David Stitelman, MD
Assistant Professor of Surgery (Pediatrics)
Research & Publications
Biography
News
Research Summary
The level of sophistication of prenatal imaging and genetic diagnostics is growing rapidly, however cures for many congenital anomalies lag behind our diagnostic abilities. In developmental defects where babies are born with a disease phenotype, fetal therapy offers an opportunity to prevent or cure these disease. This is an opportunity that is lost after birth.
There are 3 broad aims of my basic science laboratory: 1) In Utero gene editing for the treatment of genetic diseases, 2) In Utero reversal of lung hypoplasia in diaphragmatic hernia 3) Minimally invasive In Utero therapy for spina bifida.
Coauthors
Research Image
Particles Binding Fetal Spina Bifida
Green particles were injected into the amniotic space and can be appreciated binding to the exposed spinal cord in a pre-clinical rat model of spina bifida.
Selected Publications
- Life-Long Transgene Expression in Skeletal Muscle Without Transduction of Satellite Cells Following Embryonic Myogenic Progenitor Transduction by Lentivirus Administered in Utero.Stitelman DH, Brazelton TR, Endo M, Bora A, Traas J, Zoltick PW, Flake AW. Life-Long Transgene Expression in Skeletal Muscle Without Transduction of Satellite Cells Following Embryonic Myogenic Progenitor Transduction by Lentivirus Administered in Utero. Stem Cells And Development 2015, 24:1878-87.
- Robust in vivo transduction of nervous system and neural stem cells by early gestational intra amniotic gene transfer using lentiviral vector.Stitelman DH, Endo M, Bora A, Muvarak N, Zoltick PW, Flake AW, Brazelton TR. Robust in vivo transduction of nervous system and neural stem cells by early gestational intra amniotic gene transfer using lentiviral vector. Molecular Therapy : The Journal Of The American Society Of Gene Therapy 2010, 18:1615-23.
- In utero nanoparticle delivery for site-specific genome editing.Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9:2481.
- Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele.Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli GL, Ahle SL, Freedman-Weiss MR, Luks VL, Saltzman WM, Stitelman DH. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele. Journal Of Pediatric Surgery 2019, 54:80-85.
- Complications in pediatric enteral and vascular access.Farrelly JS, Stitelman DH. Complications in pediatric enteral and vascular access. Seminars In Pediatric Surgery 2016, 25:371-379.
- Surgical tray optimization as a simple means to decrease perioperative costs.Farrelly JS, Clemons C, Witkins S, Hall W, Christison-Lagay ER, Ozgediz DE, Cowles RA, Stitelman DH, Caty MG. Surgical tray optimization as a simple means to decrease perioperative costs. The Journal Of Surgical Research 2017, 220:320-326.
- Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions.Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine : Official Journal Of The American Institute Of Ultrasound In Medicine 2019, 38:2361-2372.
- An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy.Freedman-Weiss MR, Chiu AS, Worhunsky D, Manchisi A, Torres-Maldonado I, Sagnella L, Caty MG, Cowles RA, Ozgediz DE, Christison-Lagay ER, Solomon DG, Stitelman DH. An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy. Journal Of Pediatric Surgery 2020, 55:106-111.