternsAmygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment
Ibrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.Peer-Reviewed Original ResearchConceptsSocial impairmentPrefrontal cortexEmotion processingMaladaptive aggressionAggressive behaviorSocial deficitsEmotion perception taskImplicit emotion processingFace emotion processingFunctional magnetic resonance imagingGreater social impairmentAmygdala-prefrontal connectivityChildhood-onset psychiatric disordersVentral prefrontal cortexDorsolateral prefrontal cortexFearful facesSocial cognitionPerception taskCalm facesSocial cuesTransdiagnostic sampleAmygdala reactivityParent ratingsPFC connectivityDiminished connectivity
2021
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking childrenLarge-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.Peer-Reviewed Original ResearchConceptsLarge-scale functional networksChildhood aggressionSeverity of aggressionIndividual differencesBrain networksAdolescent Brain Cognitive Development (ABCD) studyConnectome-based predictive modelingReactive-Proactive Aggression QuestionnaireEmotion perception taskLarge-scale functional brain networksAssociation of connectivityFunctional networksCognitive Development StudyAggressive behaviorFunctional brain networksIndependent samplesCognitive controlEmotion regulationEmotion processingPerception taskCalm facesMaladaptive aggressionPsychiatric disordersTransdiagnostic sampleFrontoparietal network
2020
Developmental Course and Risk Factors of Physical Aggression in Late Adolescence
Henriksen M, Skrove M, Hoftun GB, Sund ER, Lydersen S, Tseng WL, Sukhodolsky DG. Developmental Course and Risk Factors of Physical Aggression in Late Adolescence. Child Psychiatry & Human Development 2020, 52: 628-639. PMID: 32852728, PMCID: PMC8238740, DOI: 10.1007/s10578-020-01049-7.Peer-Reviewed Original ResearchConceptsRisk factorsMale genderAggressive behaviorLate adolescenceHeavy drinkingEarly adolescenceStudy sampleLongitudinal studyPhysical aggressionAdolescencePhysical aggressive behaviorAdolescentsNorwegian adolescentsPhysical fightsAttention problemsYoung adolescentsDrinkingDevelopmental courseGenderSmokingFactorsStudyThe Role of Gender in the Associations Among Posttraumatic Stress Symptoms, Anger, and Aggression in Russian Adolescents
Isaksson J, Sukhodolsky DG, Koposov R, Stickley A, Ruchkin V. The Role of Gender in the Associations Among Posttraumatic Stress Symptoms, Anger, and Aggression in Russian Adolescents. Journal Of Traumatic Stress 2020, 33: 552-563. PMID: 32384585, DOI: 10.1002/jts.22502.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsAnger ruminationSocial aggressionRussian adolescentsPosttraumatic stress symptomsAggressive behaviorFull path analysisMeasures of angerClinical levelSelf-reported dataInteraction effectsCognitive componentsRole of genderVerbal aggressionStress disorderStress symptomsAngerPath analysisAggressionAdolescentsRuminationDepressive symptomsBoysVeteran populationFixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior
Grazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG. Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 5: 490-498. PMID: 32144044, PMCID: PMC7214205, DOI: 10.1016/j.bpsc.2019.12.018.Peer-Reviewed Original ResearchConceptsWhite matter densityCorpus callosumFiber densityAggressive behaviorCingulum bundleAbnormal interhemispheric connectivityHealthy control childrenWhite matter abnormalitiesAttention-deficit/hyperactivity disorderMiddle cerebellar peduncleSuperior thalamic radiationMagnetic resonance imagingInferior fronto-occipital fasciculusWhole-brain analysisInferior longitudinal fasciculusFronto-occipital fasciculusPotential neural mechanismsWhite matter microstructureDiffusion magnetic resonance imagingInterhemispheric connectivityCortical pathwaysCerebellar peduncleChild Behavior ChecklistThalamic radiationFiber bundle density
2019
Behavioral Interventions for Irritability in Children and Adolescents
Sukhodolsky D, Gladstone T, Marsh C, Cimino K. Behavioral Interventions for Irritability in Children and Adolescents. 2019, 255-274. DOI: 10.1093/med-psych/9780190846800.003.0013.Peer-Reviewed Original ResearchParent management trainingCognitive behavioral therapyDialectical behavior therapySocial problem-solving skillsDisruptive mood dysregulation disorderProblem-solving skillsCo-occurring symptomsDimensions of psychopathologyEmotion regulationEmotion dysregulationAversive patternInterpersonal conflictChild noncomplianceAnger outburstsBehavior therapyBehavioral skillsFamily interactionsBehavioral principlesForm of interventionBehavioral interventionsChildhood disordersAcceptance techniquesManagement trainingAggressive behaviorTreatment studies
2018
Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome
Tudor M, Bertschinger E, Piasecka J, Sukhodolsky D. Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome. Clinical Case Studies 2018, 17: 220-232. DOI: 10.1177/1534650118782438.ChaptersTourette syndromeOppositional defiant disorderAnger outburstsPrimary clinical concernContext of TSBehavioral therapy treatmentCognitive behavioral therapy treatmentCognitive behavioral therapySelect supplementsUseful treatmentMotor ticsDisruptive behaviorClinical concernPosttreatment assessmentBehavioral therapyWeekly sessionsAnxiety disordersTherapy treatmentSyndromeNeurodevelopmental disordersSignificant decreaseDefiant disorderInitial assessmentDisordersAggressive behaviorAn Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
Lewis AS, van Schalkwyk GI, Lopez MO, Volkmar FR, Picciotto MR, Sukhodolsky DG. An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2018, 48: 2748-2757. PMID: 29536216, PMCID: PMC6394231, DOI: 10.1007/s10803-018-3536-7.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderTransdermal nicotineDouble-blind crossover trialAggressive behaviorPreliminary efficacyAggressive symptomsSleep ratingsAggressionSubscale changesNicotinic acetylcholine receptorsNAChR agonistsPrimary outcomeNicotine treatmentCrossover trialExploratory trialΑ7 nAChRsAcetylcholine receptorsNicotineAdultsDisordersPlaceboNAChRsFurther investigationTrials
2016
Cognitive-Behavioral Therapy for a 9-Year-Old Girl With Disruptive Mood Dysregulation Disorder
Tudor ME, Ibrahim K, Bertschinger E, Piasecka J, Sukhodolsky DG. Cognitive-Behavioral Therapy for a 9-Year-Old Girl With Disruptive Mood Dysregulation Disorder. Clinical Case Studies 2016, 15: 459-475. PMID: 29081722, PMCID: PMC5658126, DOI: 10.1177/1534650116669431.Peer-Reviewed Original ResearchDisruptive mood dysregulation disorderCognitive behavioral therapyAttention deficit hyperactivity disorderCo-occurring attention deficit hyperactivity disorderCurrent case studyRelevant treatment studiesNon-episodic irritabilityDeficit hyperactivity disorderUnspecified anxiety disorderClinical presentationCBT sessionsHyperactivity disorderBehavioral therapyMood disruptionAffected youthAnxiety disordersChildhood-onset disordersBooster sessionsTemper outburstsUnique clinical presentationAngerProlonged displayAggressive behaviorAggressionIntake evaluationNeural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward
Sukhodolsky DG, Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyReactive aggressionResearch Domain Criteria (RDoC) constructsSessions of CBTEmotional face perceptionEmotion regulation circuitryBrain-behavior associationsAggressive behaviorFunctional magnetic resonanceFace perceptionNon-RewardTraditional diagnostic categoriesNoGo taskFMRI scanningRDoC constructsElectrophysiological correlatesNeural mechanismsCriterion constructsFunctional neuroimagingBehavioral levelStrategic research prioritiesAge 8AggressionAdolescentsSupportive psychotherapyBehavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents
Sukhodolsky DG, Smith SD, McCauley SA, Ibrahim K, Piasecka JB. Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 58-64. PMID: 26745682, PMCID: PMC4808268, DOI: 10.1089/cap.2015.0120.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyParent management trainingAnger/irritabilityTransdiagnostic approachBehavioral interventionsDisruptive behaviorAggressive behaviorChild disruptive behaviorCallous-unemotional traitsDisruptive behavior disordersTreatment of irritabilityEmotion regulationAversive patternFamily interactionsBehavioral problemsAngerMental health referralsAggressionManagement trainingBehavior disorderMood disordersTreatment targetsIrritabilityChildrenPsychiatric diagnosis
2004
Cognitive-behavioral therapy for anger in children and adolescents: a meta-analysis
Sukhodolsky D, Kassinove H, Gorman B. Cognitive-behavioral therapy for anger in children and adolescents: a meta-analysis. Aggression And Violent Behavior 2004, 9: 247-269. DOI: 10.1016/j.avb.2003.08.005.Peer-Reviewed Original ResearchCognitive behavioral therapySkills trainingAnger-related problemsEffect sizeTreatment outcome studiesEffects of psychotherapySocial skillsAnger experienceMean effect sizeAffective educationProblem-solving treatmentProblem solvingMultimodal interventionHomework techniquesAggressive behaviorMedium rangeAdolescentsDifferential effectsChildren